Tag: M.W=250-300

Granados, Albert; Ballesteros, Anna; Vallribera, Adelina published the artcile< Enantioenriched quaternary α-pentafluoroethyl derivatives of alkyl 1-indanone-2-carboxylates>, Name: 1-Fluoro-3,3-dimethyl-1,2-benziodoxole, the main research area is enantioenriched pentafluoroethylated alkyl indanone carboxylate preparation pybox ligand catalyst; pentafluoroethylation alkyl indanone carboxylate pybox ligand catalyst.

An electrophilic enantioselective catalytic method for the α-pentafluoroethylation of 3-oxoesters is described. Under the use of La(OTf)3 in combination with a (S,R)-indanyl-pybox ligand, good results in terms of yield and enantioselectivities were achieved (up to 89% ee). The reaction proceeds under mild conditions, leading to the formation of enantioenriched quaternary centers. This methodol. uses an hypervalent iodine(III)-CF2CF3 reagent, and mechanistic investigations are consistent with the involvement of a radical pathway. An electrophilic enantioselective catalytic method for the α-pentafluoroethylation of alkyl 1-indanone-2-carboxylates is described. Under the use of La(OTf)3 in combination with (S,R)-indanyl-pybox ligand good results in terms of yield and enantioselectivities were achieved (up to 89% ee). The reaction proceeds under mild conditions leading to the formation of enantioenriched quaternary centers. This methodol. uses an hypervalent iodine(III)-CF2CF3 reagent and mechanistic investigations are consistent with the involvement of a radical pathway.

Journal of Organic Chemistry published new progress about Absolute configuration. 1391728-13-4 belongs to class iodides-buliding-blocks, and the molecular formula is C9H10FIO, Name: 1-Fluoro-3,3-dimethyl-1,2-benziodoxole.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Jie, Jingrui; Xu, Qinqin; Yang, Guang; Feng, Yaqing; Zhang, Bao published the artcile< Porphyrin sensitizers involving a fluorine-substituted benzothiadiazole as auxiliary acceptor and thiophene as π bridge for use in dye-sensitized solar cells (DSSCs)>, Category: iodides-buliding-blocks, the main research area is photosensitizing dye sensitized solar cell fluorine substitution zinc porphyrin.

Three ′donor-acceptor-π bridge-acceptor′ (D-A-π-A) type zinc porphyrin sensitizers TH-0F, TH-1F and TH-2F with a benzothiadiazole (BTD) unit bearing no fluorine, one fluorine and two fluorine atoms, resp., as the auxiliary acceptor and thiophene as the π bridge were designed and synthesized for use in dye-sensitized solar cells (DSSCs). The influence of fluorine atom and thiophene unit on the photophys. and photochem. properties of the sensitizers was investigated. It was shown that the photon to current conversion efficiencies (PCE) of three sensitizer-based devices increased in the order of TH-2F > TH-1F > TH-0F, with the highest PCE of 6.98% achieved for the TH-2F-based device. To further understand the mol. structure of the TH series of dyes, a d. functional (DFT) calculation was performed. The result suggests that the strong electron-withdrawing ability of the fluorine atom, along with the intramol. interaction between the auxiliary acceptor and thiophene, optimized the electronic configuration, thereby facilitating the intramol. charge transfer efficiency and ultimately improving the performance of the corresponding device.

Dyes and Pigments published new progress about Bond angle, dihedral. 88105-22-0 belongs to class iodides-buliding-blocks, and the molecular formula is C6H5IO2S, Category: iodides-buliding-blocks.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Cortes Gonzalez, Miguel A.; Jiang, Xingguo; Nordeman, Patrik; Antoni, Gunnar; Szabo, Kalman J. published the artcile< Rhodium-mediated 18F-oxyfluorination of diazoketones using a fluorine-18-containing hypervalent iodine reagent>, Electric Literature of 1391728-13-4, the main research area is alpha fluoro ether preparation; diazoketone trimethyl orthoformate oxyfluorination rhodium catalyst.

Geminal 18F-oxyfluorination of diazoketones was performed in the presence of rhodium catalyst and hypervalent iodine-based [18F]fluoro-benziodoxole reagent to get various α-[18F]fluoro ethers I [R = Ph, 2-furyl, 4-MeC6H4, etc.] in high radiochem. yield (up to 98%) and molar activity (216 GBq μmol-1).

Chemical Communications (Cambridge, United Kingdom) published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 1391728-13-4 belongs to class iodides-buliding-blocks, and the molecular formula is C9H10FIO, Electric Literature of 1391728-13-4.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

D’Auria, Maurizio; Piancatelli, Giovanni; Ferri, Tommaso published the artcile< Photochemical reactivity of halofuran and halothiophene derivatives in the presence of arylalkenes and arylalkynes>, Name: Methyl 5-iodothiophene-2-carboxylate, the main research area is photochem substitution iodothiophene vinylarene ethynylarene; halofuran photochem substitution vinylarene; ethylene furyl thienyl.

Photochem. reactions of 5-iodo-2-thiophenecarboxaldehyde, 2-acetyl-5-iodothiophene (I), and 5-bromo- and 5-iodo-2-furancarboxaldehyde with styrene, 2-vinylthiophene and -furan (II), 4-methyl-5-vinyl-1,3-thiazole, and benzofuran are described. All the reactions give the substitution products as cis-trans mixtures E.g., I and II give a 1:1 cis-trans mixture of furylthienylethylene III. Reactions of iodothiophenes with ethynylarenes are also described; products resulting from substitution on the CCH group or on the thiophene ring are both obtained. The mechanism of the reactions is discussed in terms of an electron-transfer process.

Journal of Organic Chemistry published new progress about Photosubstitution reaction. 88105-22-0 belongs to class iodides-buliding-blocks, and the molecular formula is C6H5IO2S, Name: Methyl 5-iodothiophene-2-carboxylate.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Xu, Kang; Yang, Ruiqi; Yang, Shuang; Jiang, Cheng; Ding, Zhenhua published the artcile< Hypervalent iodane mediated reactions of N-acetyl enamines for the synthesis of oxazoles and imidazoles>, Quality Control of 1391728-13-4, the main research area is vinyl acetamide preparation fluoro dimethylbenziodoxole boron trifluoride etherate heterocyclization; aryl methyloxazole preparation; acetamido phenylacrylate preparation nitrile fluoro dimethylbenziodoxole zinc fluoroborate cyclocondensation; phenyl imidazolyl carboxylate preparation.

A hypervalent iodane reagent used for the intramol. cyclization of N-acetyl enamines and intermol. cyclocondensation of enamines and nitriles was investigated. The reaction was performed under mild conditions and gave oxazoles and imidazoles resp., in moderate to excellent yields. This transformation exhibited good reactivity, selectivity and functional group tolerance. The selectivity of the intra- or intermol. reaction was depended on the structure of N-acetyl enamines.

Organic & Biomolecular Chemistry published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1391728-13-4 belongs to class iodides-buliding-blocks, and the molecular formula is C9H10FIO, Quality Control of 1391728-13-4.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Koo, Seung Moh; Vendola, Alex J.; Momm, Sarah Noemi; Morken, James P. published the artcile< Alkyl Group Migration in Ni-Catalyzed Conjunctive Coupling with C(sp3) Electrophiles: Reaction Development and Application to Targets of Interest>, Recommanded Product: tert-Butyl (3-iodopropyl)carbamate, the main research area is alkyl migration cross coupling nickel catalyst; organoboronic ester preparation cross coupling nickel catalyst; coniine indolizidine 209D preparation cross coupling nickel catalyst.

A catalytic conjunctive cross-coupling reaction was developed that allows the construction of chiral organoboronic esters from alkylboron ate complexes and alkyl iodide electrophiles. The process occurs most efficiently with a Ni/Pybox-comprised catalyst and with an acenaphthoquinone-derived boron ligand. Because of the broad functional group tolerance of this reaction, it can be a versatile tool for organic synthesis. Applications to the construction of (R)-coniine and (-)-indolizidine 209D are described.

Organic Letters published new progress about Boronic acids, esters Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 167479-01-8 belongs to class iodides-buliding-blocks, and the molecular formula is C8H16INO2, Recommanded Product: tert-Butyl (3-iodopropyl)carbamate.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Gruber, Stefan; Waser, Valerie; Thiel, Zacharias; Ametamey, Simon M. published the artcile< Prodrug Approach toward the Development of a PET Radioligand for Imaging the GluN2A Subunits of the NMDA Receptor>, Application In Synthesis of 1391728-13-4, the main research area is fluorine 18 labeled prodrug AFA233 phosphate ester preparation.

A straightforward synthesis of a F-18-labeled prodrug of AFA233 is reported. The key step in the preparation of [18F]AFA233-prodrug is the selective deprotection of the tert-Bu protection groups of the quinoxalinedione moiety without cleavage of the tert-butyl-S-acyl-2-thioethyl protection groups on the phosphate esters. The preparation of the nonradioactive prodrug reference compound of AFA233 is reported.

Organic Letters published new progress about Imaging (F-18-labeled prodrug AFA233). 1391728-13-4 belongs to class iodides-buliding-blocks, and the molecular formula is C9H10FIO, Application In Synthesis of 1391728-13-4.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Satonaka, Hajime; Abe, Kazuhisa; Hirota, Minoru published the artcile< Carbon-13 NMR spectra of substituted 2-thiophenecarboxylic acid methyl esters and MNDO calculations>, Electric Literature of 88105-22-0, the main research area is NMR methyl thiophenecarboxylate; MNDO methyl thiophenecarboxylate; conformation methyl thiophenecarboxylate.

The 13C NMR spectra have been reported on substituted 2-thiophenecarboxylic acid Me esters. The chem. shift of ring carbons in Me 4- and 5-substituted 2-thiophenecarboxylates was correlated linearly with that of the corresponding carbons in substituted thiophenes. Plots of the 13C-H coupling constants also showed a good linear relation. The 13C NMR data were interpreted by the stable conformation and percent s character of C-H bonds obtained by MNDO calculation

Bulletin of the Chemical Society of Japan published new progress about Electron configuration. 88105-22-0 belongs to class iodides-buliding-blocks, and the molecular formula is C6H5IO2S, Electric Literature of 88105-22-0.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Rahimidashaghoul, Kheironnesae; Klimankova, Iveta; Hubalek, Martin; Korecky, Michal; Chvojka, Matus; Pokorny, Daniel; Matousek, Vaclav; Fojtik, Lukas; Kavan, Daniel; Kukacka, Zdenek; Novak, Petr; Beier, Petr published the artcile< Reductant-induced free radical fluoroalkylation of nitrogen heterocycles and innate aromatic amino acid residues in peptides and proteins>, HPLC of Formula: 1391728-13-4, the main research area is peptides protein synthesis reductant induced free radical fluoroalkylation tryptophan; nitrogen heterocycle amino acid fluoroalkylation bioconjugation fluorine iodine radical; myoglobin ubiquitin human carbonic anhydrase functionalization mol modeling; fluoroalkylation reaction mechanism sodium ascorbate catalyst; bioconjugation; fluorine; iodine; radicals; tryptophan.

A series of fluoroalkylated cyclic λ3-iodanes and their hydrochloride salts was prepared and used in a combination with sodium ascorbate in buffer or aqueous methanol mixtures for radical fluoroalkylation of a range of substituted indoles, pyrroles, tryptophan or its derivatives, and Trp residues in peptides. As demonstrated on several peptides, the aromatic amino acid residues of Trp, Tyr, Phe, and His are targeted with high selectivity to Trp. The functionalization method is biocompatible, mild, rapid, and transition-metal-free. The proteins myoglobin, ubiquitin, and human carbonic anhydrase I were also successfully functionalized.

Chemistry – A European Journal published new progress about Fluoroalkylation. 1391728-13-4 belongs to class iodides-buliding-blocks, and the molecular formula is C9H10FIO, HPLC of Formula: 1391728-13-4.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Biller, Scott A.; Abt, Jeffrey W.; Pudzianowski, Andrew T.; Rich, Lois C.; Slusarchyk, Dorothy A.; Ciosek, Carl P. Jr. published the artcile< Aromatic isosteres as conformational probes for an isoprenyl subunit: application to inhibitors of squalene synthase>, Related Products of 88105-22-0, the main research area is aromatic isotere squalene synthase inhibitor; isoprenyl subunit conformational probe.

A series of aromatic isosteres of the farnesyl chain of potent squalene synthase inhibitor I were prepared and evaluated. The results are consistent with the local conformation indicated in structure II.

Bioorganic & Medicinal Chemistry Letters published new progress about Stereoselective synthesis. 88105-22-0 belongs to class iodides-buliding-blocks, and the molecular formula is C6H5IO2S, Related Products of 88105-22-0.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com