Tag: M.W=200-300

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5876-51-7, name is 5-Iodobenzo[d][1,3]dioxole, A new synthetic method of this compound is introduced below., Product Details of 5876-51-7

The 248 mg (1mmol) 4 – bromophenylacetic methyl ether, 186 mg (2mmol) aniline, 9.5 mg (0.05mmol) CuI, 10.8 mg (0.05mmol) ligand L2, 424mg (4mmol) potassium phosphate, 1 ml ethanol,, adding 10 ml reaction tube, sealing, 25 C reaction under the condition 12h. After the stop of the reaction, water, extracted with ethyl acetate, washing, saturated salt water washing, after drying with anhydrous sodium sulfate, filtered, the filtrate is distilled under reduced pressure, purification by silica gel chromatography separation column column, shall be 3, 4 – methylenedioxy phenylaniline 192 mg, yield 90%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Sun Yat-sen University; Wan Yiqian; Ding Xiaomei; Huang Manna; Zhu Xinhai; Yi Zhou; CN106883132; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 6828-35-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6828-35-9 as follows.

General procedure: A mixture of 2-iodoaniline 1 (0.5 mmol) and Pd(OAc)2 (5.6 mg, 0.025 mmol, 5.0 mol%) in CH3CN (3 mL) was added into a Schlenk flask (25 mL) and stirred at room temperature. Followed by the addition of ethyl acrylate 2a (100 mg, 1.0 mmol, 2.0 equiv) and triethylamine (101 mg, 1.0 mmol, 2.0 equiv), the mixture was stirred at 100 C until the reaction was finished. Then the mixture was filtered and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (petroleum ether/ethyl acetate, 5:1 to 2:1) afforded the corresponding alkenylanilines 3.

According to the analysis of related databases, 6828-35-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Chen, Xia; Zhou, Xiao-Yu; Wang, Liang-Guang; Synthetic Communications; vol. 47; 22; (2017); p. 2096 – 2102;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 59528-27-7, name is (4-Iodophenyl)methanamine hydrochloride, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C7H9ClIN

Example 2 : Obtaining the 4-iodobenzylamide of 1- pentanoylamine-cyclopentanocarboxylic acid (VI) .8.2 g (18.6 mmol) of BOP is added to a suspension of 3.96 g (18.6 mmol) of 1-pentanoylamine-cyclopentanocarboxylic acid, 5.0 g (18.6 mmol) of hydrochloride of 4- iodobenzylamine and 6.5 mL (37,2 mmol) of diisopropylamine in 40 mL of dimethylformamide, and this is stirred for 10 hr . The reaction mixture is poured onto a mixture of EtOAc (400 mL) and water (400 mL) and stirred for 30 min. Following decanting, the organic phase is washed with saturated solution of sodium bicarbonate (200 mL x 2), with 5% solution of sodium bisulphite (200 mL) , with saturated solution of sodium chloride (100 mL) , dried with magnesium sulphate and evaporated. The residue is recrystallised from 60 mL of toluene to give 6.0 g (75%) of the title compound in the form of a white solid.M. p. = 150-152CIR (KBr, cm-1) : 3340, 3280, 1660, 1650, 1540.RMN IH (DMSO-d6), delta (ppm) : 0.80 (t, 3H, CH3) , 1.10-2.20(m, 14H), 4.20 (d, 2H, CH2-Ar) , 7.05 (d, 2H, H-Ar), 7.60(d, 2H. H.Ar) .

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 59528-27-7.

Reference:
Patent; INKE, S.A.; WO2006/89927; (2006); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 25245-27-6, name is 1-Iodo-3,5-dimethoxybenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25245-27-6, Recommanded Product: 1-Iodo-3,5-dimethoxybenzene

1mmol of o-phenylenediamine, 1.2mmol of benzaldehyde, 1mmol3,5-dimethoxy iodobenzene as raw materials, into the 50mL pressure tube, using 10mol% CuSO4 as a catalyst, 2mmol KOH as a base,1,10-phenanthroline is used in an amount of 20 mol%N, N-dimethylformamide was used in an amount of 5 mL and the temperature was 120 C. The reaction was stirred for 24 h.The reaction solution was filtered through the residue and distilled under reduced pressure to give a white solid.The yield was 88% and 1- (3,5-dimethoxyphenyl) -2-phenyl-1H-benzimidazole was obtained as a white solid

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Jiangsu Xian Ke Pharmaceutical Co., Ltd.; Liang Zhuowang; Huang Yuan; Xu Liangliang; (16 pag.)CN104557725; (2017); B;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 460-37-7, These common heterocyclic compound, 460-37-7, name is 1,1,1-Trifluoro-3-iodopropane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 479 mg (1.68 mmol) of the compound from Ex. 34A in 20 ml of DMF were added 582 mg (4.21 mmol) of potassium carbonate, and the mixture was stirred at RT for 15 min. Then 1.17 g (5.05 mmol) of 1,1,1-trifluoro-3-iodopropane were added, and the mixture was stirred at 50 C. for 20 h. The DMF was very substantially distilled off and the residue obtained was partitioned between semisaturated sodium chloride solution (100 ml) and ethyl acetate (50 ml). The water phase was extracted with ethyl acetate. The combined organic phases were dried over sodium sulfate, filtered and concentrated. The residue obtained was chromatographed using a silica gel cartridge (Biotage, 100 g of silica gel, eluent: hexane/ethyl acetate 94:6?50:50). In this way, 517 mg (85% of theory) of the title compound were obtained. 1H-NMR (400 MHz, DMSO-d6, delta/ppm): 10.09 (s, 1H), 4.13 (d, 2H), 2.84-2.69 (m, 5H), 2.30-2.23 (m, 1H), 1.15 (d, 3H), 1.07-0.95 (m, 1H), 0.90-0.81 (m, 2H). LC/MS (Method 4, ESIpos): Rt=1.2 min, m/z=361 [M+H]+.

The synthetic route of 460-37-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; HAERTER, Michael; KOSEMUND, Dirk; CANCHO GRANDE, Yolanda; DELBECK, Martina; KALTHOF, Bernd; LUSTIG, Klemens; SUESSMEIER, Frank; US2020/16159; (2020); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 847685-01-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 847685-01-2, name is 4,5-Difluoro-2-iodoaniline belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

16.1 (4-Chloro-phenyl)-(4,5-difluoro-2-iodo-phenyl)-diazene; Chloro-4-nitroso-benzene (9.1 g, 64 mmol; [932-98-9]) was added to a solution of 4,5-difluoro-2-iodo-phenylamine (10.9 g, 43 mmol; [847685-01-2]) in acetic acid (430 ml). The reaction mixture was heated under reflux conditions for 14 h. Ice water (1 1) and EtOAc (1 1) was added, the layers were separated and the aqueous layer was extracted two times with EtOAc. The combined extracts were washed with water and brine and dried over Na2SO4. The solvent was removed under reduced pressure and the residue was purified by column chromatography (silica gel, CH2Cl2/heptane) to give the title compound (4.34 g, 11 mmol; 27%) as orange solid. MS: m/e=377.9 [M+].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4,5-Difluoro-2-iodoaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Benson, Gregory Martin; Bleicher, Konrad; Feng, Song; Grether, Uwe; Kuhn, Bernd; Martin, Rainer E.; Plancher, Jean-Marc; Richter, Hans; Rudolph, Markus; Taylor, Sven; US2010/76026; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 1094759-93-9, name is 4-Chloro-5-fluoro-2-iodoaniline, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1094759-93-9, SDS of cas: 1094759-93-9

Step C: 2-Amino-5-chloro-4-fluoro-benzonitrile A solution of 4-chloro-5-fluoro-2-iodo-phenylamine (2.5 g, 9.21 mmol) and copper (I) cyanide (1.65 g, 18.4 mmol) in DMA (45 ml) was heated to 130 C. overnight. Most of the DMA was removed under reduced pressure and the remaining residue was diluted with EtOAc and dichloromethane. The slurry was filtered and the filter cake was washed with dichloromethane and EtOAc. The filtrate was concentrated and the remaining residue was purified by column chromatography (silica gel, heptane/EtOAc 98:2-85:15) to afford the title compound (1232 mg, 78%) as light red solid. MS (ESI): 169.2 (M-H)-.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Hoffmann-La Roche Inc.; Ceccarelli, Simona M.; Conte, Aurelia; Kuehne, Holger; Kuhn, Bernd; Neidhart, Werner; Obst Sander, Ulrike; Rudolph, Markus; US2013/116234; (2013); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 17533-08-3, The chemical industry reduces the impact on the environment during synthesis 17533-08-3, name is 1,2,4-Trifluoro-5-iodobenzene, I believe this compound will play a more active role in future production and life.

General procedure: preparation of 3,3,3-trifluoro-2-hydroxy-1-morpholino-2-phenylpropan-1-one 8b (Table 2, entry 1). To a solution of phenyl iodide 5a (300 lL, 2.68 mmol)in THF (4 mL) at 0 C, isopropylmagnesium chloride in THF (1338 lL,2.68 mmol, 2 M) was added dropwise. After stirring at 0 C for 1 h, a solutionof methyl trifluoropyruvate 7a (273 lL, 2.68 mmol) in THF (3 mL) was addeddropwise at 78 C. The mixture was stirred at 78 C for 1 h and thenwarmed to 0 C, morpholine 6b (350 lL, 4.01 mmol) and isopropylmagnesiumchloride (2.0 mL, 4.01 mmol, 2 M) were added dropwise. At the end of theaddition, the external cooling was removed, and the reaction was aged at roomtemperature overnight. At 0 C, the reaction mixture was quenched with slowaddition of satd. NH4Cl and extracted with EtOAc. The combined organic layerswere dried over anhydrous Na2SO4, filtered, and concentrated in vacuo.Purification by flash chromatography (0-60% EtOAc/hexane) provided thedesired amide

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,2,4-Trifluoro-5-iodobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Meng, Zhaoyang; Butcher, William E.; Tetrahedron Letters; vol. 54; 37; (2013); p. 5133 – 5136;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 35674-27-2, A common heterocyclic compound, 35674-27-2, name is 4-Iodo-3-nitrobenzoic acid, molecular formula is C7H4INO4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 1 Preparation of 4-iodo-3-nitrobenzoic Acid Methyl Ester Using Methanol/Sulfuric Acid To a solution of 4-iodo-3-nitrobenzoic acid (3 g, 10 mmol) in methanol (30 ml) cooled to 0 C., sulfuric acid (3.4 g, 34.6 mmol) is added slowly. The reaction mixture is warmed to room temperature and then refluxed (?70 C.) for 8 hours. After cooling, the reaction mixture is neutralized with solid NaHCO3 and the salts are filtered. The filtrate is evaporated under reduced pressure. To the residue obtained, water (30 ml) is added and the mixture extracted with MTBE (30 ml*2). The combined organic phase is washed with brine, dried using anhydrous sodium sulfate and filtered. After evaporating the solvent under reduced pressure, 4-iodo-3-nitro-benzoic acid methyl ester is obtained as a yellow solid (2.67 g, 85% yield, 98% HPLC).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; DIVI’S LABORATORIES LIMITED; Divi, Murali Krishna Prasad; Rao, Mysore Aswatha Narayana; Rajuri, Venkataramana; US2013/172618; (2013); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of 108078-14-4,Some common heterocyclic compound, 108078-14-4, name is 2-Iodo-3-methylbenzoic acid, molecular formula is C8H7IO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 1-iodo-3-methylbenzoic acid, 20-1 , (5 g), 1-benzyl-3~methyl-1 H- pyrazof-5-amine, 20-2, (3.93 g), K2CO3 (2.64 g) and copper powder (0,61 g) in water (20 mL) was heated at reflux overnight. The resulting mixture was cooled to RT. The pH was adjusted to 14 with 1N aqueous NaOH and the mixture was extracted with CH2CI2. Concentrated HCI was added to the aqueous solution to adjust the pH to 3 and the mixture was filtered. The white solid was dried in a vacuum oven at 50 0C to give 20-3 (3.05 g). LCMS: M is 321. Found: MH+ is 322. The solid was used without further purification.

The synthetic route of 108078-14-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SCHERING CORPORATION; HO, Ginny D; YANG, Shu-Wei; SMITH, Elizabeth M; MCELROY, William Thomas; BASU, Kallol; SMOTRYSKI, Jennifer; TAN, Zheng; MCKITTRICK, Brian A.; TULSHIAN, Deen B.; WO2010/62559; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com