Tag: M.W=250-300

Qian, Yong published the artcileActivity-Based Proteome Profiling Probes Based on Woodward’s Reagent K with Distinct Target Selectivity, COA of Formula: C10H7IN2, the publication is Angewandte Chemie, International Edition (2016), 55(27), 7766-7771, database is CAplus and MEDLINE.

Woodward’s reagent K (WRK) is a reactive heterocyclic compound that has been employed in protein chem. to covalently and unspecifically label proteins at nucleophilic amino acids, notably at histidine and cysteine. The authors have developed a panel of WRK-derived activity-based probes and show that surprisingly and unexpectedly, these probes are fairly selective for a few proteins in the human proteome. The WRK-derived probes show unique reactivity towards the catalytic N-terminal proline in the macrophage migration inhibitory factor (MIF) and can be used to label and, if equipped with a fluorophore, to image MIF activities in living cells.

Angewandte Chemie, International Edition published new progress about 41270-96-6. 41270-96-6 belongs to iodides-buliding-blocks, auxiliary class Pyrimidine,Iodide,Benzene,Immunology/Inflammation,MIF, name is 4-Iodo-6-phenylpyrimidine, and the molecular formula is C10H7IN2, COA of Formula: C10H7IN2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Aurelio, Luigi published the artcileFrom Sphingosine Kinase to Dihydroceramide Desaturase: A Structure-Activity Relationship (SAR) Study of the Enzyme Inhibitory and Anticancer Activity of 4-((4-(4-Chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II), Quality Control of 39115-95-2, the publication is Journal of Medicinal Chemistry (2016), 59(3), 965-984, database is CAplus and MEDLINE.

The sphingosine kinase (SK) inhibitor, SKI-II, has been employed extensively in biol. investigations of the role of SK1 and SK2 in disease and has demonstrated impressive anticancer activity in vitro and in vivo. However, interpretations of results using this pharmacol. agent are complicated by several factors: poor SK1/2 selectivity, addnl. activity as an inducer of SK1-degradation, and off-target effects, including its recently identified capacity to inhibit dihydroceramide desaturase-1 (Des1). In this study, we have delineated the structure-activity relationship (SAR) for these different targets and correlated them to that required for anticancer activity and determined that Des1 inhibition is primarily responsible for the antiproliferative effects of SKI-II and its analogs. In the course of these efforts, a series of novel SK1, SK2, and Des1 inhibitors have been generated, including compounds with significantly greater anticancer activity.

Journal of Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Quality Control of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Aitov, I. A. published the artcileReaction of quinolinium salts with 2-cyano-2-(ethoxymethylene)acetanilide, Application of 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Zhurnal Organicheskoi Khimii (1994), 30(2), 291-4, database is CAplus.

Reaction of quinolinium halides I (R = Me, Et, allyl; R¹ = H, Me; X = I, Br) with EtOCH:C(CN)CONHPh (II) in the presence of Et₃N gave merocyanines III in 16-79% yield. Reaction of phenacylquinolinium bromides IV (R² = H, Cl, Br) with II gave merocyanines V and inner salts VI.

Zhurnal Organicheskoi Khimii published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Application of 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lin, Shizhuo published the artcileLayered Double Hydroxides as Reusable Catalysts for Cyclocondensation of Amidines and Aminoalcohols: Access to Multi-functionalized Oxazolines, Computed Properties of 134322-01-3, the publication is Journal of Organic Chemistry (2022), 87(2), 1366-1376, database is CAplus and MEDLINE.

An efficient catalytic protocol based on reusable MgAl-layered double hydroxides has been developed for the synthesis of multi-functionalized oxazolines via the cyclocondensation of amidines and aminoalcs. The developed method has a broad substrate scope and excellent functional group tolerance and uses a reusable catalyst. The catalyst can be conveniently recycled by filtration and reused for at least five times without obvious deactivation. Addnl., the selective ortho C-H silylation of oxazolines was performed using Ru(II) as the catalyst and tri-Et silane as the silylating reagent, which proved to be a convenient and practical method for the synthesis of versatile organosilyl-functionalized oxazolines with advantageous biol. and phys. properties.

Journal of Organic Chemistry published new progress about 134322-01-3. 134322-01-3 belongs to iodides-buliding-blocks, auxiliary class Salt,Iodide,Amine,Amidine,Benzene, name is 4-Iodobenzimidamide hydrochloride, and the molecular formula is C7H8ClIN2, Computed Properties of 134322-01-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhang, Ziyi published the artcileStudies on acylthiosemicarbazides and related heterocyclic derivatives. (XVII). Synthesis of 1-arylformyl-4-[4′-(2,2,6,6-tetramethylpiperidine)-1-oxy]thiosemicarbazide compounds, COA of Formula: C7H7IN2O, the publication is Gaodeng Xuexiao Huaxue Xuebao (1991), 12(8), 1056-60, database is CAplus.

Twenty-one title compounds I (R = Ph, pyridyl, 1-naphthyl, 2-phenyl-4-quinolyl, R¹C₆H₄; R¹ = 2-F, 3-F, 4-F, 2-Cl, 3-Cl, 4-Cl, 2-Br, 3-Br, 4-Br, 4-iodo, 4-Me, 3-Me, 2-MeO, 4-MeO, 2-NO₂, 3-NO₂, 4-NO₂) were prepared and characterized by IR, mass spectrometry, and ESR. Preliminary results show that I are inhibitors of L₇₇₁₂ leukemia cells.

Gaodeng Xuexiao Huaxue Xuebao published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C4H7BrO2, COA of Formula: C7H7IN2O.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sakamoto, Takao published the artcileSynthesis and reaction of tributylstannylpyrazoles, Quality Control of 141998-77-8, the publication is Heterocycles (1992), 33(2), 813-18, database is CAplus.

1,3-Dipolar cycloaddition reaction of diazomethane and Et diazoacetate with tributylstannylacetylenes occurred regioselectively to afford the corresponding 3(5)-tributylstannylpyrazoles. The cycloaddition reaction of 3-phenylsydnone with the stannylacetylenes proceeded also regioselectively, and 3-tributylstannyl-1-phenylpyrazoles were isolated. 4-Tributylstannyl- and 5-tributylstannyl-1-phenylpyrazole were prepared by the stannylation of 4-lithio- and 5-lithio-1-phenylpyrazole with tributylstannyl chloride. Iodination, benzoylation, and phenylation of the stannylpyrazoles were examined

Heterocycles published new progress about 141998-77-8. 141998-77-8 belongs to iodides-buliding-blocks, auxiliary class Pyrazole,Iodide,Ester,Pyrazole, name is Ethyl 5-iodo-1H-pyrazole-3-carboxylate, and the molecular formula is C6H7IN2O2, Quality Control of 141998-77-8.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tominaga, Yoshinori published the artcileSynthesis of methylthiomaleimides for the preparation of pyridazines and related compounds, COA of Formula: C12H14IN, the publication is Journal of Heterocyclic Chemistry (2002), 39(3), 571-591, database is CAplus.

New functionalized maleimides [3-(methylthio)-2,5-dioxo-1H-pyrroles] were obtained by the reaction of ketene dithioacetals with nitromethane or the reaction of nitro ketene dithioacetal with active methylene compounds in the presence of the appropriate base in DMSO followed by treatment with methanol. These maleimides reacted with various nucleophilic reagents such as electron-rich aromatic and heteroaromatic compounds like dialkylanilines, aminophenols, indoles, indolizines, and cyclazines to give the corresponding 3-aryl- or -heteroaryl-1H-pyrrole-2,5-diones. Styryl and merocyanine dyes, and polycyclic pyridazinediones as chemiluminophors and succinimides were also obtained from these maleimides with good results.

Journal of Heterocyclic Chemistry published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C18H23N3O4S, COA of Formula: C12H14IN.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Salvador, Maria A. published the artcileDelocalized cationic azo dyes containing a thiazole moiety, Related Products of iodides-buliding-blocks, the publication is Tetrahedron (2008), 64(2), 299-303, database is CAplus.

Several new delocalized cationic azo dyes incorporating a bathochromic thiazole moiety have been prepared in moderate to good yields. The synthesis involved the Knoevenagel condensation of an intermediate azo compound, bearing a terminal formyl group, with methylenic bases generated in situ from benzazolium and quinolinium salts. All dyes display strong absorption around 700 nm and have shown neg. solvatochromic behavior. The possible application of the dyes as sensitizers for photodynamic therapy was briefly discussed.

Tetrahedron published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Salvador, Maria A. published the artcileDelocalized cationic azo dyes derived from 2-aminoselenazole-5-carbaldehyde, Formula: C12H14IN, the publication is ARKIVOC (Gainesville, FL, United States) (2008), 90-95, database is CAplus.

Several delocalized cationic azo dyes incorporating a selenazole ring were prepared by Knoevenagel condensation of an intermediate azo compound bearing a 5-formylselenazole group with methylene bases derived from indolenine, benzothiazole, benzoselenazole, and quinoline. All dyes display a strong absorption at around 700 nm, bathochromically shifted relative to their thiazole analogs, and show a neg. solvatochromic behavior.

ARKIVOC (Gainesville, FL, United States) published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Formula: C12H14IN.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Stewart, Georgina M. published the artcileSynthesis of substituted 9-oxo-9,10-dihydroacridine-4-carboxylic acids. I. Factors affecting the direction of ring closure of substituted N-(2-carboxyphenylamino)benzoic acids, Quality Control of 145343-76-6, the publication is Australian Journal of Chemistry (1984), 37(9), 1939-50, database is CAplus.

The cyclodehydration of (2-carboxyphenylamino)benzoic acids I (R = NO₂, CO₂H, Cl, Br, etc.) by H₂SO₄, POCl₃, or by Et polyphosphate to give mixtures of dihydroacridinecarboxylic acids II and III depended on the electronic and steric effects of R. Judicious choice of substituent and cyclizing reagent gave a large excess of 1 isomer.

Australian Journal of Chemistry published new progress about 145343-76-6. 145343-76-6 belongs to iodides-buliding-blocks, auxiliary class Chloride,Iodide,Carboxylic acid,Benzene, name is 2-Chloro-4-iodobenzoic acid, and the molecular formula is C22H12F6O6S2, Quality Control of 145343-76-6.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com