Tag: M.W=250-300

Ermolenko, Mikhail S. published the artcilePyrazole-3/5-carboxylic acids from 3/5-trifluoromethyl NH-pyrazoles, HPLC of Formula: 866638-72-4, the publication is Tetrahedron (2013), 69(1), 257-263, database is CAplus.

The transformations of substituted 3/5-trifluoromethylpyrazoles to the corresponding NH-pyrazole-3/5-carboxylic acids are reported. Moreover, from 4- or 5-iodinated-3/5-trifluoromethylpyrazoles building blocks and the use of Suzuki-Miyaura or Negishi reactions followed by the trifluoromethyl hydrolysis, we illustrate short and original accesses to many series of NH-pyrazole-3/5-carboxylic acids otherwise difficult to prepare

Tetrahedron published new progress about 866638-72-4. 866638-72-4 belongs to iodides-buliding-blocks, auxiliary class Trifluoromethyl,Pyrazole,Fluoride,Iodide, name is 4-Iodo-3-(trifluoromethyl)-1H-pyrazole, and the molecular formula is C4H2F3IN2, HPLC of Formula: 866638-72-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Qi, Ya-Lin published the artcileTwo birds with one stone: a NIR fluorescent probe for mitochondrial protein imaging and its application in photodynamic therapy, Product Details of C12H14IN, the publication is Journal of Materials Chemistry B: Materials for Biology and Medicine (2021), 9(30), 6068-6075, database is CAplus and MEDLINE.

Mitochondrial proteins, most of which are encoded in the nucleus and the rest of which are regulated by the mitochondrial genome, play pivotal roles in essential cellular functions. However, fluorescent probes that can be used for monitoring mitochondrial proteins have not yet been widely developed, thereby severely limiting the exploration of the functions of proteins in mitochondria. Towards this end, here we propose a near-IR (NIR) fluorescence probe MPP to effectively illuminate the dynamic changes in mitochondrial proteins in live cells under oxidative stress, with excellent temporal and spatial resolution Of particular importance, MPP extends the study of the pharmacol. involved in apoptosis induced by anti-cancer drugs (hydroxycamptothecin (HCPT), epirubicin (Epi) and cyclophosphamide (CPA)) for the first time. Furthermore, employing a protein-activatable strategy, this probe could serve as an excellent phototherapeutic agent in photodynamic therapy (PDT). Finally, in vivo experiments suggest that this versatile probe can be used to image tumors in HeLa tumor-bearing mice for 24 h, which demonstrates that our probe could play a dual role as a robust phototherapeutic and imaging agent.

Journal of Materials Chemistry B: Materials for Biology and Medicine published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Product Details of C12H14IN.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Mason, Stephen J. published the artcileSolid-phase methods for the synthesis of cyanine dyes, Recommanded Product: 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Journal of Organic Chemistry (2005), 70(8), 2939-2949, database is CAplus and MEDLINE.

We report here a series of studies that explore solid-phase methodologies for the synthesis of various cyanine dyes. The scope of the previously reported catch-and-release method using sulfonyl chloride resin has now been extended to include pentamethine and water-soluble cyanine dyes. We also report a new and chem. distinct synthetic strategy, employing the stepwise attack of heterocyclic carbon nucleophiles on immobilized polyene-chain precursors, allowing the clean synthesis of hydrophobic and hydrophilic trimethine and pentamethine dyes from more easily obtained starting materials. Overall, both approaches appear to be robust and versatile strategies to delivering a wide range of cyanine-based dyes in high purity.

Journal of Organic Chemistry published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Recommanded Product: 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yang, Chun-Hua published the artcileDirect Intramolecular Aminoboration of Allenes, Safety of (2-Iodo-4-nitrophenyl)methanol, the publication is Organic Letters (2020), 22(13), 5090-5093, database is CAplus and MEDLINE.

Direct intramol. aminoboration of sulfonamidoallenes was realized using BCl₃ as a boron source. The reactions benefited from the interaction between BCl₃ and sulfonamides and provided a variety of borylvinyl heterocycles, e.g. I, in good isolated yields. When chiral substrates were involved in the reactions, high stereoselectivity was observed, as can be ascertained by single-crystal X-ray diffraction experiments Derivatization of the thus-obtained borylvinyl compounds proceeded readily, and different functionalities could be obtained via oxidation, halogenation, and Suzuki coupling reactions.

Organic Letters published new progress about 500563-90-6. 500563-90-6 belongs to iodides-buliding-blocks, auxiliary class Nitro Compound,Iodide,Benzene,Alcohol, name is (2-Iodo-4-nitrophenyl)methanol, and the molecular formula is C7H5Br2F, Safety of (2-Iodo-4-nitrophenyl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Chan, Bryan K. published the artcileDiscovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor, Quality Control of 1260672-72-7, the publication is Journal of Medicinal Chemistry (2016), 59(19), 9080-9093, database is CAplus and MEDLINE.

Inhibitors targeting the activating mutants of the epidermal growth factor receptor (EGFR) have found success in the treatment of EGFR mutant pos. nonsmall-cell lung cancer. A secondary point mutation (T790M) in the inhibitor binding site has been linked to the acquired resistance against those first generation therapeutics. Herein, the authors describe the lead optimization of a series of reversible, pan-mutant (L858R, del_746-750, T790M/L858R, and T790M/del_746-750) EGFR inhibitors. By use of a noncovalent double mutant (T790M/L858R and T790M/del_746-750) selective EGFR inhibitor I as a starting point, activities against the single mutants (L858R and del_746-750) were introduced through a series of structure-guided modifications. The in vitro ADME-PK properties of the lead mols. were further optimized through a number of rational structural changes. The resulting inhibitor II exhibited excellent cellular activity against both the single and double mutants of EGFR, demonstrating target engagement in vivo and ADME-PK properties that are suitable for further evaluation. The reversible, noncovalent inhibitors described complement the covalent pan-mutant EGFR inhibitors that have shown encouraging results in recent clin. trials.

Journal of Medicinal Chemistry published new progress about 1260672-72-7. 1260672-72-7 belongs to iodides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Iodide, name is 6-Chloro-3-iodo-1H-pyrazolo[4,3-c]pyridine, and the molecular formula is C6H3ClIN3, Quality Control of 1260672-72-7.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Manoussakis, G. E. published the artcileHalogen ring monosubstituted benzoic acid hydrazides as ligands. 1. Preparation and interpretation of infrared spectra, Safety of 4-Iodobenzohydrazide, the publication is Chimika Chronika (1972), 1(3-4), 182-7, database is CAplus.

The ortho-, meta-, and para-halo derivatives of benzoic acid hydrazides were obtained by allowing the Et ester of the halo-substituted acid to react with H2NNH2.H2O. The ir spectra of the hydrazides indicated that the donor properties of the halogen atoms were not significant, but enhanced possibilities for intra- and intermol. H bonding. The coordination of these hydrazides with metals is discussed.

Chimika Chronika published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Safety of 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Manoussakis, George published the artcileHalogen ring monosubstituted benzoic acid hydrazides as ligands. II. Ultraviolet spectra and pK determination, Safety of 4-Iodobenzohydrazide, the publication is Canadian Journal of Chemistry (1973), 51(5), 811-14, database is CAplus.

The uv spectra of 12 halogen-substituted benzoic acid hydrazides were reported. A very intense band in the region 225-260 mμ and second one of low intensity at 270-290 mμ were assigned to π â†?π* and n â†?π* transition, resp. The pK1 and pK2 of these hydrazides, corresponding to the Broensted acids XC6H4C(O)NHNH2 and XC6H4C(OH):NNH2 respectively were obtained spectrophotometrically (X = o-, m-, or p-F, Cl, Br, iodo). The influence of the nature and the position of the halogen atom on the pK values was discussed.

Canadian Journal of Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Safety of 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

El Maghraby, M. A. published the artcileSymmetrical dicationic cyanine dyes incorporating pyrazolo-pyrano oxazone (pyrimidine) moiety, Formula: C12H14IN, the publication is Aswan Science & Technology Bulletin (1991), 3-14, database is CAplus.

3-Amino-6-methyl-5-aryl-2,5-dihydropyrano[2,3-c]pyrazole-4-carbonitriles were acid hydrolyzed to the corresponding -4-carboxylic acids (55-57% yield), which were condensed with Ac₂O to give 3,7-dimethyl-4-aryl-1-acetylpyrazolopyranooxazinones (58-61%); the corresponding pyrimidinones (42-45%) were obtained using ammonia. Oxidation of these products with SeO₂ converted the 2 Me groups (58-64%) to CHO groups. Condensation with α-picoline or quinaldine ethiodides gave 45-65% I (X = Cl, NO₂; Y = 1-ethylpyridinium-2-yl iodide, 1-ethylquinolinium-2-yl iodide; Z = O, NH). The visible absorption spectra of I were recorded.

Aswan Science & Technology Bulletin published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Formula: C12H14IN.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

El Maghraby, M. A. published the artcileStyryl and dicationic cyanine dyes incorporating pyrazole moiety, Application of 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Aswan Science & Technology Bulletin (1991), 24-38, database is CAplus.

I (R = H, Ph, Ac, Bz; X = 1-ethylquinolinium-2-yl iodide, 1-ethylpyridinium-2-yl iodide), II (R’ = H, Ph; Y = NO₂, NMe₂), and III (R’, X, Y as above) were obtained from 3,5-dimethylpyrazoles.

Aswan Science & Technology Bulletin published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Application of 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Fritzemeier, Russell published the artcileDiscovery of In Vivo Active Sphingosine-1-phosphate Transporter (Spns2) Inhibitors, Recommanded Product: 4-Iodobenzohydrazide, the publication is Journal of Medicinal Chemistry (2022), 65(11), 7656-7681, database is CAplus and MEDLINE.

Sphingosine 1-phosphate (S1P) is a pleiotropic signaling mol. that interacts with five G-protein-coupled receptors (S1P1-5) to regulate cellular signaling pathways. S1P export is facilitated by Mfsd2b and spinster homolog 2 (Spns2). While mouse genetic studies suggest that Spns2 functions to maintain lymph S1P, Spns2 inhibitors are necessary to understand its biol. and to learn whether Spns2 is a viable drug target. Herein, we report a structure-activity relationship study that identified the first Spns2 inhibitor 16d (SLF1081851)(I). In vitro studies in HeLa cells demonstrated that 16d inhibited S1P release with an IC₅₀ of 1.93 μM. Administration of 16d to mice and rats drove significant decreases in circulating lymphocyte counts and plasma S1P concentrations, recapitulating the phenotype observed in mice made deficient in Spns2. Thus, 16d has the potential for development and use as a probe to investigate Spns2 biol. and to determine the potential of Spns2 as a drug target.

Journal of Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Recommanded Product: 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com