Tag: M.W=250-300

Kolmel, Dominik K. published the artcileOn-DNA Decarboxylative Arylation: Merging Photoredox with Nickel Catalysis in Water, HPLC of Formula: 145343-76-6, the publication is ACS Combinatorial Science (2019), 21(8), 588-597, database is CAplus and MEDLINE.

A new catalytic manifold that merges photoredox with nickel catalysis in aqueous solution is presented. Specifically, the combination of a highly active, yet air-stable, nickel precatalyst with a new electron-deficient pyridyl carboxamidine ligand was key to the development of a water-compatible nickel catalysis platform, which is a crucial requirement for the preparation of DNA-encoded libraries (DELs). Together with an iridium-based photocatalyst and a powerful light source, this dual catalysis approach enabled the efficient decarboxylative arylation of α-amino acids with DNA-tagged aryl halides. This C(sp²)-C(sp³) coupling tolerates a wide variety of functional groups on both the amino acid and the aryl halide substrates. Due to the mild and DNA-compatible reaction conditions, the presented transformation holds great potential for the construction of DELs. This was further evidenced by showing that well plate-compatible LED arrays can serve as competent light sources to facilitate parallel synthesis. Lastly, we demonstrate that this procedure can serve as a blueprint toward the adaptation of other established nickel metallaphotoredox transformations to the idiosyncratic requirements of a DEL.

ACS Combinatorial Science published new progress about 145343-76-6. 145343-76-6 belongs to iodides-buliding-blocks, auxiliary class Chloride,Iodide,Carboxylic acid,Benzene, name is 2-Chloro-4-iodobenzoic acid, and the molecular formula is C7H4ClIO2, HPLC of Formula: 145343-76-6.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Feng, Huan published the artcileResponsive Fluorescence Probe for Selective and Sensitive Detection of Hypochlorous Acid in Live Cells and Animals, Safety of 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Chemistry – An Asian Journal (2018), 13(18), 2611-2618, database is CAplus and MEDLINE.

The development of effective bioanal. methods for rapid, sensitive and specific detection of HOCl in vitro and in vivo plays a key role for better understanding the roles of this mol. in normal and diseased conditions, but remains challenging due to the highly reactive nature of HOCl and the complicated biol. conditions. A new fluorescence probe, PQI(I), was developed for monitoring of the HOCl level in biol. samples. PQI was easily synthesized by a one-step condensation reaction. Upon addition of HOCl, significant changes in the absorption spectra and the color of the solution were noticed, facilitating the “naked eye” detection of HOCl in PBS buffer. The fluorescence of PQI is significantly increased within a few seconds, leading to “OFF-ON” fluorescence response towards HOCl. The sensing mechanism, oxidation of thioether by HOCl, was confirmed by HRMS titration anal. PQI features a large Stokes shift, high sensitivity and selectivity, and rapid fluorescence response towards HOCl. Quant. detection of HOCl in single live cells was demonstrated through fluorescence imaging and flow cytometry anal. PQI was then successfully used in visualization of HOCl in live zebrafish and nude mice.

Chemistry – An Asian Journal published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Safety of 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Gupta, Jeetendra Kumar published the artcileAntimicrobial screening of some newly synthesized triazoles, Category: iodides-buliding-blocks, the publication is Journal of Pure & Applied Microbiology (2017), 11(2), 1067-1077, database is CAplus.

4-Iodobenzoic acid was taken as initial reactant material which was converted into Me ester then to hydrazide and finally into triazole via dithiocarbazate salt. This triazole was treated with chloroacetyl chloride and further with secondary amines which yielded amine linked triazoles I [R = pyrrolidin-1-yl, 2-methyl-piperidin-1-yl, 4-benzyl-1-piperazinyl, etc.]. The synthesized compounds were screened for their antibacterial and antifungal activities. The study was carried out against four bacteria and three fungi by disk diffusion method using ciprofloxacin and fluconazole as reference drug for antibacterial and antifungal activities resp. Among the synthesized compounds, compounds I [R = 4-methyl-1-piperazinyl, 4-benzyl-1-piperazinyl] showed highest antibacterial and antifungal activities.

Journal of Pure & Applied Microbiology published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Upadhyay, Prabhat K. published the artcileSynthesis and antimicrobial screening of some 1,3,4-oxadiazoles and their molecular properties prediction through ‘rule of five’, SDS of cas: 39115-95-2, the publication is Pakistan Journal of Pharmaceutical Sciences (2019), 32(3), 1025-1032, database is CAplus and MEDLINE.

In the current study, a series of 5-(4-substituted phenyl)-1,3,4-oxadiazole-2-thiols I (R = F, Cl, Br, I, Me, OMe, OH, OEt) were prepared from 4-substituted benzoic acid hydrazides 4-RC₆H₄C(O)NHNH₂. All these synthesized compounds I were investigated for their antibacterial activities against bacterial strains i.e. Staphylococcus aureus, Bacillus substilis, Escherichia coli and Pseudomonas aeruginosa. The strains, Aspergillus niger and Candida albicans were also examined for antifungal screening. The zone of inhibition was measured and percentage inhibition was calculated by comparing with standard drug. The min. inhibitory concentrations (MICs) of potent synthesized compounds I were determined Then, all the synthesized compounds I were computed to assess the drug-like properties through Lipinski’s rule of five. The results of in-vitro assay showed that the compounds I (R = F, Cl, I) possess significant antibacterial activity, whereas compounds I (R = F, OMe, OEt) possess significant antifungal activity. The predicted drug likeness score of all these compounds I were also meritorious among 1,3,4-oxadiazoles. The results recommended that these compounds I might be used in future to generate derivatives for emergent antimicrobial agents with improved pharmacokinetic profile.

Pakistan Journal of Pharmaceutical Sciences published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C18H28B2O4, SDS of cas: 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Upadhyay, Prabhat Kumar published the artcileMicrowave assisted synthesis and evaluation of some substituted 1,3,4-oxadiazoles as free radical scavenger, Category: iodides-buliding-blocks, the publication is Journal of the Indian Chemical Society (2018), 95(6), 661-666, database is CAplus.

A series of 5-(4-substituted phenyl)-1,3,4-oxadiazoles I [R = Me, Br, OH, etc.] was synthesized from 4-substituted benzoic acid hydrazides and carbon disulfide. Structures of the synthesized compounds were confirmed on the basis of IR, ¹³C NMR, mass spectral methods and elemental anal. The compounds were screened for antioxidant activities using hydrogen peroxide scavenging method comparing with ascorbic acid as standard antioxidant. The results revealed that the compounds possess significant free radical scavenging activities, among them compound I [R = OH] showed highest scavenging activity.

Journal of the Indian Chemical Society published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C12H25Br, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Haristos, Demetrius A. published the artcileKinetic study of the oxidation of benzoic acid hydrazide by mercury(II) acetate, SDS of cas: 39115-95-2, the publication is Chimika Chronika (1982), 11(3), 193-200, database is CAplus.

The oxidation kinetics of RC₆H₄CONHNH₂ (I; R = H, p-F, m-Cl, p-Cl, m-Br, p-Br, p-iodo, m-MeO, p-MeO, m-NO₂) by Hg(OAc)₂ are not dependent on inductive or resonance effects. Two possible mechanisms can explain the kinetics. In one of these, the NH₂ group N atom is involved as an electron donor in a complex with Hg²⁺. This electron transfer reaction leads to the C-N bond cleavage which gives RC₆H₄C⁺(O) and •NHNH₂. The alternative mechanism involves a 4-electron transfer in which RC₆H₄CON:NH is an intermediate.

Chimika Chronika published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, SDS of cas: 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Heald, Robert A. published the artcileAntitumor polycyclic acridines. 8.Synthesis and telomerase-inhibitory activity of methylated pentacyclic acridinium salts, Product Details of C12H14IN, the publication is Journal of Medicinal Chemistry (2002), 45(3), 590-597, database is CAplus and MEDLINE.

Two short routes to novel methylated pentacyclic quinoacridinium salts have been devised. New compounds display telomerase-inhibitory potency (<1 μM) in the TRAP assay. 3,11-Difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate ( RHPS4, NSC 714187) has a higher selectivity for triplex and quadruplex DNA structures than the 3,6,8,11,13-pentamethyl analog (RHPS3, NSC 714186) and a low overall growth-inhibitory activity in the NCI 60 cell panel (mean GI₅₀ 13.18 μM); in addition, the activity profile of NSC 714187 does not COMPARE with agents of the topoisomerase II class. Compound NSC 714187 is soluble in water, stable in the pH range of 5-9, efficiently transported into tumor cells, and is currently the lead structure for further elaboration in this new class of telomerase inhibitor.

Journal of Medicinal Chemistry published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Product Details of C12H14IN.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Bozzi, Fabio published the artcileMIF/CD74 axis is a target for novel therapies in colon carcinomatosis, HPLC of Formula: 41270-96-6, the publication is Journal of Experimental & Clinical Cancer Research (2017), 16/1-16/15, database is CAplus and MEDLINE.

Background: Strategies aimed at obtaining a complete cytoredn. are needed to improve long-term survival for patients with colorectal cancer peritoneal carcinomatosis (CRC-pc). Methods: We established organoid models from peritoneal metastases of two naïve CRC patients. A standard paraffin inclusion was conducted to compare their 3D structure and immunohistochem. profile with that of the corresponding surgical samples. RNA expression levels of the CRC stem cell marker LGR5 was measured by in situ hybridization. The secretome of organoids was profiled by mass spectrometry. Energy homeostasis of organoids was interfered with 4-IPP and metformin. Biochem. and metabolic changes after drug treatments were investigated by western blot and mass spectrometry. Mitochondria impairment was evaluated by electron microscopy and mitotraker staining. Results: The two organoids recapitulated their corresponding clin. samples in terms of 3D structure and immmunoistochem. profile and were pos. for the cancer stem cells marker LGR5. Proteomic analyses of organoids highlighted their strong dependence on energy producing pathways, which suggest that their targeting could be an effective therapeutic approach. To test this hypothesis, we treated organoids with two drugs that target metabolism acting on AMP-activated protein kinase (AMPK), the main regulator of cellular energy homeostasis, which may act as metabolic tumor suppressor in CRC. Organoids were treated with 4-IPP, an inhibitor of MIF/CD74 signalling axis which activates AMPK function, or metformin that inhibits mitochondrial respiratory chain complex I. As a new finding we observed that treatment with 4-IPP downregulated AMPK signalling activity, reduced AKT phosphorylation and activated a JNK-mediated stress-signalling response, thus generating mitochondrial impairment and cell death. Metformin treatment enhanced AMPK activation, decreasing the activity of the anabolic factors ribosomal protein S6 and p4EBP-1 and inducing mitochondrial depolarization. Conclusions: We provide evidence that the modulation of AMPK activity may be a strategy for targeting metabolism of CRC-pc organoids.

Journal of Experimental & Clinical Cancer Research published new progress about 41270-96-6. 41270-96-6 belongs to iodides-buliding-blocks, auxiliary class Pyrimidine,Iodide,Benzene,Immunology/Inflammation,MIF, name is 4-Iodo-6-phenylpyrimidine, and the molecular formula is C10H7IN2, HPLC of Formula: 41270-96-6.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Boev, V. I. published the artcile2- And 4-methylmercurated quinolinium salts, Application of 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Zhurnal Obshchei Khimii (1994), 64(7), 1128-33, database is CAplus.

Mercuration of 2- and 4-methylquinolinium salts with HgX₂ (X = OAc, O₂CCF₃) gave the corresponding mono-, di-, and trimethylmercurated quinolinium salts depending on the ratio of reactants. Some reactions of these salts are reported with CaCl₂, KI, NaOH, and Br₂ in HOAc.

Zhurnal Obshchei Khimii published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Application of 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Zhong’an published the artcileSupramolecular Assembly of Complementary Cyanine Salt J-Aggregates, Safety of 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Journal of the American Chemical Society (2015), 137(37), 11920-11923, database is CAplus and MEDLINE.

An understanding of structure-property relationships in cyanine dyes is critical for their design and application. Anionic and cationic cyanines can be organized into complementary cyanine salts, offering potential building blocks to modulate their intra/intermol. interactions in the solid state. Here, we demonstrate how the structures of these complementary salts can be tuned to achieve highly ordered J-type supramol. aggregate structures of heptamethine dyes in crystalline solids.

Journal of the American Chemical Society published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Safety of 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com