Tag: M.W=200-250

Dowd, Paul published the artcileA general approach to substituted itaconate esters, Application In Synthesis of 31253-08-4, the publication is Synthetic Communications (1993), 23(16), 2307-22, database is CAplus.

General approaches to the synthesis of various itaconates, including 3-substituted esters, are presented. The complementary nature of the 3 methods is also shown. Thus, alkylation of Me₂NCH₂CH₂CO₂Et by treatment with LiN(CHMe₂)₂ (LDA), then RCHXCO₂R² (e.g., R = H, R² = Et, X = Br) affords Me₂NCH₂CH(CO₂R¹)CHRCO₂R² (42-82% yield) which are then quaternized with MeI and treated with DBU to give the elimination products, itaconate diesters RCH(CO₂R²)C(:CH₂)CO₂R¹ (86-93% yield). Deprotonation of Me₂NCH₂CH(CO₂R¹)CH₂CO₂R² (e.g., R¹ = R² = Et) with LDA and subsequent alkylation with RX (e.g., MeI) affords Me₂NCH₂CH(CO₂R¹)CHRCO₂R² in 17-46% yield. Subsequent quaternization and elimination reaction of the latter afford itaconate diesters RCH(CO₂R²)C(:CH₂)CO₂R¹ in good yield. A third alternative procedure consists of deprotonation of (EtO)₂P(O)CH₂CO₂R¹ with NaH, alkylation with RCHXCO₂R² to give (EtO)₂P(O)CH(CO₂R¹)CHRCO₂R² (51-74% yield), and subsequent methylenation with HCHO to give the itaconate diesters in 55-93% yield.

Synthetic Communications published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Application In Synthesis of 31253-08-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zingaro, Ralph A. published the artcileInfrared studies of amine-halogen interactions, Application In Synthesis of 6443-90-9, the publication is Journal of Physical Chemistry (1960), 1705-11, database is CAplus.

The marked changes which are brought about in the 1000-cm.^-1 region of the infrared spectrum of pyridine on the addition of I are generally characteristic of amine-halogen solutions Infrared studies on a series of solutions of amines and halogens revealed corresponding infrared shifts. Several new solid amine-halogen complexes were isolated, and, in every case, the frequency shifts in solution were correlated with infrared bands characteristic of the solids.

Journal of Physical Chemistry published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C13H19Br2ClN2O, Application In Synthesis of 6443-90-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Rousseau, Lidie published the artcileRelevance of Single-Transmetalated Resting States in Iron-Mediated Cross-Couplings: Unexpected Role of σ-Donating Additives, Application In Synthesis of 638-45-9, the publication is Inorganic Chemistry (2021), 60(11), 7991-7997, database is CAplus and MEDLINE.

Control of the transmetalation degree of organoiron(II) species is a critical parameter in numerous Fe-catalyzed cross-couplings to ensure the success of the process. In this report, we however demonstrate that the selective formation of a monotransmetalated Fe^II species during the catalytic regime counterintuitively does not alone ensure an efficient suppression of the nucleophile homocoupling side reaction. It is conversely shown that a fine control of the transmetalation degree of the transient Fe^III intermediates obtained after the activation of alkyl electrophiles by a single-electron transfer (SET), achievable using σ-donating additives, accounts for the selectivity of the cross-coupling pathway. This report shows for the first time that both coordination spheres of Fe^II resting states and Fe^III short-lived intermediates must be efficiently tuned during the catalytic regime to ensure high coupling selectivities.

Inorganic Chemistry published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Application In Synthesis of 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Mendoza, Manuel published the artcileIndolactam dipeptides as nanomolar Gli inhibitors, Recommanded Product: 1-Iodohexane, the publication is ACS Medicinal Chemistry Letters (2022), 13(7), 1036-1042, database is CAplus and MEDLINE.

The Gli transcription factors within the Hedgehog (Hh) signaling pathway play essential roles in human development. However, the reactivation of Gli proteins in adult tissue is tumorigenic and drives the progression of several cancers, including the majority of basal cell carcinomas. Here we describe a novel set of indolactam dipeptides that target protein kinase C (PKC), exploiting the unique capacity of PKC isoenzymes to act as regulators of Gli. We devised an efficient synthetic route for the indolactam-based natural product (-)-pendolmycin and a series of analogs, and we evaluated these analogs in mechanistically distinct Gli reporter assays. The lead compound from these studies, N-hexylindolactam V (I), exhibits superior Gli suppression relative to clin. inhibitors and blocks the growth of Gli-dependent basal cell carcinoma cells. More broadly, our structure-activity studies provide inroads for the development of novel Gli antagonists and new avenues for combating Gli-driven cancers.

ACS Medicinal Chemistry Letters published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Recommanded Product: 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tornero, J. D. published the artcileMixed halide complexes of tin(IV) with pyridine, Recommanded Product: Pyridine Iodochloride complex, the publication is Anales de Quimica, Serie B: Quimica Inorganica y Quimica Analitica (1986), 82(2), 145-9, database is CAplus.

By oxidative-addition reactions of X₂ (X = Br, I) and XI.py (X = Cl, Br) to SnCl₂ in the presence of pyridine, SnCl₂X₂py₂ (X = Br, I), SnCl₃Ipy₂ and SnCl₂BrIpy₂ were obtained and studied by vibrational and ¹¹⁹Sn Moessbauer spectroscopy. A C_2v symmetry, with the ligands in trans positions, was proposed for SnCl₂Br₂py₂, whereas Moessbauer spectra of the remaining species show the presence of some impurities. A linear regression between the position of some pyridine bands in the IR spectra and the average electronegativity of halogens was observed, the υ₄ frequency being the most sensitive with respect to the metal-ligand bond strength.

Anales de Quimica, Serie B: Quimica Inorganica y Quimica Analitica published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C3H5BN2O2, Recommanded Product: Pyridine Iodochloride complex.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Kashin, A. N. published the artcileReactivity of organotin compounds. XXVII. New method for the activation of organotin compounds in electrophilic substitution reactions. Study of the reaction kinetics of α-stannylated esters with iodine in the presence of triorganoiodostannanes, Synthetic Route of 31253-08-4, the publication is Zhurnal Organicheskoi Khimii (1984), 20(8), 1611-20, database is CAplus.

The kinetics of the reactions of R₃SnCHR¹CO₂R² (R = Me, Et, Bu; R¹ = H, Me, Ph; R² = Me, Et, Me₂CH, Me₃C) with iodine in DMF containing KI was studied. The reaction is autocatalytic with formation of R₃SnI, and the final product is ICHR¹CO₂R². In the presence of excess R₃SnI the reaction is 2nd order overall, 1st order in each reactant, and its rate is not dependent on the KI and R₃SnI concentrations

Zhurnal Organicheskoi Khimii published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Synthetic Route of 31253-08-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lightfoot, Andrew P. published the artcileOn the mechanism and origin of the stereoselectivity in iodo-deboronation and chloro-deboronation of hindered alkenyl boronate esters using either ICl-NaOMe or ICl-pyridine, Product Details of C5H5ClIN, the publication is Tetrahedron Letters (2004), 45(46), 8557-8561, database is CAplus.

Conversion of hindered alkenyl boronate esters into the corresponding iodoalkene, or alkenyl chloride can be carried out stereoselectively using ICl. In the presence of NaOMe, direct reaction of ICl is favored yielding the E-iodoalkene, however, the reaction with ICl followed by NaOMe can be used to give different major alkenyl iodide and chloride products, depending upon reaction temperature, ICl source and alkenyl boronate stereoelectronics.

Tetrahedron Letters published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, Product Details of C5H5ClIN.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Verma, Supriy published the artcileDrastic influence of amide functionality and alkyl chain length dependent physical, thermal and structural properties of new pyridinium-amide cation based biodegradable room temperature ionic liquids, Product Details of C6H13I, the publication is Journal of Molecular Structure (2022), 1250(Part_1), 131679, database is CAplus.

A series of new room-temperature ionic liquids (RTILs) based on biodegradable pyridinium carboxamide cation and conformationally flexible NTf₂ anion have been synthesized. The variation of thermo-phys. properties of these RTILs with alkyl chain length size has been studied and compared with corresponding parental pyridinium NTf₂ ILs. A drastic change in thermophys. properties has been noted on the introduction of the amide functionality on pyridinium cation moiety. The crucial role of amide functionality is also important concerning biodegradability as it acts as an active site for an enzymic attack, helpful toward biodegradation Besides, the dependence of thermal and phys. properties on alkyl chain length is also noteworthy. A detailed DFT based theor. studies substantiate the exptl. observation of chain length dependence m.p. variation and successfully correlated that with stabilization energy. Conformational dynamics of NTf₂ anion (between transoid and cisoid) has been elucidated by Raman spectroscopic studies. Interestingly, the data demonstrate that the conformation of NTf₂ anion depends on the chain length of the cation, clearly indicating anionic interaction with the hydrophobic region of the cation. This information is crucial as it vindicates the fact that multiple weak interaction do exist in ILs making it a complex nanostructured system composed of ions.

Journal of Molecular Structure published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C7H6ClN3, Product Details of C6H13I.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Khansole, Sandeep V. published the artcileKinetics of iodination of aniline and substituted anilines by pyridinium iodochloride in methanol, Recommanded Product: Pyridine Iodochloride complex, the publication is Physical Chemistry: An Indian Journal (2007), 2(3), 167-170, database is CAplus.

The kinetics of iodination of the aniline and substituted anilines using pyridinium iodochloride in methanol has been studied under varying conditions. The rates shows first order kinetics each in pyridinium iodochloride and anilines. The rates of reactions are measured at different temperature and activation parameters for all amines computed. Hammett plot is found to be valid and the correlation between the enthalpies and free energies of activations is reasonably linear with an isokinetic temperature 347 K. Similarly log A values of all the amines are optimized corresponding to Ea of amines through the equation, log A = logk_obs + Ea/2.303RT.

Physical Chemistry: An Indian Journal published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, Recommanded Product: Pyridine Iodochloride complex.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Chen, Chen published the artcilePhoto-selective chain end transformation of polyacrylate-iodide using cysteamine and its application to facile single-step preparation of patterned polymer brushes, Application In Synthesis of 31253-08-4, the publication is Chemical Communications (Cambridge, United Kingdom) (2018), 54(97), 13738-13741, database is CAplus and MEDLINE.

Cysteamine, which is an inexpensive and non-toxic aminothiol, was successfully employed as a photo-selective chain end transformation agent of iodo-terminated polymer chains (polymer-I). Polymer-I was selectively transformed to hydrogen-terminated (polymer-H) and thiol-terminated (polymer-SH) polymers with and without UV irradiation, resp. This method is applicable to acrylate polymers. This photo-selective reaction offered a single-step preparation of patterned polymer brushes with SH and H chain end functionalities as a unique application.

Chemical Communications (Cambridge, United Kingdom) published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Application In Synthesis of 31253-08-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com