Tag: M.W=250-300

Xiang, Jian-nan published the artcileSynthesis of diheterocyclic compounds on 1,3,4-oxadiazole and 1,2,4-triazole, Product Details of C7H7IN2O, the publication is Hunan Daxue Xuebao, Ziran Kexueban (2009), 36(3), 63-66, database is CAplus.

A method for the synthesis of the title compounds [i.e., 1,3,4-oxadiazole-2-thione and 1,2,4-triazole-3-thione derivatives] is reported here. Said compounds were prepared by a coupling reaction of (4-iodophenyl)(fluoroalkyl)-1,2,4-triazole-3-thione derivatives and (4-iodophenyl)(fluoroalkyl)-1,3,4-oxadiazole-2-thione derivatives with (ethynyl)(fluoroalkyl)-1,2,4-triazole-3-thione. This approach is based mol. design technol., such as activity substructure connection. Structures of the target compounds were determined by NMR, ¹⁹F-NMR, IR, MS, elemental anal.

Hunan Daxue Xuebao, Ziran Kexueban published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C39H35N5O8, Product Details of C7H7IN2O.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Liu, Congrong published the artcilePalladium/Copper Cocatalyzed Coupling Reaction of Aroyl Hydrazides with Indoles, SDS of cas: 39115-95-2, the publication is Chinese Journal of Chemistry (2016), 34(12), 1213-1217, database is CAplus.

An unprecedented palladium/copper cocatalyzed coupling reaction of indoles with simple aroyl hydrazides has been developed under aerobic conditions. A range of aroyl hydrazides underwent palladium/copper cocatalyzed oxidative arylation with indoles open to air in a 1:1 mixture of DMSO and nitromethane to give structurally diverse 2-arylindoles or 3-arylindoles in moderate to good yields. The reaction well tolerates a wide variety of functional groups such as alkoxy, halo, ester.

Chinese Journal of Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, SDS of cas: 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Zheng published the artcileMicrowave-accelerated solvent-free synthesis of 1,3,4-oxadiazoles using polymer supported dehydration reagent, Related Products of iodides-buliding-blocks, the publication is Synthetic Communications (2004), 34(16), 2981-2986, database is CAplus.

2-Aryl-5-(coumarin-3′-yl)-1,3,4-oxadiazoles are efficiently synthesized by microwave accelerated solvent-free procedure in high yield via the condensation of coumarin-3-carboxylic acid with (un)substituted benzoic acid hydrazides using poly(ethylene glycol) (PEG) supported dichlorophosphate as dehydration reagent.

Synthetic Communications published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sun, Li-Wen published the artcileTransition-metal-free hydroamination/defluorination/cyclization of perfluoroalkyl alkynes with amidines, Related Products of iodides-buliding-blocks, the publication is Organic Chemistry Frontiers (2022), 9(1), 109-116, database is CAplus.

An efficient defluorinative net-[3 + 3]-cyclization strategy for the construction of perfluoroalkyl-substituted pyrimidine derivatives by using a series of perfluoroalkyl alkynes and amidines as starting materials was developed. The present reaction proceeded successfully under transition-metal-free conditions to form two new C-N bonds and a new heterocyclic ring through a sequence of hydroamination, defluorination, and annulation. The desired pyrimidines could be obtained with good functional group tolerance and moderate to good yields. Moreover, the distinctive fluorine effects of perfluoroalkyl substituents are vital for tuning the reactivity of alkynes for the anticipated defluorinative annulation. The pendant π system would lower associated bond dissociation energy significantly compared to that of a nonactivated C(sp3)-F bond.

Organic Chemistry Frontiers published new progress about 134322-01-3. 134322-01-3 belongs to iodides-buliding-blocks, auxiliary class Salt,Iodide,Amine,Amidine,Benzene, name is 4-Iodobenzimidamide hydrochloride, and the molecular formula is C10H14O, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Long, Lingliang published the artcileConstruction of a fluorescent probe for selectively detecting singlet oxygen with a high sensitivity and large concentration range based on a two-step cascade sensing reaction, Application of 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Chemical Communications (Cambridge, United Kingdom) (2019), 55(58), 8462-8465, database is CAplus and MEDLINE.

A novel fluorescent probe XQ-1 for selectively detecting ¹O₂ on the basis of a two-step cascade reaction has been rationally constructed. The probe responded to ¹O₂ not only showing a high sensitivity, but also displaying a large concentration range, which means that the probe can be used as a powerful tool to monitor the efficacy of PDT toward cancer and concurrently track the adverse effects on healthy cells.

Chemical Communications (Cambridge, United Kingdom) published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Application of 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yokoyama, Takuya published the artcileIdentification of candidate molecular targets of the novel antineoplastic antimitotic NP-10, SDS of cas: 39115-95-2, the publication is Scientific Reports (2019), 9(1), 1-13, database is CAplus and MEDLINE.

We previously reported the identification of a novel antimitotic agent with carbazole and benzohydrazide structures: N’-[(9-ethyl-9H-carbazol-3-yl)methylene]-2-iodobenzohydrazide (code number NP-10). However, the mechanism(s) underlying the cancer cell-selective inhibition of mitotic progression by NP-10 remains unclear. Here, we identified NP-10-interacting proteins by affinity purification from HeLa cell lysates using NP-10-immobilized beads followed by mass spectrometry. The results showed that several mitosis-associated factors specifically bind to active NP-10, but not to an inactive NP-10 derivative Among them, NUP155 and importin β may be involved in NP-10-mediated mitotic arrest. Because NP-10 did not show antitumor activity in vivo in a previous study, we synthesized 19 NP-10 derivatives to identify more effective NP-10-related compounds HMI83-2, an NP-10-related compound with a Cl moiety, inhibited HCT116 cell tumor formation in nude mice without significant loss of body weight, suggesting that HMI83-2 is a promising lead compound for the development of novel antimitotic agents.

Scientific Reports published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C4H6O3, SDS of cas: 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Han, Jie published the artcileSynthesis, liquid crystalline and photoluminescent properties of 1,3,4-oxadiazole derivatives: From calamitic monomers, H-Shaped dimers to calix[4]arene-based tetramers, Quality Control of 39115-95-2, the publication is Dyes and Pigments (2018), 234-241, database is CAplus.

A new class of calamitic 1,3,4-oxadiazole monomers H-shaped dimers , and calix [4]arene-based tetramer have been synthesized and characterized fully by means of ¹H NMR (proton NMR), ¹³C-NMR, high resolution mass spectroscopy (HRMS) and elemental anal., and the thermal properties and photoluminescent behaviors have been investigated systemically. All of the monomers display stable liquid crystalline properties with smectic and/or nematic mesophases determined by the electronic and steric nature of the terminal groups. In contrast, both the H-shaped dimers and the calix [4]arene based tetramer are not mesogenic, while they show specific recognition for Cu²⁺ through the fluorescent emission intensity quenching. The relationship between the mol. structures and properties has been discussed according to the mol. shapes.

Dyes and Pigments published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Quality Control of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Gu, Yu-lei published the artcileGene knockout or inhibition of macrophage migration inhibitory factor alleviates lipopolysaccharide-induced liver injury via inhibiting inflammatory response, Application of 4-Iodo-6-phenylpyrimidine, the publication is Hepatobiliary & Pancreatic Diseases International (2021), 20(5), 469-477, database is CAplus and MEDLINE.

Background: Liver injury is one of the most common complications during sepsis. Macrophage migration inhibitory factor (MIF) is an important proinflammatory cytokine. This study explored the role of MIF in the lipopolysaccharide (LPS)-induced liver injury through genetically manipulated mouse strains. Methods: The model of LPS-induced liver injury was established in wild-type and Mif-knockout C57/BL6 mice. Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bilirubin (TBil) were detected, and the expressions of MIF, tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) were measured. Liver histopathol. was conducted to assess liver injury. Moreover, the inhibitions of MIF with (S, R)-3-(4-hydroxyphenyl)-4, 5-dihydro-5-isoxazole acetic acid Me ester (ISO-1) and 4-iodo-6-phenylpyrimidine (4-IPP) were used to evaluate their therapeutic potential of liver injury. Results: Compared with wild-type mice, the liver function indexes and inflammation factors presented no significant difference in the Mif^-/- mice. After 72 h of the LPS-induced liver injury, serum levels of ALT, AST, and TBil as well as TNF-α and IL-1β were significantly increased, but the knockout of Mif attenuated liver injury and inflammatory response. In liver tissue, m RNA levels of TNF-α, IL-1β and NF-κB p65 were remarkably elevated in LPS-induced liver injury, while the knockout of Mif reduced these levels. Moreover, in LPS-induced liver injury, the inhibitions of MIF with ISO-1 and 4-IPP alleviated liver injury and slightly attenuated inflammatory response. Importantly, compared to mice with LPS-induced liver injury, Mif knockout or MIF inhibitions significantly prolonged the survival of the mice. Conclusions: In LPS-induced liver injury, the knockout of Mif or MIF inhibitions alleviated liver injury and slightly attenuated inflammatory response, thereby prolonged the survival of the mice. Targeting MIF may be an important strategy to protect the liver from injury during sepsis.

Hepatobiliary & Pancreatic Diseases International published new progress about 41270-96-6. 41270-96-6 belongs to iodides-buliding-blocks, auxiliary class Pyrimidine,Iodide,Benzene,Immunology/Inflammation,MIF, name is 4-Iodo-6-phenylpyrimidine, and the molecular formula is C10H7IN2, Application of 4-Iodo-6-phenylpyrimidine.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yuan, Chen published the artcileDiscovery of [1,2,4]triazole derivatives as new metallo-β-lactamase inhibitors, Quality Control of 39115-95-2, the publication is Molecules (2020), 25(1), 56, database is CAplus and MEDLINE.

The emergence and spread of metallo-β-lactamase (MBL)-mediated resistance to β-lactam antibacterials has already threatened the global public health. A clin. useful MBL inhibitor that can reverse β-lactam resistance has not been established yet. We here report a series of [1,2,4]triazole derivatives and analogs, which displayed inhibition to the clin. relevant subclass B1 (Verona integron-encoded MBL-2) VIM-2. 3-(4-Bromophenyl)-6,7-dihydro-5H-[1,2,4]triazolo [3,4-b][1,3]thiazine (5l) manifested the most potent inhibition with an IC50 (half-maximal inhibitory concentration) value of 38.36μM. Investigations of 5l against other B1 MBLs and the serine β-lactamases (SBLs) revealed the selectivity to VIM-2. Mol. docking analyses suggested that 5l bound to the VIM-2 active site via the triazole involving zinc coordination and made hydrophobic interactions with the residues Phe61 and Tyr67 on the flexible L1 loop. This work provided new triazole-based MBL inhibitors and may aid efforts to develop new types of inhibitors combating MBL-mediated resistance.

Molecules published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C9H7N5O, Quality Control of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zheng, Yuhuan published the artcileRole of myeloma-derived MIF in myeloma cell adhesion to bone marrow and chemotherapy response, Recommanded Product: 4-Iodo-6-phenylpyrimidine, the publication is Journal of the National Cancer Institute (2016), 108(11), djw131/1-djw131/11, database is CAplus and MEDLINE.

Multiple myeloma (MM) remains an incurable cancer characterized by accumulation of malignant plasma cells in the bone marrow (BM). The mechanism underlying MM homing to BM is poorly elucidated. The clin. significance of migration inhibitory factor (MIF) expression was examined by analyzing six independent gene expression profile databases of primary MM cells using the Student’s t test and Kaplan-Meier test. ELISA was used to examine MIF expression. In vivo bioluminescent imaging was used to determine MM cell localization and treatment efficacy in human MM xenograft mouse models, with three to four mice per group. MM cell attachment to BM stromal cells (BMSCs) was monitored by cell adhesion assay. MIF regulation of the expression of adhesion mols. was determined by chromatin immunoprecipitation (ChIP) assay. Statistical tests were two-sided. High levels of MIF were detected in MM BM (MIF level in BM plasma: healthy = 10.72 ± 5.788 ng/mL, n = 5; MM = 1811 ± 248.7 ng/mL, n = 10; P < .001) and associated with poor survival of patients (Kaplan-Meier test for MM OS: 87 MIF high patients, 86 MIFlow patients, P = .02). Knocking down MIF impaired MM cell adhesion to BMSCs in vitro and led to formation of extramedullary tumors in SCID mice. MIF acted through surface receptor CXCR4 and adaptor COPS5 to regulate the expression of adhesion mols. ALCAM, ITGAV, and ITGB5 on MM cells. More importantly, MIF-deficient MM cells were sensitive to chemotherapy in vitro when cocultured with BMSCs and in vivo. MIF inhibitor 4-IPP sensitized MM cells to chemotherapy. MIF is an important player and a novel therapeutic target in MM. Inhibiting MIF activity will sensitize MM cells to chemotherapy.

Journal of the National Cancer Institute published new progress about 41270-96-6. 41270-96-6 belongs to iodides-buliding-blocks, auxiliary class Pyrimidine,Iodide,Benzene,Immunology/Inflammation,MIF, name is 4-Iodo-6-phenylpyrimidine, and the molecular formula is C9H6BrNO, Recommanded Product: 4-Iodo-6-phenylpyrimidine.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com