Tag: M.W=250-300

El Ashry, E. S. H. published the artcileThe scope of the reactions of hydrazines and hydrazones. Part VI. Reaction of hydrazines with dimedone, Computed Properties of 39115-95-2, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1978), 16B(10), 871-5, database is CAplus.

The reactions of dimedone (I) with hydrazines were studied. I and p-tolylhydrazine gave II (R = NHNHC₆H₄Me-p), which was deprotonated to give II (R = N:NC₆H₄Me-p). With excess p-tolylhydrazine, I gave III (Z¹ = Z³ = NNHC₆H₄Me-p, Z² = O) which was identified as its 2-p-nitrobenzoylhydrazone and III (Z¹-Z³ = NNHC₆H₄Me-p). Reactions of I and II (R = NHNHR¹, N:NR¹; R¹ = Ph, C₆H₄Me-p) with R²C₆H₄CONHNH₂ (R² = H, Me, OMe, Cl, Br, I, OH, NO₂) gave the corresponding hydrazones. Reaction of I with semicarbazide, thiosemicarbazide and gluconylhydrazines gave the monohydrazones.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Computed Properties of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Simon, P. published the artcileNew NIR dyes for ammonia sensing, Computed Properties of 606-55-3, the publication is Sensors and Actuators, B: Chemical (2003), 90(1-3), 9-14, database is CAplus.

Three series of new cyanine dyes were synthesized and the visible-NIR spectra of the dyes were measured and interpreted by semi-empirical methods of quantum chem. As a basic building block for the synthesis, 4-(dimethylaminomethylene)-5-oxo-2-furfurylidenedimethyliminium perchlorate (I) was used. The dyes were prepared by condensing I with appropriate salts. The tests for sensitivity to ammonia showed that mono-substituted dyes III are reversibly sensitive to ammonia in ethanol solutions The dyes exhibit a peak at 620-680 nm arising from the interaction with ammonia and, hence, these dyes are promising as chem. transducers for distributed fiber-optic ammonia sensors.

Sensors and Actuators, B: Chemical published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C6H13BO3, Computed Properties of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reddy, M. L. Chenna published the artcileSynthesis of New Sulfoximine-Tethered Alkynones and Further Extension towards Metal-Free Synthesis of Pyrimidines, Amino Pyrimidines, Pyrazoles and Isoxazoles, Category: iodides-buliding-blocks, the publication is ChemistrySelect (2019), 4(33), 9573-9577, database is CAplus.

A metal-free and divergent synthetic method has been successfully developed for the synthesis of sulfoximine-tethered pyrimidines, aminopyrimidines, pyrazoles and isoxazoles. Two key sulfoximine tethered alkynone intermediates ((tert-butyldiphenylsilyl)imino)(2-oxo-4-phenylbut-3-yn-1-yl)(phenyl)-λ6-sulfanone and ((tert-butyldiphenylsilyl)imino)(2-oxopent-3-yn-1-yl)(phenyl)-λ6-sulfanone were reported for the first time and were used as the common building blocks to construct these heterocycles. Good functional group tolerability was observed and the products were isolated in excellent yields.

ChemistrySelect published new progress about 134322-01-3. 134322-01-3 belongs to iodides-buliding-blocks, auxiliary class Salt,Iodide,Amine,Amidine,Benzene, name is 4-Iodobenzimidamide hydrochloride, and the molecular formula is C7H8ClIN2, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ichijo, Keisuke published the artcileCrystal Structures and Optical Properties of Cyanine Dyes Depending on Various Counter Anions, Product Details of C12H14IN, the publication is ACS Omega (2021), 6(42), 28421-28431, database is CAplus and MEDLINE.

In this study, cyanine cations with various counter anions were prepared as examples of ionic materials constructed using charged π-conjugated systems. A series of ion pairs was obtained by anion exchange reactions using iodide salts of carbocyanine dyes. The optical properties were measured by UV/vis absorption and fluorescence spectroscopy; measurements performed in CHCl₃ (less-polar solvent) were altered by the influence of the counter anions. The packing structures of nine crystals were determined by single-crystal X-ray anal. Moreover, the locations of the anions relative to the cations were stabilized by hydrogen bonding and categorized into two types. In addition, delocalization of the neg. charge of the anions on cyanine cations was explained by d. functional theory calculations Furthermore, it was concluded that the stack formation of cyanine cations depends on the size and structure of the anions.

ACS Omega published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Product Details of C12H14IN.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Pacardo, Dennis B. published the artcileExploring the mechanism of Stille C-C coupling via peptide-capped Pd nanoparticles results in low temperature reagent selectivity, Product Details of C7H4ClIO2, the publication is Catalysis Science & Technology (2013), 3(3), 745-753, database is CAplus.

Stille coupling of PhSnCl₃ with aryl halides was catalyzed by palladium 2 nm nanoparticles, capped with Pd4 peptide, TSNAVHPTLRHL, the effects of halogen, substitution and temperature being qual. evaluated. The atom-leaching mechanism of Pd nanoparticle-driven Stille coupling is suggested, comprising initial oxidative addition at the particle surface, Pd atom abstraction and further reactions in solution The fate of the highly active Pd⁰ atoms released in solution was further elucidated. As a result, two reaction sites are present, the particle surface and pre-leached Pd atoms, thus different degrees of reactivity are possible. This effect was probed via aryl halide combinations that varied the halogen identity allowing for oxidative addition of two substrates simultaneously. The results demonstrate that the system was highly reactive for iodo-based compounds in the mixture at room temperature; however, reactivity at bromo-based substrates was only observed at slightly elevated temperatures of 40.0°. As such, substrate selectivity was evident from the catalytic materials that can be controlled based upon the aryl halide composition and reaction temperature Furthermore, both intermol. and intramol. selectivity is possible, thus raising the degree of reaction complexity that can be achieved.

Catalysis Science & Technology published new progress about 145343-76-6. 145343-76-6 belongs to iodides-buliding-blocks, auxiliary class Chloride,Iodide,Carboxylic acid,Benzene, name is 2-Chloro-4-iodobenzoic acid, and the molecular formula is C7H4ClIO2, Product Details of C7H4ClIO2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sapountzis, Ioannis published the artcileGeneral preparation of functionalized o-nitroarylmagnesium halides through an iodine-magnesium exchange, Recommanded Product: 4-Iodo-3-nitrobenzonitrile, the publication is Angewandte Chemie, International Edition (2002), 41(9), 1610-1611, database is CAplus and MEDLINE.

Highly functionalized aryl Grignard reagents with an ortho-nitro substituent were synthesized from 2-iodonitroaryl compounds through an I-Mg exchange reaction with PhMgCl or mesityl Mg bromide. These Grignard reagents are stable (T < – 20° for several hours) and undergo various cross-coupling reactions in the presence of Cu or Pd catalysts (dba = trans,trans-dibenzylideneacetone; tfp = tri-o-furylphosphine). E.g., ClMgC₆H₄NO₂-2 reacted with PhCHO at -40° to give 2-NO₂C₆H₄CH(OH)Ph in 87% yield.

Angewandte Chemie, International Edition published new progress about 101420-79-5. 101420-79-5 belongs to iodides-buliding-blocks, auxiliary class Nitrile,Nitro Compound,Iodide,Benzene,Benzene Compounds, name is 4-Iodo-3-nitrobenzonitrile, and the molecular formula is C7H3IN2O2, Recommanded Product: 4-Iodo-3-nitrobenzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Koenigstein, Christian published the artcileOrigin of the high-energy emission of 1,1′-diethyl-2,2′-cyanine dye, Recommanded Product: 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Journal of Photochemistry and Photobiology, A: Chemistry (1994), 84(3), 245-8, database is CAplus.

In addition to the yellow emission ascribed to the J aggregates of 1,1′-diethyl-2,2′-cyanine, this compound also exhibits a high-energy emission around 400 nm in dilute aqueous solutions (c<10^-3 mol l^-1). It was found using time-resolved emission measurements that protonation of 1,1′-diethyl-2,2′-cyanine is responsible for this emission. At pH<4, the excited state protolytic reaction competes with ground state protonation. Both pathways give the same excited species, luminescing at 400 nm. The non-protonated form shows only weak fluorescence. The excited state lifetime of the protonated form is 4.5 ns.

Journal of Photochemistry and Photobiology, A: Chemistry published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Recommanded Product: 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Kratky, Martin published the artcileIodinated 1,2-diacylhydrazines, benzohydrazide-hydrazones and their analogues as dual antimicrobial and cytotoxic agents, Category: iodides-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry (2021), 116209, database is CAplus and MEDLINE.

Here in, authors synthesized and screened twenty-two iodinated hydrazide-hydrazones I (R¹ = H, Me, t-Bu, etc.; R² = 2-OH, 4-OH), ten 1,2-diacylhydrazines II (R = H, t-Bu, CF₃, etc.)and their three reduced analogs for their antibacterial, antifungal, and cytotoxic properties. Hydrazide-hydrazones were prepared by condensation of 4-substituted benzohydrazides with 2-/4-hydroxy-3,5-diiodobenzaldehydes, diacylhydrazines from identical benzohydrazides and 3,5-diiodosalicylic acid via its chloride. These compounds were investigated in vitro against eight bacterial and eight fungal strains. The derivatives were found potent antibacterial agents against Gram-pos. cocci including methicillin-resistant Staphylococcus aureus with the lowest values of min. inhibitory concentrations (MIC) of 7.81μM. Four compounds inhibited also human pathogenic fungi (MIC of ≥ 1.95μM). The derivatives had different degrees of cytotoxicity for HepG2 and HK-2 cell lines (IC₅₀ values from 11.72 and 26.80μM, resp.) and normal human cells exhibited lower sensitivity. The apoptotic effect was also investigated. In general, the presence of 3,5-diiodosalicylidene scaffold in compd I (R² = 2-OH) is translated into enhanced both antimicrobial and cytotoxic properties whereas its 4-hydroxy isomers I (R² = 4-OH) share a low biol. activity. Compounds II have a non-homogeneous activity profile. Focusing on 4-substituted benzohydrazide part, the presence of an electron-withdrawing group (F, Cl, CF₃, NO₂) was found to be beneficial.

Bioorganic & Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Abd El-Aal, R. M. published the artcileThe use of oxonium salts in the synthesis of mono-, β-substituted dimethine and styryl cyanine dyes, Safety of 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Dyes and Pigments (2005), 66(3), 201-209, database is CAplus.

Pyrazolopyrylium perchlorate salt derivatives were obtained from the reaction of 5-chloro-4-formyl-3-methyl-1-phenylpyrazole with methylphenylpyrazolone, 4(2-propenyl)-1,6-ene-2-cyclohexanone, and cyclohexanone. Reaction of the salts with 2(4)-Me-substituted heterocyclic quaternary salts gave the pyrazolopyrylium 4[2(4)]-monomethine cyanine dyes. Meanwhile, reaction with amide compounds gives intermediate compounds which when reacted with 2(4)-Me-substituted heterocyclic quaternary salts gave the pyrazolopyrylium 4[2(4)]-β-substituted dimethines. Reaction of the intermediate compounds with various aromatic aldehydes followed by the reaction with 2-methylquinolinium ethiodide gave bis styryl cyanine dyes. Elemental analyses and visible absorption, IR, ¹H NMR, and mass spectra established the structures of these compounds The relationship between the structure and properties of these dyes is discussed.

Dyes and Pigments published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Safety of 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Abed El-Aal, R. M. published the artcileSynthesis and photophysics in organic solvents of mesosubstituted pentamethine and related metal complexes cyanine dyes, Computed Properties of 606-55-3, the publication is Dyes and Pigments (2002), 54(2), 121-129, database is CAplus.

The reaction in a ratio of 1 mol of diacetylchloromethane with 1 mol of heterocyclic nitrogen bases afforded N-substituted heterocyclidinium ylide halides. Reaction at a ratio of 1 mol of ylides with 2 and 3 mol of 2(4)-methylheterocyclic quaternary salts in basic catalyst afforded meso-substituted pentamethine and monomethine meso-substituted pentamethine cyanine dyes, resp. Reaction of equimolar ratios of metal chloride adducts of the ylides with equi- (bi)molar ratios of 2(4)-methylheterocyclic quaternary salts in basic medium afforded asym. (sym.) meso-substituted mono- (bis)monomethine metal complex cyanine dyes. Elemental analyses and IR and ¹H NMR spectral data confirmed the structures of the newly synthesized compounds The electronic absorption spectra of these dyes in ethanol and their photophysics in different solvents are discussed.

Dyes and Pigments published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Computed Properties of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com