Tag: M.W=250-300

Shaikh, Zara published the artcileChemistry and antioxidant properties of titanium(IV) complexes, COA of Formula: C7H7IN2O, the publication is Transition Metal Chemistry (Dordrecht, Netherlands) (2015), 40(6), 665-671, database is CAplus.

The synthesis of Ti(IV) complexes with biol. active hydrazide ligands was carried out. The complexes were characterized by spectroscopic methods (IR, ¹H NMR and ¹³C NMR), elemental anal. and conductivity studies. These studies suggest bidentate coordination of the ligands through carbonyl O and primary amine N, resulting in octahedral geometries. Hydrazides with pyridyl substituents displayed 1:2 metal-to-ligand ratio, and hydrazides with imino substituents exhibited 1:3 metal-to-ligand ratio resulting in an outer sphere complex. The remaining complexes displayed inner sphere coordination with 1:1 metal-to-ligand ratio. These complexes exhibit varying degrees of radical scavenging properties against DPPH, superoxide and nitric oxide free radicals. The free ligands showed inhibition against DPPH, but were inactive against superoxide and nitric oxide free radicals. The structure-activity relations of the complexes are discussed.

Transition Metal Chemistry (Dordrecht, Netherlands) published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C6H8O4, COA of Formula: C7H7IN2O.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Denny, William A. published the artcilePotential antitumor agents. Part 38. 3-Substituted 5-carboxamido derivatives of amsacrine, Recommanded Product: 2-Chloro-4-iodobenzoic acid, the publication is Journal of Medicinal Chemistry (1983), 26(11), 1619-25, database is CAplus and MEDLINE.

The title compounds I (R = Cl, NH₂, NO₂, Me, or MeO; R¹ = CONH₂, CONHMe, CONHCH₂CONH₂, or p-CO₂C₆H₄NO₂) as the HCl salt prepared by the reaction of a halobenzoic acid with an aminobenzoate ester, ring closure of the half ester formed with polyphosphate ester to an acridanone ester, slow hydrolysis to the acid, conversion to the appropriate chloro derivative and reaction with 4-aminomethanesulfon-m-anisidide  [57165-06-7], and I (R = H, Br, Cl, I, NH₂, NO₂, Me, or MeO; R¹ = H, CONH₂, CONHMe) were evaluated for in vivo activity against animal leukemia models. Structure-activity relations are discussed.

Journal of Medicinal Chemistry published new progress about 145343-76-6. 145343-76-6 belongs to iodides-buliding-blocks, auxiliary class Chloride,Iodide,Carboxylic acid,Benzene, name is 2-Chloro-4-iodobenzoic acid, and the molecular formula is C7H4ClIO2, Recommanded Product: 2-Chloro-4-iodobenzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Patnaik, Anup published the artcileDiscovery of a novel indole pharmacophore for the irreversible inhibition of myeloperoxidase (MPO), Application of 4-Iodo-3-(trifluoromethyl)-1H-pyrazole, the publication is Bioorganic & Medicinal Chemistry (2020), 28(12), 115548, database is CAplus and MEDLINE.

Myeloperoxidase (MPO) activity and subsequent generation of hypochlorous acid has been associated with the killing of host-invading microorganisms (e.g. bacteria, viruses, and fungi). However, during oxidative stress, high MPO activity can damage host tissue and is linked to several chronic inflammatory conditions. Herein, we describe the development of a novel biaryl, indole-pyrazole series of irreversible mechanism-based inhibitors of MPO. Derived from an indole-containing high-throughput screen hit, optimization efforts resulted in potent and selective 6-substituted indoles with good oral bioavailability and in vivo activity.

Bioorganic & Medicinal Chemistry published new progress about 866638-72-4. 866638-72-4 belongs to iodides-buliding-blocks, auxiliary class Trifluoromethyl,Pyrazole,Fluoride,Iodide, name is 4-Iodo-3-(trifluoromethyl)-1H-pyrazole, and the molecular formula is C4H2F3IN2, Application of 4-Iodo-3-(trifluoromethyl)-1H-pyrazole.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tseng, Chih-Chung published the artcileThe Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB₁ Receptor Positive Allosteric Modulators, HPLC of Formula: 101420-79-5, the publication is Journal of Medicinal Chemistry (2019), 62(10), 5049-5062, database is CAplus and MEDLINE.

3-Nitroalkyl-2-phenylindoles were prepared as analogs of known CB₁ receptor pos. allosteric modulators; related 3-(trifluoroalkyl)-2-phenylindoles such as I were prepared to test if the trifluoromethyl group could act as a bioisostere of the nitro group. The trifluoromethyl-bearing compounds were generally more potent than their nitro equivalent and also showed improved in vitro metabolic stability. The racemate of I has similar activity to the known CB₁ receptor pos. allosteric modulator (±)-ZCZ011, with both showing promising efficacy in a mouse model of neuropathic pain.

Journal of Medicinal Chemistry published new progress about 101420-79-5. 101420-79-5 belongs to iodides-buliding-blocks, auxiliary class Nitrile,Nitro Compound,Iodide,Benzene,Benzene Compounds, name is 4-Iodo-3-nitrobenzonitrile, and the molecular formula is C6H8O4, HPLC of Formula: 101420-79-5.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Mason, Stephen J. published the artcileSolid-phase catch, activate, and release synthesis of cyanine dyes, Recommanded Product: 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Organic Letters (2002), 4(24), 4261-4264, database is CAplus and MEDLINE.

Trimethine cyanine dyes were synthesized by capture and activation of a hemicyanine intermediate on a sulfonyl chloride resin followed by reaction and concomitant cleavage by a heterocyclic carbon nucleophile. A small array of dyes was synthesized and characterized to demonstrate the versatility of this chem. for a number of hemicyanines and heterocyclic nucleophiles.

Organic Letters published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Recommanded Product: 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Abd El-Aal, R. M. published the artcileSynthesis and solvatochromic behavior of new asymmetrical mono-(tri)-methine cyanine dyes, Synthetic Route of 606-55-3, the publication is Proceedings – Indian Academy of Sciences, Chemical Sciences (1998), 110(4), 433-444, database is CAplus.

6-Amino-5-cyano-3-methyl-1,4-diarylpyrano[2,3-c]pyrazole cationic derivatives were prepared via the interaction of α,β-unsaturated nitriles with 3-methyl-1-phenyl-5-pyrazolone as starting materials in the synthesis of new asym. mono-(tri)-methine cyanine dyes. The new cyanines were characterized by elemental anal. and IR and ¹H-NMR spectral data. The visible absorption spectra of some selected dyes were investigated in pure and mixed solvents as well as in aqueous buffer solutions

Proceedings – Indian Academy of Sciences, Chemical Sciences published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Synthetic Route of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

El Ashry, El Sayed H. published the artcileHeterocycles from carbohydrate precursors. Part XI. Transformation of the hydrazones of 6-chloro-3-(L-threo-2,3,4-trihydroxy-1-oxobutyl)-2-quinoxalinone into other heterocyclic compounds, COA of Formula: C7H7IN2O, the publication is Carbohydrate Research (1978), 67(2), 403-14, database is CAplus.

The difference in reactivity of the two amino groups in 3,4-(H₂N)₂C₆H₃Cl allowed it to react with L–threo-2,3-hexodiulosono-1,4-lactone to give, after further reaction with various hydrazines, quinoxalinones I (R = 4-R¹C₆H₄, 4-R²C₆H₄CO; R¹ = Me, OMe, Br, I, NO₂, SO₂NH₂, R² = H, Me, Cl, I), whose structures were deduced from their reactions, as well as from mass spectrometry of the p-nitrophenylhydrazones. Elimination of one mol of water per mol from these hydrazones gave the 1-aryl-6-chloro-3-(L-glycerol-1-yl)flavazoles; the mass spectrum of one of these flavazoles is discussed. Elimination of two mols of water per mol from I (R = C₆H₄Me-4, C₆H₄Br-4, C₆H₄I-4) occurred with simultaneous cyclization to give 3-[1-aryl-5-(hydroxymethyl)pyrazol-3-yl]-6-chloro-2-quinoxalinones, whose acetylation gave the corresponding monoacetyl derivatives that could also be obtained by the action of boiling Ac₂O on the starting hydrazones. Periodate oxidation of the hydrazones and the flavazole derivatives afforded the corresponding aldehydes.

Carbohydrate Research published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, COA of Formula: C7H7IN2O.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Koraiem, Ahmed I. published the artcileSynthesis and photophysical characterization of highly stable cyanine dyes based on pyrazolo[5,4-b]pyrido[2,1-c]pyrimidine and pyrazolo [5,4-b]pyrido[2,1-d][1,3,4] triazepine, Recommanded Product: 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Journal of Applicable Chemistry (Lumami, India) (2018), 7(4), 821-834, database is CAplus.

Outstanding stable cyanine dyes covering the types of monomethine, trimethine, styryl, azastyryl and apocyanines with absorption band reached to 550 nm have been developed and synthesized. These dyes based on high stable N-bridgehead heterocycles namely Pyrazolo[5,4-b]pyrido[2,1-c] pyrimidine, pyrazolo[5,4-b]pyrido[2,1-d][1,3,4] triazepines as precursors for the synthesis of the target dyes. The absorption spectra properties of such selected dyes were investigated in 95% ethanol to attempt and throw some light on the influence of such new heterocyclic nuclei and to compare or evaluate spectral behaviors. Such Heterocyclic precursors and related dyes were identified by elemental and spectral analyzes.

Journal of Applicable Chemistry (Lumami, India) published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Recommanded Product: 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Qurrat-ul-Ain published the artcileMulti-activity tetracoordinated pallado-oxadiazole thiones as anti-inflammatory, anti-Alzheimer, and anti-microbial agents: Structure, stability and bioactivity comparison with pallado-hydrazides, Application In Synthesis of 39115-95-2, the publication is Biomedicine & Pharmacotherapy (2022), 112561, database is CAplus and MEDLINE.

Herein, we report a comparative study based on structure, thermal and solution stability, and biopotency against lipoxygenase (LOX), butyrylcholinesterase (BChE) and microbes for Pd(II) compounds of N,O,S bearing 5-(C₅H₄XR)-1,3,4-oxadiazole-2-thiones (L′) of type [PdL′Cl₂] (P′n) and N,O bearing resp. hydrazides (L) of type trans-[PdL₂Cl₂] (Pn) {X = C, R = 4-I, 2-Br, 4-NO₂, 3-NO₂, 2-Cl, 3-Cl (n = 1-6, serially); X = N (n = 7)}. Spectral techniques (IR, EI-MS, NMR) and physicochem. evaluations successfully characterized the new compounds The L′ behaved as bidentate S-N donors bonded through exocyclic sulfur and N-3′ nitrogen, while L acted as amino N donors. UV-vis (solution speciation) and thermal degradation profiles consistently confirmed the greater stability for P′n than Pn compounds These compounds manifested varying degree in vitro potential to inhibit LOX, BChE and several bacteria and fungi, affected mainly by Pd(II) presence, M-L binding mode, nature and position of R, or halo groups electronegativity. Mol. docking with human 5-LOX and BChE further validated the resp. exptl. inhibition findings and explored several putative mechanistic interactions (H-bonding, π-stacking, π-alkyl, π-S, etc.) at the enzyme active sites. Pn generally offered superior antimicrobial and anti-LOX (anti-inflammatory) potential than resp. P′n compounds, with P3/P′5, P(2,3,7)/P′3, and P6 being comparable, better and equivalent to ampicillin, nystatin and baicalein, the reference antibacterial, antifungal and anti-LOX drugs, resp. Contrarily, the anti-BChE activity of P′n was found better than Pn compounds, showing P′2/P1 as the most promising anti-Alzheimer drug candidates. This study bares important structural and mechanistic aspects in optimizing antimicrobial, anti-inflammatory and anti-Alzheimer activities, highlighting some potential future pallado-drug candidates.

Biomedicine & Pharmacotherapy published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Application In Synthesis of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

El-Deen Mohamed, Naglaa Salah published the artcileSynthesis, spectroscopic and antimicrobial studies of some novel cyanine dyes based on bis-coumarin heterocycles derivatives, Synthetic Route of 606-55-3, the publication is European Journal of Chemistry (2016), 7(1), 66-72, database is CAplus.

Novel sym. and unsym. cyanine dyes, incorporating merocyanine monomethine like, pentamethine cyanine, monomethine-meso-substituted-pentamethine and mono-5[2(4)]-methine cyanine dye were prepared through the synthesis of new starting compound derivatives named as 1,3-bis-(2-oxo-2H-chromen-3-yl) propane-1,3-dione and (3-oxo1,3-bis(2-oxo-2H-chromen-3-yl)prop-1-enyloxy) copper, cobalt and nickel chloride salt complexes. Structure determination of the new compounds has been characterized on the basis of elemental anal., IR, ¹H NMR and MS spectra. Structure photosensitization relationship of new dyes have been discussed on the basis of their spectral behavior as criteria of photosensitizing effect through the UV visible-absorption spectra of all synthesized dyes which investigated in 95% ethanol. Antimicrobial properties of some selected cyanine dyes have been investigated against Streptococcus sp, Staphylococcus sp, Salmonella sp. and Shigella sp.

European Journal of Chemistry published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Synthetic Route of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com