Tag: M.W=250-300

Valente, Sergio published the artcile1,3,4-Oxadiazole-Containing Histone Deacetylase Inhibitors: Anticancer Activities in Cancer Cells, Application of 4-Iodobenzohydrazide, the publication is Journal of Medicinal Chemistry (2014), 57(14), 6259-6265, database is CAplus and MEDLINE.

We describe 1,3,4-oxadiazole-containing hydroxamates and 2-aminoanilides as histone deacetylase inhibitors. Among them, N-hydroxy-3-(4-((5-(1-naphthylmethyl)-1,3,4-oxadiazol-2-yl)methyl)phenyl) acrylamide (1), N-hydroxy-4-((5-(1-naphthylmethyl)-1,3,4-oxadiazol-2-yl)methyl)benzamide (2), and N-(2-aminophenyl)-4-((5-(1-naphthylmethyl)-1,3,4-oxadiazol-2-yl)methyl)benzamide (3) were the most potent and selective against HDAC1. In U937 leukemia cells, (1) was more potent than vorinostat (SAHA) in inducing apoptosis, and (3) displayed cell differentiation with a potency similar to MS-275. In several acute myeloid leukemia (AML) cell lines, as well as in U937 cells in combination with doxorubicin, (3) showed higher antiproliferative effects than SAHA.

Journal of Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C14H10N2O, Application of 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Xanthopoulos, C. E. published the artcileStructural properties and potential reactivity of substituted 3-aroyldithiocarbazates, Formula: C7H7IN2O, the publication is Structural Chemistry (1994), 5(3), 147-54, database is CAplus.

The substituted 3-aroyldithiocarbazates I (X = H, halo, nitro, alkyl, etc.) were prepared The corresponding acid dissociation constants were determined potentiometrically. Semiempirical PM3 MO calculations suggest the existence of several tautomeric forms of the compounds Geometrical parameters, proton affinities, and static reactivity indexes have been examined Structural properties and protonation sites are well described by calculations The strong correlations between the pK_a values and the Hammett σ constants as well as the N(3) calculated proton affinities indicate that the N(3) atom is the most probable protonation site. The thermodn. of the protonation process are mainly controlled by HOMO-LUMO rather than electrostatic interactions. According to PM3 results, 3-aroyldithiocarbazic acid should be quite stable in the gas phase, while a mechanism for its decomposition in solution is proposed.

Structural Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C5H6BNO2, Formula: C7H7IN2O.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Charistos, D. A. published the artcileSynthesis and UV and IR spectral study of some 2-aryl-Δ²-1,3,4-oxadiazoline-5-thiones, Formula: C7H7IN2O, the publication is Journal of Heterocyclic Chemistry (1994), 31(6), 1593-8, database is CAplus.

Twenty four 2-aryl-Δ²-1,3,4-oxadizoline-5-thiones (2) were synthesized and their UV and IR spectra were studied. Correlation between σ-Hammett constants of the aryl substituents and the differences in absorption maxima (Δν = ν₁-ν₂ in kK) of the electronic spectra of the deprotonated species were also evaluated. A new method for the synthesis of 2 (aryl = o-, m-, or p-aminophenyl) is also reported.

Journal of Heterocyclic Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Formula: C7H7IN2O.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

De Valk, J. published the artcilePyrimidines from this laboratory. XXXI. ANRORC [addition nucleophile ring opening ring closing] mechanism. V. Occurrence of the ANRORC [addition nucleophile ring opening ring closing] mechanism in aminations of substituted haloaza-aromatics with potassium amide in liquid ammonia, Formula: C10H7IN2, the publication is Recueil des Travaux Chimiques des Pays-Bas (1973), 92(3), 442-8, database is CAplus.

Evidence is presented that the amination of 4-chloro-2,6-diphenylpyrimidine with KNH2 in liquid ammonia into the corresponding 4-amino compound occurs to the extent of about 45% by the ANRORC mechanism. In the amination of the 4-iodo- and 4-fluoro derivatives of 2,6-diphenylpyrimidine however, the ANRORC mechanism is not operative at all. The amination of 5-bromo-4-chloro-2,6-diphenylpyrimidine into 4-amino-5-bromo-2,6-diphenylpyrimidine occurs to the extent of about 18% by the ANRORC mechanism. The synthesis of 5-bromo-4-chloro-2,6-diphenylpyrimidine-1(3)-15N and of the 4-fluoro, 4-chloro and 4-iodo derivatives of 2,6-diphenylpyrimidine-1(3)-15N is described.

Recueil des Travaux Chimiques des Pays-Bas published new progress about 41270-96-6. 41270-96-6 belongs to iodides-buliding-blocks, auxiliary class Pyrimidine,Iodide,Benzene,Immunology/Inflammation,MIF, name is 4-Iodo-6-phenylpyrimidine, and the molecular formula is C10H7IN2, Formula: C10H7IN2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

De Bie, Dick A. published the artcilePhotoreactivity of diazines. III. Pyrimidines. XXXVIII. Photoamination of halopyrimidines, Quality Control of 41270-96-6, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1974), 1363-5, database is CAplus.

4-Amino-6-phenylpyrimidine was prepared by uv-induced amination of 4-halo-6-phenylpyrimidines in liquid NH3. A pyrimidinyl radical was formed by cleavage of C-halogen bonds. The order of reactivity was I > Br > Cl. 4-Phenylpyrimidine was also formed from the iodo and bromo compounds

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 41270-96-6. 41270-96-6 belongs to iodides-buliding-blocks, auxiliary class Pyrimidine,Iodide,Benzene,Immunology/Inflammation,MIF, name is 4-Iodo-6-phenylpyrimidine, and the molecular formula is C10H7IN2, Quality Control of 41270-96-6.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Bagrov, F. V. published the artcile2-Diphenylphosphinoyloxybenzaldehyde 4-Nitrophenyl-, 4-Phenyl-1-phthalazinyl-, and Aroylhydrazones and Thiosemicarbazone, Application In Synthesis of 39115-95-2, the publication is Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) (2002), 38(9), 1309-1313, database is CAplus.

Condensation of aryl- and aroylhydrazines and thiosemicarbazide with 2-diphenylphosphinoyloxybenzaldehyde results in formation of the corresponding hydrazones and thiosemicarbazone. The products give rise to conformational equilibrium between rotational and Z,E isomers, which is strongly displaced toward the E,E’,Z” isomer and is determined by the nature of substituent in the hydrazine fragment.

Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Application In Synthesis of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Xiao, Yufeng published the artcileDiscovery of histone deacetylase 3 (HDAC3)-specific PROTACs, Synthetic Route of 39115-95-2, the publication is Chemical Communications (Cambridge, United Kingdom) (2020), 56(68), 9866-9869, database is CAplus and MEDLINE.

Histone deacetylases (HDACs) are validated drug targets for cancer treatment. Increased HDAC isoenzyme selectivity and novel strategies to inhibit HDAC activity could lead to safer and more effective drug candidates. Nonetheless, it is quite challenging to develop isoenzyme-specific HDACi due to the highly conserved catalytic domain. We discovered XZ9002, a first-in-class HDAC3-specific PROTAC that potently degraded HDAC3. Importantly, XZ9002 is more effective to inhibit cancer cell proliferation than its proteolysis-inactive counterpart, suggesting HDAC3 degradation is a novel and promising anticancer approach.

Chemical Communications (Cambridge, United Kingdom) published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C4H3Cl2N3, Synthetic Route of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Konishi, Hideyuki published the artcilePd-Catalyzed Selective Synthesis of Cyclic Sulfonamides and Sulfinamides Using K₂S₂O₅ as a Sulfur Dioxide Surrogate, SDS of cas: 500563-90-6, the publication is Organic Letters (2017), 19(7), 1578-1581, database is CAplus and MEDLINE.

A variety of cyclic sulfonamides and sulfinamides could be selectively synthesized under Pd catalysis using haloarenes bearing amino groups and a sulfur dioxide (SO₂) surrogate. The amount of base was key in determining the selectivity. Mechanistic studies revealed that sulfinamides were initially formed via an unprecedented formal insertion of sulfur monoxide and were oxidized to sulfonamides in the presence of an iodide ion and DMSO.

Organic Letters published new progress about 500563-90-6. 500563-90-6 belongs to iodides-buliding-blocks, auxiliary class Nitro Compound,Iodide,Benzene,Alcohol, name is (2-Iodo-4-nitrophenyl)methanol, and the molecular formula is C7H6INO3, SDS of cas: 500563-90-6.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Takale, Balaram S. published the artcileMild and Robust Stille Reactions in Water using Parts Per Million Levels of a Triphenylphosphine-Based Palladacycle, Synthetic Route of 602303-26-4, the publication is Angewandte Chemie, International Edition (2021), 60(8), 4158-4163, database is CAplus and MEDLINE.

An inexpensive and new triphenylphosphine-based palladacycle has been developed as a pre-catalyst, leading to highly effective Stille cross-coupling reactions in water under mild reaction conditions. Only 500-1000 ppm of Pd suffices for couplings involving a variety of aryl/heteroaryl halides with aryl/hetaryl stannanes. Several drug intermediates can be prepared using this catalyst in aqueous nanoreactors formed by 2 wt % Brij-30 in water.

Angewandte Chemie, International Edition published new progress about 602303-26-4. 602303-26-4 belongs to iodides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Iodide, name is 7-Chloro-2-iodothieno[3,2-b]pyridine, and the molecular formula is C8H15ClN2, Synthetic Route of 602303-26-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Chen, Linfeng published the artcileNovel Colorimetric Method for Simultaneous Detection and Identification of Multimetal Ions in Water: Sensitivity, Selectivity, and Recognition Mechanism, Quality Control of 606-55-3, the publication is ACS Omega (2019), 4(3), 5915-5922, database is CAplus and MEDLINE.

Accurate recognition and speciation anal. of heavy metal ions in complex hydrol. environments is always a serious challenge. Here, we propose a small mol. based ultrasensitive colorimetric detection strategy, and apply to the accurate detection of Fe²⁺, Fe³⁺, Co²⁺ and Hg²⁺ in groundwater through the specific recognition of multiple ligands for different metals. The detection limits for Hg²⁺, Co²⁺, Fe²⁺ and Fe³⁺ are calculated as 6.51, 0.34, 0.49 and 1.01 ppb, resp., which are far below the drinking water standards and superior to most of the reported colorimetric sensors. The speciation anal. of Fe²⁺/Fe³⁺ also was realized by a 1-step method without complex pretreatment. The speciation and concentration of Fe²⁺ and Fe³⁺ in actual water samples can be accurately identified and monitored. For a visual on-site detection, we developed a simple test strip and applied to visual monitoring of 4 metals with the detection limit estimated by the naked eye as low as ppb-levels. This colorimetric method realizes the rapid, sensitive and portable multiple metal recognition and Fe²⁺/Fe³⁺ speciation anal., displaying great potential for on-site rapid water quality anal.

ACS Omega published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Quality Control of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com