Tag: M.W=200-250

Sheka, I. A. published the artcileThe dielectric properties of the iodine halide complexes with some organic compounds, Synthetic Route of 6443-90-9, the publication is Zhurnal Fizicheskoi Khimii (1956), 109-16, database is CAplus.

The dielec. properties of ICl systems with dioxane, pyridine, and quinoline, and of IBr with dioxane, CHCl₃, and CCl₄ as solvents were investigated. The maximum deviations of the dielec. constants and polarization from the calculated values corresponds to the formation of definite complex compounds in solution In the ICl-C₅H₅N and ICl-quinoline systems in CHCl₃, solution, the maximum deviations of ΔAP and Δε are very sharp, and their values exceed by many times the deviations in the systems of IBr and ICl with dioxane and CCl₄. A comparison of the values of the polarization deviations and the instability constants of C₄H₈O₂.ICl and C₄H₈O₂. IBr shows that the systems formed in ICI and IBr by dioxane must be considered irrational, while ICl forms with pyridine and quinoline rational systems. With ICl quinoline forms 2 compounds: C₉H₇N.ICl and C₉H₇N.2ICl; the second is more stable in CHCl₄ solution than is the analogous compound with pyridine.

Zhurnal Fizicheskoi Khimii published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5NO3S, Synthetic Route of 6443-90-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Watari, Fumio published the artcileFar infrared spectra of pyridine-iodine monochloride and pyridine-iodine monobromide complexes, Application of Pyridine Iodochloride complex, the publication is Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (1967), 23(6), 1917-21, database is CAplus.

The far ir spectra of pyridine-iodine monochloride (I) and pyridine-iodine monobromide (II) complexes have been measured in the region from 500 to 80 cm.-1 in paraffin mulls. Three absorption bands were observed and assigned as I: ν16b (pyridine) = 425, νICl = 265, νNI = 170 cm.-1; II, ν16b(pyridine) = 421, νIBr = 200, and νNI = 160 cm.-1 Under assumptions of a linear triat. model and fNI,ICl = fNI,IBr, the force constants were calculated: fICl = 1.18 (estimated by the Badger rule), fIBr = 1.05, fNI(Cl) = 0.91, fNI(Br) = 0.85, and fNI,ICl = fNI,IBr = 0.22 (millidyne)/A.). The force constant of the interhalogen vibration, fIX, is one half of that of the free mol. The interaction constant is larger than that of a usual mol., which will be characteristic of the mol. complex. 16 references.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C8H14O4, Application of Pyridine Iodochloride complex.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhou, Fang published the artcileCatalytic Asymmetric Hydroalkylation of α,β-Unsaturated Amides Enabled by Regio-Reversed and Enantiodifferentiating syn-Hydronickellation, Formula: C6H13I, the publication is ACS Catalysis (2021), 11(14), 8766-8773, database is CAplus.

Here, an enantioselective nickel-hydride catalyzed hydroalkylation of readily accessible β-alkyl-α,β-unsaturated amides to form structurally diverse β-chiral amides e.g., I was reported. This process was proposed to proceed through an enantiodifferentiating syn-hydrometalation of nickel hydride, forming chiral alkylnickel at β-position in which regioselectivity is different than that with copper hydride. This regio-reversed hydronickellation process provided a complementary approach to access enantioenriched β-functionalization amides with a stereocenter at β-position.

ACS Catalysis published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C5H5F3O2, Formula: C6H13I.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Hassel, O. published the artcileStructures of electron-transfer and related molecular complexes in the solid state, SDS of cas: 6443-90-9, the publication is Molecular Physics (1958), 241-6, database is CAplus.

Results obtained in recent years from x-ray investigations of solid addition compounds thought to be formed by electron transfer between mols. containing closed shells are discussed. (1) Addition compounds of ethers (or thioethers) and halogen (X): The arrangement O-X-X (or with S) as well as O-X-X-O (dioxane) is linear. In cases of combinations of 2 different halogens the stronger bond is linked to the donor atom, e.g. RO-I-Cl. This is corroborated by the altered bond distances. (2) Pyridine and ICl (1:1): The whole complex is definitely planar, the bond distances being 2.30 and 2.54 A. for N-I and I-Cl bonds, resp. (3) Hexamethylenetetramine and Br (1:2): Both N-Br-Br are linear, one N-Br and the three C-N bonds forming a nearly regular tetrahedron. Exactly the same configuration is established for Me₃N-XY. For X,Y = I the distances for I-I and N-I, resp., 2.85 and 2.27 A. are obtained; if X = I, Y = Cl, the values are 2.53 and 2.30 A. for I-Cl and N-I, resp. These results invalidate Hantsch’s concept of solid addition compounds of the type (R₃NX)⁺Y^–. The assumption that the direct reaction products obtained from amines and halogens may without risk be recrystallized from nonaqueous solvents is also fallacious. As regards the structure of charge-transfer complexes, the space group (C 2/m) is determined as the most likely one for C₆H₆.Br₂. The crystal is built of chains consisting of alternating C₆H₆ and Br₂ mols. with the Br atoms symmetrically located about the common major axis of 2 neighboring C₆H₆ rings. The Br-Br distance differs little from the one in the isolated mol. The distance Br → center of nearest ring amounts to 3.36 A. Crystal structures of addition compounds between ethers and mols. containing active H are also being studied. There exists a bond between O of Et₂O and C of CHCl₂Br, the O-H-C separation being 3.1 A. It is certain that the 1:1 compound of dioxane and H₂SO₄ is built of chains, alternating in the components, with both H atoms of the acid taking part in H-bonding with the O atoms of the ether. The O-H-O bond appears to be of normal length. The surprisingly short N-X distances indicate a bond not essentially weaker than ordinary covalent bonds, whereas the lengthening of the adjacent X-X distances in comparison to X₂ purports weakening. As both X atoms are linked to the O atoms of dioxane in the crystalline addition compounds, there is strong indication that the second X in 1:1 complexes, evidently present in liquid mixtures, is essentially not altered by bond formation between O and the first X. It is, therefore, suggested that the X, which is directly bound to the donor, forms a 10-electron system, whereas the second X retains its original octet. In this case a linear arrangement would be expected (viz. I₃^–), as is found. In regard to the probable structure of addition complexes in liquid mixtures it is believed that the amine-X₂ and ether-X₂ complexes exhibit the linear arrangement. The keto-halogen structures (1:1) in the solid state are predicted to be chains, each keto O being linked to 2 independent X atoms; in this case an angle of about 110° is to be expected between 2 linear O-X-X-O arrangements meeting in the keto O.

Molecular Physics published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, SDS of cas: 6443-90-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Hassel, Odd published the artcileWeak intermolecular bonds in solids, Name: Pyridine Iodochloride complex, the publication is Dansk Tidsskrift for Farmaci (1962), 41-54, database is CAplus and MEDLINE.

A brief review of studies on charge-transfer bonds in complex compounds between halides (electron acceptors) and mols. containing O, N, and S, or the π-electrons of aromatic hydrocarbons, as electron donors. Electron-d. projections are given for pyridine-2I₂, pyridine-ICl, 2 acetonitrile-Br₂, CHI₃-3-quinoline, CHI₃-3S₈; the complexes 1,4-dioxane-halogen, acetone-Br₂ (1:1), hexamethylenetetramine-2Br₂, halogen-benzene, SbI₃-3S₈, oxalyl chloride (or bromide)-1,4-dioxane, and CHI₃-dithiane are discussed. Charge-transfer bonds were also found in crystals of cyanuric halides and oxalyl bromide, where an electron donor and acceptor are present.

Dansk Tidsskrift for Farmaci published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, Name: Pyridine Iodochloride complex.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Hofmann, Thomas published the artcileIdentification of Novel Colored Compounds Containing Pyrrole and Pyrrolinone Structures Formed by Maillard Reactions of Pentoses and Primary Amino Acids, Recommanded Product: Ethyl 2-Iodopropionate, the publication is Journal of Agricultural and Food Chemistry (1998), 46(10), 3902-3911, database is CAplus.

Heating of pentoses with alanine in a ratio of 10:1 in aqueous solution at pH 7.0 generated the yellow 2-[(2-furyl)methylidene]-4-hydroxy-5-methyl-2H-furan-3-one, being well in line with data reported in the literature. Decreasing the relative concentrations of the pentose produced further colored nitrogen-containing compounds, among which (S)-4-hydroxy-5-methyl-2-[N-(1′-carboxyethyl)pyrrolyl-2-methylidene]-2H-furan-3-one could be identified by spectroscopic and synthetic experiments On the other hand, thermal treatment of an aqueous solution of pentose and L-alanine in the presence of furan-2-carboxaldehyde led to the formation of the novel red (2R)-4-oxo-3,5-bis[(2-furyl)methylidene]tetrahydropyrrolo[1,2-c]-5(S)-(2-furyl)oxazolidine and its 5(R)-(2-furyl)oxazolidine diastereomer, which were characterized by several 1D- and 2D-NMR techniques, LC/MS, and UV-vis spectroscopy as well as by synthesis of the chromophoric substructure. In addition, the red compounds (S)-4-[(E)-1-formyl-2-(2-furyl)ethenyl]-5-(2-furyl)-2-[(E)-(2-furyl)methylidene]-2,3-dihydro-α-amino-3-oxo-1H-pyrrole-1-acetic acid and the corresponding 2-[(Z)-(2-furyl)methylidene] isomer were identified in this Maillard mixture Quant. studies on the formation of these colorants clearly demonstrates the key role of 3-deoxypentos-2-ulose as an intermediate. Reaction pathways leading to the colorants from pentoses and alanine are discussed.

Journal of Agricultural and Food Chemistry published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Recommanded Product: Ethyl 2-Iodopropionate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhou, Yu published the artcileGold(I)-Catalyzed One-Pot Tandem Coupling/Cyclization: An Efficient Synthesis of Pyrrolo-/Pyrido[2,1-b]benzo[d][1,3]oxazin-1-ones, Name: (2-Amino-5-iodophenyl)methanol, the publication is Advanced Synthesis & Catalysis (2010), 352(2+3), 373-378, database is CAplus.

A highly efficient method has been developed for the one-pot synthesis of multiring heterocyclic compounds, e.g. I (R¹ = H, Ph, etc.; R² = H, Me; R³ = H, n-C₆H₁₃) and II (R⁴ = H, Cl, Ph, etc.) via a gold(I)-catalyzed tandem coupling/cyclization reaction of o-aminobenzyl alcs. with HCCCH₂CH(R³)CO₂H and HCC(CH₂)₃CO₂H, resp. The strategy presents a straightforward and efficient approach to construct novel tricyclic or polycyclic mol. architectures in which two new C-N bonds and one C-O bond are formed in a one-pot reaction operation from two simple starting materials. Moreover, a broad spectrum of substrates can participate in the process effectively to produce the desired products in good yields.

Advanced Synthesis & Catalysis published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C3H3Br2ClO, Name: (2-Amino-5-iodophenyl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Shan published the artcileEnantioselective access to chiral aliphatic amines and alcohols via Ni-catalyzed hydroalkylations, Quality Control of 638-45-9, the publication is Nature Communications (2021), 12(1), 2771, database is CAplus and MEDLINE.

A nickel-catalyzed enantioselective hydroalkylation of acyl enamines R¹C(O)N(R²)CH=CH₂ (R¹ = C₆H₅, 1-naphthyl, 2-furyl, etc.; R² = H, Me) and enol esters R³C(O)OCH=CH₂R⁴ (R³ = C₆H₅, 4-CH₃OC₆H₄, 2-naphthyl; R⁴ = H, C₄H₉, C₆H₁₃, (CH₂)₄Cl) with alkyl halides R⁵I [R⁵ = 2-phenylethyl, 3-(thiophen-2-yl)propyl, 3-(9H-carbazol-9-yl)propyl, etc.] to afford enantioenriched α-branched aliphatic acyl amines (R)-R¹C(O)N(R²)CH(R⁵)Me and esters R³C(O)OCH(R⁵)CH₂R⁴ in good yields with excellent levels of enantioselectivity has been described. The operationally simple protocol provides a straightforward access to chiral secondary alkyl-substituted amine and secondary alkyl-substituted alc. derivatives from simple starting materials with great functional group tolerance.

Nature Communications published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C17H16O2, Quality Control of 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Song, Di published the artcileAcridinium-conjugated aromatic heterocycles as highly potent FtsZ inhibitors: Design, synthesis, and biological evaluation, Application In Synthesis of 638-45-9, the publication is Archiv der Pharmazie (Weinheim, Germany) (2022), 355(6), 2100400, database is CAplus and MEDLINE.

The epidemic of multidrug resistance (MDR) is a serious threat to public health, and new classes of antibiotics with novel mechanisms of action are in critical need. We rationally designed and efficiently synthesized three series of new chem. entities with potential antibacterial activity targeting filamenting temperature-sensitive mutant Z (FtsZ). Evaluation of these compounds against a panel of Gram-pos. bacteria including MDR and vancomycin-resistant Enterococcus strains indicated that most compounds showed enhanced antibacterial efficacy, comparable or even superior to the reference drugs. The newly synthesized compounds proved to be substrates of the Escherichia coli efflux pump AcrB, thus affecting the activity. Their structure-activity relationships were summarized in detail. The most potent compound 10f quickly eliminated bacteria in a bactericidal mode, with low susceptibility to induce bacterial resistance. Further mechanistic studies with the BsFtsZ protein revealed that 10f functioned as an effective FtsZ inhibitor through altering the dynamics of FtsZ self-polymerization via a stimulatory mechanism, which leads to inhibition of cell division and cell death. Besides, 10f not only displayed no obvious cytotoxicity to mammalian cells but also had a high efficacy in a murine model of bacteremia in vivo. Regarded as a whole, our findings highlight 10f as a promising new FtsZ-targeting bactericidal agent.

Archiv der Pharmazie (Weinheim, Germany) published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C5H10O2S, Application In Synthesis of 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Ling published the artcilePreparation and Application of α-Imino Ketones through One-Pot Tandem Reactions Based on Heyns Rearrangement, Quality Control of 53279-83-7, the publication is Organic Letters (2021), 23(17), 6819-6824, database is CAplus and MEDLINE.

A metal-free and operationally simple strategy was developed to generate α-imino ketones with high regioselectivity. Meanwhile, the method allowed for the preparation of various N,O-ketals with high regioselectivities and diastereoselectivities through cascade reactions in one pot.

Organic Letters published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C7H8INO, Quality Control of 53279-83-7.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com