Tag: M.W=200-300

Application of 25245-29-8, These common heterocyclic compound, 25245-29-8, name is 5-Iodo-1,2,3-trimethoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Referential Example 49Synthesis of 4-iodo-2,6-dimethoxyphenol:; [] To a solution of 5-iodo-1,2,3-trimethoxybenzene (3.2 g) in 1,2-dichloroethane (40 mL) was added aluminum chloride (1.6 g). The mixture was stirred at 60C for 4 hours and concentrated under reduced pressure. The residue was dissolved in 1 M aqueous sodium hydroxide solution and washed with ether. The aqueous layer was then acidified and extracted with chloroform. The organic layer was washed with brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give the title compound as white crystalline powder. Yield: 1.0 g (31%)

The synthetic route of 25245-29-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kowa Co., Ltd.; EP1568691; (2005); A1;,
Iodide – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 33184-48-4, name is 4-Chloro-2-iodo-1-methylbenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 33184-48-4, Recommanded Product: 4-Chloro-2-iodo-1-methylbenzene

The boronate ester (1.0 equiv), iodo-benzene (1.0 equiv), palladium catalyst (0.1 equiv) and potassium carbonate (3.0 equiv) was added to a solution of deoxygenated DMF. The flask was flushed with argon for 15 minutes, fitted with a dry tube and run over night at 110 0C. The reaction was poured onto water and extracted three times with ethyl acetate. The organic layers were washed with a brine solution, dried over anhydrous sodium sulfate. The reaction was purified through a 10 g SPE tube in a mixture of ethyl acetate and hexanes. IH NMR was used to confirm the purity of the product.; 4-(5-Chloro-2-methyl-phenyl)-3,6-dihydro-2H pyridine- 1-carboxylic acid tert-butyl ester was synthesized from 4-(4,4,5,5-tetramethyl-[l,3,2]dioxaborolan-2-yl)-3,6-dihydro-2H-pyridin-l- carboxylic acid tert-butyl ester ( 0.200 g, 0.647 mmol), 4-chloro-2-iodo-l -methyl-benzene ( 0.163 mg, 0.647 mmol), Pd Cl2 (dppf) (0.053 g, 0.0647 mmol) and potassium carbonate (0.268 g, 1.94 mmol) in 20.0 mL of DMF. The reaction was purified by eluting through a 10 g SPE tube using a solution of 10% ethyl acetate and hexanes to yield a brown liquid (0.236 g, 124%). 1H NMR (300 MHz, CDC3) delta ppm: 1.54 (s, 9H), 2.02 (s, 2H), 2.39 (s, 3H), 3.66 (br, 2H), 4.15-4.06 (br, 2H), 5.52 (br, IH), 7.78-7.07 (m, 3H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2006/71730; (2006); A1;,
Iodide – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 887266-99-1, name is 3-Fluoro-4-iodobenzonitrile, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 887266-99-1, COA of Formula: C7H3FIN

To a solution of 3-fluoro-4-iodobenzonitrile (2.7 g, 0.010 mmol) in DMSO (6.0 mL), K2C03 (0.450 g, 0.003 mmol) and 30% H2O2 (2.4 mL) were added at 0-10C and the reaction mass was stirred at RT for 2 h. After completion of the reaction, the reaction mass was quenched in ice cold water. The obtained solid product was filtered off to afford 2.0 g of the desired title product. 1H NMR (400 MHz, DMSO d6): delta 7.48- 7.51 (m, 2H), 7.66 (br s, 1H), 7.69- 7.70 (m, 1H), 8.09 (brs, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Fluoro-4-iodobenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GLENMARK PHARMACEUTICALS S.A.; GHARAT, Laxmikant Atmaram; MUTHUKAMAN, Nagarajan; KHAIRATKAR-JOSHI, Neelima; KATTIGE, Vidya Ganapati; WO2013/186692; (2013); A1;,
Iodide – Wikipedia,
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699016-40-5, name is 2-Fluoro-4-iodobenzaldehyde, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 2-Fluoro-4-iodobenzaldehyde

Under nitrogen at room temperature, to a solution of 2,2,2-trifluoro-N-[(1R)-2-(4-mercaptophenyl)-1-methylethyl]acetamide (4.0 g) in N,N-dimethylformamide (40 ml) was added 2-fluoro-4-iodobenzaldehyde (4.18 g) and potassium carbonate (2.31 g), and the mixture was stirred at 60 C. for 2 hours.The resulting mixture was poured into water and the aqueous mixture was extracted with ethyl acetate.The organic layer was washed successively with water (two times) and brine, dried over anhydrous magnesium sulfate and evaporated under reduced pressure.The residue was purified by column chromatography on silica gel (chloroform/ethyl acetate=10:1) to give 2,2,2-trifluoro-N-[(1R)-2-[4-[(2-formyl-5-iodophenyl)thio]phenyl]-1-methylethyl]acetamide (5.02 g). (+)ESI-MS (m/z): 516 (M+Na)+

The synthetic route of 699016-40-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; FUJISAWA PHARMACEUTICAL CO., LTD.; US2004/106653; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 127654-70-0, name is 1-Chloro-3-fluoro-2-iodobenzene, A new synthetic method of this compound is introduced below., Computed Properties of C6H3ClFI

1-Chloro-3-fluoro-2-iodobenzene (100 g, 0.39 mol), (5-bromo-2-methoxyphenyl) boronic acid (90.0 g, 0.39 mol) Dissolved in 2000 mL of tetrahydrofuran. To this was added a 2M solution of sodium carbonate (Na2CO3) (750 mL) Tetrakis (triphenylphosphine) palladium (0) (4.5 g, 3.9 mmol) was added and refluxed for 9 hours. After the reaction was completed, the reaction mixture was cooled to room temperature, The water layer was separated and removed, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The mixture was recrystallized from chloroform and ethanol to give Compound A1 (104.9 g, yield 86%, MS: [M + H] + = 315 ).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; LG Chem, Ltd.; Lee Jeong-ha; Park Tae-yun; Jeong Min-u; Lee Dong-hun; Moon Jeong-uk; (77 pag.)KR2018/41607; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 3058-39-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3058-39-7, name is 4-Iodobenzonitrile belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Styrene (1.4mmol) was added to a stirring mixture of arylhalide (1.0 mmol), K2CO3(1.5 mmol), nano-pd catalyst(1.5mol%), TBAB (0.5mmol) in DMF (3.0mL) and thenthe reaction mixture was heated at 130 C for the appropriatetime. The mixture was cooled down to room temperatureand the catalyst was isolated using an externalmagnet. Then, the residue was diluted with H2O(10.0mL)and extracted with EtOAc (10 × 3). The combined organicphases were combined and dried over anhydrous Na2SO4.Concentration of the mixture and column chromatographyon silica gel afforded the desired cross-coupling productsin high yield.

The synthetic route of 4-Iodobenzonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Article; Khalili, Dariush; Banazadeh, Ali Reza; Etemadi-Davan, Elham; Catalysis Letters; vol. 147; 10; (2017); p. 2674 – 2687;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Some common heterocyclic compound, 5100-98-1, name is 3-Chloro-2-iodotoluene, molecular formula is C7H6ClI, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 5100-98-1

To a souton of I nethybenzene (4.0 g, 16 mmo) n CC4 (12 mL), were added Nbromosuccnmde (NBS) (5.6 g, 32 nno) and 11azobs(cycohexanecarbonftre (ABN) (3.9 g, 16 mmo). Then,xture was degassed wfth nitrogen and then heated at 90 °C for I h. After coohng to rt,sHca ge was added, and the sovent was removed in vacuo. Purflcaton (FCC, SO2; 0 ? 5percent EtOAc/hexanes) provded the Ute compound as an o (3.7 g, 70percent yed). 1H NMR(400 MHz, CDC3): 3 7.37 (rn, 2H), 7.29 – 7.23 (m, I H), 4.65 (s, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5100-98-1, its application will become more common.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; RAVULA, Suchitra; SWANSON, Devin M.; SAVALL, Bradley M.; AMERIKS, Michael K.; (250 pag.)WO2016/176449; (2016); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

These common heterocyclic compound, 455-13-0, name is 4-Iodobenzotrifluoride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C7H4F3I

General procedure: A 25 mL Schlenk tube was charged with Cu2O (0.05 mmol), ArX (0.5 mmol), NHR1R2 (0.75 mmol), NaOH (1 mmol), TBAB (0.1 mmol), L2 (0.1 mmol) and H2O/EtOH (1 mL, 1/1, v/v). The mixture was stirred at 120 C for 12 h. The reaction mixture was extracted with ethyl acetate (3 10 mL), washed with water and brine, dried over anhydrous Na2SO4, and concentrated in vacuo. The residue was purified by flash column chromatograph on silica gel(ethyl acetate/petroleum ether as the eluent) to provide the target products 3a-3w and 6.

The synthetic route of 4-Iodobenzotrifluoride has been constantly updated, and we look forward to future research findings.

Reference:
Article; Xie, Jian-Wei; Yao, Zhen-Bin; Wang, Xiao-Chuang; Zhang, Jie; Tetrahedron; vol. 75; 27; (2019); p. 3788 – 3792;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 153898-63-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 153898-63-6, name is 2-Iodo-5-methoxyaniline belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A mixture of o-iodoaniline (0.5 mmol, 1 equiv), arylacetic acid (0.6 mmol), elemental sulfur (1.5mmol), Cu(OAc)2·H2O (20 mmol%), and NaOH (1.0 mmol) in DMSO (3 mL) was put into a sealed pressure vessel (25 mL) containing a magnetic stirring bar. The tube was purged with nitrogen three times, and then capped and stirred in a preheated oil bath at 130 C for 24 h. The reaction mixture then cooled to room temperature and extracted with ethyl acetate (3×10 mL), the organic layer was washed with saturated NaCl (2×10 mL), dried over anhydrous Na2SO4, evaporated under vacumm and then purified by silica gel column chromatography by using petroleum ether and ethyl acetate (PE:EA=200:1) as eluent.

The synthetic route of 2-Iodo-5-methoxyaniline has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wang, Xin; Li, Xiaotong; Hu, Renhe; Yang, Zhao; Gu, Ren; Ding, Sai; Li, Pengyi; Han, Shiqing; Synlett; vol. 29; 2; (2018); p. 219 – 224;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 618-91-7, The chemical industry reduces the impact on the environment during synthesis 618-91-7, name is Methyl 3-iodobenzoate, I believe this compound will play a more active role in future production and life.

General procedure: Cross-Coupling of ortho-, meta-, and para-Substituted, Electron-Rich and Electron-Deficient Aryl Halides and Aryl Mesylates with Aryl Neopentylglycolboronates Catalyzed by NiIICl(1-naph-thyl)(PCy3)2/PCy3 in Anhydrous THF at 23 C; General Procedure 2In an oven-dried test tube charged with a Teflon coated stirring barwere added aryl halide or aryl mesylate (0.3 mmol), aryl neopentyl-glycolboronates (0.315 mmol), K3PO4(H2O)3.2 (191.00 ± 1.00 mg, 0.9mmol), and NiIICl(1-naphthyl)(PCy3)2 (11.73 ± 0.0510 mg, 0.015mmol, 5% catalyst loading). The test tube was brought into a N2 filledglove box (moisture level <2 ppm) through three degassing cycles andPCy3 (8.4 mg, 0.03 mmol, 10% loading) ligand was added. Distilled sol-vent (1 mL) was added inside the glove box and the test tube wassealed by a rubber septum and left stirring at 23 C. A sample was tak-en by syringe and transferred outside the glove box. The sample wasdiluted by distilled THF (0.2 mL) and filtered through a short columnof Al2O3. The filtrate was concentrated and the GC analysis was car-ried out. The reaction mixture was diluted with CH2Cl2 (2 mL), filteredthrough a layer of Al2O3, and washed with CH2Cl2 (3 1 mL). The fil-trate was collected and concentrated under vacuum. The crude prod-uct was purified by column chromatography on silica gel with EtO-Ac/hexane mixture as eluent. The reductive elimination side-productwas also isolated and characterized. In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-iodobenzoate, other downstream synthetic routes, hurry up and to see. Reference:
Article; Malineni, Jagadeesh; Jezorek, Ryan L.; Zhang, Na; Percec, Virgil; Synthesis; vol. 48; 17; (2016); p. 2795 – 2807;,
Iodide – Wikipedia,
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