Tag: M.W=200-300

Synthetic Route of 54413-93-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 54413-93-3, name is 2-Iodo-5-methoxybenzoic acid belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: NaIO4 (6.7 g, 31 mmol, 1.0 equiv) and2-iodobenzoic acid (7.4 g, 30 mmol, 1.0 equiv) were suspended in 30% (v:v) aqueousacetic acid (45 mL). The reaction mixture was vigorously stirred and refluxed for 3 hprotecting from light. Cold water (120 mL) was then added and allowed to cool toroom temperature. After 1 h, the crude product was collected by filtration, washedwith ice water (3 x 30 mL) and acetone (3 x 30 mL). After air-drying in the dark,hydroxybenziodoxole 2 was yielded as a white solid.

The synthetic route of 2-Iodo-5-methoxybenzoic acid has been constantly updated, and we look forward to future research findings.

Reference:
Article; Pan, Yue; Jia, Kunfang; Chen, Yali; Chen, Yiyun; Beilstein Journal of Organic Chemistry; vol. 14; (2018); p. 1215 – 1221;,
Iodide – Wikipedia,
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Application of 41252-96-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 41252-96-4, name is 2-Chloro-1-iodo-4-nitrobenzene, This compound has unique chemical properties. The synthetic route is as follows.

Step A: Preparation of 2-chloro-4-nitro-biphenyl. A mixture of potassium carbonate (1.48 g, 10.7 mmol), phenylboronic acid (645 mg, 5.29 mmol), 3-chloro-4-iodonitro benzene (1.00 g, 3.53 mmol), and THF (31 ml) was degassed with nitrogen in a sealable tube for 10 min. The dichloromethane adduct of 1,1′-bis(diphenylphosphino)ferrocene]dichloro palladium (351 mg, 0.429 mmol) was added to the reaction mixture and the pressure tube was sealed. The reaction mixture was stirred at 100 C. for 42 h. The mixture was cooled to 23 C., diluted with DCM (40 ml), and filtered. The filtrate was concentrated. The residue was purified by FCC (3-50% EtOAc/hexanes) to yield the titled compound (796 mg, 97%). 1H NMR (600 MHz, DMSO-d6): 8.42-8.41 (m, 1H), 8.26 (dd, J=8.5, 2.2, Hz 1H), 7.72 (d, J=8.5 Hz, 1H), 7.55-7.48 (m, 5H).

The chemical industry reduces the impact on the environment during synthesis 2-Chloro-1-iodo-4-nitrobenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Bembenek, Scott D.; Hocutt, Frances M.; Leonard, JR., Barry Eastman; Rabinowitz, Michael H.; Rosen, Mark D.; Tarantino, Kyle T.; Venkatesan, Hariharan; US2010/204226; (2010); A1;,
Iodide – Wikipedia,
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Reference of 52914-23-5,Some common heterocyclic compound, 52914-23-5, name is 2-(4-Iodophenyl)ethanol, molecular formula is C8H9IO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1. 2-[(4-Methyl-2-nitroanilino)phenyl]ethanol The title compound was prepared according to the procedure described in step 1 Example 45 from 4-methyl-2-nitroaniline and 4-iodophenylethyl alcohol. 1H-NMR (CDCl3) delta9.35 (1H, br.s), 8.00 (1H, s), 7.33-7.09 (6H, m), 3.91-3.89 (2H, m), 2.89 (2H, t, J=6.4 Hz), 2.30 (3H, s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(4-Iodophenyl)ethanol, its application will become more common.

Reference:
Patent; Audoly, Laurent; Okumura, Takako; Shimojo, Masato; US2002/77329; (2002); A1;,
Iodide – Wikipedia,
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Reference of 61272-76-2, A common heterocyclic compound, 61272-76-2, name is 4-Fluoro-2-iodoaniline, molecular formula is C6H5FIN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Step B: Pyridine (1.5 mmol) was added to the o-iodo derivative as prepared above (1 mmol) in DCM (5 mL) at 0 °C under nitrogen atmosphere. To this was added methane/p-toluene sulfonyl chloride (1.2 mmol) slowly at 0 °C. Then, the reaction mixture was stirred at room temperature for 5-6 h. After completion of the reaction (monitored by TLC), the reaction mixture was diluted with ethyl acetate (30 mL), washed with 2N HCl solution (10 mL) followed by brine solution (20 mL), dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by column chromatography using ethyl acetate-hexane to give the desired product 2.

The synthetic route of 61272-76-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Rambabu; Raja, Guttikonda; Yogi Sreenivas; Seerapu; Lalith Kumar; Deora, Girdhar Singh; Haldar, Devyani; Rao, M.V.Basaveswara; Pal, Manojit; Bioorganic and Medicinal Chemistry Letters; vol. 23; 5; (2013); p. 1351 – 1357;,
Iodide – Wikipedia,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1450754-38-7, name is 3-(But-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Formula: C7H9IN2

(g) Compound 6 (400 mg, 1.6 mmol, 1.0 eq), sodium azide (125 mg, 1.92 mmol, 1.2 eq) and DMF (4 ml) were added to the reaction flask.Raise to 70 C, avoid light reaction for 5 hours; add water to quench,Extract with ethyl acetate, dry, spin dry,A crude product of 200 mg of compound 7,Yield: 76%.

The synthetic route of 1450754-38-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Suzhouguangdian Biological Technology Co., Ltd.; Ni Runyan; Wang Wei; (8 pag.)CN109503615; (2019); A;,
Iodide – Wikipedia,
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Related Products of 153898-63-6,Some common heterocyclic compound, 153898-63-6, name is 2-Iodo-5-methoxyaniline, molecular formula is C7H8INO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: a suspension of 3-iodo-4-aminopyridine (1 mmol), methyl 2-mercaptoacetate (1.5 equiv), copper (I) iodide (0.05 mmol), trans-N,N’-dimethylcyclohexane-1,2-diamine (0.1 mmol) and cesium carbonate(2 equiv) in dry 1,4-dioxane (4 mL) in a vial was degassed by bubbling N2 into the suspension for 3 min while stirring. The vial was then capped tightly. The mixture was heated at 100 C (oil bath temperature) for 15 h. After coolingto rt, filtration was carried out. The combined filtrates were concentrated on rotavap and the residue was subjected to silica gel column chromatographpurification (5% methanol in methylene chloride) furnishing 3b as a beige solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Iodo-5-methoxyaniline, its application will become more common.

Reference:
Article; Huang, Wei-Sheng; Xu, Rongsong; Dodd, Rory; Shakespeare, William C.; Tetrahedron Letters; vol. 54; 38; (2013); p. 5214 – 5216;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 14452-30-3,Some common heterocyclic compound, 14452-30-3, name is 1-(3-Iodophenyl)ethanone, molecular formula is C8H7IO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Arylhalide (1a,b18a,b, 1.2 equiv, typically ca. 50 mg), NNCu(bdmpphen) (1.0 equiv, typically ca. 50 mg), Pd2(dba)3¢CHCl3 (5 mol% in most cases), and DPPF (10 mol% in mostcases) were dissolved in dry THF under nitrogen. The mixturewas refluxed until the starting Cu-complex was consumed(monitored by TLC, typically 30min in most cases for ArI).After the reaction mixture was concentrated under reducedpressure, toluene (3 mL) was added into the residue. The residualmixture was separated and purified by chromatography,to afford the corresponding cross-coupling product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-(3-Iodophenyl)ethanone, its application will become more common.

Reference:
Article; Yamada, Kiyomi; Zhang, Xun; Tanimoto, Ryu; Suzuki, Shuichi; Kozaki, Masatoshi; Tanaka, Rika; Okada, Keiji; Bulletin of the Chemical Society of Japan; vol. 91; 7; (2018); p. 1150 – 1157;,
Iodide – Wikipedia,
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608-28-6, Adding a certain compound to certain chemical reactions, such as: 608-28-6, name is 2-Iodo-1,3-dimethylbenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 608-28-6.

2,2′,6-trimethyl-1,1′-biphenyl (89): To a mixture of Ni-Cat.(0.0125 mmol Nil2+0.025 mmol VIa) and Ar-I 87 (0.036mL, 0.058 g, 0.25 mmol) 1.0 mL of CPME was added. Themixture was stirred for 10 mins. Then the water (0.02 mL,0.02 g, 1.11 mmol) was added. To the mixture, boronic acid88 (0.068 g, 0.5 mmol), bases (0.160 g, 0.75 mmol) wereadded. The reaction mixture was stirred at 105 C. (asmentioned) and aliquot was taken after different time intervalto analyze the data by GC/MS. After that the reactionmixture was filtered through neutral alumina, concentratedunder vacuum, purified by flash chromatography withhexane.1 H NMR (CDC13, 400 MHz): o1.99 (s, 6H), 2.01 (s,3H), 7.05-7.08 (m, lH), 7.14-7.35 (m, 6H); 13C NMR(CDC13, 100 MHz): o19.4, 20.3, 126.0, 126.9, 126.9, 127.2,128.8, 130.0, 135.6, 135.8, 140.5, 141.0.

According to the analysis of related databases, 608-28-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Boehringer Ingelheim International GmbH; Desrosiers, Jean-Nicolas; Fandrick, Daniel Robert; Haddad, Nizar; Li, Guisheng; Patel, Nitinchandra D.; Qu, Bo; Rodriguez, Sonia; Senanayake, Chris Hugh; Sieber, Joshua Daniel; Tan, Zhulin; Wang, Xiao-Jun; Yee, Nathan K.; Zhang, Li; Zhang, Yongda; (58 pag.)US2018/155375; (2018); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

619-58-9, name is 4-Iodobenzoic acid, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 4-Iodobenzoic acid

i. 4-Iodobenzyl alcohol. To a solution of 4-iodobenzoic acid (22 g) in tetrahydrofuran (450 mL) was added borane dimethylsulfide complex (35.5 mL, 10M in tetrahydrofuran), and the solution was allowed to stir overnight. The reaction was quenched by addition of methanol, and the solvent was evaporated. The residue was dissolved in ethyl acetate and filtered. The solvent was evaporated to give a solid, which was recrystallized from ether to yield a white solid, which was chromatographed, eluding with ether, to give 4-iodobenzyl alcohol (15.1 g).

The synthetic route of 619-58-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Zeneca Limited; US5521179; (1996); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

5326-47-6, These common heterocyclic compound, 5326-47-6, name is 2-Amino-5-iodobenzoic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Concentrated H2SO4 (3.7 mL) was added dropwise at 20 C under argon atmosphere to a stirred solution of 5-iodoanthranilic acid (5.0 g, 19 mmol) in MeOH (20 mL), and the mixture was refluxed for 7 h. The mixture was then concentrated in vacuo to the volume of 10 mL, poured into a vigorously stirred saturated solution of NaHCO3 (80 mL), and extracted with EtOAc. The organic layer was washed with a brine solution, dried over Na2SO4, and concentrated in vacuo; the residue was purified by chromatography on SiO2 (eluent was benzene). Ester 6 (3.68 g) was isolated as yellow crystals, m.p. 80-82 C (LP). 1H NMR (CDCl3), delta: 3.87 (s, 3 H, MeO); 5.76 (br.s, 2 H, H2N); 6.46 (d, 1 H, HC(3), J = 8.7 Hz); 7.48 (dd, 1 H, HC(4), J = 8.7 Hz, J = 2.2 Hz); 8.14 (d, 1 H, 2 HC(6), J = 2.2 Hz); which is similar to that reported previously.24

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 5326-47-6.

Reference:
Article; Lozanova; Stepanov; Mel?nik; Zlokazov; Veselovsky; Russian Chemical Bulletin; vol. 68; 1; (2019); p. 64 – 67; Izv. Akad. Nauk, Ser. Khim.; 1; (2019); p. 64 – 67,4;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com