Tag: M.W=400-450

Page, J. E. published the artcilePharmacology of diethylamine salt of 3,5-diiodo-4-pyridone-N-acetic acid, Related Products of iodides-buliding-blocks, the publication is Quarterly Journal of Pharmacy and Pharmacology (1948), 283-91, database is CAplus.

The diethylamine salt (I) is more toxic to mice than the diethanolamine salt (II) intravenously. The cardiac, blood pressure, and respiratory effects of the 2 salts are closely similar. The rate of excretion of I is slower than that of II.

Quarterly Journal of Pharmacy and Pharmacology published new progress about 101-29-1. 101-29-1 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Carboxylic acid,Ketone, name is 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, and the molecular formula is C7H5I2NO3, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Billion, H. published the artcileThe distribution of radioactive Perabrodil M in humans and its application in renal clearance, Application of 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, the publication is Klinische Wochenschrift (1955), 1089-93, database is CAplus.

Human subjects were treated intravenously with 200-2250 mg. of Perabrodil M (I) labeled with radioactive iodine. Serum and urine radioactivity was determined for 180 min. as a measure of the I concentration Excretion of I in the urine paralleled the decline in serum I concentration At dose levels of 200-400 mg. and 2250 mg. the urinary excretion of I was 79.1 and 94.1%, resp., in 3 hrs., with half-time values of 44.5 and 32 min., resp. Renal clearance values obtained by slow infusion of I compared favorably with those obtained using p-aminohippuric acid.

Klinische Wochenschrift published new progress about 101-29-1. 101-29-1 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Carboxylic acid,Ketone, name is 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, and the molecular formula is C7H5I2NO3, Application of 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Shanazarov, K. S. published the artcilePreparation of esters of pelvirinic acid [3,5-diiodo-4-oxo-1(4H)-pyridineacetic acid], Application In Synthesis of 101-29-1, the publication is Khimiko-Farmatsevticheskii Zhurnal (1968), 2(4), 40-2, database is CAplus.

Esterification of 3,5-diiodo-4-oxo-1(4H)-pyridineacetic acid (I) was accomplished in the presence of KU 2 catalyst. The following esters were prepared (% yield and m.p. given): Pr, 94.8, 188-9°; iso-Pr, 91.2, 214-15°; and Bu, 87, 194°.

Khimiko-Farmatsevticheskii Zhurnal published new progress about 101-29-1. 101-29-1 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Carboxylic acid,Ketone, name is 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, and the molecular formula is C14H20BNO4, Application In Synthesis of 101-29-1.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Khlopin, N. Ya. published the artcileThe determination of the number of electrons participating in the reduction of stypticin at a dropping mercury electrode. II, Application In Synthesis of 101-29-1, the publication is Zhurnal Obshchei Khimii (1958), 264-7, database is CAplus.

cf. C.A. 52, 8796f. With the aid of polarographic coulometry, it was found that in the reduction process of stypticin at a small Hg electrode two electrons were active. On the basis of the structure of stypticin, this reaction took place at the expense of the double bond of the heterocyclic ring.

Zhurnal Obshchei Khimii published new progress about 101-29-1. 101-29-1 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Carboxylic acid,Ketone, name is 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, and the molecular formula is C7H5I2NO3, Application In Synthesis of 101-29-1.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Swirska, Alicja published the artcileFuran derivatives of 3,5-diiodo-1,4-dihydro-4-oxo-1-pyridineacetic acid, Name: 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, the publication is Acta Poloniae Pharmaceutica (1962), 19(6), 549-52, database is CAplus.

I and II were prepared and tested as radiopaque contrast media with neg. results. Na 3,5-diiodo-1,4-dihydro-4-oxo-1-pyridineacetate (21.3 g.), 11.1 g. 5-iodofurfural, and 60 ml. Ac₂O was heated at 130-5° for 6 hrs., the mixture diluted with 30 ml. H₂O and steam-distilled, and the residue acidified with HCl to give 33.5 g. (crude) I, m. 162-3° (decomposition) (MeOH). (3,5-Diiodo-1,4-dihydro-4-oxo-1-pyri-dineacetyl)hydrazine (0.02 mole) was dissolved in 700 ml. H₂O and 10 ml. H₂SO₄ and the solution rapidly cooled to 30-40°, treated with 0.02 mole of a furan aldehyde in 200 ml. MeOH, and refluxed (or left at room temperature ) 1 hr. to yield II (R, reaction temperature, % yield, and m.p. (decomposition) given): iodo, 90-5°, 95, 251-2° (dilute C₅H₅N); Br, 90-5°, 97, 245-6° (dilute C₅H₅N); NO₂, 80-90°, 92, 263-4° (dilute C₅H₅N); Me, 20-5°, 84, 262-4° (dilute C₅H₅N); H, 20-5°, -, 205-6° (dilute AcOH).

Acta Poloniae Pharmaceutica published new progress about 101-29-1. 101-29-1 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Carboxylic acid,Ketone, name is 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, and the molecular formula is 0, Name: 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Slack, R. published the artcile3,5-Diiodo-2-pyridone-N-acetic acid, Application of 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, the publication is Journal of the Society of Chemical Industry, London (1945), 188, database is CAplus.

3,5-Diiodo-2-pyridone (I) was prepared in 87% yield by the method of Caldwell (C.A. 38, 5806.3), using Cellosolve for recrystallization I reacted with NaOH and ClCH₂CO₂H to produce 80% of 3,5-diiodo-2-pyridone-1-acetic acid (II), as colorless needles; m. 248-50° (decomposition). II formed salts with diethanolamine and triethanolamine which gave stable 70% aqueous solutions at 15°. A 50% triethanolamine salt solution was toxic to mice at 1.6 mg./g. while a like solution of 3,5-diiodo-4-pyridone-1-acetic acid (Diodone) was toxic at 4.5 mg./g. The latter is used as an x-ray contrast medium.

Journal of the Society of Chemical Industry, London published new progress about 101-29-1. 101-29-1 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Carboxylic acid,Ketone, name is 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, and the molecular formula is C20H19NO4, Application of 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Krasnova, M. A. published the artcileQuantitative analysis of iodine-containing pharmaceutical preparations by combustion in oxygen, Safety of 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, the publication is Farmatsiya (Moscow, Russian Federation) (1969), 18(3), 57-60, database is CAplus and MEDLINE.

Anal. of I-containing (50-69% of I) pharmaceutical preparations by combustion in O utilizes a new modification of the method and a comparison is made with the existing ones. The sample (0.02-0.03 g.) is placed on the Pt grid (initially not in contact with the solution), 10 ml. 2N KOH and 50 ml. H2O are poured into a flask and O bubbled through 5 min. Then the sample is burned (20-30 sec.) and the flask tightly stopped. The content is then shaken (5-6 min.) and allowed to stand for 10 min. more. Br (5 ml.) and AcOH are then added, the solution stirred and 0.3 ml. 85% HCO2H added. After the solution has lost its color, 20 ml. of N H2SO4 and 0.05 g. KI are added, and the flask allowed to stand in dark 5 min. The liberated I is titrated with 0.1N Na2S2O3 (1% starch indicator). The time of anal. is 30 min. The relative error is �.4%.

Farmatsiya (Moscow, Russian Federation) published new progress about 101-29-1. 101-29-1 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Carboxylic acid,Ketone, name is 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, and the molecular formula is C7H5I2NO3, Safety of 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Bojarska-Dahlig, Halina published the artcile4-Pyridone-N-acetic acid and derivatives, Recommanded Product: 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, the publication is Roczniki Chemii (1955), 119-28, database is CAplus.

For pharmacol. investigations were prepared 4-pyridone-N-acetic acid (I) and some of its derivatives To 9.5 g. of 4-pyridone nitrate in 15 ml. H₂O and 8.88 g. NaOH was added 11.4 g. ClCH₂CO₂H (Ia) and the mixture refluxed 1 hr., then acidified with concentrated HCl, and kept 3 days to precipitate 7.2 g. I, m. 253-5° (from water). To 8.4 g. 3-nitro-4-pyridone (II) in 15 ml. H₂O and 11.4 g. NaOH was added 11.4 g. of Ia, the mixture refluxed 1 hr., and acidified with concentrated HCl to precipitate 8.9 g. 3-O₂N derivative (III) of I, m. 268-9°. III (4.95 g.) with 6.5 g. n-octyl alc. and 0.55 ml. H₂SO₄ in 15 ml. benzene boiled 2 hrs., 100 ml. H₂O added, the mixture neutralized with NaHCO₃, and the C₆H₆ distilled off to give 49% n-octyl ester of III, m. 135° (from 50% alc.). II (14 g.), 700 ml. 78% alc., 7 g. CaCl₂, 10 ml. H₂O, and 210 g. Zn dust refluxed 10 hrs., the mixture filtered, acidified with 10 ml. concentrated HCl, heated on a water bath until crystalline, and 20 ml. concentrated HCl added to yield 41% 3-amino-4-pyridone-2HCl (IV), m. 228-30° (from concentrated HCl). IV (4.48 g.), 20 ml. H₂O, 4.2 g. NaOH, and 2.82 g. Ia were heated 1 hr. on boiling water bath, concentrated HCl added to pH 5, and the mixture kept 10 hrs. to give 69.3% 3-H₂N derivative of I, dark colored crystals, m. 242-5° (from 50% alc.). To 7 g. II, 11.7 g. Na₂CO₃ hydrate, and 100 ml. H₂O at 50° was added dropwise 10.5 g. iodine and 10.5 g. KI in 100 ml. H₂O, the mixture heated 1 hr. at 50° and 2 hrs. 95-100°, saturated with SO₂ and kept 10 hrs. to give 58% 3-nitro-5-iodo-4-pyridone (V), yellow crystals, darken 270°, decompose 310° (from 50% alc.). To 16 g. V, 8.64 g. NaOH, and 20 ml. H₂O was added 11.4 g. Ia, the mixture heated on a water bath 1 hr., and acidified with concentrated HCl to give 87.6% 3-nitro-5-iodo-4-pyridone-N-acetic acid (VI), m. 252-4° (from H₂O); NH₄ salt (prepared in 25% NH₃), yellow needles, m. 225-8°; (HOCH₂CH₂)₂NH salt, m. 156-8° (from 90% alc.); Et ester, m. 122° (from 96% alc.); n-octyl ester, m. 105-7°. To 8.1 g. VI and 5.75 g. granulated Zn was gradually added 15 ml. concentrated HCl, the mixture heated 3 hrs. on boiling water bath, concentrated in vacuo to a sirup, 100 ml. H₂O added, and the solution saturated with H₂S, ZnS filtered off, and the filtrate concentrated on water bath to give the HCl salt (VII), m. 216-18° (from dilute HCl), of the 3-H₂N analog of VI. To 6.6 g. VII in 40 ml. 15% HCl was added with stirring during 10 min. 1.73 g. NaNO₂ in 5 ml. H₂O and the mixture kept 20 min. at 0° to give 94% N-carboxymethyl-5-iodo-4-pyridone-3-diazonium chloride, yellow crystals, m. 141-3°.

Roczniki Chemii published new progress about 101-29-1. 101-29-1 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Carboxylic acid,Ketone, name is 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, and the molecular formula is C7H5I2NO3, Recommanded Product: 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Xiao, Shouhua published the artcileInfluences of grafting on aromatic compounds in muskmelon by solid phase microextraction with GC-MS, Application In Synthesis of 101-29-1, the publication is Acta Horticulturae (2010), 365-375, database is CAplus.

There has been an increase in popularity of grafting technique on muskmelon in agricultural production because grafting of melon increased its disease resistance to fusarium wilt, but melon’s (Cucumis melo L.) quality has been more serious inferior than its own-rooted melon. The volatiles substance plays an important role in melon fruit quality. We have found very little reports in literature for melon grafting varieties and using solid-phase microextraction (SPME). The objective of this experiment was to identify volatile and semivolatile compounds in two melon cultivars ‘Lu135’ and ‘Lu7475’, using solid-phase microextraction (SPME) with gas chromatog.-mass spectrometry (GC-MS). Fully ripe melon was squeezed through miracloth to produce rapid juice extracts for immediate headspace SPME GC-MS. One hundred forty two volatile compounds were separated in ripe muskmelon, they consisted of 56 esters, 27 alcs., 3 aldehydes, 17 ketones, 21 alkenes and 18 other substances. Among these compounds, types of esters and alcs. were the important aroma components accounting for over 74.75-93.46% of total peak area. The most abundant compounds in two cultivars were acetic acid, phenylmethyl ester (21.65-36.43%), acetic acid, hexyl ester (6.05-12.95%), Et acetate (2.89-9.94%), 1-butanol, 2-methyl-, acetate (5.84-7.82%). The total aromatic compounds and characteristic aromatic esters contents decreased in grafted melons than the own-rooted melon. The delightful fruit aroma in grafting melon was lower and thinner in comparison to own-rooted. Meanwhile, the aroma components of melon were altered because of grafting in adopting of melon. However, the effect of grafting on aroma components was different between two varieties. The total esters content and category in ‘Lu135’ was obviously lower in grafting melons than own-rooted and it had little chance on ‘Lu7475’.

Acta Horticulturae published new progress about 101-29-1. 101-29-1 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Carboxylic acid,Ketone, name is 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, and the molecular formula is C5H10N2OS, Application In Synthesis of 101-29-1.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Boerdalen, Bjoern E. published the artcileOsmotic properties of some contrast media, Safety of 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, the publication is Investigative Radiology (1970), 5(6), 559-65, database is CAplus and MEDLINE.

The contrast media, when compared on the basis of I concentration, showed only minor differences in osmolality and water activity when calculated from concentrations and osmotic coefficients A plot of osmolality vs. I concentration for different contrast media showed a slightly curved line with Angio-Conray at the top and isopaque 260 at the bottom. The mols. of some of the contrast media deviated from the theoretically assumed spherical sym.

Investigative Radiology published new progress about 101-29-1. 101-29-1 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Carboxylic acid,Ketone, name is 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, and the molecular formula is C7H5I2NO3, Safety of 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com