Tag: M.W=250-300

Jolly, V. S. published the artcileCyanine dyes Part 2, Recommanded Product: 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Oriental Journal of Chemistry (2001), 17(2), 275-278, database is CAplus.

4-[Bis(2-cyanoethyl)amino]-2-methoxybenzaldehyde and 4-[bis(2-cyanoethyl)amino]-2-ethoxybenzaldehyde (I) on reaction with a number of quaternized heterocyclic amines gave a series of highly colored and lustrous cyanine dyes. Potentialities of the dyes for dyeing cotton, wool, and silk were investigated. The dye obtained by condensation of Fischer’s base hydriodide with I dyed cotton, wool, and silk in a bright red shade resistant to washing. One of the dyes showed some photosensitive activity.

Oriental Journal of Chemistry published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Recommanded Product: 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ohira, Makoto published the artcileA novel anti-microtubule agent with carbazole and benzohydrazide structures suppresses tumor cell growth in vivo, HPLC of Formula: 39115-95-2, the publication is Biochimica et Biophysica Acta, General Subjects (2015), 1850(9), 1676-1684, database is CAplus and MEDLINE.

The mitotic spindles are among the most successful targets of anti-cancer chemotherapy, and they still hold promise as targets for novel drugs. The anti-mitotic drugs in current clin. use, including taxanes, epothilones, vinca alkaloids, and halichondrins, are all microtubule-targeting agents. Although these drugs are effective for cancer chemotherapy, they have some critical problems; e.g., neurotoxicity caused by damage to neuronal microtubules, as well as innate or acquired drug resistance. To overcome these problems, a great deal of effort has been expended on development of novel anti-mitotics. We identified novel microtubule-targeting agents with carbazole and benzohydrazide structures: N’-[(9-ethyl-9H-carbazol-3-yl)methylene]-2-methylbenzohydrazide (code number HND-007) and its related compounds We investigated their activities against cancer cells using various methods including cell growth assay, immunofluorescence anal., cell cycle anal., tubulin polymerization assay, and tumor inhibition assay in nude mice. HND-007 inhibits tubulin polymerization in vitro and blocks microtubule formation and centrosome separation in cancer cells. Consequently, it suppresses the growth of various cancer cell lines, with IC₅₀ values in the range 1.3-4.6 μM. In addition, HND-007 can inhibit the growth of taxane-resistant cancer cells that overexpress P-glycoprotein. Finally, HND-007 can inhibit HeLa cell tumor growth in nude mice. Taken together, these findings suggest that HND-007 is a promising lead compound for development of novel anti-mitotic, anti-microtubule chemotherapeutic agents.

Biochimica et Biophysica Acta, General Subjects published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, HPLC of Formula: 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Shamshad, Bushra published the artcileStudies on Chemistry, Spectroscopy and Antioxidant Activities of Chromium(III)-Hydrazide Complexes, Product Details of C7H7IN2O, the publication is Medicinal Chemistry (Sharjah, United Arab Emirates) (2015), 11(8), 798-806, database is CAplus and MEDLINE.

Acid hydrazides are vital chem. entities due to their biol. activities. Upon complexation with certain metal ions, their biol. activities are known to be pos. enhanced. The present work describes the synthesis of Cr(III)-hydrazide complexes, and their structural, spectroscopic and antioxidant properties to reveal their chem. and biochem. Phys. (magnetic moment, conductivity measurements), anal. (C, H, N and Cr anal.) and spectral (EI-Mass, FTIR) techniques were used for the characterization of synthesized compounds All Cr(III)-hydrazide complexes exhibit octahedral geometry with formula [Cr(L)₂(H₂O)₂]Cl₃. In these complexes, the hydrazide ligands are coordinated via carbonyl O and terminal amino N in a bidentate fashion. All Cr(III)-hydrazide complexes were screened for in vitro diphenyldipicrylhydrazine (DPPH), superoxide dismutase and nitric oxide radical scavenging activities. A majority of the Cr(III)-hydrazide complexes are more potent scavengers than their uncoordinated hydrazide ligands. This study demonstrates an interesting structure-activity relation (SAR) which is presented here.

Medicinal Chemistry (Sharjah, United Arab Emirates) published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C26H41N5O7S, Product Details of C7H7IN2O.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ashiq, Uzma published the artcileEnzyme inhibition, radical scavenging, and spectroscopic studies of vanadium(IV)-hydrazide complexes, Category: iodides-buliding-blocks, the publication is Journal of Enzyme Inhibition and Medicinal Chemistry (2009), 24(6), 1336-1343, database is CAplus and MEDLINE.

Spectroscopic, enzyme-inhibition, and free-radical scavenging properties of a series of hydrazide ligands and their vanadium(IV) complexes have been investigated. Anal. and spectral data indicate the presence of a dimeric unit with two oxovanadium(IV) ions (VO²⁺) coordinated with two hydrazide ligands along with two water mols. All complexes are stable in the solid state, but exhibit varying degrees of stability in solution Binding of the coordinating solvent such as DMSO is indicated at the 6th position of vanadium in the dimeric unit followed by conversion to a monomeric intermediate species, [VOL(DMSO)3]1+ (L = hydrazide ligand). The free hydrazide ligands are inactive against snake venom phosphodiesterase I (SVPD), whereas oxovanadium(IV) complexes of these ligands show varying degrees of inhibition and are non-competitive inhibitors. The superoxide and nitric oxide radical scavenging properties have been determined Hydrazide ligands are inactive against these free radicals, whereas their V(IV) complexes show varying degrees of inhibition. Structure-activity relation studies indicate that the electronic and/or steric factors that change the geometry of the complexes play an important role in their inhibitory potential against SVPD and free radicals.

Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Anil Kumar, G. N. published the artcileQuantitative Investigation of Halogen and Hydrogen Bonding in 2-Chloro, 4-X-Benzoic Acids, Application In Synthesis of 145343-76-6, the publication is ChemistrySelect (2022), 7(3), e202104338, database is CAplus.

The crystal structure, Hirshfeldsurface anal., topol. anal. of the electron d. and total interaction energies of four compounds, 2-Chloro, 4-X-Benzoic Acids (where X=I, Br, Cl and F) have been analyzed. The packing similarity was evaluated in all compounds using the XPac anal. The qual. information about intermol. interactions is derived from the crystal structure and Hirshfeld surface analyses whereas quant. information are determined by the QTAIM anal. as well as total interaction energies from CrystalExplorer. The topol. properties are estimated for all compounds in both crystal geometry and gas phase using TOPOND and AIMALL, resp. The carboxylic acid O-H···O HB dimers, C-H···O HBs and Cπ···Cπ aromatic stacking interactions are found to be common interactions in all compounds The topol. properties and bond paths demonstrate them as non-covalent stabilizing interactions in the crystalline state. The hierarchy of interactions concerning their strength is observed in the following order such that O-H···O HB dimers>C_π···C_π aromatic stacking interactions>C-H···O HBs>Type II X···Cl interactions and C-H···Cl HBs>Type I homo-halogen X···X interactions in all compounds Addnl., the strength of Type I homo-halogen X···X interactions vary in the order: I···I>Br···Br>Cl···Cl>F···F. The hierarchy of interactions is further supported by mol. electrostatic potential surfaces associated with both pos. and neg. potential regions.

ChemistrySelect published new progress about 145343-76-6. 145343-76-6 belongs to iodides-buliding-blocks, auxiliary class Chloride,Iodide,Carboxylic acid,Benzene, name is 2-Chloro-4-iodobenzoic acid, and the molecular formula is C7H4ClIO2, Application In Synthesis of 145343-76-6.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Szczesniak, Pawel published the artcileExtracellular MIF, but not its homologue D-DT, promotes fibroblast motility independently of its receptor complex CD74/CD44, Category: iodides-buliding-blocks, the publication is Journal of Cell Science (2021), 134(3), jcs217356, database is CAplus and MEDLINE.

Macrophage migration inhibitory factor (MIF) and its homolog D-dopachrome tautomerase (D-DT) are widely expressed pro-inflammatory cytokines with chemokine-like functions that coordinate a wide spectrum of biol. activities, such as migration. Here, we biotin-tagged intracellular MIF/D-DT in vivo to identify important cytosolic interactors and found a plethora of actin cytoskeleton-associated proteins. Although the receptor complex between CD74 and CD44 (CD74/CD44) is essential for signalling transduction in fibroblasts via extracellular MIF/D-DT, our interactome data suggested direct effects. We, thus, investigated whether MIF/D-DT can modulate cell migration independently of CD74/CD44. To distinguish between receptor- and non-receptor-mediated motility, we used fibroblasts that are either deficient or that express CD74/CD44 proteins, and treated them with recombinant MIF/D-DT. Interestingly, only MIF could stimulate chemokinesis in the presence or absence of CD74/CD44. The pro-migratory effects of MIF depended on lipid raft/caveolae-mediated but not clathrin-mediated endocytosis, on its tautomerase activity and, probably, on its thiol protein oxidoreductase activity. As MIF treatment restrained actin polymerization in vitro, our findings establish a new intracellular role for MIF/D-DT in driving cell motility through modulation of the actin cytoskeleton.

Journal of Cell Science published new progress about 41270-96-6. 41270-96-6 belongs to iodides-buliding-blocks, auxiliary class Pyrimidine,Iodide,Benzene,Immunology/Inflammation,MIF, name is 4-Iodo-6-phenylpyrimidine, and the molecular formula is C5H8N2O, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sah, Peter P. T. published the artcilep-Iodobenzohydrazide as a reagent for the identification of aldehydes and ketones, Safety of 4-Iodobenzohydrazide, the publication is Recueil des Travaux Chimiques des Pays-Bas et de la Belgique (1940), 349-56, database is CAplus.

cf. C. A. 29, 466.2; 30, 2875.6. p-Iodobenzohydrazide is prepared as follows: 3 g. p-IC₆H₄CO₂Me and 4 cc. of N₂H₄.H₂O (40%) are boiled while 4 cc. of absolute alc. are added. After refluxing for 8 hrs. and cooling, the hydrazide seps. and may be recrystallized from 50% alc. Yield 2.7 g., m. 168-9° (corrected). The following compounds gave hydrazones with the indicated corrected m. p.: AcH 224°, EtCHO 196°, PrCHO 201°, iso-PrCHO 209-10°, BuCHO 152°, iso-BuCHO 218-19°, AmCHO 148-9°, iso-AmCHO 171-2°, heptaldehyde 190-1°, octaldehyde 155°, nonylaldehyde 135-6°, decylaldehyde 151-2°, acetone 214-15°, MeCOEt 164-5°, Me hexyl ketone 125-6°, BzH 237-8°, benzylideneacetone 229-30° (decomposition), 2-furaldehyde 235° (decomposition), acetophenone 212°, p-methylacetophenone 214°, p-ethylacetophenone 167-8°, AcCH₂CO₂Et 107-9°, levulinic acid 184-5°, Me levulinate 163-4°, Et levulinate 127-8°, benzylideneacetophenone 182°, salicylaldehyde 214-15°, p-hydroxybenzaldehyde 295-6° (decomposition), cyclohexanone 188-9°, camphor 153-4°, citral 99-100°, fenchone 168-9°. The m. ps. of the hydrazones differ sufficiently to make identification possible without the use of mixed m. ps. and for that reason this reagent is recommended as a substitute for 2,4-dinitrophenylhydrazine and semicarbazide. The yields of the hydrazones are so high that 300 mg. of the reagent are sufficient.

Recueil des Travaux Chimiques des Pays-Bas et de la Belgique published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Safety of 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Maier, Martin S. published the artcileOxidative Approach Enables Efficient Access to Cyclic Azobenzenes, Computed Properties of 101420-79-5, the publication is Journal of the American Chemical Society (2019), 141(43), 17295-17304, database is CAplus and MEDLINE.

Azobenzenes are versatile photoswitches that found widespread use in a variety of fields, ranging from photopharmacol. to the material sciences. In addition to regular azobenzenes, the cyclic diazocines have recently emerged. Although diazocines have fascinating conformational and photophys. properties, their use was limited by their synthetic accessibility. Herein, the authors present a general, high-yielding protocol that relies on the oxidative cyclization of dianilines. In combination with a modular substrate synthesis, it allows for rapid access to diversely functionalized diazocines on gram scales. The authors’ work systematically explores substituent effects on the photoisomerization and thermal relaxation of diazocines. It will enable their incorporation into a wide variety of functional mols., unlocking the full potential of these emerging photoswitches. The method can be applied to the synthesis of a new cyclic azobenzene with a nine-membered central ring and distinct properties.

Journal of the American Chemical Society published new progress about 101420-79-5. 101420-79-5 belongs to iodides-buliding-blocks, auxiliary class Nitrile,Nitro Compound,Iodide,Benzene,Benzene Compounds, name is 4-Iodo-3-nitrobenzonitrile, and the molecular formula is C7H3IN2O2, Computed Properties of 101420-79-5.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Khattab, M. A. published the artcileIntramolecular charge migration and substituent effect in some benzoic hydrazide derivatives, Safety of 4-Iodobenzohydrazide, the publication is Egyptian Journal of Chemistry (1982), 25(5), 427-34, database is CAplus.

UV data for I (R = p-O₂N, p-Cl, o-Cl, p-I, H, O-Me, o-NH₂, etc.) were determined in EtOH and cyclohexane solvents. A plot of band position vs. σ indicate a valid LFER. IR data are given.

Egyptian Journal of Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Safety of 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tahtaoui, Chouaib published the artcileOn the Use of Nonfluorescent Dye Labeled Ligands in FRET-Based Receptor Binding Studies, Synthetic Route of 606-55-3, the publication is Journal of Medicinal Chemistry (2005), 48(24), 7847-7859, database is CAplus and MEDLINE.

The efficiency of fluorescence resonance energy transfer (FRET) is dependent upon donor-acceptor proximity and spectral overlap, whether the acceptor partner is fluorescent or not. The authors report here on the design, synthesis, and characterization of two novel pirenzepine derivatives that were coupled to patent blue VF and pinacyanol dyes. These nonfluorescent compounds, when added to cells stably expressing enhanced green fluorescent protein (EGFP)-fused muscarinic M1 receptors, promote EGFP fluorescence extinction in a time-, concentration-, and atropine-dependent manner. They display nanomolar affinity for the muscarinic receptor, determined using either FRET or classical radioligand binding conditions. The authors provide evidence that these compounds behave as potent acceptors of energy from excited EGFP with quenching efficiencies comparable to those of analogous fluorescent bodipy or rhodamine red pirenzepine derivatives The advantages they offer over fluorescent ligands are illustrated and discussed in terms of reliability, sensitivity, and wider applicability of FRET-based receptor binding assays.

Journal of Medicinal Chemistry published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Synthetic Route of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com