Tag: M.W=200-300

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Journal of the American Chemical Society called Benzoisothiazolone Organo/Copper-Cocatalyzed Redox Dehydrative Construction of Amides and Peptides from Carboxylic Acids using (EtO)3P as the Reductant and O2 in Air as the Terminal Oxidant, Author is Liebeskind, Lanny S.; Gangireddy, Pavankumar; Lindale, Matthew G., which mentions a compound: 180258-46-2, SMILESS is O=C(C1=NC(N)=CN1C)OCC.[H]Cl, Molecular C7H12ClN3O2, Electric Literature of C7H12ClN3O2.

Carboxylic acids and amine/amino acid reactants can be converted to amides and peptides at neutral pH within 5-36 h at 50° using catalytic quantities of a redox-active benzoisothiazolone and a copper complex. These catalytic “”oxidation-reduction condensation”” reactions are carried out open to dry air using O2 as the terminal oxidant and a slight excess of tri-Et phosphite as the reductant. Tri-Et phosphate is the easily removed byproduct. These simple-to-run catalytic reactions provide practical and economical procedures for the acylative construction of C-N bonds.

Although many compounds look similar to this compound(180258-46-2)Electric Literature of C7H12ClN3O2, numerous studies have shown that this compound(SMILES:O=C(C1=NC(N)=CN1C)OCC.[H]Cl), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Journal of the American Chemical Society called Benzoisothiazolone Organo/Copper-Cocatalyzed Redox Dehydrative Construction of Amides and Peptides from Carboxylic Acids using (EtO)3P as the Reductant and O2 in Air as the Terminal Oxidant, Author is Liebeskind, Lanny S.; Gangireddy, Pavankumar; Lindale, Matthew G., which mentions a compound: 180258-46-2, SMILESS is O=C(C1=NC(N)=CN1C)OCC.[H]Cl, Molecular C7H12ClN3O2, Electric Literature of C7H12ClN3O2.

Carboxylic acids and amine/amino acid reactants can be converted to amides and peptides at neutral pH within 5-36 h at 50° using catalytic quantities of a redox-active benzoisothiazolone and a copper complex. These catalytic “”oxidation-reduction condensation”” reactions are carried out open to dry air using O2 as the terminal oxidant and a slight excess of tri-Et phosphite as the reductant. Tri-Et phosphate is the easily removed byproduct. These simple-to-run catalytic reactions provide practical and economical procedures for the acylative construction of C-N bonds.

Although many compounds look similar to this compound(180258-46-2)Electric Literature of C7H12ClN3O2, numerous studies have shown that this compound(SMILES:O=C(C1=NC(N)=CN1C)OCC.[H]Cl), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Groeger, Kathrin; Baretic, Domagoj; Piantanida, Ivo; Marjanovic, Marko; Kralj, Marijeta; Grabar, Marina; Tomic, Sanja; Schmuck, Carsten published an article about the compound: Ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate hydrochloride( cas:180258-46-2,SMILESS:O=C(C1=NC(N)=CN1C)OCC.[H]Cl ).Electric Literature of C7H12ClN3O2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:180258-46-2) through the article.

Two novel guanidiniocarbonyl pyrrole-pyrene conjugates III and IV as spectroscopic probes for ds-polynucleotides were synthesized and their interaction with different ds-DNAs/RNAs studied. Compared to a previously reported first set of conjugates (I and II) the significant extension and increased rigidity of the central part of the structure resulted in a switch of DNA binding mode from intercalative (previously studied derivatives I and II with a nonbinding and flexible linker) to minor groove binding of the two novel guanidiniocarbonyl-pyrrole-pyrene conjugates III and IV. These two compounds interact strongly with ds-DNAs, but only weakly with ds-RNA. The newly incorporated heterocyclic moieties within the central part of the structure of III and IV were able to control by steric and hydrogen-bonding effects the alignment of the mols. within various, structurally different forms of DNA minor grooves, whereby even small differences in the position of the attached pyrene within the groove were reflected in different fluorimetric responses. In addition, III and IV revealed intriguing in vitro selectivity among various human tumor cell lines.

Although many compounds look similar to this compound(180258-46-2)Electric Literature of C7H12ClN3O2, numerous studies have shown that this compound(SMILES:O=C(C1=NC(N)=CN1C)OCC.[H]Cl), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Solution-Phase Synthesis of Pyrrole-Imidazole Polyamides, published in 2009-05-27, which mentions a compound: 180258-46-2, mainly applied to pyrrole imidazole polyamide oligomeric solution phase synthesis, Recommanded Product: 180258-46-2.

A solution-phase alternative to typical solid-phase synthesis of pyrrole-imidazole polyamides, which are DNA-binding mols. programmable for a large repertoire of DNA sequences, is reported. An 8-ring hairpin polyamide, which targets the DNA sequence 5′-WGWWCW-3′, was chosen for this synthesis as this oligomer exhibits androgen receptor antagonism in cell culture models of prostate cancer. A convergent solution-phase synthesis of this polyamide from a small set of com. available building blocks presented highlights principles for preparing gram quantities of pyrrole-imidazole oligomers with minimal chromatog.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Chenoweth, David M.; Harki, Daniel A.; Dervan, Peter B. published the article 《Solution-Phase Synthesis of Pyrrole-Imidazole Polyamides》. Keywords: pyrrole imidazole polyamide oligomeric solution phase synthesis.They researched the compound: Ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate hydrochloride( cas:180258-46-2 ).Synthetic Route of C7H12ClN3O2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:180258-46-2) here.

A solution-phase alternative to typical solid-phase synthesis of pyrrole-imidazole polyamides, which are DNA-binding mols. programmable for a large repertoire of DNA sequences, is reported. An 8-ring hairpin polyamide, which targets the DNA sequence 5′-WGWWCW-3′, was chosen for this synthesis as this oligomer exhibits androgen receptor antagonism in cell culture models of prostate cancer. A convergent solution-phase synthesis of this polyamide from a small set of com. available building blocks presented highlights principles for preparing gram quantities of pyrrole-imidazole oligomers with minimal chromatog.

Although many compounds look similar to this compound(180258-46-2)Synthetic Route of C7H12ClN3O2, numerous studies have shown that this compound(SMILES:O=C(C1=NC(N)=CN1C)OCC.[H]Cl), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (S)-4-Benzyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole, is researched, Molecular C19H16N2O, CAS is 2058236-52-3, about Enantioselective Construction of α-Chiral Silanes by Nickel-Catalyzed C(sp3)-C(sp3) Cross-Coupling, the main research direction is alpha silylated alkyl iodide cross coupling alkylzinc reagent; enantioselective alpha chiral silane preparation nickel catalyzed coupling; nickel benzyl Pybox catalyzed enantioselective coupling alpha silylated iodoalkane; cross-coupling; nickel; radical reactions; silicon; synthetic methods.Related Products of 2058236-52-3.

An enantioselective C(sp3)-C(sp3) cross-coupling of racemic α-silylated alkyl iodides and alkylzinc reagents is reported. The reaction is catalyzed by NiCl2/(S,S)-Bn-Pybox and yields α-chiral silanes with high enantiocontrol. The catalyst system does not promote the cross-coupling of the corresponding carbon analog, corroborating the stabilizing effect of the silyl group on the alkyl radical intermediate (α-silicon effect). Both coupling partners can be, but do not need to be, functionalized, and hence, even α-chiral silanes with no functional group in direct proximity of the asym. substituted carbon atom become accessible. This distinguishes the new method from established approaches for the synthesis of α-chiral silanes.

In some applications, this compound(2058236-52-3)Related Products of 2058236-52-3 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Chenoweth, David M.; Harki, Daniel A.; Dervan, Peter B. published an article about the compound: Ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate hydrochloride( cas:180258-46-2,SMILESS:O=C(C1=NC(N)=CN1C)OCC.[H]Cl ).Recommanded Product: 180258-46-2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:180258-46-2) through the article.

A solution-phase alternative to typical solid-phase synthesis of pyrrole-imidazole polyamides, which are DNA-binding mols. programmable for a large repertoire of DNA sequences, is reported. An 8-ring hairpin polyamide, which targets the DNA sequence 5′-WGWWCW-3′, was chosen for this synthesis as this oligomer exhibits androgen receptor antagonism in cell culture models of prostate cancer. A convergent solution-phase synthesis of this polyamide from a small set of com. available building blocks presented highlights principles for preparing gram quantities of pyrrole-imidazole oligomers with minimal chromatog.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography, published in 2008-09-02, which mentions a compound: 180258-46-2, Name is Ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate hydrochloride, Molecular C7H12ClN3O2, SDS of cas: 180258-46-2.

The biodistribution profiles in mice of two pyrrole-imidazole polyamides were determined by PET. Pyrrole-imidazole polyamides are a class of small mols. that can be programmed to bind a broad repertoire of DNA sequences, disrupt transcription factor-DNA interfaces, and modulate gene expression pathways in cell culture experiments The 18F-radiolabeled polyamides were prepared by oxime ligation between 4-[18F]-fluorobenzaldehyde and a hydroxylamine moiety at the polyamide C terminus. Small animal PET imaging of radiolabeled polyamides administered to mice revealed distinct differences in the biodistribution of a 5-ring β-linked polyamide vs. an 8-ring hairpin, which exhibited better overall bioavailability. In vivo imaging of pyrrole-imidazole polyamides by PET is a min. first step toward the translation of polyamide-based gene regulation from cell culture to small animal studies.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 2058236-52-3, is researched, Molecular C19H16N2O, about Enantioselective Palladium-Catalyzed Oxidative Cascade Cyclization of Aliphatic Alkenyl Amides, the main research direction is acrylamide heterocyclization stereoselective catalyst palladium pyrox preparation pyrrolizidinone; crystal structure pyrrolizidinone preparation stereoselective heterocyclization acrylamide transition state; mol structure pyrrolizidinone preparation stereoselective heterocyclization acrylamide transition state.Application of 2058236-52-3.

The catalyst system of Pd(TFA)2/(S,S)-diPh-pyrox is reported to promote the highly efficient enantioselective oxidative cascade cyclization of alkene-tethered aliphatic acrylamides under mild aerobic conditions. Pyrrolizidine derivatives were synthesized in good yield and excellent enantioselectivity. D-labeling experiments revealed that the reaction proceeded through an anti-aminopalladation (anti-AP) pathway with high selectivity. The transition states for the anti-AP step account for the observed enantioselectivity.

In addition to the literature in the link below, there is a lot of literature about this compound((S)-4-Benzyl-2-(isoquinolin-1-yl)-4,5-dihydrooxazole)Application of 2058236-52-3, illustrating the importance and wide applicability of this compound(2058236-52-3).

Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Formula: C7H12ClN3O2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate hydrochloride, is researched, Molecular C7H12ClN3O2, CAS is 180258-46-2, about Solid Phase Synthesis of Polyamides Containing Imidazole and Pyrrole Amino Acids. Author is Baird, Eldon E.; Dervan, Peter B..

The solid phase synthesis of sequence specific DNA binding polyamides containing N-methylimidazole (Im) and N-methylpyrrole (Py) amino acids is described. Two monomer building blocks, Boc-Py-OBt ester and Boc-Im acid, are prepared on a 50 g scale without column chromatog. Using com. available Boc-β-alanine-Pam resin, cycling protocols were optimized to afford high stepwise coupling yields (>99%). Deprotection by aminolysis affords up to 100 mg quantities of polyamide. Solid phase methodol. increases both the number and complexity of minor groove binding polyamides which can be synthesized and analyzed with regard to DNA binding affinity and sequence specificity. The solid phase synthesis of a representative eight-residue polyamide is reported.

In addition to the literature in the link below, there is a lot of literature about this compound(Ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate hydrochloride)Formula: C7H12ClN3O2, illustrating the importance and wide applicability of this compound(180258-46-2).

Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com