Tag: M.W=250-300

Blakemore, Caroline A. published the artcileScalable, telescoped hydrogenolysis-enzymic decarboxylation process for the asym. synthesis of (R)-α-heteroaryl propionic acids, SDS of cas: 884495-13-0, the publication is Organic Process Research & Development (2021), 25(3), 421-426, database is CAplus.

Enantiopure α-aryl propionic acids are useful building blocks for pharmaceutical research and can be accessed enzymically using arylmalonate decarboxylases (AMDases) from the corresponding malonic acids. However, the intrinsic instability of malonic acids is a major drawback to this approach in which spontaneous decarboxylation can occur, subsequently eroding enantioselectivity and giving rise to racemic products. This was particularly evident for a panel of N-heterocyclic propionic acids that we wished to access using the approach. Herein, we describe a process to overcome the spontaneous decarboxylation problem in which hydrogenolysis of the corresponding dibenzyl malonates was performed in a biphasic toluene-basic aqueous buffer mixture and telescoped into the subsequent AMDase step. This procedure enabled compounds to be accessed in high enantioselectivities and was successfully demonstrated on 120 g with high yield (76%) and ee (98%).

Organic Process Research & Development published new progress about 884495-13-0. 884495-13-0 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Fluoride,Iodide,Ether, name is 5-Fluoro-4-iodo-2-methoxypyridine, and the molecular formula is C6H5FINO, SDS of cas: 884495-13-0.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Dejiang published the artcileSynthesis and fungicidal activities of 2,5-bis(3-aryl)-1,2,4-triazolo[3,4-b]-[1,3,4]thiadiazole-6-yl] pyridines, Recommanded Product: 4-Iodobenzohydrazide, the publication is Heterocyclic Communications (2006), 12(5), 383-388, database is CAplus.

In search of better bio-active compounds, a series of novel 2,5-bis[(3-aryl)-1,2,4-triazolo[3,4-b]-[1,3,4]thiadiazole-6-yl]pyridines were synthesized in high yields by cyclization of 3-aryl-4-amino-5-mercapto-1,2,4-triazoles with 2,5-pyridine dicarboxylic acid. The compounds, bis(aryl)-triazolothiadiazolyl-pyridines, exhibited good fungicidal activities against Cerospora beticola sacc.

Heterocyclic Communications published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Recommanded Product: 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zheng, Lin published the artcileMacrophage migration inhibitory factor (MIF) inhibitor 4-IPP suppresses osteoclast formation and promotes osteoblast differentiation through the inhibition of the NF-kappaB signaling pathway, Category: iodides-buliding-blocks, the publication is FASEB Journal (2019), 33(6), 7667-7683, database is CAplus and MEDLINE.

Current pharmacol. intervention for the treatment of osteolytic bone diseases such as osteoporosis focuses on the prevention of excessive osteoclastic bone resorption but does not enhance osteoblast-mediated bone formation. In our study, we have shown that 4-iodo-6-phenylpyrimidine (4-IPP), an irreversible inhibitor of macrophage migration inhibitory factor (MIF), can inhibit receptor activator of NF-kappaB ligand (RANKL)-induced osteoclastogenesis and potentiate osteoblast-mediated mineralization and bone nodule formation in vitro. Mechanistically, 4-IPP inhibited RANKL-induced p65 phosphorylation and nuclear translocation by preventing the interaction of MIF with thioredoxin-interacting protein-p65 complexes. This led to the suppression of late osteoclast marker genes such as nuclear factor of activated T cells cytoplasmic 1, resulting in impaired osteoclast formation. In contrast, 4-IPP potentiated osteoblast differentiation and mineralization also through the inhibition of the p65/NF-kappaB signaling cascade. In the murine model of pathol. osteolysis induced by titanium particles, 4-IPP protected against calvarial bone destruction. Similarly, in the murine model of ovariectomy-induced osteoporosis, 4-IPP treatment ameliorated the bone loss associated with estrogen deficiency by reducing osteoclastic activities and enhancing osteoblastic bone formation.

FASEB Journal published new progress about 41270-96-6. 41270-96-6 belongs to iodides-buliding-blocks, auxiliary class Pyrimidine,Iodide,Benzene,Immunology/Inflammation,MIF, name is 4-Iodo-6-phenylpyrimidine, and the molecular formula is C10H10O2, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Betageri, Raj published the artcileNon-steroidal dissociated glucocorticoid agonists: indoles as A-ring mimetics and function-regulating pharmacophores, SDS of cas: 101420-79-5, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(22), 6842-6851, database is CAplus and MEDLINE.

We report a SAR of non-steroidal glucocorticoid mimetics that utilize indoles as A-ring mimetics. Detailed SAR is discussed with a focus on improving PR and MR selectivity, GR agonism, and in vitro dissociation profile. SAR anal. led to compound (I) which showed high PR and MR selectivity, potent agonist activity, and reduced transactivation activity in the MMTV and aromatase assays. The compound is equipotent to prednisolone in the LPS-TNF model of inflammation. In mouse CIA, at 30 mg/kg I inhibited disease progression with an efficacy similar to the 3 mg/kg dose of prednisolone.

Bioorganic & Medicinal Chemistry Letters published new progress about 101420-79-5. 101420-79-5 belongs to iodides-buliding-blocks, auxiliary class Nitrile,Nitro Compound,Iodide,Benzene,Benzene Compounds, name is 4-Iodo-3-nitrobenzonitrile, and the molecular formula is C7H3IN2O2, SDS of cas: 101420-79-5.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Gurupadaswamy, Handuvinahalli Devanna published the artcileSynthesis of Pyrimidones and Evaluation of Their Xanthine Oxidase Inhibitory and Antioxidant Activities, COA of Formula: C7H7IN2O, the publication is Archiv der Pharmazie (Weinheim, Germany) (2013), 346(11), 805-811, database is CAplus and MEDLINE.

The increasing prevalence of gout has been accompanied by a growing number of patients intolerant to or with disease refractory to the available urate-lowering therapies. This metabolic disease is a common disease with a higher prevalence in men older than 30 years and in women older than 50 years. These findings highlight the need for emerging treatments to effectively lower urate levels. In this view, we describe the xanthine oxidase (XO) inhibitory activities of the synthesized compounds I(R = Cl, Br, I, Me, tBu, OMe, CF₃, OCF₃, NO₂, NMe₂) and also their antioxidant activities. Compounds I(R = I, Me, OMe, OCF₃, NMe₂) exhibited good inhibitory activities against XO. On the other hand, compounds I(R = CF₃, OCF₃) exhibited moderate antioxidant activity.

Archiv der Pharmazie (Weinheim, Germany) published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, COA of Formula: C7H7IN2O.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Shindy, H. A. published the artcileNovel carbocyanine and biscarbocyanine dyes: synthesis, visible spectra studies, solvatochromism and halochromism, Related Products of iodides-buliding-blocks, the publication is Chemistry International (2016), 2(4), 222-231, database is CAplus.

Novel carbocyanine dyes (trimethine cyanine dyes) and bis carbocyanine dyes (bis trimethine cyanine dyes) derived from the nucleus of benzo[2,3-b; 2′,3′-b’] bis furo[2,3-d]imidazoline-3,5,8,10-tetra one were synthesized. The electronic visible adsorption spectra of all the synthesized cyanine dyes were investigated in 95% ethanol solution Solvatochromism and/or halochromism for some selected dyes were examined in pure solvents having different polarities (water, DMF, ethanol, chloroform, carbon tetrachloride and dioxane) and/or in aqueous universal buffer solutions owing varied pH values (1.45, 2.03, 3.72, 5.09, 7.57, 8.91, 10.20 and 12.04 units), resp. Structural confirmations were determined by elemental anal., visible, mass, IR and ¹H NMR spectral data.

Chemistry International published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C15H14N2, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Shindy, Hassan Abazied published the artcileSynthesis, spectral behavior and biological activity of some novel 1,3,4-oxadiazine cyanine dyes, Recommanded Product: 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is European Journal of Chemistry (2015), 6(2), 151-156, database is CAplus.

New methine cyanine dyes covering monomethine cyanine dyes and dimethine cyanine dyes derived from benzo[(2,3-b)benzoxazine; (2,3-e)1,3,4-oxadiazine]-5,12-dione were prepared The electronic visible absorption spectra of all the synthesized cyanine dyes were investigated in 95% ethanol solution Biol. activity for a number of selected compounds was tested and evaluated against various bacterial strains (Bacillus subtilis, Escherichia coli, Pseudomona aeruginosa and Staphylococcus aureus). Structural determination was carried out via elemental anal., visible, mass, IR and 1_H NMR spectroscopic data.

European Journal of Chemistry published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C6H20Cl2N4, Recommanded Product: 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Shindy, Hassan Abazied published the artcileDicarbocyanine and tricarbocyanine dyes: Novel synthetic approaches, photosensitization evaluation and antimicrobial screening, SDS of cas: 606-55-3, the publication is Chemistry International (2020), 6(1), 30-41, database is CAplus.

Novel dicarbocyanine dyes (pentamethine cyanine dyes), bis dicarbocyanine dyes (bis pentamethine cyanine dyes), tricarbocyanine dyes (heptamethine cyanine dyes) and bis tricarbocyanine dyes (bis heptamethine cyanine dyes) derived from the nucleus of furo[(3,2-d)pyrazole; (3′,2′-d)oxazole] were prepared using novel synthetic approaches. The electronic visible absorption spectra were investigated in 95% ethanol to evaluate the photosensitization properties. The cyanine dyes were better photosensitizers in visible light to initiate the electronic transitions at higher wavelength bands (bathochromic shifted and/or red shifted dyes). Consequently, the photosensitization of the cyanine dyes decreases in visible light to initiate the electronic transitions at lower wavelength bands (hypsochromic shifted and/or blue shifted dyes). Antimicrobial activity of ten selected compounds was tested against four bacterial strains (Bacillus subtilis, Escherichia coli,Pseudomona aeruginosa and Staphylococcus aureus). The compounds were thought to be better antimicrobial active when they give higher inhibition zone against the tested strains. Consequently, the antimicrobial activity was promising and variable among all synthesized compounds against tested strains. Structural characterization and confirmations were determined by elemental anal., visible, mass, IR and ¹H NMR spectral data.

Chemistry International published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C14H21BO2, SDS of cas: 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Koraiem, Ai published the artcileNovel cyanine dyes based on N-bridgehead heterobicyclic: synthesis, solvatochromism and physicochemical studies, HPLC of Formula: 606-55-3, the publication is Organic Chemistry: An Indian Journal (2018), 14(2), 125, database is CAplus.

Cyanine dyes of zero methine, monomethine, acyclic metro cyanine dyes incorporating pyrazolo (3,2-a) pyridine, payroll (3,4-c) pyrazolo (3,2-a) pyridine or quinolin (1,2-a) imidazo (2.3-c) pyrano (2,3-c) pyrazole and imidazo (1,2-a) quinoline resp. were synthesized and characterized by UV-Visible, elemental and spectral anal. The absorption spectra properties of such selected dyes were investigated in 95% ethanol to attempt and throw some light on the influence of such new heterocyclic nuclei and to compare or evaluate spectral behaviors. The solvatochromic behavior and color changes of some selected newly synthesized cyanine dyes are observed in solvents having different polarities. This permits a selection of optimal solvent (fractional solvent) when such dyes are applied as photosensitizers. The spectral behavior of some selected cyanine dyes in mixed solvents of different polarities has been studied to estimate number of hydrogen bond formed between the solute & solvent mols. and to allow measurement of certain energies such as hydrogen bonding, orientation and free energies.

Organic Chemistry: An Indian Journal published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, HPLC of Formula: 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Koraiem, Ahmed I. published the artcileTheoretical and experimental spectroscopic investigation of new polymethine donor-π-acceptor cyanine dyes: Synthesis, photophysical, and TDDFT studies, Category: iodides-buliding-blocks, the publication is Journal of Molecular Structure (2018), 406-416, database is CAplus.

New series of polymethine cyanine dyes with different length of π-chain were synthesized and characterized. These new dyes are based on D-π-A architecture with long π-electron systems. The UV-visible/emission spectral studies showed that the dyes are absorbed in the region of λ_max (485-570) nm and emitted at (540-600) nm. This makes these dyes favorable for the detection of biol. and chem. analytes. Their electron cloud delocalization in HOMO/LUMO levels were studied by DFT using Gaussian 09 software. DFT results reveal that the dyes showed effective charge separation in its MOs levels, which reflected in its ICT behavior. Time-dependent d. functional theory (TD-DFT) were applied to theor. explored the first excitation energy (E_0-0) of these dyes which in high compatibility with exptl. results with an accuracy of 0.1-0.3 eV. This approach was successfully applied to describe the great effect of π-conjugation length and substituents of chromophore on the variations of maximum absorption and excitation energy of the dyes.

Journal of Molecular Structure published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com