Tag: M.W=250-300

Liu, Weiwei published the artcileSynthesis of novel glycosyl 1,3,4-oxadiazole derivatives, Quality Control of 39115-95-2, the publication is Heterocyclic Communications (2014), 20(6), 333-338, database is CAplus.

A convenient and practical protocol was developed to synthesize glycosyl 1,3,4-oxadiazoles from D-glucosamine with good to excellent yields. The key step involved p-TsCl/pyridine-mediated cyclization under mild conditions. Subsequent removal of the acetyl groups in the last step, conducted using the system of NaOMe/MeOH, gave the desired N-acetyl-D-glucosamine 1,3,4-oxadiazole derivatives

Heterocyclic Communications published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Quality Control of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Liu, Wei-wei published the artcileSynthesis, characterization, and biological evaluation of some novel glycosyl 1,3,4-thiadiazole derivatives as acetylcholinesterase inhibitors, Formula: C7H7IN2O, the publication is Heterocycles (2015), 91(2), 275-286, database is CAplus.

The corresponding 4-substituted glycosyl thiosemicarbazide derivatives were obtained by the reaction of glycosyl isothiocyanate with various hydrazides. Further cyclization with the system of p-TsCl/TEA led to the formation of N-glycosyl-5-substituted 1,3,4-thiadiazole-2-amine. Subsequent removal of the acetyl groups were conducted using the system of NaOMe/MeOH. The chem. structures of all new products were confirmed by IR, 1H NMR and ESI-HRMS. The acetylcholinesterase (AChE) inhibitory activities of those compounds were tested by Ellman’s method. Among them, the compound I possessed the best acetylcholinesterase-inhibition activity with IC₅0 of 18.38 ± 0.89 μM.

Heterocycles published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Formula: C7H7IN2O.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Shindy, H. A. published the artcileNew cyanine dyes from 4,9-dioxopiperidino[2,3-g]-1,2,3,4,6,7,8,9-octahydroquinolinoquinone, Computed Properties of 606-55-3, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (2001), 40B(5), 426-429, database is CAplus.

Sym. bis(styryl, tetramethine, azastyryl) cyanine dyes containing arylidene, heterylidene, and schiff base moieties have been obtained by the interaction of 4,9-dioxopiperidino[2,3-g]-1,2,3,4,6,7,8,9-octahydroquinolinoquinone with aromatic aldehyde, heterocyclic aldehyde and nitroso compounds followed by condensation with 2(4)-Me quaternary ethiodide salts. The UV spectra in 95% ethanol of all the synthesized cyanine dyes show that the photosensitization of the dyes increases (or decreases) by increasing (or decreasing) conjugation, by the presence of electron donating (attracting) groups and the more (less) planarity of the dyes. The new compounds have been identified by elemental anal. and IR and ¹H NMR spectral data.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C6H13I, Computed Properties of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Shindy, H. A. published the artcileSyntheses and absorption-structure relationships of some new photosensitizer cyanine dyes, Recommanded Product: 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Proceedings – Indian Academy of Sciences, Chemical Sciences (2002), 114(2), 125-136, database is CAplus.

3-Methyl-1,4-diphenyl-1H-pyrazolo[4,5-d][1,3]oxazol-5-one was synthesized as starting material to prepare new photosensitizing mono-, tri-, and substituted triazadimethine and mixed cyanine dyes. Absorption-structure relationships of the synthesized cyanine dyes were determined by studying their electronic spectral behavior in ethanol. The structures of the dyes were identified by elemental anal. and IR and ¹H NMR spectral data.

Proceedings – Indian Academy of Sciences, Chemical Sciences published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C6H6N2O, Recommanded Product: 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Abu El-Hamd, R. M. published the artcileSynthesis, visible spectral studies and biological activity of some new heterocyclic quinone trimethine and merocyanine dyes, Synthetic Route of 606-55-3, the publication is Indian Journal of Heterocyclic Chemistry (1996), 5(4), 305-310, database is CAplus.

New asym. cyanine dyes (I; A = α-picolinyl, quinaldinyl, γ-picolinyl; Z = S, O; II; A = as above; III; R = COMe, CO₂Et; and IV) incorporating naphthoquinone in conjunction with thiazole/oxazole and/or oxadiazine moieties were prepared Mol. complex formation with ethanol was verified by mixed solvent studies. The variation of absorbance with pH was utilized for the determination of the pKa value for a selected dye. Bactericidal and fungicidal activity of selected cyanines were determined

Indian Journal of Heterocyclic Chemistry published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Synthetic Route of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Makane, Vitthal B. published the artcileNovel 1,3,4-oxadiazoles as antitubercular agents with limited activity against drug-resistant tuberculosis, Safety of 4-Iodobenzohydrazide, the publication is Future Medicinal Chemistry (2019), 11(6), 499-510, database is CAplus and MEDLINE.

In recent times, heterocyclic chemotypes are being explored for the development of new antimycobacterials that target the drug-resistant tuberculosis. Here, we are disclosing the 5-substitued 2-mercapto-1,3,4-oxadiazoles I (R₁ = Ph, 2-BrC₆H₄, 4-OHC₆H₄, etc.) as potent antitubercular agents. A small library of 2-mercapto-1,3,4-oxadiazoles I was synthesized using various acids. The compounds were evaluated for antituberculosis activity against M. tuberculosis H37Rv. Compound I (R₁ = 4-OHC₆H₄) was identified as antitubercular lead with MIC of 0.6μg/mL against M. tuberculosis H37Rv. This compound was nontoxic to CHO-K1 cells and showed selectivity index of 39. Of note, I (R₁ = 4-OHC₆H₄) showed antitubercular activity against pre-extensively drug-resistant clin. isolate of Mycobacterium with MIC of 2μg/mL. This study provides potent antitubercular agent which can be further optimized to discover novel antibiotics.

Future Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Safety of 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Karthigha, S. published the artcileSynthesis, growth, structural, optical and third order nonlinear optical properties of new quinolinium derivative single crystal: 1-ethyl-2-[2-(3,4,5-trimethoxy-phenyl) vinyl]-quinolinium iodide, Computed Properties of 606-55-3, the publication is Journal of Materials Science: Materials in Electronics (2017), 28(18), 13507-13520, database is CAplus.

An organic quinolinium derivative crystal 1-ethyl-2-[2-(3,4,5-trimethoxy-phenyl) vinyl]-quinolinium iodide has been synthesized by knoevenagel condensation reaction and the crystals were grown by solution growth method for the first time. The grown crystal structure was confirmed by single crystal X-ray diffraction anal. and it showed that TMQI crystal belong to the triclinic space group P-1. The mol. structure and composition of the crystal was further confirmed by Fourier transform IR (FT-IR) and NMR (FT-NMR) spectroscopic techniques. The thermal stability of the title crystal has been investigated by TG/DSC curves. The linear optical response of the grown crystal has been examined by using UV-Vis-NIR spectral anal., and the photoluminescence spectrum exhibits strong emission radiation at 558 nm. The chem. etching anal. was carried to reveal the growth pattern of TMQI crystal. Laser induced damage threshold of the title crystal was found to be 1.15 GW/cm². The third order nonlinear optical property of grown crystal was studied using Z-scan technique and the magnitude of third order nonlinear susceptibility has found to be in the order of 10^-3 esu, which is higher than the reported quinolinium derivative crystals.

Journal of Materials Science: Materials in Electronics published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Computed Properties of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Karthigha, S. published the artcileSynthesis, growth, crystal structure, optical and third order nonlinear optical properties of quinolinium derivative single crystal: PNQI, Safety of 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Journal of Physics and Chemistry of Solids (2018), 133-140, database is CAplus.

An organic quinolinium derivative nonlinear optical (NLO) crystal, 1-ethyl-2-[2-(4-nitro-phenyl)-vinyl]-quinolinium iodide (PNQI) was synthesized and successfully grown by slow evaporation solution growth technique. Formation of a crystalline compound was confirmed by single crystal X-ray diffraction. The quinolinium compound PNQI crystallizes in the triclinic crystal system with a centrosym. space group of P-1 symmetry. The mol. structure of PNQI was confirmed by ¹H NMR and ¹³C NMR spectral studies. The thermal properties of the crystal have been investigated by thermogravimetric (TG) and differential scanning calorimetry (DSC) studies. The optical characteristics obtained from UV-Vis-NIR spectral data were described and the cut-off wavelength observed at 506 nm. The etching study was performed to analyze the growth features of PNQI single crystal. The third order NLO properties such as nonlinear refractive index (n₂), nonlinear absorption coefficient (β) and nonlinear susceptibility (χ ⁽³⁾) of the crystal were investigated using Z-scan technique at 632.8 nm of He-Ne laser.

Journal of Physics and Chemistry of Solids published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Safety of 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lee, Shin Heon published the artcileMacrophage migration inhibitory factor (MIF) inhibitor 4-IPP downregulates stemness phenotype and mesenchymal trans-differentiation after irradiation in glioblastoma multiforme, Product Details of C10H7IN2, the publication is PLoS One (2021), 16(9), e0257375, database is CAplus and MEDLINE.

Radiation therapy is among the most essential treatment methods for glioblastoma multiforme (GBM). Radio-resistance and cancer stem cell properties can cause therapeutic resistance, cancer heterogeneity, and poor prognoses in association with GBM. Furthermore, the GBM subtype transition from proneural to the most malignant mesenchymal subtype after radiation therapy also accounts for high resistance to conventional treatments. Here, we demonstrate that the inhibition of macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase (DDT) by 4-iodo-6-phenylpyrimidine (4-IPP), a dual inhibitor targeting MIF and DDT, downregulates stemness phenotype, intracellular signaling cascades, mesenchymal trans-differentiation, and induces apoptosis in proneural glioma stem cells (GSCs). In an anal. of The Cancer Genome Atlas, high MIF and DDT expression were associated with poor prognosis. GSC growth was effectively inhibited by 4-IPP in a time- and dose-dependent manner, and 4-IPP combined with radiation therapy led to significantly reduced proliferation compared with radiation therapy alone. The expression of stemness factors, such as Olig2 and SOX2, and the expression of pAKT, indicating PI3K signaling pathway activation, were decreased in association with both 4-IPP monotherapy and combination treatment. The expression of mesenchymal markers, TGM2 and NF-κB, and expression of pERK (indicating MAPK signaling pathway activation) increased in association with radiation therapy alone but not with 4-IPP monotherapy and combination therapy. In addition, the combination of 4-IPP and radiation therapy significantly induced apoptosis compared to the monotherapy of 4-IPP or radiation. In vivo results demonstrated a significant tumor-suppressing effect of 4-IPP when combined with radiation therapy. Collectively, our results showed that the targeted inhibition of MIF and DDT has the potential to strengthen current clin. strategies by enhancing the anticancer effects of radiation therapy.

PLoS One published new progress about 41270-96-6. 41270-96-6 belongs to iodides-buliding-blocks, auxiliary class Pyrimidine,Iodide,Benzene,Immunology/Inflammation,MIF, name is 4-Iodo-6-phenylpyrimidine, and the molecular formula is C10H7IN2, Product Details of C10H7IN2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Fan, Yi Chiao published the artcilePhosphine/Palladium-Catalyzed Syntheses of Alkylidene Phthalans, 3-Deoxyisoochracinic Acid, Isoochracinic Acid, and Isoochracinol, SDS of cas: 500563-90-6, the publication is Organic Letters (2012), 14(13), 3264-3267, database is CAplus and MEDLINE.

In this study, we used sequential catalysis-PPh₃-catalyzed nucleophilic addition followed by Pd(0)-catalyzed Heck cyclization-to construct complex functionalized alkylidene phthalans, e.g., I (R¹ = H, R, R² = H, OCH₂Ph, OMe, CF₃, etc., R³ = H, OCH₂Ph, OMe, Me, R⁴ = H, Me, MeO), rapidly, in high yields, and with good stereoselectivities (E/Z ratios of up to 1:22). The scope of this Michael-Heck reaction includes substrates bearing various substituents around the alkylidene phthalan backbone. Applying this efficient sequential catalysis, we accomplished concise total syntheses of 3-deoxyisoochacinic acid II (X = none, Y = CO₂H) isoochracinic acid II (X = O, Y = CO₂H), and isoochracinol II (X = O, Y = CH₂OH).

Organic Letters published new progress about 500563-90-6. 500563-90-6 belongs to iodides-buliding-blocks, auxiliary class Nitro Compound,Iodide,Benzene,Alcohol, name is (2-Iodo-4-nitrophenyl)methanol, and the molecular formula is C7H6INO3, SDS of cas: 500563-90-6.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com