Tag: M.W=200-350

Zhang, Dacheng published the artcileEnantio-Relay Catalysis Constructs Chiral Biaryl Alcohols over Cascade Suzuki Cross-Coupling-Asymmetric Transfer Hydrogenation, Application of Ethyl 3-(4-iodophenyl)-3-oxopropanoate, the main research area is chiral biaryl alc green preparation cascade enantio relay catalysis; haloacetophenone arylboronic acid Suzuki cross coupling asym transfer hydrogenation.

The use of an imidazolium-based organopalladium-functionalized organic-inorganic hybrid silica and ethylene-coated chiral organoruthenium-functionalized magnetic nanoparticles to catalyze a cascade Suzuki cross-coupling-asym. transfer hydrogenation reaction to prepare chiral biaryl alcs. in a two-step, one-pot process is reported. As expected, the site-isolated active species, salient imidazolium phase-transfer character and high ethylene-coated hydrophobicity can synergistically boost the catalytic performance. Furthermore, enantio-relay catalysis has the potential to efficiently prepare a variety of chiral biaryl alcs. This synthetic strategy is a general method that shows the potential of developing enantio-relay catalysis towards environmentally benign and sustainable organic synthesis.

Scientific Reports published new progress about Alcohols, chiral Role: SPN (Synthetic Preparation), PREP (Preparation) (biaryl). 63131-30-6 belongs to class iodides-buliding-blocks, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, and the molecular formula is C11H11IO3, Application of Ethyl 3-(4-iodophenyl)-3-oxopropanoate.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Menozzi, Giulia published the artcileRational design, synthesis and biological evaluation of new 1,5-diarylpyrazole derivatives as CB1 receptor antagonists, structurally related to rimonabant, Safety of Ethyl 3-(4-iodophenyl)-3-oxopropanoate, the main research area is diarylpyrazole rimonabant regioisomer preparation mol modeling cannabinoid receptor antagonism.

Among cannabinoid type-1 (CB1) receptor antagonists, those developed around the 1,5-diarylpyrazole scaffold of rimonabant (I, Acomplia) are the most extensively investigated. In recent years, many SAR and QSAR reports on this topic have been published, focusing on the substitution and orientation of the N1 and C5 aryl functionalities and on the substituents at the 3-carboxamide position. In this context, the purpose of our study was to design and synthesize a set of 1-(2,4-dichlorophenyl)-5-arylpyrazoles strictly related to rimonabant, but with the hydrazide/amide group shifted from position 3 to position 4 of the pyrazole scaffold. The synthesized compounds were evaluated in vitro for their affinity on human CB1 and CB2 (cannabinoid type-2) receptors. Computational studies, performed both in the design step and after biol. assays, contributed to rationalize the obtained results in terms of specific mol. interactions between antagonists and the human CB1 receptor.

European Journal of Medicinal Chemistry published new progress about Cannabinoid receptor 2 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (antagonists). 63131-30-6 belongs to class iodides-buliding-blocks, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, and the molecular formula is C11H11IO3, Safety of Ethyl 3-(4-iodophenyl)-3-oxopropanoate.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Forschner-Dancause, Stephanie published the artcileQuorum sensing inhibition and structure-activity relationships of β-keto esters, Recommanded Product: Ethyl 3-(4-iodophenyl)-3-oxopropanoate, the main research area is keto ester structure quorum sensing inhibition; Vibrio harveyi; quorum sensing inhibition; β-keto esters.

A panel of 19 β-keto ester analogs was tested for the inhibition of bioluminescence (a quorum sensing-controlled phenotype) in the marine pathogen Vibrio harveyi. Initial screening demonstrated the need of a Ph ring at the C-3 position for antagonistic activity. Further additions to the Ph ring with 4-substituted halo groups or a 3- or 4-substituted methoxy group resulted in the most active compounds with IC50 values ranging 23-53μM. The compounds addnl. inhibit green fluorescent protein production by Escherichia coli JB525. Evidence is presented that aryl β-keto esters may act as antagonists of bacterial quorum sensing by competing with N-acyl homoserine lactones for receptor binding. Expansion of the β-keto ester panel will enable us to obtain more insight into the structure-activity relations needed to allow for the development of novel anti-virulence agents.

Molecules published new progress about Quorum sensing. 63131-30-6 belongs to class iodides-buliding-blocks, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, and the molecular formula is C11H11IO3, Recommanded Product: Ethyl 3-(4-iodophenyl)-3-oxopropanoate.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lu, Xi published the artcilePractical carbon-carbon bond formation from olefins through nickel-catalyzed reductive olefin hydrocarbonation, Application In Synthesis of 939759-26-9, the main research area is carbon bond formation nickel catalyst chemoselective regioselective olefin hydrocarbonation.

A general process for the intermol. reductive coupling of unactivated olefins with alkyl or aryl electrophiles under the promotion of a simple nickel catalyst system was reported. This new reaction presented a conceptually unique and practical strategy for the construction of C(sp2)-C(sp3) and C(sp3)-C(sp3) bonds without using any organometallic reagent. The reductive olefin hydrocarbonation also exhibited excellent compatibility with varieties of synthetically important functional groups and therefore, provided a straightforward approach for modification of complex organic mols. containing olefin groups.

Nature Communications published new progress about C-C bond formation. 939759-26-9 belongs to class iodides-buliding-blocks, name is Benzyl 3-iodoazetidine-1-carboxylate, and the molecular formula is C11H12INO2, Application In Synthesis of 939759-26-9.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Song, Gui-Ting published the artcileSynthesis of monofluorooxazoles with quaternary C-F centers through photoredox-catalyzed radical addition of methylene-2-oxazolines, Application In Synthesis of 63131-30-6, the main research area is monofluorooxazole quaternary carbon fluorine center preparation; bromo fluoro oxoarylpropionate preparation methylene oxazoline radical addition photocatalyst.

A novel photoredox-catalyzed radical addition of methylene-2-oxazolines I (R = Ph, hexyl, cyclohexyl, thiophen-2-yl, etc.) has been developed under visible light irradiation to synthesize monofluorooxazoles II (R1 = Ph, furan-2-yl, 3-methylphenyl, etc.) with a quaternary carbon center using 2-bromo-2-fluoro-3-oxo-3-phenylpropionates R1C(O)C(F)(Br)C(O)OEt as radical source. This method with a simple protocol, scalability and high yield offers a facile path to get diverse monofluorinated oxazoles II with quaternary C-F centers, which are a class of highly valuable motifs and synthons.

Organic & Biomolecular Chemistry published new progress about Photochemical redox reaction. 63131-30-6 belongs to class iodides-buliding-blocks, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, and the molecular formula is C11H11IO3, Application In Synthesis of 63131-30-6.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Parmar, Dixit published the artcileIron catalysed cross-couplings of azetidines – application to the formal synthesis of a pharmacologically active molecule, Formula: C11H12INO2, the main research area is iron catalyzed coupling azetidine Grignard reagent; azetidine pharmacol active agent preparation CNS disorder.

A protocol for the coupling of 3-iodoazetidines with Grignard reagents in the presence of an iron catalyst has been developed. A variety of aryl, heteroaryl, vinyl and alkyl Grignards were shown to participate in the coupling process to give the products in good to excellent yields. Furthermore, a short formal synthesis towards a pharmacol. active mol. was shown.

Chemical Communications (Cambridge, United Kingdom) published new progress about Central nervous system disease. 939759-26-9 belongs to class iodides-buliding-blocks, name is Benzyl 3-iodoazetidine-1-carboxylate, and the molecular formula is C11H12INO2, Formula: C11H12INO2.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Qiu, Zhenjiang published the artcileRegioselective α-benzylation of 3-iodoazetidines via Suzuki cross-coupling, Computed Properties of 939759-26-9, the main research area is benzyl azetidine preparation regioselective; iodoazetidine benzylboronic acid pinacol ester benzylation Suzuki palladium catalyst.

An efficient protocol for the synthesis of α-benzyl azetidines I [R = 4-F3COC6H4, 2-F-C6H4, naphthalen-2-yl, etc.; R1 = C(O)OCH2C6H5, C(O)OC(CH3)3] starting from benzylboronic acid pinacol ester derivatives II and 3-iodoazetidine III was developed. A wide range of α-benzyl azetidine derivatives I was obtained in moderate to good yields with high regioselectivity (>99%).

Tetrahedron Letters published new progress about Benzylation catalysts (regioselective). 939759-26-9 belongs to class iodides-buliding-blocks, name is Benzyl 3-iodoazetidine-1-carboxylate, and the molecular formula is C11H12INO2, Computed Properties of 939759-26-9.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lu, Xi published the artcileNickel-Catalyzed Defluorinative Reductive Cross-Coupling of gem-Difluoroalkenes with Unactivated Secondary and Tertiary Alkyl Halides, Name: Benzyl 3-iodoazetidine-1-carboxylate, the main research area is arylfluoroalkene chemoselective diastereoselective preparation; nickel imidazolinylpyridine catalyst defluorinative reductive coupling aryldifluoroalkene bromoalkane iodoalkane; secondary tertiary bromoalkane chloroalkane reductive coupling aryldifluoroalkene nickel catalyst.

In the presence of Ni(cod)2 and an imidazolinylpyridine ligand, 1,1-difluoroalkenes such as I underwent chemoselective and diastereoselective reductive defluorinative coupling reactions with secondary alkyl bromides and iodides such as iodocyclohexane mediated by bis(pinacolato)diboron and tripotassium phosphate to yield (Z)-arylfluoroalkenes such as II in 36-95% yields and in 8:1->50:1 Z:E diastereoselectivities; the reaction was also used to couple difluoroalkenes with primary alkyl iodides and 1,1-difluoroalkyl bromides using a catalyst generated from NiBr2(diglyme) and 4,7-dimethoxy-1,10-phenanthroline.

Journal of the American Chemical Society published new progress about Bromoalkanes Role: RCT (Reactant), RACT (Reactant or Reagent). 939759-26-9 belongs to class iodides-buliding-blocks, name is Benzyl 3-iodoazetidine-1-carboxylate, and the molecular formula is C11H12INO2, Name: Benzyl 3-iodoazetidine-1-carboxylate.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Watson, Rebecca B. published the artcileIron(III) Chloride Catalyzed Formation of 3,4-Dihydro-2H-pyrans from α-Alkylated 1,3-Dicarbonyls. Selective Synthesis of α- and β-Lapachone, Safety of Ethyl 3-(4-iodophenyl)-3-oxopropanoate, the main research area is dihydropyran preparation iron chloride catalyzed cyclization; lapachone synthesis iron chloride catalyzed cyclization.

A mild, catalytic method for the synthesis of 3,4-dihydro-2H-pyrans is described. The FeCl3-catalyzed transformation of aryl- and alkyl β-diketones enables synthetic access to functionalized pyran core structures incorporated in many natural products and biol. active target structures. The method represents a mild alternative to currently available reaction protocols relying on stoichiometric reagents and harsh reaction conditions. This FeCl3-catalyzed transformation has enabled the selective synthesis of α-lapachone in two synthetic transformations and subsequently β-lapachone in three synthetic transformations, which is currently undergoing clin. trials as a potent anticancer agent.

Organic Letters published new progress about Cyclization. 63131-30-6 belongs to class iodides-buliding-blocks, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, and the molecular formula is C11H11IO3, Safety of Ethyl 3-(4-iodophenyl)-3-oxopropanoate.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tejo, Ciputra published the artcileBronsted acid catalyzed amination of 1,3-dicarbonyl compounds by iminoiodanes, Related Products of iodides-buliding-blocks, the main research area is Bronsted acid catalyst amination dicarbonyl compound iminoiodane.

A synthetic method to aminate 1,3-dicarbonyl compounds with PhI:NTs using Bronsted acid catalysis is described herein. The method was shown to be applicable to β-keto esters and phosphonates as well as 1,3-diones, providing the corresponding α,α-acyl amino acid derivatives in moderate to excellent yields. E.g., amination of PhCOCH2CO2Et with PhI:NTs in the presence of 10 mol% of TFA and 4 Å MS in dichloromethane at 0 °C for 90 min gave 85% aminated product I.

Synlett published new progress about Amination. 63131-30-6 belongs to class iodides-buliding-blocks, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, and the molecular formula is C11H11IO3, Related Products of iodides-buliding-blocks.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com