Tag: M.W=250-300

El-Aal, R. M. Abd published the artcileSynthesis, absorption spectra studies and biological activity of some novel conjugated dyes, COA of Formula: C12H14IN, the publication is Journal of the Chinese Chemical Society (Taipei) (2000), 47(2), 389-395, database is CAplus.

Novel monomethine, dimethine, and tetramethine cyanine dyes were prepared as conjugated dyes. Such dyes incorporated coumarin and/or quinoline derivatives These dyes were synthesized to study their spectral behavior, solvatochromism, and biol. activity. These dyes were characterized by elemental anal. and IR, ¹H NMR, and mass spectra.

Journal of the Chinese Chemical Society (Taipei) published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, COA of Formula: C12H14IN.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Haristos, Demetrius A. published the artcileStudy of the hydrolysis of halo-substituted benzoic acid hydrazides, SDS of cas: 39115-95-2, the publication is Chimika Chronika (1981), 10(2), 163-74, database is CAplus.

Alk. hydrolysis kinetics of RC₆H₄CONHNH₂ (R = o-, m-, or p-F, Cl, Br, I) were spectrally determined at 40-60°. The reaction involves successive enolization and hydrolysis with rate constants ∼10³ s^-1 and ∼10⁵ mol L s^-1, resp. The enolization kinetics are slightly affected by temperature and substituents. The substituent, its position, and the temperature have a large effect on the hydrolysis.

Chimika Chronika published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, SDS of cas: 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ishii, Marina published the artcileSynthesis, molecular modeling and preliminary biological evaluation of a set of 3-acetyl-2,5-disubstituted-2,3-dihydro-1,3,4-oxadiazole as potential antibacterial, anti-Trypanosoma cruzi and antifungal agents, Recommanded Product: 4-Iodobenzohydrazide, the publication is Bioorganic & Medicinal Chemistry (2011), 19(21), 6292-6301, database is CAplus and MEDLINE.

A series of 3-acetyl-2,5-disubstituted-2,3-dihydro-1,3,4-oxadiazole derivatives was synthesized and their activity screened in vitro against Staphylococcus aureus, Trypanosoma cruzi, and Candida albicans. The bioactivity was expressed as min. inhibitory concentration (MIC) for S. aureus strains, and as IC₅₀ of parasite population growth for T. cruzi. A mol. modeling approach was performed to establish qual. relationships regarding the biol. data and the compounds’ physicochem. properties. Oxadiazole derivatives I [R = OBu, OAc] were the most active compounds for S. aureus ATCC 25923 (MIC = 1.95 -1.25 μg/mL) and T. cruzi (IC₅₀ = 7.91 μM), resp. Also, a preliminary evaluation against C. albicans involving some compounds was performed and I [R = CF₃] was the most active compound (MIC = 3.28-2.95 μg/mL). In this preliminary study, all synthesized 3-acetyl-2,5-disubstituted-2,3-dihydro-1,3,4-oxadiazole derivatives were active against all microorganisms tested.

Bioorganic & Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Recommanded Product: 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Palace-Berl, Fanny published the artcile5-Nitro-2-furfuriliden derivatives as potential anti-Trypanosoma cruzi agents: Design, synthesis, bioactivity evaluation, cytotoxicity and exploratory data analysis, Product Details of C7H7IN2O, the publication is Bioorganic & Medicinal Chemistry (2013), 21(17), 5395-5406, database is CAplus and MEDLINE.

The anti-Trypanosoma cruzi activity of 5-nitro-2-furfuriliden derivatives as well as the cytotoxicity of these compounds on J774 macrophages cell line and FN1 human fibroblast cells were investigated in this study. The most active compounds of series I and II were 4-butyl-[N’-(5-nitrofuran-2-yl) methylene] benzidrazide (3g; IC₅₀ = 1.05 μM ± 0.07) and 3-acetyl-5-(4-butylphenyl)-2-(5-nitrofuran-2-yl)-2,3-dihydro,1,3,4-oxadiazole (4g; IC₅₀ = 8.27 μM ± 0.42), resp. Also, compound 3g was more active than the standard drugs, benznidazole (IC₅₀ = 22.69 μM ± 1.96) and nifurtimox (IC₅₀ = 3.78 μM ± 0.10). Regarding the cytotoxicity assay, the 3g compound presented IC₅₀ value of 28.05 μM (SI = 26.71) against J774 cells. For the FN1 fibroblast assay, 3g showed IC₅₀ value of 98 μM (SI = 93.33). On the other hand, compound 4g presented a cytotoxicity value on J774 cells higher than 400 μM (SI >48), and for the FN1 cells its IC₅₀ value was 186 μM (SI = 22.49). Moreover, an exploratory data anal., which comprises hierarchical cluster (HCA) and principal component anal. (PCA), was carried out and the findings were complementary. The mol. properties that most influenced the compounds’ grouping were C log P and total dipole moment, pointing out the need of a lipophilic/hydrophilic balance in the designing of novel potential anti-T. cruzi mols.

Bioorganic & Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Product Details of C7H7IN2O.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zorzi, Rodrigo Rocha published the artcileExploring 5-nitrofuran derivatives against nosocomial pathogens: synthesis, antimicrobial activity and chemometric analysis, Name: 4-Iodobenzohydrazide, the publication is Bioorganic & Medicinal Chemistry (2014), 22(10), 2844-2854, database is CAplus and MEDLINE.

The burden of nosocomial or health care-associated infection (HCAI) is increasing worldwide. According to the World Health Organization (WHO), it is severalfold higher in low- and middle-income countries. Considering multidrug-resistant infections, the development of new and more effective drugs is crucial. Here, two series (I and II) of 5-nitrofuran derivatives were designed, synthesized and assayed against microorganisms, including Gram-pos. and -neg. bacteria, and fungi. Sets I and II were composed by substituted-[N’-(5-nitrofuran-2-yl)methylene]benzhydrazide and 3-acetyl-5-(substituted-phenyl)-2-(5-nitro-furan-2-yl)-2,3-dihydro-1,3,4-oxadiazole compounds, resp. The selection of the substituent groups was based upon physicochem. properties, such as hydrophobicity and electronic effect. The compounds exhibited good activity against Staphylococcus aureus, Escherichia coli, and Enterococcus faecalis. It is noteworthy that the compound 4-butyl-[N’-(5-nitrofuran-2-yl)methylene]benzhydrazide had a similar MIC value to vancomycin, which is the reference drug for multidrug-resistant S. aureus infections.

Bioorganic & Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C10H14O, Name: 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Bajorek, Agnieszka published the artcileNovel, N-ethyl-2-styrylquinolinum iodides as fluorophores for monitoring of polymerization process, Part I, Synthetic Route of 606-55-3, the publication is Dyes and Pigments (2009), 82(3), 372-378, database is CAplus.

A series of p-substituted 2-styrylquinolinium iodides were prepared by the condensation of N-ethyl-2-methylquinolinium salts with p-substituted benzaldehydes. The spectroscopic properties of the styryl quinolinium dyes are characterized in organic solvents of varying polarities. The electronic absorption and fluorescence emission spectra of the dyes demonstrate their high sensitivity to the nature of substituents introduced into the aromatic ring. The dyes were investigated as fluorescent probes for monitoring the progress of the photochem. initiated free-radical polymerization of a mixture of 2-ethyl-2-(hydroxymethyl)-1,3-propanediol triacrylate and 1-methyl-2-pyrrolidinone. During the course of the polymerization an increase in the fluorescence intensity of the dyes by at least one order of magnitude was recorded; a feature which renders the dyes as good fluorescent probes for such polymerization reactions. The term “probe sensitivity” has been defined and appears in the range from 0.08 to 11 for the styryl dyes.

Dyes and Pigments published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Synthetic Route of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Karthigha, S. published the artcileCrystal growth, structural investigation and characterization of newly grown quinolinium derivative single crystal: 1-Ethyl-2-(2-p-tolyl-vinyl)quinolinium; iodide, Category: iodides-buliding-blocks, the publication is Journal of Crystal Growth (2016), 77-89, database is CAplus.

A new N-Et quinolinium derivative of 1-Ethyl-2-(2-p-tolyl-vinyl)-quinoliniumiodide (PTQI) was synthesized by knoevenagel condensation reaction and single crystal was successfully grown by slow evaporation technique. The grown crystal exhibit a centric monoclinic space group P2₁/C with a third order nonlinear optical response in their crystalline form. The mol. structure of the crystal was studied by single crystal XRD and NMR spectral anal. FTIR reveal the existence of vinyl group and functional groups of the grown crystal. The m.p. and thermal behavior of PTQI were studied using TG/DTA anal. The linear optical study was done by UV-visible-NIR anal. show that the crystal is transparent in the wavelength range of 472-1100 nm. Photoluminescence study shows that PTQI crystal has green luminescence emission property. The etching study reveals that the title crystal encompasses good crystalline nature and lesser amount of dislocations. Third order nonlinear optical property was determined by Z scan technique and the results making grown crystal as a promising material in the field of nonlinear optical devices.

Journal of Crystal Growth published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Karthigha, S. published the artcileSynthesis, growth and third-order nonlinear optical properties of quinolinium single crystal-PCLQI, Quality Control of 606-55-3, the publication is RSC Advances (2016), 6(39), 33159-33169, database is CAplus.

N-Et quinolinium chromophore crystal 2-[2-(4-chloro-phenyl)-vinyl]-1-ethyl-quinolinium iodide (I·I) was successfully grown by the slow evaporation technique. Single crystal X-ray diffraction studies revealed that I·I crystallized in the monoclinic crystal system with the centrosym. space group C2/c. The mol. formation of the grown crystal was initially identified using ¹H NMR and FTIR anal. The linear optical studies of crystal I·I were done by UV-vis-NIR studies and thermal studies revealed the stability till its m.p. at 239.7 °C. The grown crystal of I·I exhibited high third order optical nonlinearity which was determined by the Z-scan technique.

RSC Advances published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Quality Control of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Inturi, Surendra Babu published the artcileI₂ mediated one-pot synthesis of 1,2,4-triazoles from amidines and imidates, Related Products of iodides-buliding-blocks, the publication is Tetrahedron Letters (2016), 57(21), 2227-2230, database is CAplus.

A one-pot facile synthesis of 3,5-disubstituted-1H-1,2,4-triazole derivatives using I₂/Cs₂CO₃ was described. The method involves readily available inexpensive reagents and is applicable to a wide range of substrates. The transformation involves one-pot sequential C-N and N-N bond forming reactions with high product yields and selectivity, and offers a new and useful strategy for the synthesis of 3,5-disubstituted-1H-1,2,4-triazole derivatives

Tetrahedron Letters published new progress about 134322-01-3. 134322-01-3 belongs to iodides-buliding-blocks, auxiliary class Salt,Iodide,Amine,Amidine,Benzene, name is 4-Iodobenzimidamide hydrochloride, and the molecular formula is C7H8ClIN2, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lim, Jongwon published the artcileDiscovery of 1-(1H-Pyrazolo[4,3-c]pyridin-6-yl)urea Inhibitors of Extracellular Signal-Regulated Kinase (ERK) for the Treatment of Cancers, COA of Formula: C6H3ClIN3, the publication is Journal of Medicinal Chemistry (2016), 59(13), 6501-6511, database is CAplus and MEDLINE.

The ERK/MAPK pathway plays a central role in the regulation of critical cellular processes and is activated in more than 30% of human cancers. Specific BRAF and MEK inhibitors have shown clin. efficacy in patients for the treatment of BRAF-mutant melanoma. However, the majority of responses are transient, and resistance is often associated with pathway reactivation of the ERK signal pathway. Acquired resistance to these agents has led to greater interest in ERK, a downstream target of the MAPK pathway. De novo design efforts of a novel scaffold derived from SCH772984 by employing hydrogen bond interactions specific for ERK in the binding pocket identified 1-(1H-pyrazolo[4,3-c]pyridin-6-yl)ureas as a viable lead series. Sequential SAR studies led to the identification of highly potent and selective ERK inhibitors with low mol. weight and high LE. Compound 21 exhibited potent target engagement and strong tumor regression in the BRAF^V600E xenograft model.

Journal of Medicinal Chemistry published new progress about 1260672-72-7. 1260672-72-7 belongs to iodides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Iodide, name is 6-Chloro-3-iodo-1H-pyrazolo[4,3-c]pyridine, and the molecular formula is C6H3ClIN3, COA of Formula: C6H3ClIN3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com