Tag: M.W=250-300

Bao, Lipiao; Zhao, Baolin; Assebban, Mhamed; Halik, Marcus; Hauke, Frank; Hirsch, Andreas published the artcile< Covalent 2D Patterning, Local Electronic Structure and Polarization Switching of Graphene at the Nanometer Level>, Electric Literature of 1391728-13-4, the main research area is twodimensional patterning electronic structure polarization graphene; covalent patterning; fluorination; graphene; polarization switch; substitution.

A very facile and efficient protocol for the covalent patterning and properties tuning of graphene is reported. Highly reactive fluorine radicals were added to confined regions of graphene directed by laser writing on graphene coated with 1-fluoro-3,3-dimethylbenziodoxole. This process allows for the realization of exquisite patterns on graphene with resolutions down to 200 nm. The degree of functionalization, ranging from the unfunctionalized graphene to extremely high functionalized graphene, can be precisely tuned by controlling the laser irradiation time. Subsequent substitution of the initially patterned fluorine atoms afforded an unprecedented graphene nanostructure bearing thiophene groups. This substitution led to a complete switch of both the electronic structure and the polarization within the patterned graphene regions. This approach paves the way towards the precise modulation of the structure and properties of nanostructured graphene.

Chemistry – A European Journal published new progress about Electronic structure. 1391728-13-4 belongs to class iodides-buliding-blocks, and the molecular formula is C9H10FIO, Electric Literature of 1391728-13-4.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sen, Chiranjit; Sahoo, Tapan; Singh, Harshvardhan; Suresh, Eringathodi; Ghosh, Subhash Chandra published the artcile< Visible Light-Promoted Photocatalytic C-5 Carboxylation of 8-Aminoquinoline Amides and Sulfonamides via a Single Electron Transfer Pathway>, Recommanded Product: Methyl 5-iodothiophene-2-carboxylate, the main research area is aminoquinoline amide sulfonamide carboxylation photocatalyst electron transfer pathway.

An efficient photocatalytic method was developed for the remote C5-H bond carboxylation of 8-aminoquinoline amide and sulfonamide derivatives This methodol. uses in situ generated •CBr3 radical as a carboxylation agent with alc. and is further extended to a variety of arenes and heteroarenes to synthesize the desired carboxylated product in moderate-to-good yields. The reaction proceeding through a single electron transfer pathway was established by a control experiment, and a butylated hydroxytoluene-trapped aryl radical cation intermediate in high-resolution mass spectrometry was identified.

Journal of Organic Chemistry published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent) (8-Aminoquinoline). 88105-22-0 belongs to class iodides-buliding-blocks, and the molecular formula is C6H5IO2S, Recommanded Product: Methyl 5-iodothiophene-2-carboxylate.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

D’Auria, Maurizio published the artcile< Photochemical behavior of halogenoheterocyclic derivatives. The alternative between arylation and dehalogenation reactions>, Product Details of C6H5IO2S, the main research area is heterocyclic compound halo arylation dehalogenation PM3.

Semiempirical calculations on the transient intermediates involved in the irradiation of haloheterocyclic compounds showed that the difference between the heat of formation of the substrates and that of the radical intermediates derived from cleavage of the C-X bond can be a useful parameter to justify the observed chem. behavior towards arylation or dehalogenation.

Heterocycles published new progress about Formation enthalpy. 88105-22-0 belongs to class iodides-buliding-blocks, and the molecular formula is C6H5IO2S, Product Details of C6H5IO2S.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Riley, William; Jones, Andrew C.; Singh, Kuldip; Browne, Duncan L.; Stuart, Alison M. published the artcile< Accessing novel fluorinated heterocycles with the hypervalent fluoroiodane reagent by solution and mechanochemical synthesis>, Application In Synthesis of 1391728-13-4, the main research area is flurotetrahydropyridazine preparation; unsaturated tosyl hydrazone fluoroiodane mediated regioselective intramol fluorocyclization; fluro dihydrooxazine preparation; unsaturatedketoxime fluoroiodane mediated regioselective intramol flurocyclization.

A new and efficient strategy for the rapid formation of novel fluorinated tetrahydropyridazines and dihydrooxazines were developed by fluorocyclisation of β,γ-unsaturated hydrazones and oximes with the fluoroiodane reagent. Mechanochem. synthesis delivered fluorinated tetrahydropyridazines in similar excellent yields to conventional solution synthesis, whereas fluorinated dihydrooxazines were prepared in much better yields by ball-milling.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alcohols, unsaturated Role: RCT (Reactant), RACT (Reactant or Reagent). 1391728-13-4 belongs to class iodides-buliding-blocks, and the molecular formula is C9H10FIO, Application In Synthesis of 1391728-13-4.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Schramm, Simon; Agnetta, Luca; Bermudez, Marcel; Gerwe, Hubert; Irmen, Matthias; Holze, Janine; Littmann, Timo; Wolber, Gerhard; Traenkle, Christian; Decker, Michael published the artcile< Novel BQCA- and TBPB-derived M1 receptor hybrid ligands: orthosteric carbachol differentially regulates partial agonism>, Safety of tert-Butyl (3-iodopropyl)carbamate, the main research area is BQCA TBPB carbachol muscarinic M1 agonist; GPCRs; allostery; dualsteric ligands; muscarinic receptors; partial agonists.

Recently, investigations of the complex mechanisms of allostery have led to a deeper understanding of G protein-coupled receptor (GPCR) activation and signaling processes. In this context, muscarinic acetylcholine receptors (mAChRs) are highly relevant due to their exemplary role in the study of allosteric modulation. In this work, we compare and discuss two sets of putatively dualsteric ligands, which were designed to connect carbachol to different types of allosteric ligands. We chose derivatives of TBPB [1-(1′-(2-tolyl)-1,4′-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one] as M1-selective putative bitopic ligands, and derivatives of benzyl quinolone carboxylic acid (BQCA) as an M1 pos. allosteric modulator, varying the distance between the allosteric and orthosteric building blocks. Luciferase protein complementation assays demonstrated that linker length must be carefully chosen to yield either agonist or antagonist behavior. These findings may help to design biased signaling and/or different extents of efficacy.

ChemMedChem published new progress about Homo sapiens. 167479-01-8 belongs to class iodides-buliding-blocks, and the molecular formula is C8H16INO2, Safety of tert-Butyl (3-iodopropyl)carbamate.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sun, Zenghui; Xue, Shilin; Zhang, Yining; Xin, Shiyang; Guo, Ran; Shi, Xiaowei; Fu, Yan; Guo, Huicai; Liu, Yi; Wang, Lei published the artcile< λ3-Iodane/Lewis Acid Mediated Intramolecular Cross-Nucleophile Coupling of β-Amino Acrylates: Chemodivergent Syntheses of Indole Alkaloidal Frameworks>, COA of Formula: C9H10FIO, the main research area is indole alkaloidal framework chemodivergent synthesis; amino acrylate intramol cross nucleophile coupling Lewis acid catalyst.

Herein, an unprecedented intramol. cross-nucleophile coupling strategy of indole tethered β-amino acrylates using a catalyst system combining λ3-iodanes and Lewis acids to achieve the chemodivergent synthesis of three unique alkaloid skeletons is reported. It was worth noting that the acquisition of spiroindolenines and azepino[4,5-b]indole derivatives was switchable with choice of the Lewis acids. Moreover, the polycyclic spiroindolines containing a lactone fragment could also be accessed for the first time via cross-nucleophile coupling cascade intramol. condensation sequence.

Organic Letters published new progress about Alkaloids Role: SPN (Synthetic Preparation), PREP (Preparation). 1391728-13-4 belongs to class iodides-buliding-blocks, and the molecular formula is C9H10FIO, COA of Formula: C9H10FIO.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Abudken, Ahmed M. H.; Hope, Eric G.; Singh, Kuldip; Stuart, Alison M. published the artcile< Fluorinations of unsymmetrical diaryliodonium salts containing ortho-sidearms; influence of sidearm on selectivity>, Synthetic Route of 1391728-13-4, the main research area is arene fluoroiodane fluorination; fluoroarene preparation.

Activated aromatics were reacted with two different fluoroidoane reagents in the presence of triflic acid to prepare only the para-substituted diaryliodonium salts. With fluoroiodane the unsym. diaryliodonium salts contained an ortho-propan-2-ol sidearm, whereas the alc. sidearm was eliminated to form an ortho-styrene sidearm in the reaction with fluoroiodane. Only the diaryliodonium salts containing a styrene sidearm were fluorinated successfully to deliver para-fluorinated aromatics in good yields.

Organic & Biomolecular Chemistry published new progress about Aromatic hydrocarbons Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1391728-13-4 belongs to class iodides-buliding-blocks, and the molecular formula is C9H10FIO, Synthetic Route of 1391728-13-4.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yannacone, Seth; Oliveira, Vytor; Verma, Niraj; Kraka, Elfi published the artcile< A continuum from halogen bonds to covalent bonds: where do λ3 iodanes fit?>, Product Details of C9H10FIO, the main research area is iodane halogen bond order atomic charge substituent effect.

The intrinsic bonding nature of λ3-iodanes was investigated to determine where its hypervalent bonds fit along the spectrum between halogen bonding and covalent bonding. D. functional theory with an augmented Dunning valence triple zeta basis set (ωB97X-D/aug-cc-pVTZ) coupled with vibrational spectroscopy was utilized to study a diverse set of 34 hypervalent iodine compounds This level of theory was rationalized by comparing computational and exptl. data for a small set of closely-related and well-studied iodine mols. and by a comparison with CCSD(T)/aug-cc-pVTZ results for a subset of the investigated iodine compounds Axial bonds in λ3 -iodanes fit between the three-center four-electron bond, as observed for the trihalide species IF-2 and the covalent FI mol. The equatorial bonds in λ3 -iodanes are of a covalent nature. We explored how the equatorial ligand and axial substituents affect the chem. properties of λ3 -iodanes by analyzing natural bond orbital charges, local vibrational modes, the covalent/electrostatic character, and the three-center four-electron bonding character. In summary, our results show for the first time that there is a smooth transition between halogen bonding → 3c-4e bonding in trihalides → 3c-4e bonding in hypervalent iodine compounds → covalent bonding, opening a manifold of new avenues for the design of hypervalent iodine compounds with specific properties.

Inorganics published new progress about Atomic charge. 1391728-13-4 belongs to class iodides-buliding-blocks, and the molecular formula is C9H10FIO, Product Details of C9H10FIO.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ren, Jing; Jia, Meng-Cheng; Du, Feng-Huan; Zhang, Chi published the artcile< A general method for one-step synthesis of monofluoroiodane(III) reagents using silver difluoride>, Synthetic Route of 1391728-13-4, the main research area is iodobenzene silver difluoride oxidative fluorination; aryl monofluoroiodane preparation.

A new general method for one-step synthesis of four kinds of fluoroiodane(III) reagents by treating the corresponding aryl iodides with silver difluoride (AgF2) was reported. This is the first method applicable for the synthesis of all four fluoroiodane(III) reagents including p-iodotoluene difluoride, fluoro-benziodoxoles, fluoro-benziodoxolones and fluoro-N-acetylbenziodazole. AgF2 was firstly employed in the direct oxidative fluorination of iodobenzene and thus has shown its outstanding oxidation and fluorine-transfer ability. The use of AgF2 has improved the synthesis of fluoroiodane(III) reagents by shortening the reaction steps, avoiding the use of hazardous reagents and simplifying the exptl. operations. It was worth noting that the developed first one-step direct synthetic method for fluoro-benziodoxolones, while fluoro-benziodoxolones can only be synthesized through Cl→F ligand exchange reaction previously.

Chinese Chemical Letters published new progress about Benzoic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 1391728-13-4 belongs to class iodides-buliding-blocks, and the molecular formula is C9H10FIO, Synthetic Route of 1391728-13-4.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yang, Tao; Chen, Xianxiao; Rao, Weidong; Koh, Ming Joo published the artcile< Broadly Applicable Directed Catalytic Reductive Difunctionalization of Alkenyl Carbonyl Compounds>, Computed Properties of 167479-01-8, the main research area is alkenyl carbonyl reductive difunctionalization nickel catalyst.

Catalytic alkene difuntionalization is a convenient platform for introducing complexity in mols. and has wide applications in organic synthesis. Yet a compelling challenge that remains to be solved is the regioselective insertion of two highly functionalized carbon-based moieties, derived from stable and readily available organohalide electrophiles without the need for pre-synthesized organometallic reagents, across C=C bonds in unactivated alkyl-substituted alkenes. That catalytic amounts of an inexpensive Ni-based catalyst, in combination with a readily recyclable 8-aminoquinoline directing group, promotes efficient and site-selective addition of two different organohalides (iodides and bromides) across aliphatic alkenes under mild reductive conditions. Compared to previous studies, this protocol exhibits broad and complementary functional group tolerance that extends to aryl-alkylation, alkenyl-alkylation, and dialkylation transformations. The utility of the strategy is demonstrated through concise synthesis of biol. active mols. Kinetic studies and other control experiments shed further light on the mechanistic underpinnings of the multicomponent reaction.

Chem published new progress about Alkenylation. 167479-01-8 belongs to class iodides-buliding-blocks, and the molecular formula is C8H16INO2, Computed Properties of 167479-01-8.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com