Tag: M.W=250-300

Mehr-un-Nisa published the artcileSynthesis of novel triazoles and a tetrazole of escitalopram as cholinesterase inhibitors, Application In Synthesis of 39115-95-2, the publication is Bioorganic & Medicinal Chemistry (2015), 23(17), 6014-6024, database is CAplus and MEDLINE.

A novel series of escitalopram triazoles I and a tetrazole II have been synthesized and subjected to a study to establish the inhibitory potential of these compounds toward acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Some selectivity in inhibition has been observed The compound I (R = 4-Cl, IC₅₀, 6.71 ± 0.25 μM) and I (R = 2-Me, 70, IC₅₀, 9.52 ± 0.23 μM) escitalopram triazole derivatives depicted high AChE inhibition, while compound I (R = 2-F, IC₅₀ = 4.52 ± 0.17 μM) and I (r = 4-F, IC₅₀ = 5.31 ± 0.43 μM) have found to be excellent BChE inhibitors. It has also been observed that ortho, meta and para substituted electron donating groups increase the inhibition, while electron withdrawing groups reduce the inhibition. Docking analyses of inhibitors with AChE have depicted the binding energies for I (R = 2-Me, 4-Cl) as ΔG_bind -6.42 and -6.93 kcal/mol, resp., while ligands I (R = 2-F, 4-F) have shown the binding affinity ΔG_bind -9.04 and -8.51 kcal/mol, resp., for BChE.

Bioorganic & Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Application In Synthesis of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Nisa, Mehr-un published the artcileSynthesis of novel 5-(aroylhydrazinocarbonyl)escitalopram as cholinesterase inhibitors, Quality Control of 39115-95-2, the publication is European Journal of Medicinal Chemistry (2017), 396-406, database is CAplus and MEDLINE.

A novel series of 5-(aroylhydrazinocarbonyl)escitalopram were designed, synthesized and tested for their inhibitory potential against cholinesterases. N’-(3-Chlorobenzoyl)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbohydrazide is the most potent compound of this series having IC₅₀ 1.80 ± 0.11 μM for acetylcholinesterase (AChE) inhibition. For the butyrylcholinesterase (BChE) inhibition, N’-(2-Bromobenzoyl)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbohydrazide was the most active compound of the series with IC₅₀ 2.11 ± 0.31 μM. Structure-activity relation illustrated that mild electron donating groups enhanced enzyme inhibition while electron withdrawing groups reduced the inhibition except o-NO₂. However, size and position of the substituents affected enzyme inhibitions. In docking study of AChE, the ligands N’-(3-Chlorobenzoyl)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbohydrazide, N’-(4-Chlorobenzoyl)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbohydrazide and N’-(2-Bromobenzoyl)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbohydrazide showed the scores of 5874, 5756 and 5666 and ACE of -64.92,-203.25 and -140.29 kcal/mol, resp. In case of BChE, ligands 71, 76 and 81 depicted high scores 6016, 6150 and 5994 with ACE values -170.91, -256.84 and -235.97 kcal/mol, resp.

European Journal of Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Quality Control of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Khan, Madiha Sahar published the artcileSynthesis of novel indenoquinoxaline derivatives as potent α-glucosidase inhibitors, Application of 4-Iodobenzohydrazide, the publication is Bioorganic & Medicinal Chemistry (2014), 22(3), 1195-1200, database is CAplus and MEDLINE.

A series of new N-(11H-Indeno[1,2-b]quinoxalin-11-ylidene)benzohydrazide derivatives were synthesized and evaluated for their α-glucosidase inhibitory activity. Some of the synthesized compounds showed significant α-glucosidase inhibitory activity as compared to acrabose, a standard drug used to treat type II diabetes. Structures of the synthesized compounds were determined by using FT-IR, ¹H NMR, ¹³C NMR, mass spectrometry and elemental anal. techniques.

Bioorganic & Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Application of 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ohmomo, Yoshiro published the artcileSynthesis and evaluation of iodinated benzamide derivatives as selective and reversible monoamine oxidase B inhibitors, Related Products of iodides-buliding-blocks, the publication is Chemical & Pharmaceutical Bulletin (1992), 40(7), 1789-92, database is CAplus and MEDLINE.

A new series of iodinated analogs of N-(2-aminoethyl)benzamide were synthesized and evaluated for inhibitory potency and specificity toward monoamine oxidase type-B (MAO-B). Among them, N-(2-aminoethyl)-2-chloro-4-iodobenzamide hydrochloride (I) showed high inhibitory potency and selectivity against MAO-B. The type of MAO-B inhibition by I was noncompetitive and the inhibition constant (K_i) was 0.80 μM. Strong and selective in vivo MAO-B inhibition by I was also confirmed. The brain MAO-B inhibition by I was reversible and the enzyme activity completely returned to the control value 24h after administration. Compound I was, therefore, considered to be a candidate for advanced development as a radioiodinated ligand that may be useful for functional MAO-B studies in the living brain using single photon emission computer tomog.

Chemical & Pharmaceutical Bulletin published new progress about 145343-76-6. 145343-76-6 belongs to iodides-buliding-blocks, auxiliary class Chloride,Iodide,Carboxylic acid,Benzene, name is 2-Chloro-4-iodobenzoic acid, and the molecular formula is C7H4ClIO2, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ohmomo, Yoshiro published the artcileRadioiodinated N-(2-aminoethyl)-2-chloro-4-iodobenzamide: a new ligand for monoamine oxidase B studies with single photon emission computed tomography, Synthetic Route of 145343-76-6, the publication is Chemical & Pharmaceutical Bulletin (1994), 42(4), 913-16, database is CAplus.

In developing monoamine oxidase (MAO)-B specific radioligands, N-(2-aminoethyl)-2-chloro-4-[¹²⁵I]iodobenzamide ([¹²⁵I]FIBA) was conveniently synthesized from its tributylstannyl precursor by an iodostannylation reaction using sodium [¹²⁵I]iodide and hydrogen peroxide with high radiochem. yield. The method should be applicable for labeling with ¹²⁵I, a suitable radioisotope for in vivo imaging with single photon emission computed tomog. (SPECT). In vitro binding studies using mouse brain mitochondrial preparations showed that the specific binding of [¹²⁵I]FIBA was saturable and of high affinity. Calculated values for K_D and B_max were 201 nM and 2.5 pmol/mg protein, resp. The [¹²⁵I]FIBA binding was effectively prevented by MAO-B specific inhibitors (l-deprenyl, Ro 16-6491, FIBA) or substrate (β-phenethylamine). However, MAO-A specific inhibitor (clorgyline) and substrate (serotonin) had no significant effect. After an i.v. injection into mice, [¹²⁵I]FIBA showed high brain uptake (1.64% dose/g at 15-30 min postinjection) and long retention (1.11% dose/g at 120 min postinjection) in the brain. Good brain-to-blood radioactivity ratios of 2.19 and 2.41 at 60 and 120 min after injection, resp., were obtained. The in vitro binding data and in vivo characteristics suggested that [¹²⁵I]FIBA is potentially useful as a probe for biol. studies including specific labeling of MAO-B in vivo as well as in vitro. Moreover, the ¹²³I-labeled counterpart, [¹²⁵I]FIBA, might be valuable for noninvasive imaging and mapping of MAO-B in the living brain with SPECT.

Chemical & Pharmaceutical Bulletin published new progress about 145343-76-6. 145343-76-6 belongs to iodides-buliding-blocks, auxiliary class Chloride,Iodide,Carboxylic acid,Benzene, name is 2-Chloro-4-iodobenzoic acid, and the molecular formula is C7H4ClIO2, Synthetic Route of 145343-76-6.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

El Ashry, E. S. H. published the artcileScope of reactions of hydrazines and hydrazones. Part X. Bis(aroylhydrazones) and phenylacetylhydrazones of vic-dicarbonyl compounds and their oxidation to 1,2,3-triazoles, Application In Synthesis of 39115-95-2, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1980), 19B(7), 612-15, database is CAplus.

Treating acenaphthenequinone with hydrazines gave 40-70% monohydrazones I (Z = O, R = Ph, o-, m-, p-MeC₆H₄ m-, p-ClC₆H₄, p-IC₆H₄, p-MeOC₆H₄, p-O₂NC₆H₄, 3-, 4-pyridyl). Oxidative cyclization of I (R = Ph, Z = NNHBz) by Pb(OAc)₄ gave triazole II. The (phenylacetyl)hydrazones of benzil and phenylglyoxal were similarly prepared and cyclized to the triazoles.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Application In Synthesis of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

El Ashry, El Sayed H. published the artcileHeterocycles from carbohydrates precursors. Part XXIII. (2-Quinoxalinon-3-yl)glyoxal derivatives from L-ascorbic acid, Safety of 4-Iodobenzohydrazide, the publication is Carbohydrate Research (1980), 83(1), 79-84, database is CAplus.

Reaction of dehydro-L-ascorbic acid with o-phenylenediamine, followed by aroylhydrazines, gave 3-[1-(aroylhydrazono)-L–threo-2,3,4-trihydroxybutyl]-2-quinoxalinones (I; R = Ph, substituted Ph, 4-pyridyl) which, upon periodate oxidation, gave 3-[1-(aroylhydrazono)glyoxal-1-yl]-2-quinoxalinones. Reaction of 3-[1-(benzoylhydrazono)glyoxal-1-yl]-2-quinoxalinone with benzoylhydrazine gave 3-[1,2-bis(benzoylhydrazono)glyoxal-1-yl]-2-quinoxalinone, and its reduction gave 3-[1-(benzoylhydrazono)-2-hydroxyethyl]-2-quinoxalinone.

Carbohydrate Research published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Safety of 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Hudson, Christine M. published the artcileSynthesis and mesomorphic properties of some disubstituted unsymmetrical phenyl-1,2,4,5-tetrazines, Quality Control of 134322-01-3, the publication is Liquid Crystals (1995), 19(6), 871-81, database is CAplus.

The synthesis of unsym. phenyl-1,2,4,5-tetrazines containing a cyano group either on the Ph ring (1a) or the tetrazine ring (11a, 11b) was accomplished by the introduction of the cyano group after formation of the tetrazine ring. The mesomorphic, solubility and absorption properties of these tetrazines and alkoxy tetrazines (12a–d) were studied. The compounds containing the cyano group on the tetrazine ring showed smectic A phases while nematic phases were observed in some of the alkoxy tetrazines.

Liquid Crystals published new progress about 134322-01-3. 134322-01-3 belongs to iodides-buliding-blocks, auxiliary class Salt,Iodide,Amine,Amidine,Benzene, name is 4-Iodobenzimidamide hydrochloride, and the molecular formula is C7H8ClIN2, Quality Control of 134322-01-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Scott, Robert W. published the artcileDevelopment of a scalable synthesis to VEGFR Inhibitor AG-28262, Application In Synthesis of 602303-26-4, the publication is Organic Process Research & Development (2006), 10(2), 296-303, database is CAplus.

The synthesis of N,2-dimethyl-6-(2-(1-methyl-1H-imidazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)benzo[b]thiophene-3-carboxamide (I, AG-28262) on kilogram scale is described. Initial syntheses of key components 6-hydroxy-N-2-dimethylbenzo[b]thiophene-3-carboxamide (II) and 7-chloro-2-(1-methyl-1H-imidazol-2-yl)thieno[3,2b]pyridine (III) worked well on laboratory scale but had significant drawbacks for larger-scale manufacture Therefore, new routes to these two key fragments were developed and demonstrated to synthesize kilogram quantities. Key steps involve a two-step thiophenol alkylation/cyclization protocol to synthesize II in a convergent manner. A difficult Pd-mediated coupling to produce III was replaced with a more scalable stepwise imidazole synthesis. Key rationale for the new routes are discussed.

Organic Process Research & Development published new progress about 602303-26-4. 602303-26-4 belongs to iodides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Iodide, name is 7-Chloro-2-iodothieno[3,2-b]pyridine, and the molecular formula is C7H13NO2, Application In Synthesis of 602303-26-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lesniak, Robert K. published the artcileDiscovery of G2019S-Selective Leucine Rich Repeat Protein Kinase 2 inhibitors with in vivo efficacy, Safety of 4-Iodo-3-nitrobenzonitrile, the publication is European Journal of Medicinal Chemistry (2022), 114080, database is CAplus and MEDLINE.

The discovery and development of compound I, an indazole-based, G2019S-selective (>2000-fold vs. WT) LRRK2 inhibitor capable of entering rodent brain (K_p = 0.5) and selectively inhibiting G2019S-LRRK2 was reported. The compounds disclosed herein present a starting point for further development of brain penetrant G2019S selective inhibitors that hopefully reduce lung phenotype side-effects and pave the way to providing a precision medicine for people with PD who carry the G2019S mutation.

European Journal of Medicinal Chemistry published new progress about 101420-79-5. 101420-79-5 belongs to iodides-buliding-blocks, auxiliary class Nitrile,Nitro Compound,Iodide,Benzene,Benzene Compounds, name is 4-Iodo-3-nitrobenzonitrile, and the molecular formula is C7H3IN2O2, Safety of 4-Iodo-3-nitrobenzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com