Sigala, Ioanna published the artcileLynamicin D an antimicrobial natural product affects splicing by inducing the expression of SR protein kinase 1, Safety of tert-Butyl 5-chloro-3-iodo-1H-indole-1-carboxylate, the main research area is lynamicin D bisindolyl bisindole pyrrole alkaloid mRNA splicing SRPK1; Bisindole pyrroles; Bisindolyl alkaloids; Lynamicin D; SRPK1; mRNA splicing.
The first total synthesis of the antimicrobial natural product lynamicin D has been developed using a Suzuki coupling to construct the bisindole pyrrole skeleton. An evaluation of the biol. activity of lynamicin D reveals that it has a minor effect on cell viability but it can modulate splicing of pre-mRNAs. We provide evidence that this effect is mainly due to the ability of lynamicin D to alter the levels of SRPK1, the key kinase involved in both constitutive and alternative splicing.
Bioorganic & Medicinal Chemistry published new progress about Homo sapiens. 1048039-49-1 belongs to class iodides-buliding-blocks, name is tert-Butyl 5-chloro-3-iodo-1H-indole-1-carboxylate, and the molecular formula is C13H13ClINO2, Safety of tert-Butyl 5-chloro-3-iodo-1H-indole-1-carboxylate.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com