Tag: M.W=250-300

Bedrac, Leon published the artcileIodine(I) Reagents in Hydrochloric Acid-Catalyzed Oxidative Iodination of Aromatic Compounds by Hydrogen Peroxide and Iodine, Product Details of C10H13I, the main research area is iodine hydrochloric acid catalyzed oxidative iodination aromatic compound.

Hydrochloric acid activates the oxidative iodination of aromatic compounds with the iodine- hydrogen peroxide system through the formation of an iodine(I) compound as the iodinating reagent. Activation with hydrochloric acid is more powerful than that with sulfuric acid. The formation of dichloroiodic acid (HICl2) with various forms of hydrogen peroxide was followed using UV spectroscopy. The HICl2 was used as the iodinating reagent. In the preparative oxidative iodinaton of various aromatic compounds, hydrochloric acid was used in a catalytic amount and the iodine(I) reagent was formed in situ with 0.5 equivalent hydrogen peroxide and 0.5 equivalent mol. iodine. Two types of reactivity were observed in oxidative iodination with iodine(I) species catalyzed by hydrochloric acid: in the iodination of anisole better yields of iodination were observed with a smaller amount of hydrochloric acid, while on the contrary 4-tert-butyltoluene gave better yields of iodination upon increasing the amount of hydrochloric acid. Reactivity was further manipulated by the choice of the solvent (MeCN, trifluoroethanol, hexafluoro-2-propanol).

Advanced Synthesis & Catalysis published new progress about Aromatic compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 2100-25-6 belongs to class iodides-buliding-blocks, name is 3-Iodo-1,2,4,5-tetramethylbenzene, and the molecular formula is C10H13I, Product Details of C10H13I.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Cawood, Emma E. published the artcileModulation of amyloidogenic protein self-assembly using tethered small molecules, Recommanded Product: 2-Fluoro-4-iodonicotinic acid, the main research area is amyloidogenic protein self assembly intermediate structure tethered small mol; human beta 2 microglobulin variant aggregation intermediate structure.

Protein-protein interactions (PPIs) are involved in many of life’s essential biol. functions yet are also an underlying cause of several human diseases, including amyloidosis. The modulation of PPIs presents opportunities to gain mechanistic insights into amyloid assembly, particularly through the use of methods which can trap specific intermediates for detailed study. Such information can also provide a starting point for drug discovery. Here, we demonstrate that covalently tethered small mol. fragments can be used to stabilize specific oligomers during amyloid fibril formation, facilitating the structural characterization of these assembly intermediates. We exemplify the power of covalent tethering using the naturally occurring truncated variant (ΔN6) of the human protein β2-microglobulin (β2m), which assembles into amyloid fibrils associated with dialysis-related amyloidosis. Using this approach, we have trapped tetramers formed by ΔN6 under conditions which would normally lead to fibril formation and found that the degree of tetramer stabilization depends on the site of the covalent tether and the nature of the protein-fragment interaction. The covalent protein-ligand linkage enabled structural characterization of these trapped, off-pathway oligomers using X-ray crystallog. and NMR, providing insight into why tetramer stabilization inhibits amyloid assembly. Our findings highlight the power of “”post-translational chem. modification”” as a tool to study biol. mol. mechanisms.

Journal of the American Chemical Society published new progress about Amyloid fibril. 884494-51-3 belongs to class iodides-buliding-blocks, name is 2-Fluoro-4-iodonicotinic acid, and the molecular formula is C6H3FINO2, Recommanded Product: 2-Fluoro-4-iodonicotinic acid.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Seath, Ciaran P. published the artcileSynthesis of 2-BMIDA 6,5-bicyclic heterocycles by Cu(I)/Pd(0)/Cu(II) cascade catalysis of 2-iodoaniline/phenols, Recommanded Product: 3-Iodo-5-nitropyridin-2-amine, the main research area is BMIDA bicyclic heterocycle preparation; iodoaniline boronic acid MIDA ester heterocyclization copper palladium catalyst.

A one-pot cascade reaction for the synthesis of 2-BMIDA 6,5-bicyclic heterocycles has been developed using Cu(II)/Pd(0)/Cu(II) catalysis. 2-Iodoanilines and phenols undergo a Cu(I)/Pd(0)-catalyzed Sonogashira reaction with ethynyl BMIDA followed by in situ Cu(II)-catalyzed 5-endo-dig cyclization to generate heterocyclic scaffolds with a BMIDA functional group in the 2-position. The method provides efficient access to borylated indoles, benzofurans, and aza-derivatives, which can be difficult to access through alternative methods.

Chemical Communications (Cambridge, United Kingdom) published new progress about Heterocyclic compounds, nitrogen Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 25391-56-4 belongs to class iodides-buliding-blocks, name is 3-Iodo-5-nitropyridin-2-amine, and the molecular formula is C5H4IN3O2, Recommanded Product: 3-Iodo-5-nitropyridin-2-amine.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Misal, Balu published the artcileSulfated polyborate-H2O assisted tunable activation of N-iodosuccinimide for expeditious mono and diiodination of arenes, Application In Synthesis of 21784-73-6, the main research area is arene iodosuccinimide sulfated polyborate catalyst regioselective iodination; iodoarene preparation.

Owing to both Lewis and Bronsted acid active sites on sulfated polyborate under homogeneous conditions, iodination protocol of arenes was developed, which can meet the requirement of regioselectivity and higher yield. The sulfated polyborate activated N-iodosuccinimide for mono iodination of highly activated substrates viz. phenols, anilines under anhydrous condition. Water tuned sulfated polyborate to generate more Bronsted acid sites resulting in rapid activation of NIS for diiodination. The protocol was equally applicable to diiodination of 4-hydroxyphenylacetic acid to synthesize 4-hydroxy-3,5-diiodophenylacetic acid, an intermediate of tiratricol, a thyroid treatment drug. This protocol was further integrated via one-pot sequential iodination and Sonogashira coupling to synthesize aryl acetylenes, building blocks for the synthesis of a variety of specialty chems., API and natural products.

Tetrahedron Letters published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 21784-73-6 belongs to class iodides-buliding-blocks, name is 4-Iodo-2-nitrophenol, and the molecular formula is C6H4INO3, Application In Synthesis of 21784-73-6.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Shinde, Avinash T. published the artcileA practical iodination of aromatic compounds by using iodine and iodic acid, Recommanded Product: 4-Iodo-3-nitroaniline, the main research area is aromatic iodination iodine iodic acid; aryl iodide preparation.

This article described simple and efficient method for the iodination of different aromatic amines, hydroxy aromatic aldehydes, hydroxy acetophenones and phenols using iodine and iodic acid in ethanol as a solvent. Notable advantages include mild reaction condition, no need of catalyst, short reaction time, simple practical procedure, giving excellent yield of the product.

Synthetic Communications published new progress about Aromatic compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 105752-04-3 belongs to class iodides-buliding-blocks, name is 4-Iodo-3-nitroaniline, and the molecular formula is C6H5IN2O2, Recommanded Product: 4-Iodo-3-nitroaniline.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Patil, Arvind M. published the artcile2-methoxyethanol, a remarkably efficient and alternative reaction medium for iodination of reactive aromatics using iodine and iodic acid, SDS of cas: 105752-04-3, the main research area is aromatic iodination iodine iodic acid methoxyethanol; aryl iodide preparation solvent effect green chem.

Remarkably effective iodination of reactive aromatics carried out using iodine and iodic acid in 2-methoxyethanol as an efficient and alternative reaction medium. The comparison was made by carrying out iodination reaction in acetic acid and ethanol. The 2-methoxyethanol is excellent reaction solvent in terms of clean reaction conditions, short reaction time giving quant. yields of product and no need of further purification

Orbital: The Electronic Journal of Chemistry published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 105752-04-3 belongs to class iodides-buliding-blocks, name is 4-Iodo-3-nitroaniline, and the molecular formula is C6H5IN2O2, SDS of cas: 105752-04-3.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Mitra, Sudha Sumi published the artcilePolyhalide derivatives of poly[N-(2-aminoethyl)acrylamido]triethylammonium resins as iodinating reagents, Application In Synthesis of 105752-04-3, the main research area is polyacrylamide ammonium polyhalide iodinating reagent preparation; aryl amine iodination polyacrylamide ammonium polyhalide; phenol iodination polyacrylamide ammonium polyhalide; regioselective iodinating reagent aromatic amine phenol; iodo arene preparation.

Poly[N-(2-aminoethyl)acrylamido]triethylammonium dichloroiodate, tetrachloroiodate, and dibromoiodate resins are useful for selective iodination of aromatic amines and phenols. The influence of the various reaction parameters including nature of the solvent, effective molar concentration of the reagent, and temperature were investigated to find out optimum reaction conditions for achieving selectivity for monoiodination.

Macromolecular Chemistry and Physics published new progress about Aryl halides Role: SPN (Synthetic Preparation), PREP (Preparation). 105752-04-3 belongs to class iodides-buliding-blocks, name is 4-Iodo-3-nitroaniline, and the molecular formula is C6H5IN2O2, Application In Synthesis of 105752-04-3.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Liu-Gang published the artcileThieme chemistry journal awardees – where are they now? Synthesis of p-phenylene ethynylene based macrocycles and bimacrocycle through formation of the imine bond, Recommanded Product: 4-Iodo-2-nitrophenol, the main research area is aryl amine aromatic aldehyde imination macrocyclization; macrocyclic phenylene ethynylene imine preparation.

The synthesis of 3 monomacrocycles and 1 bimacrocycle from 2 para-phenylene ethynylene frameworks was described. For 2 of the monomacrocycles, the 2 frameworks were linked by an amide unit, and the macrocyclization involved the intramol. formation of 1 imine bond. For another monomacrocycle and the bimacrocycle, the frameworks contained 2 and 3 NH2 or CHO units, resp., and the macrocyclization involved the intermol. formation of 2 and 3 imine bonds, resp..

Synlett published new progress about Aromatic hydrocarbons, aryl alkynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 21784-73-6 belongs to class iodides-buliding-blocks, name is 4-Iodo-2-nitrophenol, and the molecular formula is C6H4INO3, Recommanded Product: 4-Iodo-2-nitrophenol.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Lei published the artcileEffect of the 3-halo substitution of the 2′-deoxy aminopyridinyl-pseudocytidine derivatives on the selectivity and stability of antiparallel triplex DNA with a CG inversion site, SDS of cas: 25391-56-4, the main research area is deoxyaminopyridinyl pseudocytidine halo derivative antiparallel triplex DNA CG inversion; Antiparallel triplex DNA; Artificial nucleoside analogue; Inversion site; Non-natural type triplex DNA.

Triplex formation against a target duplex DNA has the potential to become a tool for genome research. However, there is an intrinsic restriction on duplex DNA sequences capable of forming the triplex DNA. Recently, we demonstrated the selective formation of the stable antiparallel triplexes containing CG inversion sites using a 2′-deoxy-1-methylpseudocytidine derivative (ΨdC), whose amino group was conjugated with the 2-aminopyridine at its 5-position as an addnl. H-bonding unit (AP-ΨdC). The 1-N position of 2-aminopyridine was supposed to be protonated to form the H-bond with the guanine of the CG inversion site. Here, to test the effect of the 3-substitution of the 2-aminopyridine unit of AP-ΨdC on triplex stability, we synthesized 3-halogenated 2-aminopyridine derivatives of AP-ΨdC. The pKa values of the 1-N position of the 2-aminopyridine unit of AP-ΨdC as the monomer nucleoside were determined to be 6.3 for 3-CH3 (MeAP-ΨdC), 6.1 for 3-H (AP-ΨdC), 4.3 for 3-Cl (ClAP-ΨdC), 4.4 for 3-Br (BrAP-ΨdC), and 4.7 for 3-I (IAP-ΨdC), suggesting that all of the halogenated AP-ΨdCs are not protonated under neutral conditions. Interestingly, although the recognition selectivity depends on the sequence context, the triplex-forming oligodeoxyribonucleotides (TFOs) having the sequence of the 3′-G-(IAP-ΨdC)-A-5′ context showed selective triplex formation with the CG inversion site. These results suggest that the protonation at the 1-N position plays an important role in the stable and selective triplex formation of AP-ΨdC derivatives in any sequences.

Bioorganic & Medicinal Chemistry published new progress about GC content. 25391-56-4 belongs to class iodides-buliding-blocks, name is 3-Iodo-5-nitropyridin-2-amine, and the molecular formula is C5H4IN3O2, SDS of cas: 25391-56-4.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Pierre, Romain published the artcileNovel library synthesis of 3,4-disubstituted pyridin-2(1H)-ones via cleavage of pyridine-2-oxy-7-azabenzotriazole ethers under ionic hydrogenation conditions at room temperature, SDS of cas: 884494-51-3, the main research area is disubstituted pyridinone preparation kinase inhibitor; 7-azabenzotriazole; hinge-binder; ionic hydrogenation; library; pyridine-2(1H)-one.

A novel complementary multiparallel synthetic routes permitting the exploitation of the C-3 then C-4 vectors or vice versa to deliver library of novel 3,4-disubstituted pyridin-2(1H)-one kinase inhibitors I [R = (CH2)3OCH3, Ph, 2-EtC6H4, etc.; R1 = 4-NH2C6H10, CH2C(Me)2CH2NH2, cyclohexyl, etc.; R2 = H; R1R2 = CH2CH2OCH2CH2] starting from readily-available 2-chloro-4-fluoronicotinic acid and 2-fluoro-4-iodonicotinic acid resp. was developed. Perhaps the highlight of library route development was the novel transformation to the desired pyridin-2(1H)-one motif via in situ formation of the C2-OAt ether during HATU coupling and its cleavage under ionic hydrogenation conditions at just room temperature

Beilstein Journal of Organic Chemistry published new progress about Enzyme inhibitors (kinase). 884494-51-3 belongs to class iodides-buliding-blocks, name is 2-Fluoro-4-iodonicotinic acid, and the molecular formula is C6H3FINO2, SDS of cas: 884494-51-3.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com