Tag: M.W=250-300

Kurasaki, Haruaki published the artcileLpxC Inhibitors: Design, Synthesis, and Biological Evaluation of Oxazolidinones as Gram-negative Antibacterial Agents, Synthetic Route of 105752-04-3, the main research area is oxazolidinone derivative preparation LpxC inhibitor antibacterial; Antibacterial; Gram-negative bacteria; LpxC; oxazolidinone; scaffold hopping.

Herein we report a scaffold-hopping approach to identify a new scaffold with a zinc binding headgroup. Structural information was used to give novel oxazolidinone-based LpxC inhibitors. In particular, the most potent compound, 23j, showed a low efflux ratio, nanomolar potencies against E. coli LpxC enzyme, and excellent antibacterial activity against E. coli and K. pneumoniae. Computational docking was used to predict the interaction between 23j and E. coli LpxC, suggesting that the interactions with C207 and C63 contribute to the strong activity. These results provide new insights into the design of next-generation LpxC inhibitors.

ACS Medicinal Chemistry Letters published new progress about Antibacterial agents. 105752-04-3 belongs to class iodides-buliding-blocks, name is 4-Iodo-3-nitroaniline, and the molecular formula is C6H5IN2O2, Synthetic Route of 105752-04-3.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sohmiya, Hajime published the artcileSolid-state organic reactions proceeding by pulverization of inorganic solid-supports. Reactions of iodosobenzene with unsaturated hydrocarbons on acid-treated silica gel, Application of 3-Iodo-1,2,4,5-tetramethylbenzene, the main research area is hydrocarbon unsaturated halogenation oxidation solid state; solid state organic reaction; iodosobenzene reaction alkene acid silica gel; silica gel hydrohalogenated reaction alkene iodosobenzene.

Pulverization of solid mixtures of hydrogen halide-treated silica gels, PhIO, and alkenes or an alkyne in the absence of a solvent causes smooth and rapid reaction to give halogenated or oxidized products in good yields. Thus, treating trans-PhCH:CHPh with HCl-treated silica gel and PhIO in the solid state gives meso- and dl-PhCCl:CClPh in 65% overall yield.

Chemistry Letters published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 2100-25-6 belongs to class iodides-buliding-blocks, name is 3-Iodo-1,2,4,5-tetramethylbenzene, and the molecular formula is C10H13I, Application of 3-Iodo-1,2,4,5-tetramethylbenzene.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Kanosue, Kenta published the artcilePolyimides with Heavy Halogens Exhibiting Room-Temperature Phosphorescence with Very Large Stokes Shifts, SDS of cas: 2100-25-6, the main research area is polyimide heavy halogen exhibiting room temperature phosphorescence Stokes shift.

Semiarom. polyimides (PIs) and imide compounds containing heavy halogens (Br, I) in pyromellitic moieties were designed and synthesized to examine their photoluminescence properties. Solutions of imides and PI films exhibited reddish-color room-temperature phosphorescence (RTP) with very large Stokes shifts (ca. 10000 cm-1). In addition, the PI films showed small-Stokes-shifted fluorescence emissions at around 540 nm with absorption bands arising from aggregated PI chains at 400-500 nm. Enhanced phosphorescence observed for the PI films under vacuum indicates that the RTP lifetime is significantly influenced by the triplet-triplet energy transfer to atm. oxygen. These PIs with very-large-Stokes-shifted RTP are applicable as spectral conversion materials in displays, photovoltaic devices, and crop cultivators, as well as to oxygen/air sensors.

ACS Macro Letters published new progress about Electronic energy transfer, triplet-triplet. 2100-25-6 belongs to class iodides-buliding-blocks, name is 3-Iodo-1,2,4,5-tetramethylbenzene, and the molecular formula is C10H13I, SDS of cas: 2100-25-6.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Jin, Zuxi published the artcileSynthesis and properties of novel phenylethynyl-containing organodisulfide as cathode material for secondary lithium batteries, Formula: C10H13I, the main research area is synthesis property phenylethynyl containing organodisulfide cathode secondary lithium battery.

A novel phenylethynyl-containing conjugative organodisulfide compound 9-trimethylsilane-ethynyl-5,8-dihydro-lH,4H-2,3,6,7-tetrathia-anthracene (TMSEDTTA) was synthesized by a facile preparation method, characterized by elemental anal., FTIR spectroscopy (FTIR), Raman spectrum, XPS, and TGA, and was tested as cathode active material in rechargeable Li batteries. The electrochem. properties of S-S bonds redox behavior in the organodisulfides were studied in 1.0 M LiClO4/EC/DMC (1:1, volume/volume) solution The system has many advantages, such as high theor. charge d. (∼365 mAh g-1), fast redox process and enhanced reversibility. The fast redox process and enhanced reversibility are due to the intramol. cleavage-recombination of the S-S bond, and the intramol. electrocatalytic effect of phenylethynyl chain. The cyclic voltammogram of TMSEDTTA shows multiple redox peaks. The separation of the anodic and cathodic peak potentials for disulfide bond in TMSEDTTA is 0.4 V. The charge-discharge tests show an initial capacity of 330 mAh g-1 and the coulomb efficiency of >80% after the electrochem. activation.

Journal of Applied Electrochemistry published new progress about Battery cathodes (charging-discharging of). 2100-25-6 belongs to class iodides-buliding-blocks, name is 3-Iodo-1,2,4,5-tetramethylbenzene, and the molecular formula is C10H13I, Formula: C10H13I.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lai, Yu-Ying published the artcileSynthesis, Molecular and Photovoltaic Properties of an Indolo[3,2-b]indole-Based Acceptor-Donor-Acceptor Small Molecule, Application In Synthesis of 105752-04-3, the main research area is conjugated polymer indoloindole acceptor donor synthesis photovoltaic property; heterojunction solar cell indoloindole acceptor donor photovoltaic property.

Indolo[3,2-b]indole, containing two fused indole units, is an unexplored but promising electron-rich mol. for constructing donor-acceptor materials due to its planar, sym., and extended conjugated structure. A new synthetic pathway is successfully developed to prepare 2,7-diboronic ester-indolo[3,2-b]indole, which was then reacted with dithienodiketopyrrolo-pyrrole acceptor to afford a new acceptor-donor-acceptor (A-D-A) conjugated mol., 2,7-bis(dithienodiketopyrrolo-pyrrole)indolo[3,2-b]indole (2,7-DPPIIDPP). II is used to stand for indolo[3,2-b]indole in order to emphasize that this compound is constructed from two indole units. The A-D-A linkage through the 2,7-positions of II not only preserves the phenylene units in the para-conjugation but also renders stronger electron-donating strength. This material exhibited good thermal stability, high crystallinity, and broad UV/Vis absorption. The solution-processed bulk heterojunction device using the configuration of ITO/PEDOT:PSS/2,7-DPPIIDPP:PC71BM/Ca/Al exhibited a Voc of 0.72 V, a Jsc of 6.88 mA/cm2, and an FF of 49.6%, leading to a power conversion efficiency (PCE) of 2.45%.

European Journal of Organic Chemistry published new progress about Heterojunction semiconductor devices. 105752-04-3 belongs to class iodides-buliding-blocks, name is 4-Iodo-3-nitroaniline, and the molecular formula is C6H5IN2O2, Application In Synthesis of 105752-04-3.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhang, Wei published the artcilePalladium-Catalyzed Aromatic C-H Bond Nitration Using Removable Directing Groups: Regiospecific Synthesis of Substituted o-Nitrophenols from Related Phenols, Application In Synthesis of 21784-73-6, the main research area is pyridinyloxyphenol regiospecific nitration palladium catalyst; nitrophenol preparation.

A general and regiospecific transformation of substituted phenols into the related o-nitrophenols has been achieved via a three-step process involving the palladium-catalyzed chelation-assisted ortho-C-H bond nitration as the key step. In the process, 2-pyridinyloxy groups act as removable directing groups for the palladium-catalyzed ortho-nitration of substituted 2-phenoxypridines, and they can be readily removed in the subsequent conversion of the resulting 2-(2-nitrophenoxy)pyridines into 2-nitrophenols.

Journal of Organic Chemistry published new progress about Nitration catalysts (regiospecific). 21784-73-6 belongs to class iodides-buliding-blocks, name is 4-Iodo-2-nitrophenol, and the molecular formula is C6H4INO3, Application In Synthesis of 21784-73-6.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tsuda, Susumu published the artcileSynthesis of linked symmetrical [3] and [5]rotaxanes having an oligomeric phenylene ethynylene (OPE) core skeleton as a π-conjugated guest via double intramolecular self-inclusion, Category: iodides-buliding-blocks, the main research area is rotaxane oligomeric phenylene ethynylene cyclodextrin preparation absorption emission photoluminescence; inclusion Huisgen cycloaddition Sonogashira coupling.

Linked sym. [3] and [5]rotaxanes consisting of an oligomeric phenylene ethynylene (OPE) framework as a π-conjugated guest moiety and lipophilic permethylated α-cyclodextrins (PM α-CDs), as macrocyclic hosts have been prepared by double intramol. self-inclusion of an OPE guest unit carrying two PM α-CDs followed by capping with bulky stopper groups using click azide-alkyne Huisgen cycloaddition or Sonogashira coupling. The structures of these linked rotaxanes were determined by MALDI-TOF mass spectrum and two-dimensional NMR spectroscopy.

Tetrahedron Letters published new progress about 1,3-Dipolar cycloaddition reaction. 2100-25-6 belongs to class iodides-buliding-blocks, name is 3-Iodo-1,2,4,5-tetramethylbenzene, and the molecular formula is C10H13I, Category: iodides-buliding-blocks.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Hutton, Harold M. published the artcileDetermination of substituent effects by factor analysis and multiple linear regression for the carbon-13 nuclear magnetic resonance chemical shifts in 4-substituted phenols and 2-nitrophenols, Product Details of C6H4INO3, the main research area is LFER NMR phenol derivative.

13C NMR chem. shifts are reported for a series of 4-substituted phenols and 2-nitrophenols in Me2SO. For chem. shift correlations, it was found by factor anal. and iterative multiple linear regression that the para chem. shifts require two substituent factors whereas the ipso, ortho, and meta chem. shifts require 3 factors. Regression analyses were performed using the field and resonance parameters (σF, σR0) and the appropriate ipso, ortho, and meta parameters determined by Reynolds. Good correlations were obtained except for the 3 meta carbon analyses, where the correlation coefficients range from 0.877 to 0.963.

Canadian Journal of Chemistry published new progress about Linear free energy relationship. 21784-73-6 belongs to class iodides-buliding-blocks, name is 4-Iodo-2-nitrophenol, and the molecular formula is C6H4INO3, Product Details of C6H4INO3.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Gundoju, Narayanarao published the artcileBetulinic acid derivatives: a new class of α-glucosidase inhibitors and LPS-stimulated nitric oxide production inhibition on mouse macrophage RAW 264.7 cells, Name: 4-Iodo-3-nitroaniline, the main research area is betulinic acid alpha glucosidase inhibitor; LPS-stimulated nitric oxide production inhibition; betulinic acid; α-glucosidase inhibition.

Chem. manipulation studies were conducted on betulinic acid, twenty-one new rationally designed analogs of betulinic acid with modifications at C-28 were synthesized for their evaluation of inhibitory effects on α-glucosidase and LPS-stimulated nitric oxide production in mouse macrophage RAW 264.7 cells. 2-Oxo-2-morpholinoethyl 3β-hydroxylup-20(29)-en-28-oate (2; IC50 = 5.4 μM) exhibited an almost 1.4-fold increase in α-glucosidase inhibitory activity on yeast α-glucosidase while analogs (IC50 16.4 μM) and (IC50 16.6 μM) exhibited a 2-fold enhanced inhibitory activity on NO-production than betulinic acid.

Natural Product Research published new progress about Structure-activity relationship. 105752-04-3 belongs to class iodides-buliding-blocks, name is 4-Iodo-3-nitroaniline, and the molecular formula is C6H5IN2O2, Name: 4-Iodo-3-nitroaniline.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Orlov, V. Yu. published the artcileEffect of the electronic structure of the radical anions of 4-substituted 1,2- and 1,3-dinitrobenzenes on the regioselectivity of reduction of the nitro groups, Name: 4-Iodo-3-nitroaniline, the main research area is selective reduction dinitrobenzene regioselectivity nitro group.

Theor. and exptl. regularities of the regioselectivity of the reduction of one of the two nitro groups in unsym. dinitrobenzenes were studied. It was found that the regioselectivity of the formation of isomeric nitroanilines depends on the structure of the substrate and the nature of the reducing agent. The reduction regioselectivity model was verified, according to which radical anion protonation is the major reaction direction.

Russian Journal of General Chemistry published new progress about AM1 (molecular orbital method). 105752-04-3 belongs to class iodides-buliding-blocks, name is 4-Iodo-3-nitroaniline, and the molecular formula is C6H5IN2O2, Name: 4-Iodo-3-nitroaniline.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com