Tag: M.W=250-300

Knipe, Peter C. published the artcileA Lewis acid-mediated conformational switch, Quality Control of 105752-04-3, the main research area is pyridine alkyne ethyne benzoate preparation mol switch.

Mols. that change conformation in response to a stimulus have numerous uses, such as artificial chemoreceptors, novel drug delivery strategies and liquid crystal technol. Here the authors describe the design, synthesis and conformational behavior of an isonicotinamide-substituted diphenylacetylene upon recognition of Lewis acids, including metalloporphyrins. Binding of these at a remote site (i.e., pyridine nitrogen) increases hydrogen-bond donor ability of the proximal amide NH, causing an increased preference for the alkyne rotamer in which this hydrogen bond is maintained. The synthesis of the target compound was achieved by a reaction of 2-[2-[2-amino-6-(benzoylamino)phenyl]ethynyl]benzoic acid Me ester with 4-pyridinecarbonyl chloride. The title compound thus formed was a bis[amide] compound [[[[(pyridinyl)carbonyl]amino][(benzoyl)amino]phenyl]ethynyl]benzoic acid ester. The alkyne link permits a rapid interchange between conformers and the preferred conformation is determined by the hydrogen-donor properties of the amide bonds. Conformational changes were induced by various Lewis acids, such as [5,10,15,20-tetrakis[3,5-bis(1,1-dimethylethyl)phenyl]-21H,23H-porphinato(2-)-κN21,κN22,κN23,κN24]zinc (metalloporphyrin), trifluoroacetic acid, trifluoro[1,1′-oxybis[ethane]]boron (boron trifluoride etherate).

Organic & Biomolecular Chemistry published new progress about Chemoreceptors Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), SPN (Synthetic Preparation), PROC (Process), PREP (Preparation). 105752-04-3 belongs to class iodides-buliding-blocks, name is 4-Iodo-3-nitroaniline, and the molecular formula is C6H5IN2O2, Quality Control of 105752-04-3.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Weis, Jonathan G. published the artcileEmploying Halogen Bonding Interactions in Chemiresistive Gas Sensors, Category: iodides-buliding-blocks, the main research area is halogen bonding interaction chemiresistive gas sensor pyridine picoline detection.

This paper reports the use of halogen bonding interactions for gas-phase detection of pyridine in SWCNT-based chemiresistive sensors with sub-ppm theor. detection limits. The chemiresistors were prepared by solvent-free ball-milling of single-walled carbon nanotubes (SWCNTs) and aryl halide-based selectors, compression into a pellet, and subsequent mech. abrasion between gold electrodes on paper. The sensing responses reflect halogen bonding trends, with few exceptions. The predominant signal transduction mechanism is likely attributed to swelling of the insulating haloarene matrix.

ACS Sensors published new progress about Carbon nanotubes. 2100-25-6 belongs to class iodides-buliding-blocks, name is 3-Iodo-1,2,4,5-tetramethylbenzene, and the molecular formula is C10H13I, Category: iodides-buliding-blocks.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Shimizu, Kazuki published the artcileBoron-containing phenoxyacetanilide derivatives as hypoxia-inducible factor (HIF)-1α inhibitors, Application of 4-Iodo-2-nitrophenol, the main research area is boron containing phenoxyacetanilide derivative preparation hypoxia inducible factor inhibition; carboranylphenoxyacetanilide boronic acid derivative preparation HIF VEGF inhibition; aryloxyacetanilide pinacolboronate hypoxia induced HIF transcriptional activity inhibitor HeLa.

A series of boron-containing phenoxyacetanilide derivatives I [R1 = BPin, B(OH)2; R2 = Me, Et, Ph, Cy, 1-adamantyl, t-Bu, o-carboranyl] were synthesized as hypoxia-inducible factor (HIF)-1α inhibitors. Among the compounds synthesized, carboranylphenoxyacetanilide I [R1 = B(OH)2; R2 = o-carboranyl (II)] was found to be a potent inhibitor against HIF-1α accumulation under hypoxic conditions and inhibited the hypoxia-induced HIF-1 transcriptional activity in HeLa cells (IC50 = 0.74 μM). Compound II (GN26361) suppressed hypoxia-induced HIF-1α accumulation and vascular endothelial growth factor mRNA expression in a concentration-dependent manner without affecting the expression of HIF-1α mRNA.

Bioorganic & Medicinal Chemistry Letters published new progress about Boronic acids, esters Role: PAC (Pharmacological Activity), RCT (Reactant), SPN (Synthetic Preparation), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation). 21784-73-6 belongs to class iodides-buliding-blocks, name is 4-Iodo-2-nitrophenol, and the molecular formula is C6H4INO3, Application of 4-Iodo-2-nitrophenol.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reddy, K. Suresh Kumar published the artcileIodination of aromatic compounds using potassium iodide and hydrogen peroxide, Recommanded Product: 4-Iodo-2-nitrophenol, the main research area is arene regioselective iodination potassium iodide hydrogen peroxide; aryl iodide green preparation.

A simple, efficient, regioselective, and eco-friendly method for oxy-iodination of aromatic compounds is presented. In this method, the electrophilic substitutions of iodine generated in situ from KI as an iodine source and H2O2 as an O source were employed without any catalyst/mineral acid.

Synthetic Communications published new progress about Aryl iodides Role: SPN (Synthetic Preparation), PREP (Preparation). 21784-73-6 belongs to class iodides-buliding-blocks, name is 4-Iodo-2-nitrophenol, and the molecular formula is C6H4INO3, Recommanded Product: 4-Iodo-2-nitrophenol.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reitti, Marcus published the artcileSynthesis of Phenols and Aryl Silyl Ethers via Arylation of Complementary Hydroxide Surrogates, Related Products of iodides-buliding-blocks, the main research area is diaryliodonium salt silanol arylation; hydrogen peroxide diaryliodonium salt arylation; aryl silyl ether preparation; phenol preparation.

Two transition-metal-free methods to access substituted phenols via the arylation of silanols or hydrogen peroxide with diaryliodonium salts are presented. The complementary reactivity of the two nucleophiles allows synthesis of a broad range of phenols without competing aryne formation, as illustrated by the synthesis of the anesthetic Propofol. Furthermore, silyl-protected phenols can easily be obtained, which are suitable for further transformations.

Organic Letters published new progress about Alkynes, arynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 2100-25-6 belongs to class iodides-buliding-blocks, name is 3-Iodo-1,2,4,5-tetramethylbenzene, and the molecular formula is C10H13I, Related Products of iodides-buliding-blocks.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Albadi, Jalal published the artcileRegioselective iodination of aromatic compounds with potassium iodide in the presence of benzyltriphenylphosphonium perchlorate, Application In Synthesis of 21784-73-6, the main research area is regioselective iodination aromatic compound potassium iodide benzyltriphenylphosphonium perchlorate.

A simple and efficient method for the selective iodination of various aromatic compounds by using potassium iodide in the presence of benzyltriphenylphosphonium perchlorate, is reported. This method provides several advantages such as good selectivity between ortho and para positions of aromatic compounds and high yields of the products.

Chinese Chemical Letters published new progress about Iodination, regioselective. 21784-73-6 belongs to class iodides-buliding-blocks, name is 4-Iodo-2-nitrophenol, and the molecular formula is C6H4INO3, Application In Synthesis of 21784-73-6.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Pierre, Romain published the artcileNovel library synthesis of 3,4-disubstituted pyridin-2(1H)-ones via cleavage of pyridine-2-oxy-7-azabenzotriazole ethers under ionic hydrogenation conditions at room temperature, SDS of cas: 884494-51-3, the main research area is disubstituted pyridinone preparation kinase inhibitor; 7-azabenzotriazole; hinge-binder; ionic hydrogenation; library; pyridine-2(1H)-one.

A novel complementary multiparallel synthetic routes permitting the exploitation of the C-3 then C-4 vectors or vice versa to deliver library of novel 3,4-disubstituted pyridin-2(1H)-one kinase inhibitors I [R = (CH2)3OCH3, Ph, 2-EtC6H4, etc.; R1 = 4-NH2C6H10, CH2C(Me)2CH2NH2, cyclohexyl, etc.; R2 = H; R1R2 = CH2CH2OCH2CH2] starting from readily-available 2-chloro-4-fluoronicotinic acid and 2-fluoro-4-iodonicotinic acid resp. was developed. Perhaps the highlight of library route development was the novel transformation to the desired pyridin-2(1H)-one motif via in situ formation of the C2-OAt ether during HATU coupling and its cleavage under ionic hydrogenation conditions at just room temperature

Beilstein Journal of Organic Chemistry published new progress about Enzyme inhibitors (kinase). 884494-51-3 belongs to class iodides-buliding-blocks, name is 2-Fluoro-4-iodonicotinic acid, and the molecular formula is C6H3FINO2, SDS of cas: 884494-51-3.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Knipe, Peter C. published the artcileA Lewis acid-mediated conformational switch, Quality Control of 105752-04-3, the main research area is pyridine alkyne ethyne benzoate preparation mol switch.

Mols. that change conformation in response to a stimulus have numerous uses, such as artificial chemoreceptors, novel drug delivery strategies and liquid crystal technol. Here the authors describe the design, synthesis and conformational behavior of an isonicotinamide-substituted diphenylacetylene upon recognition of Lewis acids, including metalloporphyrins. Binding of these at a remote site (i.e., pyridine nitrogen) increases hydrogen-bond donor ability of the proximal amide NH, causing an increased preference for the alkyne rotamer in which this hydrogen bond is maintained. The synthesis of the target compound was achieved by a reaction of 2-[2-[2-amino-6-(benzoylamino)phenyl]ethynyl]benzoic acid Me ester with 4-pyridinecarbonyl chloride. The title compound thus formed was a bis[amide] compound [[[[(pyridinyl)carbonyl]amino][(benzoyl)amino]phenyl]ethynyl]benzoic acid ester. The alkyne link permits a rapid interchange between conformers and the preferred conformation is determined by the hydrogen-donor properties of the amide bonds. Conformational changes were induced by various Lewis acids, such as [5,10,15,20-tetrakis[3,5-bis(1,1-dimethylethyl)phenyl]-21H,23H-porphinato(2-)-κN21,κN22,κN23,κN24]zinc (metalloporphyrin), trifluoroacetic acid, trifluoro[1,1′-oxybis[ethane]]boron (boron trifluoride etherate).

Organic & Biomolecular Chemistry published new progress about Chemoreceptors Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), SPN (Synthetic Preparation), PROC (Process), PREP (Preparation). 105752-04-3 belongs to class iodides-buliding-blocks, name is 4-Iodo-3-nitroaniline, and the molecular formula is C6H5IN2O2, Quality Control of 105752-04-3.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Weis, Jonathan G. published the artcileEmploying Halogen Bonding Interactions in Chemiresistive Gas Sensors, Category: iodides-buliding-blocks, the main research area is halogen bonding interaction chemiresistive gas sensor pyridine picoline detection.

This paper reports the use of halogen bonding interactions for gas-phase detection of pyridine in SWCNT-based chemiresistive sensors with sub-ppm theor. detection limits. The chemiresistors were prepared by solvent-free ball-milling of single-walled carbon nanotubes (SWCNTs) and aryl halide-based selectors, compression into a pellet, and subsequent mech. abrasion between gold electrodes on paper. The sensing responses reflect halogen bonding trends, with few exceptions. The predominant signal transduction mechanism is likely attributed to swelling of the insulating haloarene matrix.

ACS Sensors published new progress about Carbon nanotubes. 2100-25-6 belongs to class iodides-buliding-blocks, name is 3-Iodo-1,2,4,5-tetramethylbenzene, and the molecular formula is C10H13I, Category: iodides-buliding-blocks.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Shimizu, Kazuki published the artcileBoron-containing phenoxyacetanilide derivatives as hypoxia-inducible factor (HIF)-1α inhibitors, Application of 4-Iodo-2-nitrophenol, the main research area is boron containing phenoxyacetanilide derivative preparation hypoxia inducible factor inhibition; carboranylphenoxyacetanilide boronic acid derivative preparation HIF VEGF inhibition; aryloxyacetanilide pinacolboronate hypoxia induced HIF transcriptional activity inhibitor HeLa.

A series of boron-containing phenoxyacetanilide derivatives I [R1 = BPin, B(OH)2; R2 = Me, Et, Ph, Cy, 1-adamantyl, t-Bu, o-carboranyl] were synthesized as hypoxia-inducible factor (HIF)-1α inhibitors. Among the compounds synthesized, carboranylphenoxyacetanilide I [R1 = B(OH)2; R2 = o-carboranyl (II)] was found to be a potent inhibitor against HIF-1α accumulation under hypoxic conditions and inhibited the hypoxia-induced HIF-1 transcriptional activity in HeLa cells (IC50 = 0.74 μM). Compound II (GN26361) suppressed hypoxia-induced HIF-1α accumulation and vascular endothelial growth factor mRNA expression in a concentration-dependent manner without affecting the expression of HIF-1α mRNA.

Bioorganic & Medicinal Chemistry Letters published new progress about Boronic acids, esters Role: PAC (Pharmacological Activity), RCT (Reactant), SPN (Synthetic Preparation), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation). 21784-73-6 belongs to class iodides-buliding-blocks, name is 4-Iodo-2-nitrophenol, and the molecular formula is C6H4INO3, Application of 4-Iodo-2-nitrophenol.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com