Tag: M.W=400-500

Related Products of 2043-57-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2043-57-4, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

The starting 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl iodide (12.69 g, 26.8 mmol) was dissolved in the mixture of pentane and diethyl ether (90 and 60 mL). The solution was stirred and cooled to -78 C before the solution of 1.6 M tert-butyllithium in hexane (18.54 mL, 29.7 mmol) was added. The mixture was stirred for 15 min and freshly distilled (2-chloroethyl)trichlorosilane (1.5 g, 7.58 mmol) slowly added with stirring. The reaction mixture was stirred for 2 h at -78 C and 1 h at 0 C then it was poured on ice (ca 10 g) and stirred for further 15 min. The resulting biphasic mixture was filtered through silica gel. The layers were separated and aqueous phase was extracted with diethyl ether (3×50 mL). The combined organic phases were dried (MgSO4) and evaporated to afford the product as a yellow oil. The yield was 8.1 g (7.15 mmol, 94%). 1H NMR: delta (ppm) 1.00 (m, 6H, CH2CH2CF2); 1.40 (t, 3JHH=7.7Hz, 2H, CH2CH2Cl); 2.11 (m, 6H, CH2CF2); 3.72 (t, 3JHH=7.7Hz, 2H, CH2Cl). 13C{1H} NMR: delta (ppm) 1.65 (s, CH2CH2CF2); 16.88 (s, CH2CH2Cl); 25.46 (t, 2JCF=24.0Hz, CH2CF2); 40.68 (s, CH2Cl); 106-122 (m, CF3, CF2). 19F NMR: delta (ppm) -127.05 (m, 2F, CF2); -124.09 (bs, 2F, CF2); -123.69 (bs, 2F, CF2); -122.70 (bs, 2F, CF2); -116.94 (m, 2F, CF2); -81.78 (t, 3JFF=11.1Hz, 3F, CF3). 29Si{1H} NMR: delta (ppm) 6.36 (s, 1Si).

The synthetic route of 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane has been constantly updated, and we look forward to future research findings.

Application of 355-43-1,Some common heterocyclic compound, 355-43-1, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-6-iodohexane, molecular formula is C6F13I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

-78 CCooled titanium-dichloride(Cp 2 TiCl 2, 59.8 mg, 0.24 mmol) in ether (2.4 mL)To the solution was added i-propyl magnesium chloride (2.0 M in ether solution, 0.24 mL, 0.48 mmol)1,4-Dioxane (46 [mu] L, 0.54 mmol)And n-tridecafluorohexyl iodide (C 6 F 13 I, 78 muL, 0.36 mmol) were charged, then the temperature was adjusted to -50 C. and stirred for 2 hours.Subsequently, benzaldehyde (20 muL, 0.20 mmol) was added, the temperature was raised, and the mixture was stirred at room temperature for 1 hour.After completion of the reaction, 1 N hydrochloric acid was added to terminate the reaction, followed by extraction with ether three times. The organic layers were combined, dried over sodium sulfate, filtered, and the solvent was distilled off under reduced pressure to obtain a crude product. The obtained crude product was purified by silica gel column chromatography (hexane / ethyl acetate = 20/1 (v / v)) to obtain 2,2,3,3,4,4,5,5,6, 6,7,7,7-tridecafluoro-1-phenyl-1-hydroxyheptane (85.2 mg, yield:> 99%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-6-iodohexane, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2043-57-4, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane, A new synthetic method of this compound is introduced below., Formula: C8H4F13I

Reactions were conducted in a manner similar to Example 1 using the catalysts of the above Preparation Examples 2 to 4. The results of analysis are shown in the table below.

The synthetic route of 2043-57-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Daikin Industries, Ltd.; US6664430; (2003); B1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

These common heterocyclic compound, 355-43-1, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-6-iodohexane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 355-43-1

General procedure: In a Pyrex glass tube were placed TTMSS (0.2 mmol), olefin (0.24 mmol), perfluoroalkyl iodide (0.24 mmol) and CH2Cl2 (5 mL). Then Na2S2O3 (0.5 mmol, 79 mg) and water (1 mL) were added to the mixture. After sealing the tube, the mixture was shaken and then irradiated with a Hg lamp at room temperature. After the reaction was completed, the mixture was extracted with CH2Cl2. The extract was washed with brine, dried over Na2SO4, filtered, and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography to afford pure product.

The synthetic route of 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-6-iodohexane has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 626-44-8, name is 1,3,5-Triiodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 626-44-8, Product Details of 626-44-8

Ethynyl-dC was synthesized following the procedure of Dodd et ah, Org. Biomol. Chem. (2010) 8:663-6665. Ethynyl-dC (0.2 g, 0.796 mmol) was then dissolved in DMF (10 mL) and maintained under nitrogen atmosphere. To this solution NEt (0.1.12 mL, 7.96 mmol), 1,3,5-triiodobenzene (1.11 g, 2.39 mmol), Pd(Ph P)4 (92 mg, 0.080 mmol) and Cul (31 mg, 0.16 mmol) were added sequentially with stirring under nitrogen. The reaction was continued at rt for 2 h and TLC (10percent MeOH in DCM) and LCMS (ES+) indicated complete disappearance of starting material. After removing the solvent under reduced pressure, the residue was chromatographed on silica gel column using 0 – 20percent MeOH gradient over DCM) to get pure product (0.324 g, 70percent). TLC:(10percent MeOH in DCM): Rf = 0.52. LCMS (ES+): (M+H) calculated mass: 579.14 and observed mass: 579.31. 1H-NMR (DMSO-d6): delta 8.82 (bs, 2H, 4-NH2), 8.38 (s, 1H, 6-H), 8.06 (t, 1H, Ar-H), 8.00 (d, 2H, Ar-H), 6.10 (t, 1H, l’-H), 5.22 (d, 1H, 2′-OH), 5.13 (t, 1H, 5′- OH), 4.22 (m, 1H, 4H), 3.80 (m, 1H, 3′-H), 3.63 – 3.68 (m, 1H, 5′-H), 3.55 – 3.61 (m, 1H, 5″-H), 2.15 – 2.22 (m, 1H, 2′-H), 1.98 – 2.04 (m, 1H, 2″-H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,3,5-Triiodobenzene, and friends who are interested can also refer to it.

These common heterocyclic compound, 626-44-8, name is 1,3,5-Triiodobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 626-44-8

General procedure: To a mixture of 3-methoxy-6-(trimethylsilyl)ethynylpyridazine(0.185 g, 0.766 mmol), 1,3,5-triiodobenzene (0.100 g, 0.219 mmol), Pd2(dba)3(0.020 g, 0.021 mmol), CuI (0.004 g, 0.021 mmol), PPh3 (0.005 g, 0.021 mmol) under nitrogen atmosphere were added dry Et3N (10 mL) and toluene (10 mL). The reaction mixture was cooled to 0 C and TBAF (1 M in THF, 1.53 mL) was added dropwise and the reaction mixture was stirred for 10 min. The solution was heated to50C for 48 h. The reaction was cooled,filtered through Celiteandevaporated under reduced pressure. The crude product was purified by column chromatography on silica gel (petroleum ether/ethyl acetate2:1) to give the title compound1as a brown solid (0.055 g, 55percent). Mp: >260C. IR (cm1, neat): 1400, 2952, 2219,1582, 1538, 1466, 1423, 1403, 1335, 1296, 1166, 1133, 1098, 1010, 965,873, 841, 759, 673;1H NMR (300 MHz, CDCl3)d(ppm): 4.19 (s, 9H),7.00 (d,J9.3 Hz, 3H), 7.54 (d,J9.3 Hz, 3H) 7.84 (s, 3H);13C NMR(75 MHz, CDCl3)d(ppm): 55.3, 87.3, 89.8, 116.8, 123.3, 132.6, 135.6,143.3, 163.7; MS (TOF MS ESI);m/z(rel int. percent): (MH) 475 (100),516 (MHacetonitrile)

The synthetic route of 1,3,5-Triiodobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Article; Martin, Flavia-Adina; Baudequin, Christine; Fiol-Petit, Catherine; Darabantu, Mircea; Ramondenc, Yvan; Ple?, Nelly; Tetrahedron; vol. 70; 15; (2014); p. 2546 – 2555;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2043-57-4, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane, A new synthetic method of this compound is introduced below., Product Details of 2043-57-4

1-Methylimidazole (4.32 g, 0.52 mol) was partially dissolved in reagent-grade toluene (50 ml) in a large round-bottomed flask and stirred vigorously. 1,1,1,2,2,3,3,4,4,5,5,6, 6-Tridecafluoro-8-iodooctane (26 g, 0.053 mol) was added, and the mixture was heated under reflux at 110 degrees C for 24 hours. The solvent was removed under vacuum giving l-methyl-3- (3,3,4,4,5,5,6,6,7,7,8,8,8- tridecafluorooctyl) imidazolium iodide (30.5 g) as a waxy solid. Potassium 1,1,2,2- tetrafluoroethanesulfonate (TFES-K, 12 g) was added to reagent grade acetone (100 ml) in a separate round- bottomed flask, and this solution was carefully added to the l-methyl-3- (3,3,4,4,5,5, 6, 6,7,7, 8, 8, 8- tridecafluorooctyl) imidazolium iodide which had been dissolved in acetone (50 ml) . The reaction mixture was heated under reflux for approximately 16 hours. The reaction mixture was then filtered using a large frit glass funnel to remove the white KI precipitate formed, and the filtrate was placed on a rotary evaporator for 4 hours to remove the acetone. The oily liquid was then filtered a second time to yield the product, as shown by proton NMR.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; WO2009/32959; (2009); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 88-82-4, name is 2,3,5-Triiodobenzoic acid, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 88-82-4

Amide derivatives (Compounds 8 and 9) that correspond to the ester, Compound 5, are generated. Compounds 6 and 7 are synthesized and their coupling to 2,3,5-triiodobenzoic acid is carried out

According to the analysis of related databases, 88-82-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Vanderbilt University; US2005/2859; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2043-57-4, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane

In a 20 liter reaction vessel, 1500 g (3.16 mol) of 1H, 1H, 2H, 2H-perfluorohexylethyl iodide and 3 L of dimethylformamide were added, and 230 g (3.5 mol) of sodium azide was added. The mixture was stirred at room temperature for 3 h, GC showed complete conversion, selectivity 99%, water 3 L, allowed to stand, layered, the aqueous layer was washed three times with methyl tert-butyl ether,The three washed organic layers were washed three times with brine to give crude 1H, 1H, 2H, 2H-perfluorooctyl azide containing methyl tert-butyl ether.

According to the analysis of related databases, 2043-57-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Juhua Group Technology Center; Wang Zhiguang; Jiang Yun; (6 pag.)CN106278921; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Chemistry is an experimental science, Formula: C8H4F13I, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 2043-57-4, Name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane, molecular formula is C8H4F13I, belongs to iodides-buliding-blocks compound. In a document, author is Khan, Khalid Mohammed.

A convenient iodination method for alcohols using cesium iodide/methanesulfonic acid and its comparison using cesium iodide/p-toluenesulfonic acid or cesium iodide/aluminium chloride

In situ generation of hydrogen iodide from cesium iodide/methanesulfonic acid was found to be an attractive reagent combination for the conversion of alkyl, allyl, and benzyl alcohols to their corresponding iodides under mild conditions. The method is compared with that using cesium iodide/p-toluenesulfonic acid or cesium iodide/aluminium chloride.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 2043-57-4. Formula: C8H4F13I.