Tag: M.W=200-300

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5326-39-6, name is 1-Iodo-4-methyl-2-nitrobenzene, This compound has unique chemical properties. The synthetic route is as follows., category: iodides-buliding-blocks

General procedure: The appropriate 4-substituted-1-iodo-2-nitrobenzene 10 (1mmol), appropriate 1,3-disubstituted-5-aminopyrazole 11 (1.3mmol), and anhydrous potassium carbonate (248mg, 1.8mmol) were heated in the presence of rac-BINAP (23mg, 0.036mmol, 3.7mol%), Pd2dba3 (23mg, 0.024mmol, 2.5mol%), and 18-crown-6 (10mg, 0.038mmol) in toluene (8mL, purged with argon) at 100C. The reaction was carried out under argon for 24h. After cooling the reaction mixture was filtered and purified using column chromatography on aluminium oxide with toluene, or a toluene-ethyl acetate mixture (10:1) as an eluent. The product was recrystallized from toluene.

According to the analysis of related databases, 5326-39-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Danel, Andrzej; Wojtasik, Katarzyna; Szlachcic, Pawe?; Gryl, Marlena; Stadnicka, Katarzyna; Tetrahedron; vol. 73; 34; (2017); p. 5072 – 5081;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 443-85-6, name is 1-Fluoro-3-iodo-2-methylbenzene, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C7H6FI

Under a protective atmosphere of inert gas, Pd(OAc)2 (2.2 mg, 10 mol%), XPhos (19.1 mg, 20 mol%), NBE-CO2K (3.5 mg, were added to a 4.0 mL reaction flask equipped with a magnetic stir bar. 10mol%),2-methyl-1-fluoro-3-iodobenzene (0.2 mmol, 1.0 equiv.), ethylene oxide (0.6 mmol, 3.0 equiv.) and dry N-methylpyrrolidone(1.0 mL). The reaction flask was capped and stirred at room temperature for about 5 minutes, after which the mixture was heated to 80 C and stirred for 24 hours.After the reaction vessel was cooled to room temperature, it was quenched with water (10 mL), extracted with methyl tert-butyl ether (3×10 mL), dried over Na2SO4Filter and concentrate under vacuum. Purified by column chromatography, the eluent was petroleum ether: ethyl acetate = 20:1 (v/v) to afford 7-methyl-6-Fluorin-2,3-dihydrobenzofuran 25mg (light yellow oily liquid, yield 65%)

According to the analysis of related databases, 443-85-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Wuhan University; Zhou Qianghui; Wu Chenggui; Cheng Honggang; (20 pag.)CN108329285; (2018); A;,
Iodide – Wikipedia,
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Reference of 5471-81-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5471-81-8, name is Methyl 4-iodo-3-methylbenzoate, This compound has unique chemical properties. The synthetic route is as follows.

A solution of methyl 4-iodo-3-methylbenzoate (2.0 g, 7.2 mmol) in THF (30 mL) under ? was cooled to -20 C, a solution of /so-propylmagnesium chloride (2 M in THF, 4 mL, 8.0 mmol) was added dropwise and the suspension stirred at -20 C for 1 hour. CO2 (g) was bubbled through the mixture, and the reaction stirred at room temperature for 1 hour. The solvent was evaporated and water was added, the aqueous layer was washed with DCM (15 mL 3) and the pH adjusted to 3 by addition of 3M HCI. The mixture was extracted with DCM (15 mL 3) and the combined organic layers dried (Na2S04) and concentrated to give the title compound as a white solid (870 mg, 88%). LCMS-C: RT 2.26 min; m/z 195.1 (0878) [M+H]

The chemical industry reduces the impact on the environment during synthesis Methyl 4-iodo-3-methylbenzoate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; CTXT PTY LTD; BERGMAN, Ylva Elisabet; FOITZIK, Richard Charles; MORROW, Benjamin Joseph; CAMERINO, Michelle Ang; WALKER, Scott Raymond; LAGIAKOS, H. Rachel; FEUTRILL, John; STEVENSON, Graeme Irvine; STUPPLE, Paul Anthony; (222 pag.)WO2016/34673; (2016); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 618-91-7,Some common heterocyclic compound, 618-91-7, name is Methyl 3-iodobenzoate, molecular formula is C8H7IO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: O-Tolualdehyde (0.24 mmol), iodobenzene (0.2 mmol), silver trifluoroacetate (0.3 mmol, 66 mg), palladium trifluoroacetate (0.02 mmol, 7 mg), Phe-Me2AA ligand (0.08 mmol, 19 mg), acetic acid (1.8 mL) and H2O (0.2 mL) were added to a vial. The mixture was heated to 90 C for 12 h. The reaction mixture was allowed to cool to room temperature and filtered through a silica gel pad, concentrated in vacuum. The desired product was isolated by a silica gel column chromatography or preparative TLC.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 3-iodobenzoate, its application will become more common.

Reference:
Article; Park, Hyojin; Yoo, Kwangho; Jung, Byunghyuck; Kim, Min; Tetrahedron; vol. 74; 16; (2018); p. 2048 – 2055;,
Iodide – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 58755-70-7, name is 1-Iodo-4-methoxy-2-nitrobenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 58755-70-7

A sealed tube was charged with CuI (0.19g, 1.0mmol, 2.5 equiv.), AgF (0.13g, 1.0mmol, 2.5 equiv.), pyridine (0.27mL, 8.3 equiv.), various iodoarenes (0.4mmol, 1.0 equiv.), triethyl(1,1,2,2-tetrafluorobut-3-en-1-yl)silane (4 : 0.19g, 0.8mmol, 2.0 equiv.) and DMF (3.2mL, 0.25M) in glove box. The sealed tube was brought under an atmosphere of argon and capped. The resulting mixture was stirred at 60C for 16h, and then cooled room temperature. The resulting mixture was passed through short column. The eluent was concentrated in vacuo to give the crude materials, which were purified by silica gel column chromatography, leading to the desired coupling products

The synthetic route of 58755-70-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yakushijin, Ryosuke; Yamada, Shigeyuki; Konno, Tsutomu; Journal of Fluorine Chemistry; vol. 225; (2019); p. 35 – 43;,
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Synthetic Route of 18698-96-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 18698-96-9, name is 2-(2-Iodophenyl)acetic acid, This compound has unique chemical properties. The synthetic route is as follows.

500mg of 2-iodophenylacetic acid (1.9 mmol), 261 mg of p-thiocresol (2.10 mmol, 1.1 eq),18 mg of copper powder (0.29 mmol, 0.15 eq) and 535 mg of potassium hydroxide (9.54mmol, 5 eq) were mixed in 12 ml of water and heated in a microwave oven at 170C for20 mn. The reaction mixture was acidified to pH = 2 with concentrated HCI and extractedthree times with 20 ml of dichloromethane. The organic phases were separated with anhydrophobic membrane, further washed with lOmI of iN HCI and concentrated todryness, yielding 473 mg of clear oil solidifying on standing and used as a crude in the next step.LCMS: mlz = 276 [M+NH4+], 534 [2M+NH4+]

The chemical industry reduces the impact on the environment during synthesis 2-(2-Iodophenyl)acetic acid. I believe this compound will play a more active role in future production and life.

Reference:
Patent; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; UNIVERSITE DE NICE SOPHIA ANTIPOLIS; GENOCHEM; MUS-VETEAU, Isabelle; POINSARD, Cedric; PIGEON, Pierre; (101 pag.)WO2019/92044; (2019); A1;,
Iodide – Wikipedia,
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Synthetic Route of 7425-53-8,Some common heterocyclic compound, 7425-53-8, name is Ethyl 4-iodobutanoate, molecular formula is C6H11IO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Ethyl 4-iodobutyrate 42 (7.00 g, 28.90 mmol) was dissolved in absolute ethanol (50.00 mL) and benzenesulfinate (6.60 g, 40.50 mmol) was added to this solution. Reaction mixture was refluxed for 12 h or until TLC indicated consumption of the starting material. The mixture was then taken up in H2O (100.00 mL) and product was extracted with diethyl ether (3 × 100.00 mL). Combined organic phase was washed with 5% NaOH (aq.) (100.00 mL), H2O (100.00 mL), and NaCl(sat. aq.) (100.00 mL), dried over Na2SO4, filtered, and solvent was removed under reduced pressure to afford title compound 43 (5.50 g, 74%). This mixture was used without further purification. 1H NMR (400 MHz, CDCl3-d) deltaH 1.23 (t, 3H, J = 7.2 Hz, CH2CH3), 1.96 – 2.13 (m, 2H, CH2CH2CH2), 2.45 (t, 2H, J = 7.1 Hz, CH2CH2), 3.12 – 3.24 (m, 2H, CH2CH2), 4.11 (q, 2H, J = 7.1 Hz, O-CH2), 7.52 – 7.63 (m, 2H, ArH), 7.67 (t, 1H, J = 7.6 Hz, ArH), 7.92 (t, 2H, J = 1.0 Hz, ArH).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 4-iodobutanoate, its application will become more common.

Reference:
Article; Hossain, Mohammad Anwar; Sattenapally, Narsimha; Parikh, Hardik I.; Li, Wei; Rumbaugh, Kendra P.; German, Nadezhda A.; European Journal of Medicinal Chemistry; vol. 185; (2020);,
Iodide – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 461-17-6, name is 1,1,1-Trifluoro-4-iodobutane, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 461-17-6, Formula: C4H6F3I

250g gamma-butyrolactone, 62.5g (440mmol) potassium 4-hydroxybutyrate, and 95.2g (400mmol) 4,4,4-trifluorobutyliodide were placed in a 500ml four-necked flask equipped with a stirrer, a reflux cooler, and a thermometer. By heating, the mixture was maintained at 75C for 5 hours while being stirred. At this point, it was determined by a gas chromatography that 98.6% of the 4,4,4-trifluorobutyliodide had been converted. Subsequently, the temperature was raised to 140C and the reaction was allowed to continue for another 2 hours. Upon completion of the reaction, the mixture was again analyzed by a gas chromatography. The results of the analysis revealed that 4,4,4-trifluorobutyliodide was converted at 100% conversion rate, and the selectivity for 4,4,4-trifluorobutanol, trifluorobutyl 4-hydroxybutyrate, and 4,4,4-trifluoro-1-butene were 86.5%, 13.3%, and 0.2%, respectively. The reaction mixture was then subjected to distillation: it was transferred to a 500ml flask equipped with a Claisen connector tube and a Liebig’s cooling tube, and was distilled at 120 to 140C under a pressure of 20 to 6kPa while the degree of vacuum was increased over a 3-hour period. As a result, 70.4g distillate was collected containing 49.2g (96.0% yield) of 4,4,4-trifluorobutanol. The gas chromatography analysis performed on the solution remaining in the flask indicated that it contained 0.8% trifluorobutyl 4-hydroxybutyrate

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,1,1-Trifluoro-4-iodobutane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Tosoh F-Tech, Inc.; EP1403238; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 41252-96-4, The chemical industry reduces the impact on the environment during synthesis 41252-96-4, name is 2-Chloro-1-iodo-4-nitrobenzene, I believe this compound will play a more active role in future production and life.

(i) Ethyl (2-chloro-4-nitrophenyl)(methyl)phosphinate To a solution of ethyl methylphosphinate (see, for example, Chebib, M. et al., WO 2006/000043, 5 January 2006; 530 mg, 4.90 mmol) in toluene (5 ml_) were added 2-chloro-1- iodo-4-nitrobenzene (835 mg, 2.95 mmol) and DIPEA (1.5 ml_, 8.59 mmol). The mixture was degassed under vacuum and back filled with nitrogen three times. XantPhos G3 precatalyst (84 mg, 0.088 mmol) was added, and the mixture was degassed three more times. The reaction was heated at 100C (block temperature) under nitrogen for 1 h. The reaction was cooled and the solvent evaporated to give a brown gum. The resulting gum was dissolved in DCM (30 ml_), 1 M HCL (20 ml_) was added and the phases were seperated. The organic phase was dried (MgSCU) and concentrated under reduced pressure. The crude material was purified by chromatography on silica gel (12 g column, dry load, 50-100% EtOAc/isohexane, product eluted at 98%) to afford the sub-title compound (519 mg) as a brown solid. 1 H NMR (400 MHz, DMSO-d6) delta: 8.40 (dd, 1 H), 8.35 (ddd, 1 H), 8.23 (dd, 1 H), 4.00 (ddq, 1 H), 3.83 (ddq, 1 H), 1.85 (d, 3H), 1.23 (t, 3H). LCMS m/z 264 (M+H)+ (ES+)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-1-iodo-4-nitrobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED; BAKER, Thomas Matthew; FYFE, Matthew Colin Thor; JONES, Geraint; THOM, Stephen Malcolm; (270 pag.)WO2016/51187; (2016); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 10297-05-9 as follows. Recommanded Product: 10297-05-9

3.98 1-(4-Chlorobutyl)-13-dihydrobenzoimidazol-2-one (56NK92) Sodium hydride (400 mg, 10 mmol, 60percent in oil) was washed with dry DMF (10 ml) under an argon atmosphere then DMF (10 ml) was added. The slurry of NaH in DMF was added slowly to 2-hydroxybenzimidazole (1.34 g, 10 mmol) in DMF (10 ml) at 0° C. under argon. The reaction was stirred at 0° C. for 20 min then 1-chloro-4-iodobutane (2.18 g, 10 mmol) in DMF (5 ml) was added slowly. The reaction was stirred at r.t. for 1.5 h then water (10 ml) was added and the reaction acidified with HCl (2M, few drops) then made basic with aqueous sodium hydrogen carbonate solution. The product was extracted with EtOAc (3*30 ml) and the organic layer was washed with aqueous sodium thiosulphate solution (10 ml), aqueous magnesium sulphate solution (4percent, 2*10 ml), brine (10 ml), dried (K2CO3), filtered and concentrated in vacuo before being purified by using an Isco CombiFlash Sq 16x [10 g silica column, eluding heptane (5 min), 0-40percent EtOAc in heptane (35 min), 40percent EtOAc in heptane (20 min)] to give the title compound (56NK92) as a pale yellow oil (416 mg, 19percent). 1H NMR (CDCl3) delta 10.48 (br. s, 1H), 7.26-7.00 (m, 4H), 3.95 (t, J=6.8 Hz, 2H), 3.59 (t, J=6.3 Hz, 2H), 1.97 (m, 2H), 1.87 (m, 2H); 13C NMR (CDCl3) delta 158.88, 130.08, 128.14, 121.56, 121.25, 109.82, 107.74, 44.32, 39.88, 29.53, 25.66; HPLC-MS (ammonium acetate) [M+H]+=225.2.

According to the analysis of related databases, 10297-05-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Kelly, Nicholas Michael; Koch, Kristian Norup; Tolf, Bo-Ragnar; US2004/67931; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com