Tag: M.W=200-250

Popov, Alexander I. published the artcileStudies on the chemistry of halogens and polyhalides. X. The reactions of iodine monochloride with pyridine and 2,2′-bipyridine, Application of Pyridine Iodochloride complex, the publication is Journal of the American Chemical Society (1957), 570-2, database is CAplus.

cf. C.A. 51, 4191i. The preparation and isolation of addition compounds of pyridine and of 2,2′-bipyridine (bp) and ICl and with HICl₂ is described. Absorption spectra of these compounds in acetonitrile solutions were determined Complexes of both 2,2′-bipyridine and the pyridine with ICl dissociate according to bpI.2ICl â‡?bpI⁺ + ICl₂^– and 2pyICl â‡?py₂I⁺ + ICl₂^–. 15 references.

Journal of the American Chemical Society published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, Application of Pyridine Iodochloride complex.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Kusche, Brian R. published the artcileNonactin biosynthesis: Setting limits on what can be achieved with precursor-directed biosynthesis, Product Details of C5H9IO2, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(4), 1233-1235, database is CAplus and MEDLINE.

Nonactin, produced by Streptomyces griseus ETH A7796, is a macrotetrolide assembled from nonactic acid. It is an effective inhibitor of drug efflux in multidrug resistant erythroleukemia K562 cells at sub-toxic concentrations and has been shown to possess both antibacterial and antitumor activity. As total synthesis is impractical for the generation of nonactin analogs the authors have studied precursor-directed biosynthesis as an alternative as it is known that nonactic acid can serve as a nonactin precursor in vivo. To determine the scope of the approach the authors prepared and evaluated a furan-based nonactic acid derivative, (I). Although no new nonactin analogs were detected when (I) was administered to S. griseus fermentative cultures, a significant inhibition of nonactin biosynthesis was noted (IC₅₀ âˆ?100 μM). Cell mass, nonactic acid production and the generation of other secondary metabolites in the culture were unaffected by (I) demonstrating that (I) selectively inhibited the assembly of nonactin from nonactic acid. While the authors were unable to generate new nonactin analogs the authors have discovered, however, a useful inhibitor that can be used to probe the mechanism of nonactin assembly with the ultimate goal of developing more successful precursor-directed biosynthesis transformations.

Bioorganic & Medicinal Chemistry Letters published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Product Details of C5H9IO2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Jones, Andrew C. published the artcileA Ball Milling-Enabled Cross-Electrophile Coupling, Quality Control of 638-45-9, the publication is Organic Letters (2021), 23(16), 6337-6341, database is CAplus and MEDLINE.

The nickel-catalyzed cross-electrophile coupling of aryl halides and alkyl halides enabled by ball-milling is herein described. Under a mechanochem. manifold, the reductive C-C bond formation was achieved in the absence of bulk solvent and air/moisture sensitive set-ups, in reaction times of 2 h. The mech. action provided by ball milling permits the use of a range of zinc sources to turnover the nickel catalytic cycle, enabling the synthesis of 28 cross-electrophile coupled products.

Organic Letters published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Quality Control of 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Yan published the artcileCobalt-catalysed enantioselective C(sp³)-C(sp³) coupling, Application In Synthesis of 638-45-9, the publication is Nature Catalysis (2021), 4(10), 901-911, database is CAplus.

Enantioselective C(sp³)-C(sp³) coupling substantially impacts organic synthesis but remains challenging. Cobalt has played an important role in the development of homogeneous organometallic catalysis, but there are few examples of its use in asym. cross-coupling. Here, a cobalt-catalyzed enantioselective C(sp³)-C(sp³) coupling reaction, namely, alkene hydroalkylation, to access chiral fluoroalkanes was reported. This reaction represents a catalyst-controlled enantioselective coupling mode in which a tailor-made auxiliary is unnecessary; via this reaction, an aliphatic C-F stereogenic center can be introduced at the desired position in an alkyl chain.

Nature Catalysis published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Application In Synthesis of 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Khaliullin, F. A. published the artcileSynthesis and Antidepressant Activity of 4-Alkyl-5-Bromo-2,4-Dihydro-2-(Thietan-3-yl)-1,2,4-Triazol-3-Ones, Quality Control of 638-45-9, the publication is Pharmaceutical Chemistry Journal (2021), 55(2), 123-129, database is CAplus.

A series of 4-alkyl-5-bromo-2,4-dihydro-2-(thietan-3-yl)-1,2,4-triazol-3-ones I (R = Me, Bn, Et, etc.) were synthesized by reacting 5-bromo-2,4-dihydro-2-(thietan-3-yl)-1,2,4-triazol-3-one (II) with alkyl halides RX (X = I, Br) and di-Me sulfate. The antidepressant activity of the synthesized compounds I in non-inbred male mice was investigated using tail-suspension and forced-swim tests. Compounds II and I (R = Me, n-Pr, Bn, 2-bromoethyl) after a single i.p. injection produced antidepressant effects in screening tests and did not cause sedative and/or psychostimulatory effects in the open-field test. Compound II produced an antidepressant effect comparable to that of fluoxetine, had low toxicity (class IV toxicity), and was superior to fluoxetine in therapeutic index and strength of the antidepressant effect after a course of administration. The calculated physicochem. properties and toxic risks showed that all synthesized compounds I complied fully with Lipinski’s rule of five. The calculated drug score and absence of predicted toxic risks for the most active compound II suggested that it was promising for creating a new pharmaceutical substance with antidepressant activity.

Pharmaceutical Chemistry Journal published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Quality Control of 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Kischkewitz, Marvin published the artcileRadical-polar crossover reactions of vinylboron ate complexes, HPLC of Formula: 31253-08-4, the publication is Science (Washington, DC, United States) (2017), 355(6328), 936-938, database is CAplus and MEDLINE.

Vinyl boronic esters are valuable substrates for Suzuki-Miyaura cross-coupling reactions. However, boron-substituted alkenes have drawn little attention as radical acceptors, and the radical chem. of vinylboron ate complexes is underexplored. We show here that carbon radicals add efficiently to vinylboron ate complexes and that their adduct radical anions undergo radical-polar crossover: a 1,2-alkyl/aryl shift from boron to the α-carbon sp² center provides secondary or tertiary alkyl boronic esters. In contrast to the Suzuki-Miyaura coupling, a transition metal is not required, and two carbon-carbon bonds are formed. The valuable boronic ester moiety remains in the product and can be used in follow-up chem., enlarging the chem. space of the method. The cascade uses com. starting materials and provides access to perfluoroalkylated alcs., γ-lactones, γ-hydroxy alkylnitriles, and compounds bearing quaternary carbon centers.

Science (Washington, DC, United States) published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, HPLC of Formula: 31253-08-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Panchaud, Philippe published the artcileRadical Carboazidation: Expedient Assembly of the Core Structure of Various Alkaloid Families, HPLC of Formula: 31253-08-4, the publication is Journal of Organic Chemistry (2004), 69(8), 2755-2759, database is CAplus and MEDLINE.

A procedure for one-pot intermol. radical addition of 2-iodo esters to terminal alkenes followed by azidation of the radical adduct has been developed. This sequential reaction represents an alkene carboazidation process. Its efficacy is demonstrated by the two-step preparation of various lactams such as pyrrolidinones, pyrrolizidinones, and indolizidinones. An easy access to spirolactams bearing an amino-substituted quaternary carbon center is also described. These compounds are important building blocks for the synthesis of numerous alkaloids such as, for instance, FR901483.

Journal of Organic Chemistry published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, HPLC of Formula: 31253-08-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Renaud, Philippe published the artcileRadical carboazidation of alkenes: an efficient tool for the preparation of pyrrolidinone derivatives, Synthetic Route of 31253-08-4, the publication is Angewandte Chemie, International Edition (2002), 41(18), 3460-3462, database is CAplus and MEDLINE.

A one-pot intermol. radical carboazidation of alkenes is reported. The utility of the reaction is demonstrated by the development of a three-component preparation of pyrrolidinones, pyrrolizidinones, and indolizidinones starting from benzenesulfonyl azide, terminal alkenes, and 2-iodo esters.

Angewandte Chemie, International Edition published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Synthetic Route of 31253-08-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Akimoto, Gaku published the artcileDeprotonative Metalation of Methoxy-Substituted Arenes Using Lithium 2,2,6,6-Tetramethylpiperidide: Experimental and Computational Study, Application of 4-Iodo-3-methoxypyridine, the publication is Journal of Organic Chemistry (2018), 83(21), 13498-13506, database is CAplus and MEDLINE.

The reaction pathways of lithium 2,2,6,6-tetramethylpiperidide (LiTMP)-mediated deprotonative metalation of methoxy-substituted arenes were investigated. Importantly, it was exptl. observed that, whereas TMEDA has no effect on the course of the reactions, the presence of more than the stoichiometric amount of LiCl is deleterious, in particular without an in situ trap. These effects were corroborated by the DFT calculations The reaction mechanisms, such as the structure of the active species in the deprotonation event, the reaction pathways by each postulated LiTMP complex, the stabilization effects by in situ trapping using zinc species, and some kinetic interpretation, are discussed herein.

Journal of Organic Chemistry published new progress about 1331850-50-0. 1331850-50-0 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Ether,Pyridine, name is 4-Iodo-3-methoxypyridine, and the molecular formula is C6H6INO, Application of 4-Iodo-3-methoxypyridine.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Niki, Aya published the artcileConstruction of acyclic all-carbon quaternary stereocenter based on asymmetric Michael addition of chiral amine, Name: Pyridine Iodochloride complex, the publication is Chemical & Pharmaceutical Bulletin (2021), 69(9), 926-930, database is CAplus.

Acyclic asym. quaternary stereocenters, which are composed of four carbon-carbon bonds, were finely constructed by utilizing a face-selective alkylation of enolate intermediates derived from an asym. Michael addition reaction of a chiral lithium amide with trisubstituted (E)-α,β-unsaturated esters. The present face-selective alkylation was able to employ diverse alkyl halides as an electrophile to afford various Michael adducts having an all-carbon quaternary stereocenter. With regard to the deprotection of the chiral auxiliary, N-iodosuccinimide used in our previous study did not work in the present cases; however, the pyridine iodine monochloride in the presence of H₂O was found effective to remove the bornyl group and the benzyl group on the amino group to provide the β-amino ester derivative

Chemical & Pharmaceutical Bulletin published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, Name: Pyridine Iodochloride complex.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com