Tag: M.W=250-300

Yu, Gang published the artcileSynthesis and bioactivity of sulfide derivatives containing 1,3,4-oxadiazole and pyridine, Category: iodides-buliding-blocks, the publication is Turkish Journal of Chemistry (2019), 43(4), 1075-1085, database is CAplus.

A series of novel sulfide derivatives containing 1,3,4-oxadiazole and pyridine were synthesized, characterized, and tested for their antibacterial activity against tobacco bacterial wilt and rice bacterial blight and for insecticidal activity toward diamondback moth. The results showed that some compounds had good insecticidal and bactericidal activity, e.g., the activities of compounds 6e and 6g-6j toward tobacco bacterial wilt were much better than those of com. thiodiazole-copper, and some of the synthesized compounds possessed good insecticidal activity against Plutella xylostella. Compounds 6d, 6h, 6j, 6l, 6p, 6r, and 6p displayed over 93% activity at 500 mg L^-1.

Turkish Journal of Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H5ClN2S, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yu, Bole published the artcileRhodium-catalyzed C-H activation of hydrazines leads to isoquinolones with tunable aggregation-induced emission properties, Recommanded Product: 4-Iodobenzohydrazide, the publication is Chemical Communications (Cambridge, United Kingdom) (2015), 51(76), 14365-14368, database is CAplus and MEDLINE.

Using an internally oxidizing directing group (DG) strategy, the authors report a Rh^III-catalyzed synthesis of isoquinolones via C-H activation/annulation of benzoylhydrazines and alkynes. Tunable double cascade cyclization of benzoylhydrazines with two equivalent of alkynes led to tetracyclic amides. These N-heterocycles demonstrated adjustable AIE properties.

Chemical Communications (Cambridge, United Kingdom) published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C42H63O3P, Recommanded Product: 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Cha, Sunyoung published the artcileNegative solvatochromism of merocyanine dyes: Application as water content probes for organic solvents, Quality Control of 606-55-3, the publication is Sensors and Actuators, B: Chemical (2011), 157(1), 14-18, database is CAplus.

Two new merocyanine dyes derived from 7-hydroxycoumarin were prepared, and their signaling ability to detect water content in organic solvents was investigated. The dyes exhibited a pronounced neg. solvatochromism, and dramatic changes in absorption spectra and λ _max as a function of water content were observed Solvatochromic behavior was pronounced in regions of less than 5% water content; therefore, these dyes could be used as chromogenic probes for detecting water in common water miscible organic solvents.

Sensors and Actuators, B: Chemical published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Quality Control of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Munchhof, Michael J. published the artcileDesign and SAR of thienopyrimidine and thienopyridine inhibitors of VEGFR-2 kinase activity, Related Products of iodides-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry Letters (2004), 14(1), 21-24, database is CAplus and MEDLINE.

Novel classes of thienopyrimidines and thienopyridines have been identified as potent inhibitors of VEGFR-2 kinase. The synthesis and structure-activity relationship of these compounds is presented, along with successful efforts to diminish EGFR activity present in the lead series. The presence of a 2-Me substituent in the indole moiety in the [(2-methyl-1H-indol-5-yl)amino]thieno[3,2-b]pyridine series [I, R = CH₂N(Me)(CH₂)₂OH, CH₂NH(CH₂)₃OH, CH₂NH(CH₂)₂O(CH₂)₂OH, CH₂NH(CH₂)₂OH, etc., R¹ = Me] was found to decrease EGFR activity more than 100-fold, while having little effect on VEGFR activity, when compared to [(1H-indol-5-yl)amino]thieno[3,2-b]pyridines I (same R, R¹ = H).

Bioorganic & Medicinal Chemistry Letters published new progress about 602303-26-4. 602303-26-4 belongs to iodides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Iodide, name is 7-Chloro-2-iodothieno[3,2-b]pyridine, and the molecular formula is C7H3ClINS, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Arazi, Eden published the artcileA regulatory domain in the K_2P2.1 (TREK-1) carboxyl-terminal allows for channel activation by monoterpenes, Computed Properties of 41270-96-6, the publication is Molecular and Cellular Neuroscience (2020), 103496, database is CAplus and MEDLINE.

Potassium K_2P (leak) channels conduct current across the entire physiol. voltage range and carry leak or background currents that are, in part, time- and voltage-independent. K_2P2.1 channels (i.e., TREK-1, KCNK2) are highly expressed in excitable tissues, where they play a key role in the cellular mechanisms of neuroprotection, anesthesia, pain perception, and depression. Here, we report for the first time that human K_2P2.1 channel activity is regulated by monoterpenes (MTs). We found that cyclic, aromatic monoterpenes containing a phenol moiety, such as carvacrol, thymol and 4-IPP had the most profound effect on current flowing through the channel (up to a 6-fold increase). By performing sequential truncation of the carboxyl-terminal domain of the channel and testing the activity of several channel regulators, we identified two distinct regulatory domains within this portion of the protein. One domain, as previously reported, was needed for regulation by arachidonic acid, anionic phospholipids, and temperature changes. Within a second domain, a triple arginine residue motif (R344-346), an apparent PIP₂-binding site, was found to be essential for regulation by holding potential changes and important for regulation by monoterpenes.

Molecular and Cellular Neuroscience published new progress about 41270-96-6. 41270-96-6 belongs to iodides-buliding-blocks, auxiliary class Pyrimidine,Iodide,Benzene,Immunology/Inflammation,MIF, name is 4-Iodo-6-phenylpyrimidine, and the molecular formula is C10H7IN2, Computed Properties of 41270-96-6.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Guillou, Sandrine published the artcileSimple preparations of 4 and 5-iodinated pyrazoles as useful building blocks, Recommanded Product: 4-Iodo-3-(trifluoromethyl)-1H-pyrazole, the publication is Tetrahedron (2011), 67(44), 8451-8457, database is CAplus.

The pyrazole nucleus has recently become a recurrent scaffold in the research fields of CropScience and oncol. We report here the preparation of an array of 4- and 5-iodinated pyrazole derivatives, such as 4-iodo-3-trifluoromethylpyrazole or Et 5-iodo-4-carboxy-3-trifluoromethylpyrazoles. This work provide access to many new pyrazole derivative, including eleven original out of sixteen iodinated building blocks, thus opening accesses to new chem. entities featuring a pyrazole nucleus.

Tetrahedron published new progress about 866638-72-4. 866638-72-4 belongs to iodides-buliding-blocks, auxiliary class Trifluoromethyl,Pyrazole,Fluoride,Iodide, name is 4-Iodo-3-(trifluoromethyl)-1H-pyrazole, and the molecular formula is C4H2F3IN2, Recommanded Product: 4-Iodo-3-(trifluoromethyl)-1H-pyrazole.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Borisevich, A. N. published the artcileSynthesis and growth regulating effect of substituted 1-acylpyrazole, Computed Properties of 39115-95-2, the publication is Fiziologicheski Aktivnye Veshchestva (1977), 47-52, database is CAplus.

Of 13 title compounds I[R = Ph, C₆H₄O-p-Me, C₆H₄–p-Cl, C₆H₄–p-Br, C₆H₄–p-I, C₆H₄–p-NO₂, 3,4,5-(H₃CO)₃C₆H₃, Ph-p-NH₂, or NH₂; R¹ and R² = Me or NHPh; X = O or S], 0.0001% 1-p-bromobenzoyl-3-anilino-5-methylpyrazole [64808-38-4] and 0.001% 1-p-nitrobenzoyl-3-anilino-5-methylpyrazole [64808-42-0] stimulated the growth of lettuce and oats, resp.

Fiziologicheski Aktivnye Veshchestva published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Computed Properties of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ashiq, Uzma published the artcileSynthesis, spectroscopy, and biological properties of vanadium(IV)-hydrazide complexes, COA of Formula: C7H7IN2O, the publication is Chemistry & Biodiversity (2008), 5(1), 82-92, database is CAplus and MEDLINE.

The synthesis, spectroscopic, enzyme-inhibition, and free-radical-scavenging properties of vanadium(IV) substituted benzohydrazide complexes, 1–10, were studied. These complexes exhibit a dimeric structure with hydrazide ligands coordinated in a bidentate fashion. All complexes are stable in the solid state, but exhibit varying degrees of stability in solution In coordinating solvent such as DMSO, stepwise binding of two solvent mols. at the 6th positions trans to the V=O bond of the dimeric unit is observed The dimeric compounds are converted to monomeric species in which both solvent mols. and the hydrazide ligands are coordinated to the V^IV center. The free substituted benzohydrazides 11–20 were inactive against α-glucosidase, but their V^IV complexes showed varying degrees of inhibition, depending on the type of ligand. The DPPH-radical-scavenging activities of 1–20 were determined, which indicated that steric and/or electronic effects responsible for changes in geometry play important roles in terms of antioxidant potential.

Chemistry & Biodiversity published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, COA of Formula: C7H7IN2O.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ara, Rifat published the artcileChemistry, urease inhibition, and phytotoxic studies of binuclear vanadium(IV) complexes, Formula: C7H7IN2O, the publication is Chemistry & Biodiversity (2007), 4(1), 58-71, database is CAplus and MEDLINE.

Vanadium plays an important role in biol. systems and exhibits a variety of bioactivities. In an effort to uncover the chem. and biochem. of vanadium with nitrogen- and oxygen-containing ligands, we report herein the synthesis and spectroscopic characterization of vanadium(IV) complexes with hydrazide ligands. Substituents on these ligands exhibit systematic variations of electronic and steric factors. Elemental and spectral data indicate the presence of a dimeric unit with two vanadium(IV) ions coordinated with two hydrazide ligands along with two H₂O mols. The stability studies of these complexes over time in coordinating solvent, DMSO, indicates binding of the solvent mols. to give [V₂O₂L₂(H₂O)₂(DMSO)₂]²⁺ (L = hydrazide ligand) and then conversion of it to a monomeric intermediate species, [VOL(DMSO)₃]¹⁺. Hydrazide ligands are inactive against urease, whereas vanadium(IV) complexes of these ligands show significant inhibitory potential against this enzyme and are found to be non-competitive inhibitors. These complexes also show low phytotoxicity indicating their usefulness for soil ureases. Structure-activity relationship studies indicate that the steric and/or electronic effects that may change the geometry of the complexes play an important role in their inhibitory potential and phytotoxicity.

Chemistry & Biodiversity published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Formula: C7H7IN2O.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Jamal, Rifat Ara published the artcile4-Iodobenzohydrazide, Formula: C7H7IN2O, the publication is Acta Crystallographica, Section E: Structure Reports Online (2008), 64(11), o2188, o2188/1-o2188/7, database is CAplus and MEDLINE.

In the structure of the title compound, C₇H₇IN₂O, the hydrazide group is inclined at 13.3 (3)° with respect to the benzene ring. The structure is stabilized by intermol. N-H···N and N-H···O hydrogen bonds involving the hydrazide group, resulting in six- and ten-membered rings with R₂²(6) and R₂²(10) graph-set notations, resp. Crystallog. data are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Formula: C7H7IN2O.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com