Tag: M.W=200-250

Sil, Diptesh published the artcileSelf-Assembled Alkylated Polyamine Analogs as Supramolecular Anticancer Agents, SDS of cas: 638-45-9, the publication is Molecules (2022), 27(8), 2441, database is CAplus and MEDLINE.

Conformationally restrained polyamine analog PG11047 is a well-known drug candidate that modulates polyamine metabolism and inhibits cancer cell growth in a broad spectrum of cancers. Here, we report a structure-activity relationship study of the PG11047 analogs (HPGs) containing alkyl chains of varying length, while keeping the unsaturated spermine backbone unchanged. Synthesis of higher sym. homologues was achieved through a synthetic route with fewer steps than the previous route to PG11047. The amphiphilic HPG analogs underwent self-assembly and formed spherically shaped nanoparticles whose size increased with the hydrophobic alkyl group′s increasing chain length. Assessment of the in vitro anticancer activity showed more than an eight-fold increase in the cancer cell inhibition activity of the analogs with longer alkyl chains compared to PG11047 in human colon cancer cell line HCT116, and a more than ten-fold increase in human lung cancer cell line A549. Evaluation of the inhibition of spermine oxidase (SMOX) showed no activity for PG11047, but activity was observed for its higher sym. homologues. Comparison with a reference SMOX inhibitor MDL72527 showed nine-fold better activity for the best performing HPG analog.

Molecules published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C15H15OP, SDS of cas: 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lee, Geonho published the artcileSynthesis and Characterization of Diketopyrrolopyrrole-Based Aggregation-Induced Emission Nanoparticles for Bioimaging, Recommanded Product: 1-Iodohexane, the publication is Molecules (2022), 27(9), 2984, database is CAplus and MEDLINE.

Conventional fluorescent dyes have the property of decreasing fluorescence due to aggregation-caused quenching effects at high concentrations, whereas aggregation-induced emission dyes have the property of increasing fluorescence as they aggregate with each other. In this study, diketopyrrolopyrrole-based long-wavelength aggregation-induced emission dyes were used to prepare biocompatible nanoparticles suitable for bioimaging. Aggregation-induced emission nanoparticles with the best morphol. and photoluminescence intensity were obtained through a fast, simple preparation method using an ultrasonicator. The optimally prepared nanoparticles from 3,6-bis(4-((E)-4-(bis(40-(1,2,2-triphenylvinyl)-[1,10-biphenyl]-4-yl)amino)styryl)phenyl)-2,5-dihexyl-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione (DP-R2) with two functional groups having aggregation-induced emission properties and addnl. donating groups at the end of the triphenylamine groups were considered to have the greatest potential as a fluorescent probe for bioimaging. Furthermore, it was found that the tendency for aggregation-induced emission, which was apparent for the dye itself, became much more marked after the dyes were incorporated within nanoparticles. While the photoluminescence intensities of the dyes were observed to decrease rapidly over time, the prepared nanoparticles encapsulated within the biocompatible polymers maintained their initial optical properties very well. Lastly, when the cell viability test was conducted, excellent biocompatibility was demonstrated for each of the prepared nanoparticles.

Molecules published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Recommanded Product: 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Baciocchi, Enrico published the artcileHomolytic substitution reactions of electron-rich pentatomic heteroaromatics by electrophilic carbon-centered radicals. Synthesis of α-heteroarylacetic acids, Application of Ethyl 2-Iodopropionate, the publication is Journal of Organic Chemistry (1992), 57(25), 6817-20, database is CAplus.

Efficient and selective homolytic substitutions (55-90% yields) of pyrrole, indole, and some pyrrole derivatives have been carried out using ambiphilic and electrophilic carbon centered radicals, generated in DMSO by Fe²⁺/H₂O₂ and α-cyano-, α-carbonyl-, and α,α’-dicarbonylalkyl iodides. The reaction is highly successful with pyrroles substituted by electron-withdrawing groups, which allowed an efficient synthesis of Tolmetin. A few extensions of this reaction to furan and thiophene are described. Thus, homolytic substitution of pyrrole with ICHRR¹ (R = H, R¹ = CO₂Me, cyano; R = R¹ = CO₂Me) gave 2-substituted pyrroles I.

Journal of Organic Chemistry published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Application of Ethyl 2-Iodopropionate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Baciocchi, Enrico published the artcileHomolytic aromatic substitutions of pentatomic heteroaromatics with electrophilic carbon radicals generated by alkyl halides and triethylborane, Name: Ethyl 2-Iodopropionate, the publication is Tetrahedron Letters (1993), 34(31), 5015-18, database is CAplus.

An efficient homolytic aromatic substitution of pyrroles, furan, and thiophene by ^{â€?/sup>CH₂CO₂Et and â€?/sup>CH(CH₃)CO₂Et has been carried out, the radicals being generated by autoxidation of BEt₃ in the presence of XCH₂CO₂Et and XCH(CH₃)CO₂Et (X = Br, I). Thus, homolytic aromatic substitution reaction of pyrrole with BrCH₂CO₂Et in the presence of BEt₃ in C₆H₆ or DMSO and hexane gave 47% substituted pyrrole I.}

Tetrahedron Letters published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Name: Ethyl 2-Iodopropionate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Baciocchi, Enrico published the artcileSynthesis of γ-haloesters and γ-ketoesters by homolytic addition of carbon radicals generated by α-haloesters and triethylborane to alkenes and silyl enol ethers, HPLC of Formula: 31253-08-4, the publication is Tetrahedron Letters (1994), 35(17), 2763-6, database is CAplus.

γ-Haloesters are efficiently prepared under very mild conditions by addition of electrophilic carbon radicals ·CH(R)CO₂Et (R=H, Me, CO₂Et) generated by XCH(R)CO₂Et (X=Br, iodo)/BEt₃/air in DMSO to alkenes and cycloalkenes. Thus, stirring ICH₂CO₂Et with 1-decene in DMSO in air gave 90% Me(CH₂)₇CHICH₂CH₂CO₂Et. γ-Ketoesters are obtained when silyl enol ethers are used as the substrates.

Tetrahedron Letters published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, HPLC of Formula: 31253-08-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Fialkov, Ya. A. published the artcilePhysicochemical investigation of the system iodine chloride-pyridine, Safety of Pyridine Iodochloride complex, the publication is Zhurnal Obshchei Khimii (1948), 1205-14, database is CAplus.

The elec. conductivity-concentration curves at both 35 and 50° showed maximum at about 8 mol.% pyridine. At 35° they rose from 4.82 × 10^-3 ohm^-1 for pure ICl to a maximum of 21.39 × 10^-3, and then dropped to 3.37 × 10^-3 ohm^-1 at 34.65 mol.% pyridine. Thermal analysis revealed 2 compounds in the system, having formulas C₅H₅N.ICl and C₅H₅N.2ICl and m.ps. of 128.50 and 35.10°, resp. There are 3 eutectics with concentrations (in mol.% pyridine) and temperatures, resp., of 20.73, -6.30°; 35.11, 23.60°; and 98.90, -50.20°. Electrolysis studies indicated that the following reactions occur: C₅H₅N + ICl = (C₅H₅-N.I)⁺ + Cl^–. During electrolysis the reactions at the electrodes are: 2 (C₅H₅N.I)⁺ + 2e = 2C₅H₅N + I₂, and 2Cl^– = Cl₂ + 2e.

Zhurnal Obshchei Khimii published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, Safety of Pyridine Iodochloride complex.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Jha, Amitabh published the artcileTransition metal-free one-pot cascade synthesis of 7-oxa-2-azatricyclo[7.4.0.0^2,6]trideca-1(9),10,12-trien-3-ones from biomass-derived levulinic acid under mild conditions, Recommanded Product: (2-Amino-5-iodophenyl)methanol, the publication is Organic & Biomolecular Chemistry (2013), 11(43), 7559-7565, database is CAplus and MEDLINE.

An efficient, environmentally benign, transition-metal free, tandem C-N, C-O bond formation reaction is developed for the synthesis of tricyclic 7-oxa-2-azatricyclo[7.4.0.0^2,6]trideca-1(9),10,12-trien-3-ones and their homologs from easily available starting materials, including renewable levulinic acid, a keto acid. The reaction of keto acids with Me chloroformate and variously substituted o-aminobenzyl alcs. using triethylamine as a base in toluene at room temperature gave good to excellent yields. This newly developed protocol was successfully utilized for the synthesis of a variety of polycyclic 7-oxa-2-azatricyclo[7.4.0.0^2,6]trideca-1(9),10,12-trien-3-ones and related compounds

Organic & Biomolecular Chemistry published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C7H8INO, Recommanded Product: (2-Amino-5-iodophenyl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Watanabe, Masaki published the artcileIncreased Molecular Flexibility Widens the Gap between K_i and K_d values in Screening for Retinoid X Receptor Modulators, Quality Control of 638-45-9, the publication is ACS Medicinal Chemistry Letters (2022), 13(2), 211-217, database is CAplus and MEDLINE.

Screening for small-mol. modulators targeting a particular receptor is frequently based on measurement of K_d, i.e., the binding constant between the receptor and the compound of interest. However, K_d values also reflect binding at receptor protein sites other than the modulatory site. We designed derivatives of retinoid X receptor (RXR) antagonist CBTF-EE (I) with modifications that altered their conformational flexibility. Compounds 6a,b and 7a,b showed quite similar K_d values, but 7a,b exhibited 10-fold higher K_i values than those of 6a,b. Further, 6a,b showed potent RXR-antagonistic activity, while 7a,b were inactive. These results suggest that increased conformational flexibility promotes binding at nontarget receptor sites. In this situation, conventional determination of K_d is less effective for screening purposes than the determination of K_i using a ligand that binds specifically to the site regulating transcriptional activity. Thus, the use of K_i values for orthosteric ligands may increase the hit rate in screening active regulatory mols.

ACS Medicinal Chemistry Letters published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C19H18O2, Quality Control of 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

de Souza, Carlos A. published the artcileScope and mechanism of the electrochemical Reformatskii reaction of α-haloesters on a graphite powder cathode in aqueous anolyte, Quality Control of 31253-08-4, the publication is Electrochimica Acta (2014), 118-126, database is CAplus.

Six α-haloesters and eighteen carbonyl compounds were submitted to electrochem. coupling on a graphite powder cathode using aqueous anolyte free of organic solvents. Preparative yields of coupling products could be obtained with Et 2-bromoisobutyrate and aromatic aldehydes. Et 2-bromopropionate was much less efficient. Extensive variation of applied potential, electrolyte composition, stoichiometry, catalyst, leaving halogen and activating substituents on the carbonyl compound indicated that the reaction mechanism in most cases proceeds via a radical intermediate generated from the halide reduction Et chloroacetate produced only trace amounts of coupling product, most probably by a carbanionic mechanism.

Electrochimica Acta published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Quality Control of 31253-08-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Suryawanshi, S. N. published the artcileFacile ω-bromination(iodination) of longifolene with bromine-pyridine(iodine) monochloride-pyridine complex, Related Products of iodides-buliding-blocks, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1979), 17B(3), 304-5, database is CAplus.

Bromination of longifolene (I, R = H) with pyridine perbromide at 0-5° gave 98% pure I (R = Br), whereas iodination of longifolene with ICl-pyridine complex in AcOH gave 90% I (R = I). However, halogenation of camphene with Br₂ or ICl or their complexes with pyridine was non-specific and gave a mixture of products.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C4H10Br2CoO2, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com