Tag: M.W=250-300

Yaddanapudi, Kavitha published the artcileControl of Tumor-Associated Macrophage Alternative Activation by Macrophage Migration Inhibitory Factor, SDS of cas: 41270-96-6, the publication is Journal of Immunology (2013), 190(6), 2984-2993, database is CAplus and MEDLINE.

Tumor stromal alternatively activated macrophages are important determinants of antitumor T lymphocyte responses, intratumoral neovascularization, and metastatic dissemination. Our recent efforts to investigate the mechanism of macrophage migration inhibitory factor (MIF) in antagonizing antimelanoma immune responses reveal that macrophage-derived MIF participates in macrophage alternative activation in melanoma-bearing mice. Both peripheral and tumor-associated macrophages (TAMs) isolated from melanoma bearing MIF-deficient mice display elevated proinflammatory cytokine expression and reduced anti-inflammatory, immunosuppressive, and proangiogenic gene products compared with macrophages from tumor-bearing MIF wild-type mice. Moreover, TAMs and myeloid-derived suppressor cells from MIF-deficient mice exhibit reduced T lymphocyte immunosuppressive activities compared with those from their wild-type littermates. Corresponding with reduced tumor immunosuppression and neo-angiogenic potential by TAMs, MIF deficiency confers protection against transplantable s.c. melanoma outgrowth and melanoma lung metastatic colonization. Finally, we report for the first time, to our knowledge, that our previously discovered MIF small mol. antagonist, 4-iodo-6-phenylpyrimidine, recapitulates MIF deficiency in vitro and in vivo, and attenuates tumor-polarized macrophage alternative activation, immunosuppression, neoangiogenesis, and melanoma tumor outgrowth. These studies describe an important functional contribution by MIF to TAM alternative activation and provide justification for immunotherapeutic targeting of MIF in melanoma patients.

Journal of Immunology published new progress about 41270-96-6. 41270-96-6 belongs to iodides-buliding-blocks, auxiliary class Pyrimidine,Iodide,Benzene,Immunology/Inflammation,MIF, name is 4-Iodo-6-phenylpyrimidine, and the molecular formula is C18H20N2O12, SDS of cas: 41270-96-6.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ragan, J. A. published the artcileCross-Coupling Methods for the Large-Scale Preparation of an Imidazole-Thienopyridine: Synthesis of [2-(3-Methyl-3H-imidazol-4-yl)- thieno[3,2-b]pyridin-7-yl]-(2-methyl-1H-indol-5-yl)-amine, Related Products of iodides-buliding-blocks, the publication is Organic Process Research & Development (2003), 7(5), 676-683, database is CAplus.

The multihundred-gram synthesis of imidazolyl-substituted thienopyridine I was developed utilizing a Stille cross-coupling of iodothienopyridine II with 5-(tributylstannyl)-1-methylimidazole. Several cross-coupling methods were evaluated for the conversion of II to (imidazolyl)thienopyridine III, but only two were effective: the Stille coupling and a Negishi cross-coupling of II with the organozinc reagent derived from 2-(tert-butyldimethylsilyl)-1-methylimidazole. The latter procedure worked well on laboratory scale (<50 g), but was capricious upon scale-up. The issues with scale-up of an organostannane reagent are discussed, including control and anal. of organotin levels.

Organic Process Research & Development published new progress about 602303-26-4. 602303-26-4 belongs to iodides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Iodide, name is 7-Chloro-2-iodothieno[3,2-b]pyridine, and the molecular formula is C7H3ClINS, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Dhote, Pawan S. published the artcileInterrupting the [Au]-Catalyzed Nitroalkyne Cycloisomerization: Trapping the Putative α-Oxo Gold Carbene with Benzo[c]isoxazole, Application In Synthesis of 101420-79-5, the publication is Organic Letters, database is CAplus and MEDLINE.

The [Au]-catalyzed nitroalkyne cycloisomerization of 2-alkynylnitrobenzenes such as 2-O₂NC₆H₄CCEt leading to anthranils has been interrupted by possible trapping of the postulated intermediate α-oxo gold carbene with an external nucleophile such as a benzo[c]isoxazole (anthranil). At the outset, this provides a simple synthesis of highly functionalized 3-acyl-(2-formylphenyl)-2H-indazoles such as I with the sequential C-O, C-N, and N-N bond formations. This provides indirect support for the existence of α-oxo gold carbenes in the [Au]-catalyzed internal redox processes of nitroalkynes.

Organic Letters published new progress about 101420-79-5. 101420-79-5 belongs to iodides-buliding-blocks, auxiliary class Nitrile,Nitro Compound,Iodide,Benzene,Benzene Compounds, name is 4-Iodo-3-nitrobenzonitrile, and the molecular formula is C7H3IN2O2, Application In Synthesis of 101420-79-5.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Pardal, A. C. published the artcileSynthesis and spectroscopic characterization of N-alkyl quaternary ammonium salts, typical precursors of cyanines, Product Details of C12H14IN, the publication is Molecules [online computer file] (2002), 7(3), 320-330, database is CAplus.

Title salts I (R = Et, pentyl, hexyl, decyl; X = S, Se, O, CMe₂, CH:CH) were prepared by quaternization of the heterocycles with RI. I, bearing an activated Me group in the 2-position, are typical precursors of cyanine dyes.

Molecules [online computer file] published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Product Details of C12H14IN.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Kramer, Claus Ruediger published the artcileDistribution of arylcarboxylic acid hydrazides in the n-octanol-water system, Product Details of C7H7IN2O, the publication is Zeitschrift fuer Chemie (1978), 18(9), 348-9, database is CAplus.

Distribution coefficients (P) of RC₆H₄CONHNH₂ (I; R = H, p-Me, m-Me, m-NH₂, o-OH, m-Cl, etc.) were determined in the octanol-water system via UV spectral data; Hansch π-substituent constants were calculated from P. Linear correlations of log P for the p– and m– substituted I with π values for the corresponding RC₆H₄CONH₂ and RC₆H₄OCH₂CO₂H were given. An observed ortho effect in I was ascribed to intramol. H bonding.

Zeitschrift fuer Chemie published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Product Details of C7H7IN2O.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Mokhtar, Hassan M. published the artcileHydrazine and quinoxaline derivatives of aryl L-ascorbic acid analogs, Recommanded Product: 4-Iodobenzohydrazide, the publication is Pharmazie (1978), 33(11), 709-11, database is CAplus and MEDLINE.

Oxidation of the hydroxytetronimides I (R = p-ClC₆H₄, p-MeOC₆H₄, m-O₂NC₆H₄, 2-phenyl-4-triazolyl), prepared from RCHO, OCHCHO.2NaHSO₃, and KCN, with HNO₂ gave the butyrolactones II. II was treated with acyl- or arylhydrazones to give the bisacyl- or bisarylhydrazones. Reaction of II with o-H₂NC₆H₄NH₂ gave quinoxaline derivatives, e.g. III, or Schiff bases, e.g. IV, depending on the reactant ratio.

Pharmazie published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Recommanded Product: 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Mokhtar, Hassan M. published the artcileSynthesis of hydrazones with antituberculous activity, Application In Synthesis of 39115-95-2, the publication is Pharmazie (1979), 34(3), 150-2, database is CAplus.

The reactions of cinnamoylacetaldehyde, Et 2,4-dioxo-6-phenylhexenoate, and 2-carboethoxy-3-hydroxy-1,4-naphthoquinone with acyl- or arylhydrazines, substituted o-phenylenediamines, and ethanolamine are reported. The hydrazones are converted to the corresponding N-acyl- or N-arylpyrazole derivatives

Pharmazie published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Application In Synthesis of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Shindy, Hassan A. published the artcileSynthesis and visible spectral behavior of some new photosensitizers: monomethine, dimethine, trimethine, styryl and mixed cyanine dyes, Safety of 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Journal of Chemical Research, Synopses (1999), 700-701, 3001-3017, database is CAplus.

New photosensitizers, monomethine, dimethine, trimethine, styryl, and mixed cyanine dyes incorporating pyrazolo/oxazole(thiazole) nuclei are prepared; the visible absorption spectra of all the synthesized cyanines are examined in 95% ethanol; structural confirmation is carried out by elemental anal. and IR and ¹H NMR spectroscopy.

Journal of Chemical Research, Synopses published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C6H11BF3KO, Safety of 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Singh, Rajeev Kumar published the artcileApproaches to synthesis of asycyanine colourants and their characterisation, Related Products of iodides-buliding-blocks, the publication is International Journal of Chemical Sciences (2007), 5(3), 1229-1235, database is CAplus.

The number of asycyanine colorants (ACC) are synthesized by the catalytic condensation of auxochromic chalcones such as 4-dimethylaminostyryl 4-nitrophenyl ketone and 4-dimethylaminostyryl 4-methoxyphenyl ketone with different electron rich quaternized azo-heteroaromatics These ACC were obtained with a view to assess their electronic absorptivity. The ACC were found to absorb at longer wavelengths and to show uniform bathochromic shifts compared with the unsubstituted colorants and β-substituted styrylogues. The wavelengths of ACC were in good agreement that weighing at 6-substitution in the heterocyclic systems affect as follows: I > Br > Cl > H and OEt > OMe > Me > H.

International Journal of Chemical Sciences published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H16O3, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tossidis, Ioannis A. published the artcileMonohalobenzoylhydrazones. I. Preparation, properties, UV and IR spectra of new monohalobenzoylhydrazones of 2-furaldehyde, 2-thiophenaldehyde, 2-pyrrolaldehyde and di-2-pyridyl ketone, Category: iodides-buliding-blocks, the publication is Chimika Chronika (1983), 12(4), 181-97, database is CAplus.

Aroylhydrazones I (X = F, Cl, Br, iodo, Z = Q-Q³) were prepared from XC₆H₄CONHNH₂ and Z:O and their UV and IR spectra determined and discussed. A halogen atom at C-2 of the benzene ring causes a violet shift of the main UV bands of the spectra and a shift to higher frequencies of the valence swinging of the C:O group in the IR spectra.

Chimika Chronika published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C13H22BN3O4, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com