Tag: M.W=200-350

Chen, Jiajia published the artcileAmide/Ester Cross-Coupling via C-N/C-H Bond Cleavage: Synthesis of β-Ketoesters, COA of Formula: C11H11IO3, the main research area is ketoester preparation chemoselective; amide enolizable ester cross coupling bond cleavage.

Activated primary, secondary, and tertiary amides RC(O)N(Ts)C6H5(R = Ph, n-Pr, c-hex, etc.) were coupled with enolizable esters R1CH2C(O)OR2 (R1 = H, Me, Et; R2 = Et, Ph, t-Bu, etc.) in the presence of LiHMDS to obtain good yields of β-ketoesters RC(O)CH(R1)C(O)OR2 at room temperature Notably, this protocol provides an efficient, mild, and high chemoselectivity method for synthesis of β-alkylketoesters using the cross-coupling between aliphatic amides and esters. Meanwhile, gram-scale secondary and primary amides reacted via in situ generated activated tertiary amides and exhibited good reactivity when coupled with esters.

Journal of Organic Chemistry published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 63131-30-6 belongs to class iodides-buliding-blocks, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, and the molecular formula is C11H11IO3, COA of Formula: C11H11IO3.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Zhen-Yu published the artcileTerminal C(sp3)-H alkylation of internal alkenes via Ni/H-catalyzed isomerization, HPLC of Formula: 939759-26-9, the main research area is internal alkene alkyl aryl halide terminal alkylation isomerization nickel.

An efficient nickel-catalyzed reductive relay cross-coupling of internal alkenes with alkyl (or aryl) halides has been developed. This method has demonstrated broad substrate scope, mild reaction conditions and excellent terminal-selectivity. Moreover, this efficient strategy could be applied to the terminal-selective alkylation of isomeric mixtures of internal alkenes.

Tetrahedron Letters published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 939759-26-9 belongs to class iodides-buliding-blocks, name is Benzyl 3-iodoazetidine-1-carboxylate, and the molecular formula is C11H12INO2, HPLC of Formula: 939759-26-9.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Liu, Zhenwei published the artcilePalladium-Catalyzed Hiyama Cross-Couplings of Arylsilanes with 3-Iodoazetidine: Synthesis of 3-Arylazetidines, Application In Synthesis of 939759-26-9, the main research area is arylazetidine preparation palladium catalyzed Hiyama cross coupling; cross coupling arylsilane iodoazetidine.

The first palladium-catalyzed Hiyama cross-coupling reactions of arylsilanes with 3-iodoazetidine were described. The protocol provides a convenient access to a variety of useful 3-arylazetidines which are of great interest in pharmaceutical laboratories in moderate to good yields (30%-88%). In addition, this strategy has the advantage of easy operation and mild reaction conditions.

Journal of Organic Chemistry published new progress about Aryl silanes Role: RCT (Reactant), RACT (Reactant or Reagent). 939759-26-9 belongs to class iodides-buliding-blocks, name is Benzyl 3-iodoazetidine-1-carboxylate, and the molecular formula is C11H12INO2, Application In Synthesis of 939759-26-9.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lu, Xiao-Yu published the artcileTrisubstituted olefin synthesis via Ni-catalyzed hydroalkylation of internal alkynes with non-activated alkyl halides, Formula: C11H12INO2, the main research area is alkene preparation stereoselective regioselective; internal alkyne alkyl halide nickel catalyst hydroalkylation.

Ni-catalyzed regio- and stereo-selective hydroalkylation of internal alkynes R1CCR2 [R1 = Ph, pyridin-3-yl, (CH2)2CH3, etc.; R2 = Me, Ph, (CH2)3CH3, etc.] with non-activated alkyl halides XR3 (R3 = cyclohexyl, butan-2-yl, 1-[(4-methylbenzene)sulfonyl]pyrrolidin-3-yl, etc.; X = I, Br) was reported. This method does not use any sensitive organometallic reagents and shows good functional group compatibility, which enables the efficient synthesis of many tri-substituted olefins R1CH=C(R2)(R3) from readily available coupling partners. It also provides a straightforward method for the modification of bioactive organic mols.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alkenes Role: SPN (Synthetic Preparation), PREP (Preparation). 939759-26-9 belongs to class iodides-buliding-blocks, name is Benzyl 3-iodoazetidine-1-carboxylate, and the molecular formula is C11H12INO2, Formula: C11H12INO2.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wei, Jiao Jiao published the artcileN,N-dimethyl-D-glucosamine as an efficient ligand for copper-catalyzed Ullmann-type coupling of N-H heterocycles with aryl halides, Recommanded Product: Ethyl 3-(4-iodophenyl)-3-oxopropanoate, the main research area is nitrogen heterocycle halobenzene glucosamine copper catalyst Ullmann coupling; arylated nitrogen heterocycle preparation green chem.

A new N,N-dimethyl-D-glucosamine ligand was developed for the copper-catalyzed Ullmann-type coupling of N-H heterocycles (e.g., indoles, benzimidazoles, pyrazoles and triazoles) with aryl halides. This method was accomplished not only featuring excellent yields, mild reaction conditions and simple operation, but also showing eco-friendly and broad-spectrum substrates and could be widely used in the construction of N-aryl heterocyclic systems.

Tetrahedron published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 63131-30-6 belongs to class iodides-buliding-blocks, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, and the molecular formula is C11H11IO3, Recommanded Product: Ethyl 3-(4-iodophenyl)-3-oxopropanoate.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yang, Han published the artcileSynthesis of 2-Aryl Azetidines through Pd-Catalyzed Migration/Coupling of 3-Iodoazetidines and Aryl Boronic Acids, Application In Synthesis of 939759-26-9, the main research area is aryl azetidine preparation regioselective; iodoazetidine boronic acid migration cross coupling reaction palladium.

A palladium-catalyzed cross-coupling of 3-iodoazetidines and nonheteroaryl boronic acids was reported. The [1,1′-biphenyl]-2-yldicyclohexylphosphane ligand enabled the reaction that favored the formation of 2-aryl azetidines. The control experiments indicated that the reaction can proceed through either a palladium-hydride/dihydroazete complex or free dihydroazete intermediate followed by hydropalladation.

Organic Letters published new progress about Arylboronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 939759-26-9 belongs to class iodides-buliding-blocks, name is Benzyl 3-iodoazetidine-1-carboxylate, and the molecular formula is C11H12INO2, Application In Synthesis of 939759-26-9.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Dong, Ziyang published the artcileDual roles of bisphosphines and epoxides: Rh-catalyzed highly chemoselective and diastereoselective (3 + 2) transannulations of 1,2,3-thiadiazoles with cyanoepoxides, Recommanded Product: Ethyl 3-(4-iodophenyl)-3-oxopropanoate, the main research area is cyanoepoxide thiadiaazole rhodium catalyst chemoselective diastereoselective regioselective cycloaddition; oxiranyl isothiazole preparation.

A highly diastereoselective and chemoselective (3 + 2) transannulation of 1,2,3-thiadiazoles with cyanoepoxides was discovered. The use of sterically larger DPEPhos allows the preparation of cis-epoxyl isothiazoles from cis-cyanoepoxides in up to 95% yields and 100 : 0 dr, while the use of sterically smaller DPPF allows the synthesis of trans-products from cis- or trans-cyanoepoxides in up to 95% yields and 100 : 0 dr. Bisphosphines and epoxides play dual roles. Bisphosphines served not only as ligands, but also as catalysts to catalyze the isomerization of cis-epoxides to trans-isomers. The diastereoselectivity was controlled by the kinetic competition between the direct transannulation of cis-cyanoepoxides and the bisphosphine-catalyzed isomerization of cis-products. The epoxy group’s large steric hindrance guarantees excellent chemoselectivity toward the (3 + 2) annulation, and its electron-withdrawing ability significantly improves the reactivity of the adjacent cyano group. To address the controversy over the organorhodium intermediates, this study suggested the resonation between Lee’s umpolung 1,3-dipoles, Bao’s cyclometalated Rh(III) complexes, and thioacyl-coordinated Rh(I) carbenes. Stereospecific access to isothiazole-fused γ-lactone was also developed.

Organic Chemistry Frontiers published new progress about [3+2] Cycloaddition reaction catalysts (chemo and stereoselective). 63131-30-6 belongs to class iodides-buliding-blocks, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, and the molecular formula is C11H11IO3, Recommanded Product: Ethyl 3-(4-iodophenyl)-3-oxopropanoate.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Cheung, Chi Wai published the artcileMild and Phosphine-Free Iron-Catalyzed Cross-Coupling of Nonactivated Secondary Alkyl Halides with Alkynyl Grignard Reagents, Computed Properties of 939759-26-9, the main research area is secondary alkyl halide alkynyl Grignard iron cross coupling catalyst; alkyne substituted preparation.

A simple protocol for iron-catalyzed cross-coupling of nonactivated secondary alkyl bromides and iodides with alkynyl Grignard reagents at room temperature has been developed. A wide range of secondary alkyl halides and terminal alkynes are tolerated to afford the substituted alkynes in good yields. A slight modification of the reaction protocol also allows for cross-coupling with a variety of primary alkyl halides.

Organic Letters published new progress about Alkynes, internal Role: SPN (Synthetic Preparation), PREP (Preparation). 939759-26-9 belongs to class iodides-buliding-blocks, name is Benzyl 3-iodoazetidine-1-carboxylate, and the molecular formula is C11H12INO2, Computed Properties of 939759-26-9.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Tao published the artcileThree-Component Minisci Reaction with 1,3-Dicarbonyl Compounds Induced by Visible Light, Synthetic Route of 63131-30-6, the main research area is quinoline preparation visible light Minisci dicarbonyl vinyl ether heterocycle; isoquinoline preparation visible light Minisci dicarbonyl vinyl ether heterocycle.

A three-component Minisci reaction coupling of 1,3-dicarbonyl compounds with vinyl ethers and quinolines or isoquinolines under visible light is developed. The 1,3-dicarbonyl compound undergoes single-electron oxidation to afford an electrophilic 1,3-dicarbonyl radical under visible light irradiation Due to the polarity of the free radical, the electrophilic radical adds to the electron-rich olefin to afford the nucleophilic radical. It coupled with the heteroarene to afford the three-component coupling products.

Organic Letters published new progress about 1,3-Dicarbonyl compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 63131-30-6 belongs to class iodides-buliding-blocks, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, and the molecular formula is C11H11IO3, Synthetic Route of 63131-30-6.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ton, Thi My Uyen published the artcileCopper(II) triflate catalyzed amination and aziridination of 2-alkyl substituted 1,3-dicarbonyl compounds, Synthetic Route of 63131-30-6, the main research area is aziridine preparation; aminomethyl dicarbonyl compound preparation; alkyl dicarbonyl compound aziridination amination copper triflate catalyst.

A method to prepare α-acyl-β-amino acid and 2,2-diacyl aziridine derivatives efficiently from Cu(OTf)2 + 1,10-phenanthroline (1,10-phen)-catalyzed amination and aziridination of 2-alkyl substituted 1,3-dicarbonyl compounds with PhI=NTs is described. By taking advantage of the orthogonal modes of reactivity of the substrate through slight modification of the reaction conditions, a divergence in product selectivity was observed In the presence of 1.2 equiv of the iminoiodane, amination of the allylic C-H bond of the enolic form of the substrate, formed in situ through coordination to the Lewis acidic metal catalyst, was found to selectively occur and give the β-aminated adduct. On the other hand, increasing the amount of the nitrogen source from 1.2 to 2-3 equiv was discovered to result in preferential formal aziridination of the C-C bond of the 2-alkyl substituent of the starting material and formation of the aziridine product.

Journal of the American Chemical Society published new progress about 1,3-Dicarbonyl compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 63131-30-6 belongs to class iodides-buliding-blocks, name is Ethyl 3-(4-iodophenyl)-3-oxopropanoate, and the molecular formula is C11H11IO3, Synthetic Route of 63131-30-6.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com