Tag: M.W=250-300

Vlasov, Vladislav M. published the artcileSubstituent effects in substrates on activation parameters in the bimolecular nucleophilic reactions in solution, Recommanded Product: 4-Iodo-3-nitrobenzonitrile, the publication is New Journal of Chemistry (2010), 34(12), 2962-2970, database is CAplus.

Changes of the activation parameters, ΔH^{â‰?/sup> and ΔSâ‰?/sup>, in the S_N2, S_NAr and acyl-transfer reactions with charged and neutral nucleophiles in various solvents were correlated with σ constants of the substituents in the aromatic ring of the substrates. The resultant δΔHâ‰?/sup> and δΔSâ‰?/sup> reaction constants are linearly related for variations of substituents at the substrate. Correlation of δΔHâ‰?/sup> vs. δΔSâ‰?/sup> allows one to estimate the contribution of changes of the internal enthalpy, δΔHâ‰?/sup>_int, to the enthalpy reaction constant, δΔHâ‰?/sup>, which gives a single linear dependence on the Hammett ρ reaction constants for all bimol. nucleophilic reactions. The deviations from dependence of δΔHâ‰?/sup>_int vs. ρ can be interpreted in terms of changes of the transition state structure or reaction mechanism. The results obtained show that the substituent effects in the substrates and nucleophiles on the charge development in the transition state are governed by the magnitude of δΔHâ‰?/sup>_int.}

New Journal of Chemistry published new progress about 101420-79-5. 101420-79-5 belongs to iodides-buliding-blocks, auxiliary class Nitrile,Nitro Compound,Iodide,Benzene,Benzene Compounds, name is 4-Iodo-3-nitrobenzonitrile, and the molecular formula is C6H3FN2, Recommanded Product: 4-Iodo-3-nitrobenzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Vlasov, Vladislav M. published the artcileSimple method for determining of the isokinetic temperature value for the S_NAr reactions in solution, Application of 4-Iodo-3-nitrobenzonitrile, the publication is Journal of Physical Organic Chemistry (2018), 31(1), n/a, database is CAplus.

The changes of the free energy of activation δΔG^{â‰?/sup>_exp and the activation entropy δΔSâ‰?/sup> in the framework of the isokinetic relationship δΔGâ‰?/sup>_exp vs. (T_iso – T_exp) δΔSâ‰?/sup> were explored quant. to predict the isokinetic temperature T_iso for the aromatic nucleophilic substitution reactions in solution}

Journal of Physical Organic Chemistry published new progress about 101420-79-5. 101420-79-5 belongs to iodides-buliding-blocks, auxiliary class Nitrile,Nitro Compound,Iodide,Benzene,Benzene Compounds, name is 4-Iodo-3-nitrobenzonitrile, and the molecular formula is C13H13N, Application of 4-Iodo-3-nitrobenzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yanagi, Kiyoshi published the artcileStudy on the syntheses of polymethinecyanines. I. The reactions of 3-phthalimido-2-propenal and its derivatives with active methyl and methylene compounds, Quality Control of 606-55-3, the publication is Nippon Kagaku Kaishi (1991), 1198-203, database is CAplus.

3-Phthalimido-2-propenal (I), its derivatives and related compounds reacted with various active Me and active methylene compounds to produce pentamethinecyanines and imido-substituted polymethinecyanine-like compounds E.g., reaction of I with benzothiazolium iodides II (R = Me, Et) in Ac₂O and AcOH in the presence of KOAc gave the corresponding pentamethinecyanines III in 87 and 90% yield resp.

Nippon Kagaku Kaishi published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C6H16OSi, Quality Control of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Rajasekaran, Deepa published the artcileTargeting distinct tautomerase sites of D-DT and MIF with a single molecule for inhibition of neutrophil lung recruitment, Application of 4-Iodo-6-phenylpyrimidine, the publication is FASEB Journal (2014), 28(11), 4961-4971, database is CAplus and MEDLINE.

We report a new inflammatory activity for extracellular D-dopachrome tautomerase (D-DT), the recruitment of neutrophils to the lung on D-DT intratracheal installation of C57BL/6J mice with an EC₅₀ of 5.6 μg. We also find that D-DT and macrophage migration inhibitory factor (MIF) have additive effects in neutrophil recruitment. Although the tautomerase site of D-DT and its homolog MIF are biophys. very different, 4-iodo-6-phenylpyrimidine (4-IPP) forms a covalent bond with Pro-1 of both proteins, resulting in a 6-phenylpyrimidine (6-PP) adduct. Recruitment of neutrophils to the lung for the 6-PP adducts of D-DT and MIF are reduced by ∼50% relative to the apo proteins, demonstrating that an unmodified Pro-1 is important for this activity, but there is no cooperativity in inhibition of the proteins together. The differences in the binding mode of the 6-PP adduct for D-DT was determined by crystallog. studies at 1.13 Å resolution and compared to the structure of the MIF-6-PP complex. There are major differences in the location of the 6-PP adduct to the D-DT and MIF active sites that provide insight into the lack of cooperativity by 4-IPP and into tuning the properties of the covalent inhibitors of D-DT and MIF that are necessary for the development of therapeutic small mols. against neutrophil damage from lung infections such as Pseudomonas aeruginosa in cystic fibrosis and immunocompromised patients.

FASEB Journal published new progress about 41270-96-6. 41270-96-6 belongs to iodides-buliding-blocks, auxiliary class Pyrimidine,Iodide,Benzene,Immunology/Inflammation,MIF, name is 4-Iodo-6-phenylpyrimidine, and the molecular formula is C10H7IN2, Application of 4-Iodo-6-phenylpyrimidine.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhang, Yadong published the artcilePolymers with Carbazole-Oxadiazole Side Chains as Ambipolar Hosts for Phosphorescent Light-Emitting Diodes, Quality Control of 39115-95-2, the publication is Chemistry of Materials (2011), 23(17), 4002-4015, database is CAplus.

Polymethacrylates, polystyrenes, and polynorbornenes bearing 2-(3-(carbazol-9-yl)phenyl)-5-phenyl-1,3,4-oxadiazole, 2-(4-(carbazol-9-yl)phenyl)-5-phenyl-1,3,4-oxadiazole, 2-((3,5-di(carbazol-9-yl)phenyl)-5-phenyl-1,3,4-oxadiazole) groups linked to the polymer backbone through the 3-position of their terminal Ph groups have been synthesized for use as solution-processable ambipolar hosts for phosphorescent light-emitting diodes. The polymers exhibit good thermal stabilities, with no weight loss below 350 °C, and have glass-transition temperatures in the range 118-209°. Spectroscopic, electrochem., and quantum-chem. data for small-mol. model compounds suggest that the side chain groups are suitable hosts for a range of phosphors, including the green-emitter fac-tris(2-phenylpyridinato-N,C²‘)iridium (Ir(ppy)₃). Light-emitting diodes were fabricated, each with a solution-processed photo-cross-linked hole-transport layer, a solution-processed emissive layer composed of a carbazole-oxadiazole-functionalized polymethacrylate doped with Ir(ppy)₃, and an evaporated electron-transport layer. The polymer with 2-(3,5-(dicarbazol-9-yl)phenyl)-5-phenyl-1,3,4-oxadiazole units in the side chain exhibited the lowest turn-on voltage (6.0 V), and the highest efficiency (external quantum efficiency of 10.0%, current efficiency of 34.1 cd/A).

Chemistry of Materials published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C15H21BO3, Quality Control of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Schindler, Lisa published the artcileMacrophage migration inhibitory factor inhibits neutrophil apoptosis by inducing cytokine release from mononuclear cells, Category: iodides-buliding-blocks, the publication is Journal of Leukocyte Biology (2021), 110(5), 893-905, database is CAplus and MEDLINE.

The chemokine-like inflammatory cytokine macrophage migration inhibitory factor (MIF) is a pivotal driver of acute and chronic inflammatory conditions, cardiovascular disease, autoimmunity, and cancer. MIF modulates the early inflammatory response through various mechanisms, including regulation of neutrophil recruitment and fate, but the mechanisms and the role of the more recently described MIF homolog MIF-2 (D-dopachrome tautomerase; D-DT) are incompletely understood. Here, we show that both MIF and MIF-2/D-DT inhibit neutrophil apoptosis. This is not a direct effect, but involves the activation of mononuclear cells, which secrete CXCL8 and other prosurvival mediators to promote neutrophil survival. Individually, CXCL8 and MIF (or MIF-2) did not significantly inhibit neutrophil apoptosis, but in combination they elicited a synergistic response, promoting neutrophil survival even in the absence of mononuclear cells. The use of receptor-specific inhibitors provided evidence for a causal role of the noncognate MIF receptor CXCR2 expressed on both monocytes and neutrophils in MIF-mediated neutrophil survival. We suggest that the ability to inhibit neutrophil apoptosis contributes to the proinflammatory role ascribed to MIF, and propose that blocking the interaction between MIF and CXCR2 could be an important anti-inflammatory strategy in the early inflammatory response.

Journal of Leukocyte Biology published new progress about 41270-96-6. 41270-96-6 belongs to iodides-buliding-blocks, auxiliary class Pyrimidine,Iodide,Benzene,Immunology/Inflammation,MIF, name is 4-Iodo-6-phenylpyrimidine, and the molecular formula is C10H7IN2, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Abd El-Aal, Reda Mahmoud published the artcileThe synthesis of some bridgehead heterocyclic monomethine cyanine dyes, Application In Synthesis of 606-55-3, the publication is Dyes and Pigments (1998), 39(4), 267-280, database is CAplus.

α-Chloroacetic acid and phenacyl bromide were used as reagents reacting with 8-hydroxyquinoline to form bridgehead heterocycles. Reaction of these heterocycles with equi- or dimolar ratios of ethiodides of α- or -γ-picoline or quinaldine afforded a series of monomethine and bismonomethine cyanine dyes. The electronic spectra of the monomethine cyanine dyes in various solvents are discussed.

Dyes and Pigments published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Application In Synthesis of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Abd El-Aal, Reda Mahmoud published the artcileSynthesis and characterization of new photosensitizer bridgehead cyanine dyes, Synthetic Route of 606-55-3, the publication is Proceedings – Indian Academy of Sciences, Chemical Sciences (1999), 111(2), 343-352, database is CAplus.

Oxazolo[1,2-a]quinoline derivatives were used to synthesize novel bridgehead cyanine dyes such as azamethine, monomethine, and trimethine cyanines. The electronic absorption spectra of these cationic dyes in ethanol and several organic solvents are discussed.

Proceedings – Indian Academy of Sciences, Chemical Sciences published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Synthetic Route of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Abu El-Hamd, R. M. published the artcileSome new fused heterocyclic cyanine dyes with ring junction, Quality Control of 606-55-3, the publication is Chemical Papers (1997), 51(2), 117-127, database is CAplus.

New asym. pyrazolo[4′,5′:4,5]imidazo[3,2-a]/pyrrolo[1,2-a]pyridinium/quinolinium bromide iodide 1[4(1)]monomethine cyanines (I; R = H, Ph; A = 2 H, C₄H₄; X = CH₂, NH; Z = 2 H, C₄H₄), 1[2(4)]trimethine cyanines (II; A = 2 H, C₄H₄; X = CH₂, NH; Z = 2 H, C₄H₄) and/or 1-styryl cyanines (III; A = 2 H, C₄H₄; X = CH₂, NH; Y = H, p-OMe, p-NO₂) were synthesized to study their spectral behavior, solvatochromism, and acid-base properties. These dyes were characterized by elemental anal., IR, ¹H NMR, and electronic absorption spectra.

Chemical Papers published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Quality Control of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Abu El-Hamd, Ragab M. published the artcileStudies on absorption spectra of newly synthesized cyanine dyes, Computed Properties of 606-55-3, the publication is Indian Journal of Heterocyclic Chemistry (1996), 5(4), 297-304, database is CAplus.

New asym. monomethine cyanines (I; R = H, Ph; X = NH, CH₂; A = H, C₄H₄; Z = H, C₄H₄), trimethine cyanines (II; X = NH, CH₂; A = H, C₄H₄; Z = H, C₄H₄), and styryl cyanines (III; R = H, OMe, NO₂; X = NH, CH₂; A = H, C₄H₄) were synthesized to study their spectral behavior, solvatochromism, mixed solvents and acid-base properties. These dyes are characterized by elemental anal., IR, ¹H NMR, and electronic absorption spectra.

Indian Journal of Heterocyclic Chemistry published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Computed Properties of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com