Tag: M.W=250-300

Missailidis, Sotiris published the artcileAntitumor polycyclic acridines. Part 12. Physical and biological properties of 8,13-diethyl-6-methylquino[4,3,2-kl]acridinium iodide: a lead compound in anticancer drug design, Computed Properties of 606-55-3, the publication is Oncology Research (2002), 13(3), 175-189, database is CAplus and MEDLINE.

The biophys. and biol. characterization of 8,13-diethyl-6-methylquino[4,3,2-k1]acridinium iodide (6) is reported. The compound binds to DNA, as measured by UV, fluorescence, and CD studies, and stabilizes the double helix and higher order DNA structures (DNA triplexes and quadruplexes) against thermal denaturation. Unlike many DNA ligands, (6) shows no specificity for binding to specific base pair combinations and does not inhibit topoisomerase I (topo I) or topo II activity. Furthermore, the biol. fingerprint elicited by (6) in in vitro evaluations does not compare with clin. agents of the topo II inhibition class. The compound provokes cell cycle arrest in response to DNA damage and the biol. sequelae are dependent on the p53 status of the cell line. DNA damage by (6) up-regulates p53 and p21^CIP/WAF1 proteins. The unusual structure of (6) and its ease of synthesis in a one-pot reaction are features that are being exploited in the design and development of a new series of G-quadruplex stabilizing telomerase inhibitors. However, although the second-generation compounds that resulted from (6) present strong telomerase inhibition, (6) in itself presents yet a different mode of action, with a strong preference for triplex DNA, sequences often found in a number of genes.

Oncology Research published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Computed Properties of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Kratky, Martin published the artcileNovel Iodinated Hydrazide-hydrazones and their Analogues as Acetyl- and Butyrylcholinesterase Inhibitors, Related Products of iodides-buliding-blocks, the publication is Current Topics in Medicinal Chemistry (Sharjah, United Arab Emirates) (2020), 20(23), 2106-2117, database is CAplus and MEDLINE.

Background: Hydrazide-hydrazones have been known as scaffold with various biol. activities including inhibition of acetyl- (AChE) and butyrylcholinesterase (BuChE). Cholinesterase inhibitors are mainstays of dementias treatment. Objective: Twenty-five iodinated hydrazide-hydrazones and their analogs were designed as potential central AChE and BuChE inhibitors. Methods: Hydrazide-hydrazones were synthesized from 4-substituted benzohydrazides and 2-/4- hydroxy-3,5-diiodobenzaldehydes. The compounds were investigated in vitro for their potency to inhibit AChE from elec. eel and BuChE from equine serum using Ellmans method. We calculated also physicochem. and structural parameters for CNS delivery. Results: The derivatives exhibited a moderate dual inhibition with IC₅₀ values ranging from 15.1-140.5 and 35.5 to 170.5 μmol.L^-1 for AChE and BuChE, resp. Generally, the compounds produced a balanced or more potent inhibition of AChE. N′-[(E)-(4-Hydroxy-3,5-diiodophenyl)methylidene]-4- nitrobenzohydrazide 2k and 4-fluoro-N′-(2-hydroxy-3,5-diiodobenzyl)benzohydrazide 3a were the most potent inhibitors of AChE and BuChE, resp. Structure-activity relationships were established, and mol. docking studies confirmed interaction with enzymes. Conclusion: Many novel hydrazide-hydrazones showed lower IC₅₀ values than rivastigmine against AChE and some of them were comparable for BuChE to this drug used for the treatment of dementia. They interact with cholinesterases via non-covalent binding into the active site. Based on the BOILEDEgg approach, the majority of the derivatives met the criteria for blood-brain-barrier permeability.

Current Topics in Medicinal Chemistry (Sharjah, United Arab Emirates) published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Pflegr, Vaclav published the artcile5-Aryl-1,3,4-oxadiazol-2-amines Decorated with Long Alkyl and Their Analogues: Synthesis, Acetyl- and Butyrylcholinesterase Inhibition and Docking Study, SDS of cas: 39115-95-2, the publication is Pharmaceuticals (2022), 15(4), 400, database is CAplus and MEDLINE.

The compounds 5-aryl-1,3,4-oxadiazoles/thiadiazols decorated with dodecyl linked via nitrogen, sulfur or directly to this heterocycle I [R = Ph, 4-MeC₆H₄, 4-tBuC₆H₄, etc.,; X = O, S; Y = NH, S] was designed as potential inhibitors of AChE and BChE. Oxadiazoles/thiadiazols derivatives I were prepared from hydrazides by reaction with dodecyl isocyanate to form hydrazine-1-carboxamides II (yields 67-98%) followed by cyclization using p-toluenesulfonyl chloride and triethylamine in 41-100% yields. The derivatives I were screened for inhibition of AChE and BChE using Ellman’s spectrophotometric method. The compounds I showed a moderate dual inhibition with IC₅₀ values of 12.8-99.2 for AChE and from 53.1μM for BChE. All the heterocycles I were more efficient inhibitors of AChE. The most potent inhibitor, N-dodecyl-5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine I [R =4-pyridyl, X= S, Y = NH] was subjected to advanced reversibility and type of inhibition evaluation. Structure-activity relationships of heterocycles I were identified. Many oxadiazoles I showed lower IC₅₀ values against AChE than established drug rivastigmine. According to mol. docking, the compounds I interact non-covalently with AChE and BChE and block entry into enzyme gorge and catalytic site, resp.

Pharmaceuticals published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, SDS of cas: 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Martinez-Lara, Fernando published the artcileStraight access to highly fluorescent angular indolocarbazoles via merging Au- and Mo-catalysis, COA of Formula: C7H3IN2O2, the publication is Organic Chemistry Frontiers (2020), 7(14), 1869-1877, database is CAplus.

A straightforward and efficient synthesis of the two less explored types of indolocarbazoles I (R¹, R² = Me, Ph; R³ = H, F, Cl, MeO, CF₃, CN) and II [R⁴-R⁶ = Me, Ph; R⁵R⁶ = (CH₂)₄] has been developed. Two different processes for the carbazole nucleus preparation, a gold-catalyzed regioselective cyclization followed by the dioxomolybdenum-catalyzed version of Cadogan reductive cyclization, enables the sequential construction of two carbazole cores. The procedure features total regioselectivity and high overall yields. The required starting α-indol-3-ylalkyl propargylic alcs. are easily and efficiently accessed from com. available reagents. In addition, the photoluminescent properties of two indolo[2,3-c]carbazoles I (R¹ = Me; R² = Me, Ph; R³ = H), with fluorescence quantum yields around 0.7, have been studied.

Organic Chemistry Frontiers published new progress about 101420-79-5. 101420-79-5 belongs to iodides-buliding-blocks, auxiliary class Nitrile,Nitro Compound,Iodide,Benzene,Benzene Compounds, name is 4-Iodo-3-nitrobenzonitrile, and the molecular formula is C7H3IN2O2, COA of Formula: C7H3IN2O2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Shigemitsu, Yasuhiro published the artcileSynthesis and electronic spectra of novel merocyanine dyes bearing a maleimide ring incorporated into the methine chains, Name: 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Dyes and Pigments (2003), 56(2), 167-179, database is CAplus.

The present article describes the synthesis of new polymethine dyes with a heterocyclic ring incorporated into the methine chain. 1-Alkyl-2- or 4-methylpyridinium salts and related compounds reacted at the exocyclic double bond with cyano- or methoxycarbonyl heterocycles bearing a methylthio group to give new polymethine dyes in good yield. This reaction occurred by an addition-elimination mechanism, involving nucleophilic attack of cyclic enamines at deficient carbon atoms on the heterocycles followed by elimination of MeSH. The polymethine dyes obtained are red, violet, and blue in color with absorption peaks at 524-614 nm. Semi-empirical as well as ab-initio quantum chem. calculations were used to theor. characterize their π-π absorption maxima in the visible region which plays a decisive role in their color appearances.

Dyes and Pigments published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C13H10O3, Name: 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhou, Fang published the artcileA new red-emitting fluorescence probe for rapid and effective visualization of bisulfite in food samples and live animals, Application In Synthesis of 606-55-3, the publication is Journal of Agricultural and Food Chemistry (2019), 67(15), 4375-4383, database is CAplus and MEDLINE.

The development of new methods for rapid and effective detection of bisulfite (HSO₃^–) in food samples and imaging of HSO₃^– intake in animals is of significant importance due to the key roles of HSO₃^– in food quality assurance and community health. In this work, a new responsive fluorescence probe, EQC, is reported for the quant. detection of HSO₃^– in food samples and visualization of HSO₃^– intake in animals. Upon addition of HSO₃^–, the UV-vis absorption and red emission of EQC were significantly decreased within 120 s. The changes in absorption and emission spectra of EQC were rationalized by theor. computations. The proposed reaction mechanism of EQC with HSO₃^– was confirmed by high-resolution mass spectrometry (HRMS) and spectroscopic titration measurements. EQC has the advantages of high sensitivity, selectivity (a detection limit of 18.1 nM), and fast response toward HSO₃^–, which enable rapid and effective HSO₃^– detection in buffer solution The practical applications of EQC were demonstrated by the detection of HSO₃^– in food samples and the imaging of HSO₃^– intake in live animals.

Journal of Agricultural and Food Chemistry published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C21H24O8, Application In Synthesis of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhang, Guangyu published the artcileDiverse and chemoselective sigmatropic shift rearrangements of multisubstituted N,O-diarylhydroxylamines, COA of Formula: C7H3IN2O2, the publication is Organic & Biomolecular Chemistry (2022), 20(27), 5470-5480, database is CAplus and MEDLINE.

Possible N/O[1,3] sigmatropic shift rearrangements of multisubstituted N,O-diarylhydroxylamines were investigated exptl. with rationally designed substrates, which were generally in situ prepared from suitable nitroaryl halides and N-arylhydroxylamines via aromatic nucleophilic substitution. The results indicate that both N- and O-(2,4,6-trimethylphenyl)hydroxylamines still favor the [3,3] sigmatropic shift followed by tautomerization rather than N[1,3] and O[1,3] sigmatropic shifts and the rearranged products of N-(2,4,6-trimethylphenyl)hydroxylamines further undergo an intramol. nucleophilic addition to afford dibenzo[b,d]furan-4a(9bH)-amine derivatives I [R = H, NO₂; EWG = NO₂, CN], while N-(4-mono- and 3,5-disubstituted phenyl)-O-(2,4,6-trinitrophenyl)hydroxylamines favorably first undergo the O[1,3] sigmatropic shift followed by tandem Smiles rearrangement and amide/ester exchange reactions, generating 2-arylaminoaryl benzoate derivatives N-Phenyl-O-(2,4,6-trinitrophenyl)hydroxylamines undergo tandem double O[1,3] sigmatropic shift rearrangement to produce formal O[1,5] shift products. However, O-(2,6-dinitrophenyl)-N-(4-substituted phenyl)hydroxylamines undergo tandem O[1,3] and double [3,3] sigmatropic shift rearrangements to give formal 3,5-shift products. The proposed mechanism was rationalized by d. functional theory (DFT) calculations The current investigation provided not only a comprehensive understanding of the chemoselective sigmatropic shift rearrangements of N,O-diarylhydroxylamines, but also some novel synthetic strategies for dibenzo[b,d]furanamines, diarylamines, diaryl ethers, 2′-amino-[1,1′-biphenyl]-2(1H)-one, and 2′-amino-[1,1′-biaryl]-4-ol derivatives

Organic & Biomolecular Chemistry published new progress about 101420-79-5. 101420-79-5 belongs to iodides-buliding-blocks, auxiliary class Nitrile,Nitro Compound,Iodide,Benzene,Benzene Compounds, name is 4-Iodo-3-nitrobenzonitrile, and the molecular formula is C10H10O2, COA of Formula: C7H3IN2O2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Koraiem, A. I. M. published the artcileStudies on some new bridgehead nitrogen heterocyclic cyanine dyes, COA of Formula: C12H14IN, the publication is Proceedings – Indian Academy of Sciences, Chemical Sciences (1999), 111(6), 709-724, database is CAplus.

New asym. mono-(tri)-methine and azomethine cyanine dyes of pyrazolo[5,4-b]quinolino[a,b]-1,4-pyra-(oxa)-zinium bromide salts were prepared The newly synthesized cyanines were identified by elemental and spectral analyses. The visible absorption spectra of some selected dyes were investigated in single and mixed solvents, and also in aqueous buffer solutions The spectral shifts were studied in relation to mol. structure and in terms of medium effects. Mol. complex formation with DMF was verified through mixed-solvent studies.

Proceedings – Indian Academy of Sciences, Chemical Sciences published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, COA of Formula: C12H14IN.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Koraiem, A. I. M. published the artcileSome new nitrogen bridgehead heterocyclic cyanine dyes, Safety of 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Chemical Papers (2000), 54(2), 78-86, database is CAplus.

New monomethine, trimethine, and azomethine cyanine dyes of pyrazolo[4′,5′:5,6](pyrazinio/1,4-oxazinio)[2,3,4-i,j]quinolin-11-ium bromides were prepared These cyanines were identified by elemental and spectral analyses. The visible absorption spectra of some selected dyes were investigated in single and mixed solvents, and also in aqueous buffer solutions The spectral shifts are discussed in relation to mol. structure and in terms of medium effects. Mol. complex formation with DMF was verified through mixed-solvent studies.

Chemical Papers published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Safety of 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Koraiem, A. I. M. published the artcileOrientation in the synthesis and absorption spectra of 1H-pyrazolo[4,3-d][1,3]oxazole methine cyanine dyes, Quality Control of 606-55-3, the publication is Chemical Papers (1998), 52(6), 762-770, database is CAplus.

3,5-Dimethyl-1-phenyl-1H-pyrazolo[4,3-d][1,3]oxazole was prepared and oriented as starting material in the synthesis of some mono-, di, and trimethine cyanine dyes. The new cyanines were characterized by IR and ¹H NMR spectral data. The visible absorption spectra of the cyanine dyes are discussed.

Chemical Papers published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Quality Control of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com