Tag: M.W=250-300

El-Aal, Reda M. Abd published the artcileSyntheses and electronic absorption spectra of some new penta- and di-methine cyanine dyes, Application In Synthesis of 606-55-3, the publication is Heteroatom Chemistry (1997), 8(3), 259-266, database is CAplus.

The reaction of a ratio of 1 mol of 5-chloro-3-methyl-1-phenylpyrazolo-4-[2(4)-ethylpyridinium]dimethine cyanine or 5-chloro-4-formyl-3-methyl-1-phenylpyrazole(I) with 2 mol of an appropriate 2(4)-heterocyclic quaternary salt afforded novel pentamethine cyanine dyes. Other reactions of I with heterocyclic nitrogen bases, followed by condensation of the quaternary nitrogen salts with methylheterocyclic iodide salts provided the corresponding unsym. dimethine cyanine dyes. The new pentamethine and dimethine cyanine dyes were identified by elemental analyses and IR and ¹H-NMR spectral data. The visible absorption spectra of some selected dyes were investigated in pure and mixed solvents as well as in universal buffer solutions The measure of the variation of absorbance with pH was utilized for the determination of the pK_a values, and these data are discussed.

Heteroatom Chemistry published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Application In Synthesis of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Koraiem, Ahmed I. M. published the artcileOxonium Salts in the Synthesis and Spectral Behavior of Pyrano(pyrylium)-mono methine Cyanine Dyes, Application of 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Journal of Heterocyclic Chemistry (2019), 56(6), 1722-1732, database is CAplus.

Pyrano- and pyrylium mono-8[4(1)] and/or 5(6)-[2(4)]methine cyanine dyes (6a-k, 7a-f) were synthesized based on acyclic heterocyclic Schiff bases of pyrolo[3,2-d]pyrazole[oxazole(imidazol-6-one)]-1-ium iodide salts, 5-acetyl-N-aryl[pyrazolinyl(pyridinyl)]pyrolo-[5,4-d]pyrazolin-iodide salts, and/or (anhydro bases) precursors (1a-i, 2a-I, 3a-i, 4a-i, and 5A,Ba-i). The structure of pyrylium-9-chloride and/or iodide and their pyrano(pyrylium)-mono-8[4(1)] and 5(6)[2(4)]methine cyanine dyes was identified by elemental and spectral data. The absorption spectra of some selected dyes were investigated in 95% EtOH, polar (nonpolar) organic solvents and in universal buffer solutions to investigate the optimal conditions for the application of such dyes as photosensitizers.

Journal of Heterocyclic Chemistry published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Application of 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

de Azevedo, Ricardo A. published the artcileMIF inhibition as a strategy for overcoming resistance to immune checkpoint blockade therapy in melanoma, Recommanded Product: 4-Iodo-6-phenylpyrimidine, the publication is OncoImmunology (2020), 9(1), 1846915/1, database is CAplus and MEDLINE.

Immune checkpoint blockade (ICB) has demonstrated an impressive outcome in patients with metastatic melanoma, yet, durable complete response; even with Ipilimumab/Nivolumab combo are under 30%. Primary and acquired resistance in response to ICB is commonly due to a tumor immune escape mechanism dictated by the tumor microenvironment (TME). Macrophage Migratory Inhibition Factor (MIF) has emerged as an immunosuppressive factor secreted in the TME. We have previously demonstrated that blockade of the MIF-CD74 signaling on macrophages and dendritic cells restored the anti-tumor immune response against melanoma. Here, we report that inhibition of the MIF-CD74 axis combined with ipilimumab could render resistant melanoma to better respond to anti-CTLA-4 treatment. We provide evidence that blocking the MIF-CD74 signaling potentiates CD8+ T-cells infiltration and drives pro-inflammatory M1 conversion of macrophages in the TME. Furthermore, MIF inhibition resulted in reprogramming the metabolic pathway by reducing lactate production, HIF-1αand PD-L1 expression in the resistant melanoma cells. Melanoma patient data extracted from the TCGA database supports the hypothesis that high MIF expression strongly correlates with poor response to ICB therapy. Our findings provide a rationale for combining anti-CTLA-4 with MIF inhibitors as a potential strategy to overcome resistance to ICB therapy in melanoma, turning a “cold” tumor into a “hot” one mediated by the activation of innate immunity and reprogramming of tumor metabolism and reduced PD-L1 expression in melanoma cells.

OncoImmunology published new progress about 41270-96-6. 41270-96-6 belongs to iodides-buliding-blocks, auxiliary class Pyrimidine,Iodide,Benzene,Immunology/Inflammation,MIF, name is 4-Iodo-6-phenylpyrimidine, and the molecular formula is C10H7IN2, Recommanded Product: 4-Iodo-6-phenylpyrimidine.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Majumdar, K. C. published the artcileThe synthesis and optical properties of novel triphenylamine containing 1,3,4-oxadiazole derivatives, Safety of 4-Iodobenzohydrazide, the publication is Journal of Luminescence (2013), 321-327, database is CAplus.

Sym. 4,4′,4”-trisubstituted triphenylamine derivatives containing 1,3,4-oxadiazole moiety bearing long aliphatic chains have been synthesized by employing convenient and simple synthetic protocols. The structures of these target mols. were established by their anal. and spectral data. They exhibit good fluorescence properties with high quantum yield and show very efficient fluorescence quenching in presence of p-nitrotoluene.

Journal of Luminescence published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Safety of 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Koraiem, A. I. M. published the artcileStudies on the synthesis and spectral behaviour of polyfunctional heterocycle cyanine dyes, Computed Properties of 606-55-3, the publication is Aswan Science & Technology Bulletin (2002), 22-35, database is CAplus.

Unsym. (sym.) incorporated cyano pyrazolo (pyrazolium) (4,5-d)oxazine (quinoxaline) 6[2(4)] or 3[4(1)] mono- and bis-3,6[4(2)] monomethine and/or substituted cyano pyrazolo(4,5-d)oxazine [quinoxaline-6-imine (one)]-N-bridgehead heterocyclic zero methine cyanine dyes were prepared The new synthesized cyanines were established by elemental and spectral anal. The spectral behavior in the visible absorption region was discussed on the basis of color – structure relationships.

Aswan Science & Technology Bulletin published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Computed Properties of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Masunari, Andrea published the artcileGeneration and analysis of interaction energy maps of p-substituted benzoic acid N’-(5-nitrothiophen-2-yl)methylenehydrazides active against multidrug-resistant Staphylococcus aureus, Category: iodides-buliding-blocks, the publication is Anti-Infective Agents in Medicinal Chemistry (2010), 9(1), 1-8, database is CAplus.

Studies in 3D mol. fields generally contain a large amount of data, some of which are redundant or not relevant. The program Volsurf, a quite fast method, is able to compress the relevant information present in 3D mol. structures into a few descriptors that represent the physicochem. properties. In this study eighteen p-substituted benzoic acid N’-(5-nitrothiophen-2-yl)methylenehydrazides with antimicrobial activity were evaluated against multidrug-resistant Staphylococcus aureus, correlating the three-dimensional characteristics of the ligands with their resp. bioactivities. Structures were obtained by CORINA program, and using a GRID force field, the following probes have been used to generate their corresponding 3D interaction energies (MIFs): water, DRY, carbonyl oxygen atom and amide NH group. Calculations using Volsurf resulted in a statistically consistent model with 48 structural descriptors showing that hydrophobicity is a fundamental property in the analyzed biol. response. Results have shown the potential of studied compounds as alternatives to the treatment of infections caused by multidrug-resistant Staphylococcus aureus.

Anti-Infective Agents in Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Pelcman, Benjamin published the artcile3-Substituted pyrazoles and 4-substituted triazoles as inhibitors of human 15-lipoxygenase-1, Computed Properties of 141998-77-8, the publication is Bioorganic & Medicinal Chemistry Letters (2015), 25(15), 3024-3029, database is CAplus and MEDLINE.

Investigation of 1N-substituted pyrazole-3-carboxanilides as 15-lipoxygenase-1 (15-LOX-1) inhibitors demonstrated that the 1N-substituent was not essential for activity or selectivity. Addnl. halogen substituents on the pyrazole ring, however, increased activity. Further development led to triazole-4-carboxanilides and 2-(3-pyrazolyl) benzoxazoles, which are potent and selective 15-LOX-1 inhibitors.

Bioorganic & Medicinal Chemistry Letters published new progress about 141998-77-8. 141998-77-8 belongs to iodides-buliding-blocks, auxiliary class Pyrazole,Iodide,Ester,Pyrazole, name is Ethyl 5-iodo-1H-pyrazole-3-carboxylate, and the molecular formula is C6H7IN2O2, Computed Properties of 141998-77-8.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ramos, S. S. published the artcileSome new symmetric rigidified triheterocyclic heptamethinecyanine dyes absorbing in the near infrared, Computed Properties of 606-55-3, the publication is Dyes and Pigments (2002), 53(2), 143-152, database is CAplus.

Several new rigidified heptamethine cyanine dyes bearing different N-alkyl chains were readily prepared by a novel semi-catalyzed method. All dyes displayed absorption within the so-called “phototherapeutic window”. In order to improve the structural versatility of the dyes, a Cl atom was incorporated in the exocyclic conjugated bridge present in the polymethine chain. In some cases the Cl underwent an unexpected in-situ substitution by a third oxygenated heterocyclic group, depending on the solubility of the chloro dye in the reaction solvent. Two possible mechanisms for the formation of these triheterocyclic dyes are proposed. The full spectroscopic characterization of all the cyanines synthesized is described.

Dyes and Pigments published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Computed Properties of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Dickerhof, Nina published the artcileMacrophage migration inhibitory factor (MIF) is rendered enzymatically inactive by myeloperoxidase-derived oxidants but retains its immunomodulatory function, SDS of cas: 41270-96-6, the publication is Free Radical Biology & Medicine (2015), 498-511, database is CAplus and MEDLINE.

Macrophage migration inhibitory factor (MIF) is an important player in the regulation of the inflammatory response. Elevated plasma MIF is found in sepsis, arthritis, cystic fibrosis and atherosclerosis. Immunomodulatory activities of MIF include the ability to promote survival and recruitment of inflammatory cells and to amplify pro-inflammatory cytokine production MIF has an unusual nucleophilic N-terminal proline with catalytic tautomerase activity. It remains unclear whether tautomerase activity is required for MIF function, but small mols. that inhibit tautomerase activity also inhibit the pro-inflammatory activities of MIF. A prominent feature of the acute inflammatory response is neutrophil activation and production of reactive oxygen species, including myeloperoxidase (MPO)-derived hypochlorous acid and hypothiocyanous acid. We hypothesized that MPO-derived oxidants would oxidize the N-terminal proline of MIF and alter its biol. activity. MIF was exposed to hypochlorous acid and hypothiocyanous acid and the oxidative modifications on MIF were examined by LC-MS/MS. Imine formation and carbamylation was observed on the N-terminal proline in response to MPO-dependent generation of hypochlorous and hypothiocyanous acid, resp. These modifications led to a complete loss of tautomerase activity. However, modified MIF still increased CXCL-8/IL-8 production by peripheral blood mononuclear cells (PBMCs) and blocked neutrophil apoptosis, indicating that tautomerase activity is not essential for these biol. functions. Pre-treatment of MIF with hypochlorous acid protected the protein from covalent modification by the MIF inhibitor 4-iodo-6-phenylpyrimidine (4-IPP). Therefore, oxidant generation at inflammatory sites may protect MIF from inactivation by more disruptive electrophiles, including drugs designed to target the tautomerase activity of MIF.

Free Radical Biology & Medicine published new progress about 41270-96-6. 41270-96-6 belongs to iodides-buliding-blocks, auxiliary class Pyrimidine,Iodide,Benzene,Immunology/Inflammation,MIF, name is 4-Iodo-6-phenylpyrimidine, and the molecular formula is C10H7IN2, SDS of cas: 41270-96-6.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Rassadin, Valentin A. published the artcileSynthesis of benzannulated sultams by intramolecular Pd-catalyzed arylation of tertiary sulfonamides, SDS of cas: 101420-79-5, the publication is Beilstein Journal of Organic Chemistry (2017), 1932-1939, database is CAplus and MEDLINE.

A new and efficient approach to five- and six-membered benzannulated sultams I [R = H, Me, 4-MeOC₆H₄CH₂; R¹ = H, Me, Cl, CO₂Me, CO₂Et; R² = H, OMe, CN; n = 0, 1] by intramol. C-arylation of tertiary 1-(methoxycarbonyl)methanesulfonamides under palladium catalysis was described. In case of the α-toluenesulfonamide derivative, an unexpected formation of a 2,3-diarylindole was observed under the same conditions. The 4-methoxybenzyl group was a suitable protective group for the sultam synthesis since it was stable under the reaction conditions and could be easily removed by acidolysis with trifluoroacetic acid.

Beilstein Journal of Organic Chemistry published new progress about 101420-79-5. 101420-79-5 belongs to iodides-buliding-blocks, auxiliary class Nitrile,Nitro Compound,Iodide,Benzene,Benzene Compounds, name is 4-Iodo-3-nitrobenzonitrile, and the molecular formula is C7H3IN2O2, SDS of cas: 101420-79-5.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com