Tag: M.W=250-300

Hamdouni, Noudjoud published the artcileIododurene, Recommanded Product: 3-Iodo-1,2,4,5-tetramethylbenzene, the main research area is iododurene crystal mol structure.

The title compound (systematic name: 1-iodo-2,3,5,6-tetramethylbenzene), C10H13I, crystallizes in the chiral space group P212121. The I atom is displaced by 0.1003(5) Å from the mean plane of the ten C atoms [maximum deviation = 0.018(6) Å]. In the crystal, there are no significant intermol. interactions present.

Acta Crystallographica, Section E: Structure Reports Online published new progress about Crystal structure. 2100-25-6 belongs to class iodides-buliding-blocks, name is 3-Iodo-1,2,4,5-tetramethylbenzene, and the molecular formula is C10H13I, Recommanded Product: 3-Iodo-1,2,4,5-tetramethylbenzene.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Pan, Wen-Bin published the artcileNitrophenol derivatives obtained by oxidation with cerium(IV) ammonium nitrate (CAN) and their cytotoxicity, Safety of 4-Iodo-2-nitrophenol, the main research area is phenol derivative nitration cerium ammonium nitrate; nitrophenol derivative preparation antitumor; cerium ammonium nitrate nitration mediator.

Nitration of a series of phenols with cerium(IV) ammonium nitrate in acetonitrile under mild conditions yielded the mixture of corresponding nitrophenols. The prepared compounds have been tested for their antitumor activity on Hep G2, Hep 3B, MCF-7 and MDA-MB-231 cancer cell lines. Some of them showed selective activities.

Journal of the Chinese Chemical Society (Taipei, Taiwan) published new progress about Antitumor agents. 21784-73-6 belongs to class iodides-buliding-blocks, name is 4-Iodo-2-nitrophenol, and the molecular formula is C6H4INO3, Safety of 4-Iodo-2-nitrophenol.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Foley, Daniel J. published the artcilePhenotyping Reveals Targets of a Pseudo-Natural-Product Autophagy Inhibitor, Formula: C5H4IN3O2, the main research area is indocinchona alkaloid synthesis palladium catalyzed annulation autophagy inhibitor; alkaloids; autophagy; chemical biology; inhibitors; natural products.

Pseudo-natural-product (NP) design combines natural product fragments to provide unprecedented NP-inspired compounds not accessible by biosynthesis, but endowed with biol. relevance. Since the bioactivity of pseudo-NPs may be unprecedented or unexpected, they are best evaluated in target agnostic cell-based assays monitoring entire cellular programs or complex phenotypes. Here, the Cinchona alkaloid scaffold was merged with the indole ring system to synthesize indocinchona alkaloids by Pd-catalyzed annulation. Exploration of indocinchona alkaloid bioactivities in phenotypic assays revealed a novel class of azaindole-containing autophagy inhibitors, the azaquindoles. Subsequent characterization of the most potent compound, azaquindole-1 (I), in the morphol. cell painting assay, guided target identification efforts. In contrast to the parent Cinchona alkaloids, azaquindoles selectively inhibit starvation- and rapamycin-induced autophagy by targeting the lipid kinase VPS34.

Angewandte Chemie, International Edition published new progress about Autophagy inhibitors. 25391-56-4 belongs to class iodides-buliding-blocks, name is 3-Iodo-5-nitropyridin-2-amine, and the molecular formula is C5H4IN3O2, Formula: C5H4IN3O2.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Luccarelli, James published the artcileUnpicking the determinants of amide NH···O=C hydrogen bond strength with diphenylacetylene molecular balances, Related Products of iodides-buliding-blocks, the main research area is diphenylacetylene preparation hydrogen bond strength conformation substituent effect.

Hydrogen bonding plays an essential part in dictating the properties of natural and synthetic materials. Secondary amides are well suited to cross-strand interactions through the display of both hydrogen bond donors and acceptors and are prevalent in polymers such as proteins, nylon and Kevlar. In attempting to measure hydrogen bond strength and to delineate the stereoelectronic components of the interaction, context frequently becomes vitally important. This makes mol. balances – systems in which direct comparison of two groups is possible – an appealing bottom up approach that allows the complexity of larger systems to be stripped away. We have previously reported a family of single mol. conformational switches that are responsive to diverse stimuli including Bronsted and Lewis acids, anions and redox gradients. In this work we assess the ability of the scaffold, based on a 2,6-disubstituted diphenylacetylene, to measure accurately the difference in hydrogen bond strength between variously functionalized amides. In all of the examples investigated hydrogen bond strength closely correlate to measures of Bronsted acidity suggesting that the scaffold is well-suited as a platform for the accurate determination of bond strength in variously substituted systems.

Organic & Biomolecular Chemistry published new progress about Bond angle, dihedral. 105752-04-3 belongs to class iodides-buliding-blocks, name is 4-Iodo-3-nitroaniline, and the molecular formula is C6H5IN2O2, Related Products of iodides-buliding-blocks.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Gould, J. P. published the artcileKinetics of the heterogeneous ozonation of nitrated phenols, Formula: C6H4INO3, the main research area is nitrophenol ozonization water wastewater.

The kinetics of the heterogeneous ozonization of PhOH and 27 nitrophenols representing a wide array of functional groups was studied. In the systems examined, the process was of zero order with respect to phenolic concentration, which indicates mass transfer as the prime control on the process. Anal. of the 1st-order rate constants permitted computation of overall mass transfer coefficients for all compounds The coefficients were 60% lower than the kLa (where kL = liquid mass transfer coefficient and a = sp. interfacial surface area) values measured by others in water and showed very little variation regardless of chem. structure of the phenol. Efforts at development of a QSAR model for the kinetics were fruitless.

Water Science and Technology published new progress about Ozonization kinetics. 21784-73-6 belongs to class iodides-buliding-blocks, name is 4-Iodo-2-nitrophenol, and the molecular formula is C6H4INO3, Formula: C6H4INO3.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ershad Halim, Md. published the artcileSynthesis of bromo- and iodo-substituted pyromellitic diimide-based [2+2]- and [3+3]macrocycles, and their absorption spectra and electrochemical and inclusion properties, Computed Properties of 2100-25-6, the main research area is pyromellitic diimide macrocycle absorption spectra electrochem inclusion.

New pyromellitic diimide-based tetrabromo[2+2]macrocycle ([2+2]MC) 2, tribromo- and hexabromo[3+3]MCs 3a and 3b, and triiodo[3+3]MC 3c were synthesized as structural units of covalently bound nanotubes, and their absorption spectra and redox properties, and inclusion phenomena of the [2+2]MC 2 were reported. Tetrabromo[2+2]MC 2 forms a 1:1 inclusion complex with toluene, whose structure was revealed by x-ray structural anal.

Tetrahedron Letters published new progress about Absorption spectra. 2100-25-6 belongs to class iodides-buliding-blocks, name is 3-Iodo-1,2,4,5-tetramethylbenzene, and the molecular formula is C10H13I, Computed Properties of 2100-25-6.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wei, Wen-Ting published the artcileRoom-Temperature, Water-Promoted, Radical-Coupling Reactions of Phenols with tert-Butyl Nitrite, Related Products of iodides-buliding-blocks, the main research area is room temperature radical cross coupling phenol tert butyl nitrite; ortho nitrated phenol preparation carbon water promoted cross coupling.

A radical-radical cross-coupling reaction of phenols with tert-Bu nitrite has been developed with the use of water as an additive. This method allows the construction of C-N bonds under an air atm. at room temperature, providing the ortho-nitrated phenol derivative in moderate to good yields.

Synlett published new progress about C-N bond formation. 21784-73-6 belongs to class iodides-buliding-blocks, name is 4-Iodo-2-nitrophenol, and the molecular formula is C6H4INO3, Related Products of iodides-buliding-blocks.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Bhat, Prasanna V. published the artcileEfficient and Scalable Process for Synthesis of 5-Nitro-7-azaindole, Computed Properties of 25391-56-4, the main research area is nitroazaindole preparation scalable process; nitrotrimethylsilanylethynylpyridinylamine preparation cycloisomerization; nitropyridinamine iodination Sonogashira reaction.

A simple and straightforward methodol. for the synthesis of 5-nitro-7-azaindole I has been developed using metal-free cycloisomerization of 5-nitro-3-trimethylsilanylethynyl-pyridin-2-ylamine. Large-scale applicability of this newly developed method was successfully demonstrated on multikilogram scale to obtain I in consistent yield and purity.

Organic Process Research & Development published new progress about Cycloisomerization. 25391-56-4 belongs to class iodides-buliding-blocks, name is 3-Iodo-5-nitropyridin-2-amine, and the molecular formula is C5H4IN3O2, Computed Properties of 25391-56-4.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Borkar, Vitthal T. published the artcileA novel ternary approach to quantitatively assess the reactivity of nitroaniline regioisomers by investigation of rapid iodination kinetics using hydrodynamic voltammetry, reduction propensities from polarography, and binding affinities from molecular docking simulations, Synthetic Route of 105752-04-3, the main research area is nitroaniline regioisomer iodination reaction mechanism kinetic study mol docking.

A novel ternary approach to assess the reactivity of nitroaniline regioisomers on a quant. scaffold has been manifested on the basis of three complementary tenets: kinetics, polarog., and mol. docking. Data from investigation of rapid iodination kinetics of nitroaniline regioisomers by hydrodynamic voltammetry in aqueous medium, reduction propensities of these regioisomers from polarog., and their binding affinities with hypoxanthine-guanine phophoribosyltransferase (HPRT1) from mol. docking simulations lead to inferences regarding their reactivity that agree in entirety. The exptl. determined magnitudes of the specific reaction rates, energies of activation, collision frequencies, entropies of activation from kinetic studies, and reduction propensities of nitroaniline regioisomers from polarograms when complemented with in silico binding energies of these regioisomer ligands with the receptor enzyme, assess their relative reactivities in unison on a quant. scaffold. This novel ternary approach unambiguously assesses the reactivity of the regioisomers of nitroaniline as 4-nitroaniline > 2-nitroaniline > 3-nitroaniline.

International Journal of Chemical Kinetics published new progress about Activation energy. 105752-04-3 belongs to class iodides-buliding-blocks, name is 4-Iodo-3-nitroaniline, and the molecular formula is C6H5IN2O2, Synthetic Route of 105752-04-3.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Saikia, L. published the artcileRegiospecific Oxyhalogenation of Aromatics Over SBA-15-Supported Nanoparticle Group IV-VI Metal Oxides, Recommanded Product: 4-Iodo-2-nitrophenol, the main research area is aromatic compound oxyhalogenation metal oxide catalyst silica support.

TiOx, VOx, MoOx and WOx supported on SBA-15 exhibit efficient catalytic activity for oxyhalogenation of aromatics with the H2O2-halide ion system. Unlike the hitherto known solid catalysts, these reusable catalysts yield the para-halogenated product with 100% selectivity at 298 K and moderate acidic pH (3-5). The catalytic activity was enhanced by five orders of magnitude when supported on SBA-15.

Catalysis Letters published new progress about Bromination catalysts. 21784-73-6 belongs to class iodides-buliding-blocks, name is 4-Iodo-2-nitrophenol, and the molecular formula is C6H4INO3, Recommanded Product: 4-Iodo-2-nitrophenol.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com