Tag: M.W=400-500

Related Products of 626-44-8,Some common heterocyclic compound, 626-44-8, name is 1,3,5-Triiodobenzene, molecular formula is C6H3I3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 3 (210.4 mg, 0.461 mmol), 4 (0.25 mL, 1.75 mmol), PdCl2(PPh3)2 (48.5 mg, 0.069 mmol), PPh3 (36.3 mg, 0.138 mmol), CuI (13.2 mg, 0.069 mmol), Et3N (2.0 mL), and THF (5.0 mL) was placed in a round-bottom flask equipped with a magnetic stirring bar. After degassing the reaction mixture several times, the reaction was carried out at 40 ¡ãC for 16 h with stirring. After the reaction mixture was cooled to room temperature, CHCl3 was added to the mixture. Precipitates were removed by filtration, and the solvent was evaporated. The residue was purified by SiO2 column chromatography (hexane as an eluent, Rf = 0.15), and crystallization was carried out to afford 5 as a colorless solid (172.5 mg, 0.373 mmol, 81percent).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,3,5-Triiodobenzene, its application will become more common.

Reference:
Article; Morisaki, Yasuhiro; Gon, Masayuki; Tsuji, Yuichi; Kajiwara, Yuichi; Chujo, Yoshiki; Tetrahedron Letters; vol. 52; 42; (2011); p. 5504 – 5507;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 2043-57-4,Some common heterocyclic compound, 2043-57-4, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane, molecular formula is C8H4F13I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Under an Ar atmosphere, BuLi (7.3 mL, 19.0 mmol, 2.6 M in hexanes) was added to a THF solution (50 mL) of iPr2NH (0.81 mL, 11.3 mmol) at -78 C and stirred for 20 min at the same temperature. The reaction mixture was stirred for 30 min at 0 C and then cooled to -78 C. A THF solution (30 mL) of 4,4′-dimethyl-2,2′-bipyridine (0.92 g, 5.0 mmol) was added and stirred for 3 h at the same temperature, and then 3-(perfluorohexyl)ethyl iodide (4.8 g, 10.2 mmol) was added. The reaction mixture was stirred at -78 C for 1 h and stirred at room temperature overnight. The mixture was diluted with brine and extracted with Et2O (30 mL¡Á3). The organic layer was dried over Na2SO4 and the solvent was removed under the reduced pressure. The residue was purified by recrystallization from MeOH to give ligand II (0.53 g, 12%) as brown scales. Mp 112-115 C; 1H NMR (400 MHz, CDCl3/TMS) delta (ppm): 2.02-2.19 (m, 8H), 2.82 (t, 4H, J=7.8 Hz), 7.17 (dd, 2H, J=5.3, 1.7 Hz), 8.28 (s, 2H), 8.61 (d, 2H, J=5.3 Hz); 13C{1H} NMR (100 MHz, CDCl3/TMS) delta (ppm): 21.0, 30.4 (t, J=22.2 Hz), 34.6, 121.1, 123.8, 149.3, 150.6, 156.3; LRMS (EI) m/z: 876 (M+); HRMS: calcd for C28H18F26N2: 876.1055, found: 876.1044; IR (neat): 3800, 3674, 3587, 3438, 2194, 2157, 1962, 1651, 1107, 843 cm-1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane, its application will become more common.

Reference:
Article; Inamoto, Kiyofumi; Nozawa, Kanako; Kadokawa, Jun; Kondo, Yoshinori; Tetrahedron; vol. 68; 38; (2012); p. 7794 – 7798;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2043-57-4, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C8H4F13I

Thiol No.1 was 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluoro-octane-1-thiol which was made as follows. Under nitrogen thiourea (1.1 equivalents) and 1-iodo-2-perfluorohexylethane (1 equivalent) were added to a degassed mixture of dimethoxyethane (DME, 9 parts) and water (1 part). The reaction mixture was held at reflux temperature for 8 hours. Most of the DME was distilled off and the distillation residue was allowed to cool to ambient temperature. Under stirring a solution of sodium methoxide in methanol (1 molar, 1.1 equivalents) was added to the suspension. Degassed water was added to the mixture. Thiol No.1 was collected quantitatively as the fluorous bottom layer.The spectroscopical data for the product were in agreement with those published elsewhere (J. Fluorine Chem. 1985, 28, 341-355 and J. Fluorine Chem. 1989, 42, 59-68).

The synthetic route of 2043-57-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPNAY; US2009/143608; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 355-43-1, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-6-iodohexane, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 355-43-1, SDS of cas: 355-43-1

General procedure: A 25 mL tube was charged with the appropriate N-arylacrylamide arylacrylamide1 (0.3 mmol), RFI 2 (0.9 mmol), Cs2CO3 (0.3 mmol), andeosin Y (5% mmol). DMA (2 mL) was added and the tube waspurged with argon. The mixture was stirred and irradiated witha 26 W compact LED lightbulb at 65 C for 16 h until the reactionwas completed. H2O (10 mL) and CH2Cl2 (10 mL) wereadded successively to the cooled reaction mixture, the organicphase was separated, and the aqueous phase was furtherextracted with CH2Cl2 (3 ¡Á 30 mL). The combined organic layerswere dried (Mg2SO4) and concentrated under vacuum. Theresidue was purified performed by flash column chromatography(silica gel).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-6-iodohexane, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Yang, Zhiyong; Tang, Anjiang; Synlett; vol. 30; 9; (2019); p. 1061 – 1066;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 88-82-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 88-82-4 name is 2,3,5-Triiodobenzoic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

[0251] Several approaches have been used to synthesize iodine-containing X-ray contrast agents. The esterification of the ethanolamide of indomethacin has been accomplished by carbodiimide coupling of indomethacin ethanolamide (Compound 4) and 2,3,5-triiodobenzoic acid (FIG. 7). The product, Compound 5, is a potent and highly selective COX-2 inhibitor (IC50 for COX-2=50 nM, IC50 for COX-1>50 muM). Higher concentrations are required for inhibition of COX-2 in the RAW264.7 macrophage cell line (IC50=3.5 muM), which might be related to the hydrophobicity of the compound (cLogP=8.5). Amide derivatives (Compounds 8 and 9) that correspond to the ester, Compound 5, are generated. Compounds 6 and 7 are synthesized and their coupling to 2,3,5-triiodobenzoic acid is carried out

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,3,5-Triiodobenzoic acid, and friends who are interested can also refer to it.

Reference:
Patent; Vanderbilt University; US2005/2859; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 2043-57-4, A common heterocyclic compound, 2043-57-4, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane, molecular formula is C8H4F13I, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(Y) Synthesis of 1-methyl-3-(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)imidazolium1,1,2,2-tetrafluoroethanesulfonate 1-Methylimidazole (4.32 g, 0.52 mol) was partially dissolved in reagent-grade toluene (50 mL) in a large round-bottomed flask and stirred vigorously. 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane (26 g, 0.053 mol) was added, and the mixture was heated under reflux at 110 C. for 24 hours. The solvent was removed under vacuum giving 1-methyl-3-(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)imidazolium iodide (30.5 g) as a waxy solid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Harmer, Mark Andrew; Junk, Christopher P.; US2007/100181; (2007); A1;; ; Patent; Harmer, Mark Andrew; Junk, Christopher P.; Vickery, Jemma; US2007/100184; (2007); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2043-57-4, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C8H4F13I

Specifically, first, 20.00 g (42.19 mmol) of 2- (perfluorohexyl) ethyl iodide and 5.32 g (42.19 mmol) of 4-mercaptophenol were placed in a 250 mL round bottom flask,Was dissolved in 100 mL of acetone, and 5.83 g (42.19 mmol) of potassium carbonate was added thereto, and the mixture was refluxed at 70 C. for 24 hours. Disappearance of the raw material was confirmed by HPLC, and cyclopentyl methyl ether, water and 1 N hydrochloric acid were added thereto. The aqueous layer was removed and the remaining organic layer was washed with water and saturated brine. After washing, the organic layer was allowed to stand for 1 hour by using anhydrous magnesium sulfate and dried, then the magnesium sulfate was removed using a fold filtration, and the obtained solution was concentrated under reduced pressure. The residue obtained by concentration was purified by column chromatography (packing agent: silica gel, developing solvent: chloroform, the same shall apply hereinafter) to obtain 19.13 g (40.51 mmol) of compound (B) as a colorless solid. The melting point of the obtained compound (B) (measured by a trace amount melting point measuring apparatus “Yanaco Micro Melting Point Apparatus MP-J3”, the same applies hereinafter) was 68 to 70 C., and the yield was 96%. Further, an infrared spectrophotometer (trade name “IRPrestige-21” manufactured by Shimadzu Corporation)Similarly. “JEOL JMN-LA 500” manufactured by Nippon Denshi Co., Ltd. When the solvent is CDCl 3, the internal standard is tetramethylsilane, and when the solvent is DMSO-d 6, the internal standard is DMSO-H 2.49 ppm, the same shall apply hereinafter), the compound (B) was identified.

The synthetic route of 2043-57-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Yamaguchi University; Okamoto, Hiroaki; Morita, Yuki; (74 pag.)JP2016/175873; (2016); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 355-43-1, The chemical industry reduces the impact on the environment during synthesis 355-43-1, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-6-iodohexane, I believe this compound will play a more active role in future production and life.

General procedure: To a 25 mL of Schlenk tube equipped with a Teflon septum were added Ru(bpy)3Cl2 (1.5 mg, 0.5 mol%), Cs2CO3 (130 mg, 1.0 equiv) and 1 (0.4 mmol, 1.0 equiv) followed by DMSO 3.0 mL) with stirring. Perfluoroalkyl iodine (2.0 equiv.) was then added subsequently under Ar. The Schlenk tube was screw capped and the reaction was then under irradiated with a 12 W blue LEDs (460 nm-470 nm). After stirring for 24 h, the reaction mixture was diluted with ethyl acetate, washed with brine, the organic phases were collected and dried over anhydrous Na2SO4, filtered and concentrated. The residue was purified with silica gel chromatography to provide pure product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-6-iodohexane, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zhang, Ben-Hou; Kong, Jing-Jing; Huang, Yang; Lou, Yue-Guang; Li, Xiao-Fei; He, Chun-Yang; Chinese Chemical Letters; vol. 28; 8; (2017); p. 1751 – 1754;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 2043-57-4, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2043-57-4, Computed Properties of C8H4F13I

1-Methylimidazole (4.32 g, 0.52 mol) was partially dissolved in reagent-grade toluene (50 ml) in a large round-bottomed flask and stirred vigorously. 1, 1, 1,2,2,3,3,4,4,5,5, 6, 6-Tridecafluoro-8-iodooctane (26 g, 0.053 mol) was added, and the mixture was heated under reflux at 110 degrees C for 24 hours. The solvent was removed under vacuum giving l-methyl-3- (3, 3, 4, 4, 5, 5, 6, 6, 7, 7, 8, 8, 8 -tridecafluorooctyl) imidazolium iodide (30.5 g) as a waxy solid. Potassium 1,1,2,2- tetrafluoroethanesulfonate (TFES-K, 12 g) was added to reagent grade acetone (100 ml) in a separate round-bottomed flask, and this solution was carefully added to the 1- methyl-3- (3, 3, 4, 4, 5, 5, 6, 6, 7, 7, 8,8,8- tridecafluorooctyl) imidazolium iodide which had been dissolved in acetone (50 ml) . The reaction mixture was heated under reflux for approximately 16 hours. The reaction mixture was then filtered using a large frit glass funnel to remove the white KI precipitate formed, and the filtrate was placed on a rotary evaporator for 4 hours to remove the acetone. The oily liquid was then filtered a second time to yield the product, as shown by proton NMR.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; WO2009/32962; (2009); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 63262-06-6, A common heterocyclic compound, 63262-06-6, name is 1,4-Dibromo-2,5-diiodobenzene, molecular formula is C6H2Br2I2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A nitrogen gas atmosphere was prepared in a reaction vessel equipped with a stirrer, then, a compound 1 (22.0 g), 2-bromophenylboronic acid (19.1 g), tetrakis(triphenylphosphine)palladium(0) (2.43 g) and tetrahydrofuran (440 mL) were added, and the mixture was heated at 45 C. Thereafier, to this was added silver carbonate (47.2 g), and the mixture was refluxed for 3 hours. The resultant reaction liquid was cooled down to room temperature, then, water and toluene were added, and the mixture was stirred at room temperature. Thereafter, the aqueous layer was separated, and the organic layer was washed with a saturated sodium chloride aqueous solution. To the resultant organic layer was added sodium sulfate, then, the layer was filtrated, and concentrated to obtain a coarse product. Thereafier, to this were added toluene and activated carbon, and the mixture was stirred at 70 C. for 1 hour. Thereafter, the mixture was filtrated through a filter pre-coated with Celite. The resultant residue was washed with toluene several times. The resultant washing liquid was concentrated, then, recrystallized using toluene, thereby obtaining 17.9 g of a compound 2 (yield:74%, purity: 98.9%) as a white solid. ?H-NMR (DMSO-d5, 300 MHz): oe (ppm)7.43 (4H, t), 7.49 (2H, t), 7.71 (2H, d), 7.76 (2H, d).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Sumitomo Chemical Company, Limited; USUI, Motoaki; FUKUSHIMA, Daisuke; TANAKA, Shin-ya; (58 pag.)US2017/137566; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com