Tag: M.W=250-300

Gromov, S. P. published the artcileCrown ether styryl dyes. 14. Synthesis, luminescence and complex formation of trans-isomers of chromogenic 15-crown-5-ether, Product Details of C12H14IN, the publication is Izvestiya Akademii Nauk, Seriya Khimicheskaya (1995), 2003-8, database is CAplus.

Novel crown ether dyes containing different heterocyclic residues were synthesized. The fluorescence and absorption spectra of trans-isomers of crown ether styryl dyes and their complexes with metal cations were studied. The effect of the heterocyclic fragment structure and temperature on the spectral characteristics of the styryl ionophores was clarified from the anal. of the spectra of styryl dyes and their metal complexes.

Izvestiya Akademii Nauk, Seriya Khimicheskaya published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Product Details of C12H14IN.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Klopman, Gilles published the artcileComputer-aided study of the relationship between structure and antituberculosis activity of a series of isoniazid derivatives, Quality Control of 39115-95-2, the publication is Chemical Physics (1996), 204(2,3), 181-93, database is CAplus.

The Multiple Computer Automated Structure Evaluation (MultiCASE) program was used to analyze the relation between the structure and antituberculous activity of a series of 136 hydrazides, most of them isoniazid related. The structural features revealed by this anal. are discussed. The most significant one seemed to be the distance between the pyridinic nitrogen and the terminal nitrogen of the hydrazido group. Given the affiliation of these two heteroatoms with a planar conjugated system, we suggest that Schiff base chem. similar to that of vitamin B₆ may be involved in the mode of action of isoniazid and its related compounds A mechanism of action of isoniazid is proposed and suggestions for the design of new isoniazid-type drugs are made.

Chemical Physics published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Quality Control of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Huang, Mei published the artcileSynthesis, Antifungal Activity, 3D-QSAR and Molecular Docking Study of Novel Menthol-Derived 1,2,4-Triazole-thioether Compounds, Formula: C7H7IN2O, the publication is Molecules (2021), 26(22), 6948, database is CAplus and MEDLINE.

A series of novel menthol-derived triazole-thioether compounds I [R = 2-MeC₆H₄, 3,4-di-MeOC₆H₃, 2-thienyl, etc.] were designed, synthesized, characterized structurally and evaluated biol. to explore more potent natural product-based antifungal agents. The bioassay results revealed that at 50μg/mL, some of the target compounds exhibited good inhibitory activity against the tested fungi, especially against Physalospora piricola. Compounds I [R = 2-MeC₆H₄, 2-ClC₆H₄, 3,4-di-MeOC₆H₃, 2-furyl, etc.] had inhibition rates of 93.3%, 79.4%, and 79.4%, resp., against P. piricola, much better than that of the pos. control chlorothalonil. Compounds I [R = 3,4-di-MeOC₆H₃, 3-FC₆H₄] held inhibition rates of 82.4% and 86.5% against Cercospora arachidicola and Gibberella zeae, resp., much better than that of the com. fungicide chlorothalonil. Compound I [R = 2-MeC₆H₄] displayed antifungal activity of 90.5% and 83.8%, resp., against Colleterichum orbicalare and Fusarium oxysporum f. sp. cucumerinum. Compound I [R = 2-IC₆H₄] had inhibition rates of 88.6%, 80.0%, and 88.0%, resp., against F. oxysporum f. sp. cucumerinu, Bipolaris maydis and C. orbiculare. Furthermore, compound I [R = 2-MeC₆H₄] showed the best and broad-spectrum antifungal activity against all the tested fungi. To design more effective antifungal compounds against P. piricola, 3D-QSAR anal. was performed using the CoMFA method, and a reasonable 3D-QSAR model (r² = 0.991, q² = 0.514) was established. The simulative binding pattern of the target compounds with cytochrome P 450 14α-sterol demethylase (CYP51) was investigated by mol. docking.

Molecules published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Formula: C7H7IN2O.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Xiu published the artcileSynthesis, antifungal activity and 3D-QSAR study of novel nopol-based 1,3,4-thiadiazole-thioether compounds, Application In Synthesis of 39115-95-2, the publication is Research on Chemical Intermediates (2021), 47(10), 4029-4049, database is CAplus.

A series of novel nopol derivatives containing 1,3,4-thiadiazole-thioether moiety I [R = H, 2-Me, 3-CF₃, etc.] were synthesized from β-pinene, which is a natural, abundant and renewable biomass resource. Their structures were characterized by FT-IR, ¹H NMR, ¹³C NMR, ESI-MS and elemental anal. In vitro antifungal activity of the target compounds was preliminarily evaluated against eight tested plant pathogens, including Fusarium oxysporum f. sp. cucumerinum, Cercospora arachidicola, Physalospora piricola, Alternaria solani, Gibberella zeae, Rhizoeotnia solani, Bipolaris maydis and Colleterichum orbicalare. The bioassay results revealed that, at the concentration of 50μg/mL, all the target compounds showed certain inhibition activity against the eight tested fungi. Compounds I [R = 3-OMe, 3-F, 3-I] had excellent inhibition rates of 77.8%, 88.9% and 77.8%, resp., against P. piricola, showing much better antifungal activity than that of the pos. control chlorothalonil. Meanwhile, compound I [R = 4-Cl] displayed antifungal activity of 80.7% against R. solani. Furthermore, the anal. of three-dimensional quant. structure-activity relationship (3D-QSAR) was performed for the relationship between the structures of the target compounds and their antifungal activity against P. piricola by CoMFA method. A reasonable CoMFA model (n = 6; q² = 0.597; r² = 0.985) was established.

Research on Chemical Intermediates published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C10H9ClN2O, Application In Synthesis of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sapountzis, Ioannis published the artcileSynthesis of Functionalized Nitroarylmagnesium Halides via an Iodine-Magnesium Exchange, SDS of cas: 101420-79-5, the publication is Journal of Organic Chemistry (2005), 70(7), 2445-2454, database is CAplus and MEDLINE.

Various nitro-substituted aryl and heteroaryl iodides undergo an iodine-magnesium exchange reaction when treated with PhMgCl leading to nitro-containing magnesium organometallics. These Grignard reagents display an excellent stability at temperatures below -40 °C and do not undergo electron-transfer reactions. They react as expected with various electrophiles. E.g., reaction of 2-IC₆H₄NO₂ with PhMgCl resulted in iodine-magnesium exchange to give a nitro-substituted Grignard reagent, which reacted with PhCHO to give 2-O₂NC₆H₄CHPhOH. In addition, transmetalation of the nitro-substituted Grignard reagents by CuCN.2LiBr, followed by reaction with electrophiles, was successful. Transmetalation of the nitro-substituted Grignard reagents by ZnBr₂ gave organozinc intermediates, which underwent Pd-catalyzed Negeshi cross-coupling reaction with aryl iodides.

Journal of Organic Chemistry published new progress about 101420-79-5. 101420-79-5 belongs to iodides-buliding-blocks, auxiliary class Nitrile,Nitro Compound,Iodide,Benzene,Benzene Compounds, name is 4-Iodo-3-nitrobenzonitrile, and the molecular formula is C7H3IN2O2, SDS of cas: 101420-79-5.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sapountzis, Ioannis published the artcileSynthesis of nitro-substituted polyfunctional biphenyls by Negishi cross-coupling of o-nitroarylzinc reagents, Quality Control of 101420-79-5, the publication is Advanced Synthesis & Catalysis (2004), 346(7), 709-712, database is CAplus.

The iodine-magnesium exchange reaction allows the preparation of polyfunctional arylmagnesium species bearing a nitro group in the ortho-position. After transmetalation to the corresponding arylzinc compound, these organometallics undergo a palladium-catalyzed Negishi cross-coupling with various aryl iodides to provide polyfunctional biphenyls bearing nitro groups in moderate to good yields. Thus, reaction of Et 4-iodo-3-nitrobenzoate with mesitylmagnesium bromide followed by treatment with ZnBr₂ gave nitroarylzinc reagent which on Pd(dba)₂-catalyzed Negishi cross-coupling with 4-iodo-1-nitrobenzene gave 85% Et 2,4′-dinitro[1,1′-biphenyl]-4-carboxylate.

Advanced Synthesis & Catalysis published new progress about 101420-79-5. 101420-79-5 belongs to iodides-buliding-blocks, auxiliary class Nitrile,Nitro Compound,Iodide,Benzene,Benzene Compounds, name is 4-Iodo-3-nitrobenzonitrile, and the molecular formula is C7H3IN2O2, Quality Control of 101420-79-5.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

de Gaudemaris, G. published the artcilep-Iodobenzohydrazide: a reagent for the carbonyl group, Recommanded Product: 4-Iodobenzohydrazide, the publication is Bulletin de la Societe Chimique de France (1950), 63-5, database is CAplus.

p-IC₆H₄CONHNH₂, prepared by the method of Sah and Hsü (C.A. 35, 4362.8), reacts with carbonyl groups in EtOH at 95° in the presence of a small amount of HOAc to give p-iodobenzoylhydrazones. These products are analyzed for iodine by reaction with Na (Drogin and Rosanoff, C.A. 10, 871) and a subsequent Volhard titration Derivatives were prepared of pinacolone, m. 154°; ethylpinacolone, m. 146-7°; iso-BuCOMe, m. 136°; Me nonyl ketone, m. 118°; MeCH:CHCOMe, m. 183-4°; MeCH:CMeCOMe, m. 158-60°; mesityl oxide, m. 141-2°; MeCHCMe:CMeCOMe, m. 138°; Me₂C(OH)COMe, m. 84-5°; Et₂C(OH)COMe, m. 135-6°; benzoin, m. 194°; EtCH(OH)COMe, m. 133-4°; MeCH(OH)CHMeCOMe, m. 150°; and the tertiary β-ketols prepared by Dubois (C.A. 43, 5004d) from Me₂CO, MeCOC₆H₁₃, Pr₂CHCOMe, and pinacolone, m. 110-12°, 167-8°, 142° and 164°, resp.

Bulletin de la Societe Chimique de France published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Recommanded Product: 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Krieg, R. published the artcileOptimization of heterocyclic 4-hydroxystyryl derivatives for histological localization of endogenous and immunobound peroxidase activity, Computed Properties of 606-55-3, the publication is Biotechnic & Histochemistry (2007), 82(4-5), 235-262, database is CAplus and MEDLINE.

Assisted by the development of light excitation and measuring techniques and the com. availability of highly sensitive equipment, luminescent labels are sensitive detection tools for life sciences research. By contrast to a wide variety of well established chromogenic techniques, fluorescent labels for detecting peroxidase (PO) have been confined to only a few substrates. We describe here novel fluorescent substrates of PO derived from heterocyclic 4-hydroxy styrenes as useful tools for detecting endogenous and exogenous targets in fixed cells and tissues. Excellent localization, high staining sensitivity, outstanding photostability, and exceptionally low background staining were achieved by optimizing the substrate through chem. synthesis. Structure/staining behavior relationships are discussed. By contrast to tyramine-fluorochrome conjugates employed in the catalyzed reporter deposition (CARD) technique, reporting and anchoring functions are no longer separated Consequently, enzymic crosslinking of the substrate yields an altered fluorochrome with different properties. Spectral properties and anchoring capability are interdependent and influenced by environmental effects and pH. We screened overall staining capability of 4-hydroxy styryl derivatives using an iterative semi-empirical approach, and ascertained optimal substitution patterns for high PO staining specificity and high fluorescence response. Reliable staining performance was achieved with alkyl chains of short or medium length at the pos. charged nitrogen, whereas introducing polar groups often impaired the staining specificity of PO. Catalytic crosslinking of heterocyclic 4-hydroxy-styryl derivatives is a promising approach for permanent fluorescent staining of PO in fixed cells and tissues, and complements the CARD technique. Histochem. and immunohistochem. applications are presented using conventional and confocal fluorescence microscopes with different excitation sources. Spectral properties of selected stains are discussed. Novel stains also are of potential interest as ‘reactive-tracers’ for living cells under multi-photon laser excitation conditions, because they exhibit pronounced nonlinear optical properties.

Biotechnic & Histochemistry published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Computed Properties of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Abdel Rahman, Mohamed M. published the artcileThe scope of the reactions of hydrazines and hydrazones, part VI. Synthesis of 3-deoxy-4-O-β-D-galactopyranosyl-D-erythro-hexos-2-ulose and of some of its derivatives from lactose, Category: iodides-buliding-blocks, the publication is Carbohydrate Research (1978), 89-99, database is CAplus.

3-Deoxy-4-O-β-D-galactopyranosyl-D–erythro-hexos-2-ulose (I) was obtained from lactose by reaction with BzNHNH₂ in the presence of an acidic solution of p-toluidine, followed by cleavage of 3-deoxy-4-O-β-D-galactopyranosyl-D–erythro-hexos-2-ulose bis(benzoylhydrazone) (II), with PhCHO. Also prepared were III (R, R⁴ = H, Bz; R¹ = H, HO, BzO; R² = H, R³ = HO, BzO; R²R³ = NNHCOR⁵; R⁵ = Ph, HOC₆H₄, MeC₆H₄, 4-MeOC₆H₄, ClC₆H₄, 4-BrC₆H₄, IC₆H₄, 4-O₂NC₆H₄, pyridyl). Quant. determination of the oxidant during the periodate oxidation of II was studied. Periodate oxidation of monosaccharide arylhydrazones gave glyoxal mono(arylhydrazones) which afforded the corresponding, mixed bis(hydrazones).

Carbohydrate Research published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Shindy, H. A. published the artcileSynthesis and spectral behaviour of some new uninuclear pyrimidine 2[2(4)]-mono(tri)-methine cyanine dyes, SDS of cas: 606-55-3, the publication is Journal of the Chinese Chemical Society (Taipei) (2000), 47(3), 519-525, database is CAplus.

New unsym. 2[2(4)]-mono- and tri (substituted tri)-methine cyanine dyes incorporating 1,2,5,6-tetrahydro-4,6-diarylpyrimidin (pyrimidinium-1-yl salt)-2-one were prepared Structural determination was carried out by elemental anal. and IR and ¹H NMR spectral data. The spectral behavior of all the synthesized cyanines was examined in 95% ethanol.

Journal of the Chinese Chemical Society (Taipei) published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C3H3Br2ClO, SDS of cas: 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com