Tag: M.W=400-500

Electric Literature of 2043-57-4,Some common heterocyclic compound, 2043-57-4, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane, molecular formula is C8H4F13I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(2) In another 20 liters of pressure-resistant reactor, 2000 g of perfluorohexylethyl iodide obtained in (1) was added, and the mixture was heated to 125 C with stirring. 6000 g of 4% aqueous dimethylformamide was added to the reactor at a rate of 80 g/min by a metering pump, and the temperature was controlled at 125 to 130 C, the pressure was not higher than 0.35 MPa, and the reaction was continued for 32 hours, and the heating was removed. Neutralize with 2222 g of 11.3% potassium hydroxide aqueous solution, separate the organic phase, and then wash once with 2222 g of deionized water, separate the organic phase, and remove the light component to obtain 1420 g of fluoroalcohol 88% and fluorinated olefin 5.5%. Intermediate product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane, its application will become more common.

Reference:
Patent; Jinan Qifu New Materials Co., Ltd.; Shandong Chemical Institute; Li Haijing; Zhang Liting; (6 pag.)CN108911983; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 355-43-1, The chemical industry reduces the impact on the environment during synthesis 355-43-1, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-6-iodohexane, I believe this compound will play a more active role in future production and life.

In a typical procedure compound 2 (50.0 g, 0.147 mol), 10% aqueous solution of Na2S2O5 (140 mL) and perfluoro hexyl iodide (67.0 g, 0.150 mol) was added into a 1.0 L flask and the mixture heated at 80 C under stirring. AIBN (1.0 g, 6.1 mol) was slowly added (four portions of 0.2 g each in 1 h). It was left to react at 80 C for 3 h under stirring. At the end the organic phase containing 110.9 g (0.14 mol, Y = 96%) of 5 was separated from the aqueous one and washed with water. Compound 5 (20.0 g, 0.025 mol) was charged in the autoclave and a solution containing 70 mL ethylacetate, 50 mL methanol, and 7 g of sodium acetate was added; 1.0 g of Pd/C (10%) suspended in 20 mL of methanol was charged. The mixture was left to react at room temperature at a pressure of 3 bar of hydrogen for 15 h. The raw mixture was filtered and solvents were removed with rotary evaporation. Successively 100 mL of water and 100 mL of Et2O were added to the solid residue. The organic phase was dried with magnesium sulphate and the solvent layer was eliminated under rotary evaporation. The crude material was distilled under vacuum in order to obtain 13.5 g (0.020 mol) of product 8 with a yield of 82%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-6-iodohexane, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Lazzari, Dario; Cassani, Maria Cristina; Solinas, Gavino; Pretto, Marisa; Journal of Fluorine Chemistry; vol. 156; (2013); p. 34 – 37;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 626-44-8, name is 1,3,5-Triiodobenzene, A new synthetic method of this compound is introduced below., COA of Formula: C6H3I3

1,3,5-triiodobenzene (22.8 g, 0.05 mol) under nitrogen protection,Pd(dppf)Cl2.CH2Cl2 (2.0g, 0.0025mol) and CuI (10.0g, 0.052mol), isopropylamine (200ml) were added to tetrahydrofuran (500ml), sodium benzotriazole (22.5g, 0.16mol) The mixture was slowly added, and the mixture was heated to 80 ° C and stirred for 12 hours. TLC showed the end of the reaction, and a silica gel column (PE/EA = 2/1 to 1/1) afforded Compound 11 (15.6 g, yield 73percent).

The synthetic route of 626-44-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shanghai Hehui Optoelectric Co., Ltd.; Wu Fan; (29 pag.)CN108623600; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Some common heterocyclic compound, 2043-57-4, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane, molecular formula is C8H4F13I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C8H4F13I

General procedure: Perfluoroalkylethyl iodide (1.0 mol equiv.) (3-4 mmol) and NaN3 (1.2 mol equiv.) were added to dry DMSO (2 mL) in a 10 mL CEM microwave glass reactor tube, a magnetic stirring bead added and the system sealed. The tube was subjected to stirring and microwave irradiation at 250 W and 65 C for 1 h then immediately cooled to r.t.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2043-57-4, its application will become more common.

Reference:
Article; Francis, Dominic V.; Miles, D. Howard; Mohammed, Adnan I.; Read, Roger W.; Wang, Xiaobei; Journal of Fluorine Chemistry; vol. 132; 11; (2011); p. 898 – 906;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 2043-57-4, A common heterocyclic compound, 2043-57-4, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane, molecular formula is C8H4F13I, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A 50 mL three-necked round bottom flask equipped with a stirrer and a dropping funnel was charged with 0.01 mol (0.97 g) of diallyl Amine and 20 mL of anhydrous ether were added to the raw material in an amount of 10% tetrabutylammonium bromide as the catalyst. The reaction was cooled with an ice-water bath. 0.011 mol (5.22 g) of perfluorohexyl ethyl iodide was slowly added dropwise to the reaction system through a dropping funnel in. After dripping, it rises to room temperature. The reaction was stirred for another 6 h. GC tracking reaction end point. After completion of the reaction, the reaction mixture was oxidized with 2% Sodium washing. The organic layer was separated, washed with water, then dried over anhydrous magnesium sulfate, and the solvent was removed by vacuum distillation and excess Fluorohexyl ethyl iodide. 4.16 g of a pale yellow liquid product was obtained in a yield of 93.9%.

The synthetic route of 2043-57-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guangzhou Liwen Technology Co., Ltd.; Jiangsu Liwen Chemical Co., Ltd.; Jiangxi Liwen Chemical Co., Ltd.; Liang Haibo; Chen Yixin; Xie Wenjian; Wang Jiangbing; Xin Weixian; Chen Xinzi; (21 pag.)CN106866470; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 355-43-1, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-6-iodohexane, A new synthetic method of this compound is introduced below., Formula: C6F13I

General procedure: In a Pyrex glass tube were placed olefin (0.2 mmol), perfluoroalkyl iodide (1.0 mmol), and CH2Cl2 (5 mL). Then Na2S2O3 (0.5 mmol, 79 mg) and water (1 mL) were added to the mixture. After sealing the tube, the mixture was shaked and then irradiated with a Hg lamp at room temperature. After the reaction was completed, the mixture was extracted with CH2Cl2. The extract was washed with brine, dried over Na2SO4, filtered, and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography to afford pure product.

The synthetic route of 355-43-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yajima, Tomoko; Jahan, Ishrat; Tonoi, Takayuki; Shinmen, Manami; Nishikawa, Aya; Yamaguchi, Kanako; Sekine, Izumi; Nagano, Hajime; Tetrahedron; vol. 68; 34; (2012); p. 6856 – 6861;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 2043-57-4, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2043-57-4, category: iodides-buliding-blocks

The alcohol of formula (2-2) was synthesized by referring to JP-A-2010-280799. Concretely, 2- (perfluorohexyl) ethyl iodide (manufactured by Daikin Industries, Ltd., 5.4 g, 11.4 mmol), 4-hydroxythiophenol (1.3 g, 10.3 mmol), potassium carbonate (1.7 g, 12.0 mmol) was dissolved in acetone (50 mL) and heated under reflux for 24 hours. After filtration of the reaction mixture, the solvent was distilled off under reduced pressure by an evaporator. Ethanol was added to the residue and dissolved by heating, water was added, and the solution was cooled with ice water to precipitate crystals. The precipitated crystals were collected by suction filtration to obtain an alcohol (4.2 g, 86%) of the formula (2-2).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Yamaguchi University; kamoto, Hiroaki; Morita, Yuki; (21 pag.)JP2016/175864; (2016); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

These common heterocyclic compound, 355-43-1, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-6-iodohexane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-6-iodohexane

General procedure: To a 25 mL of Schlenk tube equipped with a Teflon septum were added Ru(bpy)3Cl2 (1.5 mg, 0.5 mol%), Cs2CO3 (130 mg, 1.0 equiv) and 1 (0.4 mmol, 1.0 equiv) followed by DMSO 3.0 mL) with stirring. Perfluoroalkyl iodine (2.0 equiv.) was then added subsequently under Ar. The Schlenk tube was screw capped and the reaction was then under irradiated with a 12 W blue LEDs (460 nm-470 nm). After stirring for 24 h, the reaction mixture was diluted with ethyl acetate, washed with brine, the organic phases were collected and dried over anhydrous Na2SO4, filtered and concentrated. The residue was purified with silica gel chromatography to provide pure product.

The synthetic route of 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-6-iodohexane has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhang, Ben-Hou; Kong, Jing-Jing; Huang, Yang; Lou, Yue-Guang; Li, Xiao-Fei; He, Chun-Yang; Chinese Chemical Letters; vol. 28; 8; (2017); p. 1751 – 1754;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 63262-06-6, name is 1,4-Dibromo-2,5-diiodobenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 63262-06-6

Under a nitrogen atmosphere, to a 50mL three-necked flask 1,4-dibromo-2,5-di-iodobenzene 219 mg (0.45 mmol) and diethyl ether (5 ml) was added and cooled to -78 C..Thereafter, it was added dropwise n- butyllithium 0.54ml at the same temperature (1.66 M hexane solution, 0.90 mmol), and stirred for 1 hour.At Thereafter the same temperature, it was added dropwise synthesized bis previous step was dissolved in diethyl ether (1ml) (2-n- hexyl-4-thienyl) disulfide 359 mg (0.90 mmol), and stirred at room temperature for 12 hours.The reaction by the addition of water was stopped, after extraction with diethyl ether, and the organic layer was dried over anhydrous sodium sulfate.And concentrated under reduced pressure, the resulting residue was purified by silica gel column chromatography (hexane), 1,4-bis [(2-n-hexyl-4-thienyl) sulfanyl] of 2,5-dibromobenzene yellow solid 228mg was obtained (80% yield).

The synthetic route of 63262-06-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TOSOH CORPORATION; HACHIYA, HITOSHI; WATANABE, MAKOTO; UEDA, SAORI; (16 pag.)JP2015/227297; (2015); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 88-82-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 88-82-4 name is 2,3,5-Triiodobenzoic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Amide derivatives (Compounds 8 and 9) that correspond to the ester, Compound 5, are generated. Compounds 6 and 7 are synthesized and their coupling to 2,3,5-triiodobenzoic acid is carried out

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,3,5-Triiodobenzoic acid, and friends who are interested can also refer to it.

Reference:
Patent; Vanderbilt University; US2005/2859; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com