M.W=250-300 Archives - Page 27 of 39 - Iodides-buliding-blocks

Sarver, Patrick’s team published research in Journal of Medicinal Chemistry in 62 | CAS: 2055760-88-6

Journal of Medicinal Chemistry published new progress about 2055760-88-6. 2055760-88-6 belongs to iodides-buliding-blocks, auxiliary class Pyrimidine, name is 2-Chloro-5-iodo-3-methylpyrimidin-4(3H)-one, and the molecular formula is C5H4ClIN2O, Quality Control of 2055760-88-6.

Sarver, Patrick published the artcile6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors, Quality Control of 2055760-88-6, the publication is Journal of Medicinal Chemistry (2019), 62(4), 1793-1802, database is CAplus and MEDLINE.

Protein tyrosine phosphatase SHP2 is an oncoprotein associated with cancer as well as a potential immune modulator because of its role in the programmed cell death PD-L1/PD-1 pathway. In the preceding manuscript, we described the optimization of a fused, bicyclic screening hit for potency, selectivity, and physicochem. properties in order to further expand the chem. diversity of allosteric SHP2 inhibitors. In this manuscript, we describe the further expansion of our approach, morphing the fused, bicyclic system into a novel monocyclic pyrimidinone scaffold through our understanding of SAR and use of structure-based design. These studies led to the identification of SHP394 (1), an orally efficacious inhibitor of SHP2, with high lipophilic efficiency, improved potency, and enhanced pharmacokinetic properties. We also report other pyrimidinone analogs with favorable pharmacokinetic and potency profiles. Overall, this work improves upon our previously described allosteric inhibitors and exemplifies and extends the range of permissible chem. templates that inhibit SHP2 via the allosteric mechanism.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Morshedy, M.’s team published research in Alexandria Science Exchange in 7 | CAS: 39115-95-2

Alexandria Science Exchange published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Recommanded Product: 4-Iodobenzohydrazide.

Morshedy, M. published the artcileInhibition of monoamine oxidase by benzoyl hydrazide derivatives, Recommanded Product: 4-Iodobenzohydrazide, the publication is Alexandria Science Exchange (1986), 7(1), 33-8, database is CAplus.

The in vitro inhibition of mitochondrial rat liver monoamine oxidase (MAO) activity by synthetic benzoyl hydrazide (I) derivatives was studied. The tested compounds were unsubstituted I and 2- and 4-chloro-I, 2-, 3-, and 4-methyl-I, 2- and 4-iodo-I, 4-methoxy- and 2-nitro-I. 4-Methyl- and 4-chloro-I exhibited a strong inhibitory effect for MAO activity, whereas unsubstituted I was the lowest one. On the other hand, all of the substitution in the benzoyl moiety caused good improvement in the inhibitory power of the I derivative, especially the ortho-para director groups or atoms.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Saleh, Tamer S.’s team published research in Ultrasonics Sonochemistry in 36 | CAS: 39115-95-2

Ultrasonics Sonochemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Safety of 4-Iodobenzohydrazide.

Saleh, Tamer S. published the artcileSonochemical synthesis of novel pyrano[3,4-e][1,3]oxazines: A green protocol, Safety of 4-Iodobenzohydrazide, the publication is Ultrasonics Sonochemistry (2017), 474-480, database is CAplus and MEDLINE.

The atom-efficient and green protocol for formation of pyrano[3,4-e][1,3]oxazines I [R = n-Bu, NHPh, cyclohexyl, etc.] via reaction of di-Me carbonate and 3-(1-(substituted imino)ethyl)-4-hydroxy-6-methyl-2H-pyran-2-ones under ultrasound irradiation in a presence of KF/basic alumina was reported. In general, it was found that ultrasound irradiations enable the reactions to occur which could not be carried out under silent conditions. These remarkable effects appeared in sonicated reactions could be reasonably interpreted in terms of acoustic cavitation phenomenon. This protocol offered several advantages attain many principles of green chem. including, save energy, atom economy, clean reactions, inexpensive green reagent and use catalysts rather than stoichiometric reagents.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Salvador, Maria A.’s team published research in Dyes and Pigments in 82 | CAS: 606-55-3

Dyes and Pigments published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Application of 1-Ethyl-2-methylquinolin-1-ium iodide.

Salvador, Maria A. published the artcileNear-infrared absorbing delocalized cationic azo dyes, Application of 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Dyes and Pigments (2009), 82(2), 118-123, database is CAplus.

Novel, delocalized, cationic azo dyes derived from benzothiazole, benzoselenazole, indole and quinoline, displaying strong absorption around 700-800 nm, have been prepared in moderate to good yields. The synthesis involved the Knoevenagel condensation of an intermediate azo compound, possessing a 4-chloro-5-formylthiazole moiety, with methylenic bases generated in situ from benzoazolium and quinolinium salts.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sohmiya, Hajime’s team published research in Tetrahedron in 1998-11-05 | CAS: 2100-25-6

Tetrahedron published new progress about Halogenation. 2100-25-6 belongs to class iodides-buliding-blocks, name is 3-Iodo-1,2,4,5-tetramethylbenzene, and the molecular formula is C10H13I, Product Details of C10H13I.

Sohmiya, Hajime published the artcileSolid-state organic reactions proceeding by pulverization: oxidation and halogenation with iodosobenzene and inorganic solid-supports, Product Details of C10H13I, the main research area is solid state halogenation oxidation pulverization.

Pulverization-activation method was employed to accelerate solid-state organic reactions. Crushing and grinding of solid mixtures of hydrogen halide-treated silica gels, iodosobenzene, and organic substrates in the absence of a solvent brought about smooth and rapid reactions to give halogenated and/or oxidized products in good yields. Various sulfides were smoothly converted to sulfonyl chlorides in one step in excellent yields. The surface of silica gel activated by pulverization serves as a reaction field on which reagent mols. can effectively encounter with each other.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Richardson, Mark B.’s team published research in Bioconjugate Chemistry in 2020-05-20 | CAS: 105752-04-3

Bioconjugate Chemistry published new progress about Amino group. 105752-04-3 belongs to class iodides-buliding-blocks, name is 4-Iodo-3-nitroaniline, and the molecular formula is C6H5IN2O2, Quality Control of 105752-04-3.

Richardson, Mark B. published the artcilePyrocinchonimides Conjugate to Amine Groups on Proteins via Imide Transfer, Quality Control of 105752-04-3, the main research area is pyrocinchonimide conjugate amine protein imide; crystal structure.

Advances in bioconjugation, the ability to link biomols. to each other, small mols., surfaces, and more, can spur the development of advanced materials and therapeutics. The authors have discovered that pyrocinchonimide, the dimethylated analog of maleimide, undergoes a surprising transformation with biomols. The reaction targets amines and involves an imide transfer, which has not been previously reported for bioconjugation purposes. Despite their similarity to maleimides, pyrocinchonimides do not react with free thiols. Though both lysine residues and the N-termini of proteins can receive the transferred imide, the reaction also exhibits a marked preference for certain amines that cannot solely be ascribed to solvent accessibility. This property is peculiar among amine-targeting reactions and can reduce combinatorial diversity when many available reactive amines are available, such as in the formation of antibody-drug conjugates. Unlike amides, the modification undergoes very slow reversion under high pH conditions. The reaction offers a thermodynamically controlled route to single or multiple modifications of proteins for a wide range of applications.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Padin, Damian’s team published research in Organic Letters in 2020-04-03 | CAS: 21784-73-6

Organic Letters published new progress about Alkylation. 21784-73-6 belongs to class iodides-buliding-blocks, name is 4-Iodo-2-nitrophenol, and the molecular formula is C6H4INO3, COA of Formula: C6H4INO3.

Padin, Damian published the artcileRuthenium-Catalyzed Tandem Carbene/Alkyne Metathesis/N-H Insertion: Synthesis of Benzofused Six-Membered Azaheterocycles, COA of Formula: C6H4INO3, the main research area is benzofused six membered azaheterocycle preparation; alkynylaniline trimethylsilyldiazomethane ruthenium catalyst.

The Cp*RuCl-based catalyst enables expedient access to a variety of benzofused six-membered azaheterocycles from unprotected o-alkynylanilines and trimethylsilyldiazomethane through an unprecedent tandem carbene/alkyne metathesis/N-H insertion reaction. The transformation takes place under mild reaction conditions (room temperature, <15 min) and with excellent functional group tolerance. The synthetic utility of the final products and a mechanistic rationale are also discussed. Organic Letters published new progress about Alkylation. 21784-73-6 belongs to class iodides-buliding-blocks, name is 4-Iodo-2-nitrophenol, and the molecular formula is C6H4INO3, COA of Formula: C6H4INO3.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sanquer, M.’s team published research in Studies in Physical and Theoretical Chemistry in 1987 | CAS: 2100-25-6

Studies in Physical and Theoretical Chemistry published new progress about Elasticity. 2100-25-6 belongs to class iodides-buliding-blocks, name is 3-Iodo-1,2,4,5-tetramethylbenzene, and the molecular formula is C10H13I, COA of Formula: C10H13I.

Sanquer, M. published the artcileElastic constants in molecular crystals: experiments and intermolecular potentials, COA of Formula: C10H13I, the main research area is elastic constant mol crystal; durene elasticity crystal; dibenzyl elasticity crystal; chlorobenzophenone elasticity crystal.

Elastic constants were measured for dibenzyl, durene, and iododurene and compared to the computed constants obtained from atom-atom potentials applied to nonbonded atom pairs. Agreement is found for dibenzyl and for the lower and higher phases of p-dichlorobenzophenone whereas computed constants for disordered crystals are systematically too large indicating a coupling between sound waves and the mol. orientational motions.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Pinto, M. F. S.’s team published research in Journal of Molecular Structure: THEOCHEM in 2001-04-20 | CAS: 21784-73-6

Journal of Molecular Structure: THEOCHEM published new progress about Fungicides. 21784-73-6 belongs to class iodides-buliding-blocks, name is 4-Iodo-2-nitrophenol, and the molecular formula is C6H4INO3, Recommanded Product: 4-Iodo-2-nitrophenol.

Pinto, M. F. S. published the artcilePattern recognition study of structure-activity relationship of halophenols and halonitrophenols against fungus T. mentagrophytes, Recommanded Product: 4-Iodo-2-nitrophenol, the main research area is halophenol halonitrophenol structure activity relationship fungicide Trichophyton; pattern recognition structure activity relationship antifungal halophenol halonitrophenol.

Compounds (halophenols and halonitrophenols) with antifungal activity against the fungus species Trichophyton mentagrophytes are proposed with the aid of techniques of structure-activity relationship. Mol. parameters were calculated with quantum chem., structure-activity relationship and quant. structure-activity relationship programs. Principal components anal., hierarchical cluster anal. and stepwise discriminant anal. methods showed that the parameters polarizability (Pol), heat of formation (ΔHf), lowest unoccupied orbital energy (εLUMO), dipole moment (μ), hydration energy (HE) and surface area (A) are responsible for the separation between the active and inactive compounds

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Gershon, H.’s team published research in Monatshefte fuer Chemie in 1995-10-31 | CAS: 21784-73-6

Monatshefte fuer Chemie published new progress about Fungicides. 21784-73-6 belongs to class iodides-buliding-blocks, name is 4-Iodo-2-nitrophenol, and the molecular formula is C6H4INO3, Computed Properties of 21784-73-6.

Gershon, H. published the artcileAntifungal activity of halophenols and halonitrophenols/, Computed Properties of 21784-73-6, the main research area is fungicide halophenol halonitrophenol.

Thirty one compounds (phenol, 12 monohalo derivatives and 18 nitrophenols, i.e. 2- and 4-nitrophenols, 4-, 5- and 6-halo-2-nitrophenols, 3-halo-4-nitrophenols) were tested for antifungal activity against six fungi (Aspergillus niger, A. oryzae, Myrothecium verrucaria, Trichoderma viride, Mucor cirinelloides, and Trichophyton mentagrophytes) in Sabouraud dextrose broth. The two most fungitoxic compounds were 5-fluoro- and 5-iodo-2-nitrophenol, which inhibited all the fungi at <10 μg/mL. 6-Iodo-2-nitrophenol inhibited 5 fungi at <10 μg/mL and M. cirinelloides at 10-100 μg/mL. Monatshefte fuer Chemie published new progress about Fungicides. 21784-73-6 belongs to class iodides-buliding-blocks, name is 4-Iodo-2-nitrophenol, and the molecular formula is C6H4INO3, Computed Properties of 21784-73-6.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com