Tag: M.W=100-200

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 624-75-9 as follows. Safety of 2-Iodoacetonitrile

General procedure: Individual solutions of secondary N-alpha-trimethylsilylmethyl-N-benzylamines19 (5mmol) in acetonitrile (100mL) containing K2CO3 (10mmol) and 2-iodoacetonitrile (4.5mmol) were stirred for 12hat room temperature and concentrated in vacuo to give residues that were partitioned between water and CH2Cl2. The CH2Cl2 layers were dried and concentrated in vacuo to afford residues that were subjected to silica gel column chromatography (EtOAc/hexane=1: 15 – 1: 30) to yield corresponding alpha-aminonitiriles 11a18 (91%), 11b (74%), 11c (78%), 11d (85%), 11e (75%), 11f (75%), 11g (74%), 11h (75%), 11i (78%), 11j (78%) and 11k (66%).

According to the analysis of related databases, 624-75-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Lim, Suk Hyun; Cho, Dae Won; Choi, Jungkweon; An, Hyunjun; Shim, Jun Ho; Mariano, Patrick S.; Tetrahedron; vol. 73; 44; (2017); p. 6249 – 6261;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 627-32-7, name is 3-Iodo-1-propanol, A new synthetic method of this compound is introduced below., SDS of cas: 627-32-7

5 g of E-oct-4-ene-1,8-dioic acid was added to 25 mL of thionyl chloride, and the mixture was heated under reflux for 3 hours.After the reaction was cooled to room temperature, spin dry and dissolved in 50 mL of dichloromethane.Then, it was slowly added dropwise to 100 mL of tetrahydrofuran in which 33.5 g of 3-iodopropanol was dissolved at about 0 C, and the reaction was carried out at 0 C for 24 hours after completion of the dropwise addition.The reaction was completely detected by HPLC, and 50 mL of 1 M KOH was added.Sodium quenching reaction.After liquid separation, the organic phase was dried over anhydrous sodium sulfate.The compound E-oct-4-ene-1,8-dioic acid bis(3-iodopropyl) ester 12.1 g (yield 81.6%) was obtained as a pale yellow oily liquid, purity 95.3%.

The synthetic route of 627-32-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Wuhan Jianuokang Pharmaceutical Co., Ltd.; Wei Wenguo; Wang Yajun; (13 pag.)CN108503564; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 7681-82-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7681-82-5, name is Sodium iodide belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A mixture of propionic acid (10 ml), sodium iodide (3.0 g, 20 mmol) and Fe3+- montmorillonite catalyst (0.5 g) were stirred in a round-bottomed flask at 25 C for 6 h. The reaction mixture was filtered off to separate the catalyst. The resultant filtrate was titrated with 0. 1M sodium thiosulphate solution using starch as an indicator to know the amount of iodine present in the solution. The amount of iodine liberated in the reaction is 0.998 g (3.7 mmol)

The synthetic route of Sodium iodide has been constantly updated, and we look forward to future research findings.

Reference:
Patent; COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH; WO2004/50622; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 624-76-0, The chemical industry reduces the impact on the environment during synthesis 624-76-0, name is 2-Iodoethanol, I believe this compound will play a more active role in future production and life.

Method B): R-lipoyl chloride (10.0g, 44.5mmol) and tetrahydrofuran (200mL) were added to the reaction flask, stirringN, N-dimethylaniline (16.2 g, 133.5 mmol) was added to the solution. The mixture was cooled in an ice bath and 2-iodoethanol (17.6 g, 102.3 mmol)The reaction mixture was reacted at 50 C for 3h. After treatment and purification, the crude product was recrystallized from a mixed solvent of ethyl acetate and n-hexane,R-lipoic acid was 2-iodoethyl ester, light yellow solid (14.1 g), yield 88%, the reaction formula is:

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Iodoethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Suzhou Fushilai Pharmaceutical Co., Ltd.; Mo Guoning; (9 pag.)CN107089967; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 624-75-9, name is 2-Iodoacetonitrile, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 624-75-9, Quality Control of 2-Iodoacetonitrile

General procedure: Individual solutions of secondary N-alpha-trimethylsilylmethyl-N-benzylamines19 (5mmol) in acetonitrile (100mL) containing K2CO3 (10mmol) and 2-iodoacetonitrile (4.5mmol) were stirred for 12hat room temperature and concentrated in vacuo to give residues that were partitioned between water and CH2Cl2. The CH2Cl2 layers were dried and concentrated in vacuo to afford residues that were subjected to silica gel column chromatography (EtOAc/hexane=1: 15 – 1: 30) to yield corresponding alpha-aminonitiriles 11a18 (91%), 11b (74%), 11c (78%), 11d (85%), 11e (75%), 11f (75%), 11g (74%), 11h (75%), 11i (78%), 11j (78%) and 11k (66%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Lim, Suk Hyun; Cho, Dae Won; Choi, Jungkweon; An, Hyunjun; Shim, Jun Ho; Mariano, Patrick S.; Tetrahedron; vol. 73; 44; (2017); p. 6249 – 6261;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 624-76-0, The chemical industry reduces the impact on the environment during synthesis 624-76-0, name is 2-Iodoethanol, I believe this compound will play a more active role in future production and life.

To a solution of carbazole 1 (2.0 g, 11.96 mmol) in distilled DMF (20 mL) was added NaH (60% dispersion in mineral oil, 956.9 mg, 23.92 mmol) under nitrogen condition and stirred at 0 C for 30 min. To the reaction mixture was added dropwise 2-iodoethanol (4.1 g, 23.92 mmol) and stirred at 70 C for 24 h. The mixture was extracted with EtOAc and washed with water and dried over anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent, n-hexane/ EtOAc = 3:1) to afford 1.64 g (7.84 mmol , 65%) of the title compound 2.: Rf = 0.18 (n-hexane/EtOAc = 2:1); IR (neat, cm-1) 3253, 3048, 2914, 1492, 1483, 1457, 1348, 1325; 1H NMR d (400 MHz, CDCl3) d 8.07 (2H, td, J = 7.6, 1.2 Hz), 7.44-7.39 (4H, m), 7.22 (2H, td, J = 7.6, 1.2 Hz), 4.38 (2H, t, J = 5.2 Hz); 13C NMR (100 MHz, CDCl3) d 140.9, 126.0, 123.1, 120.6, 119.4, 109.0, 61.6, 45.6.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Iodoethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Jin, Guo Hua; Lee, Hwa Jin; Gim, Hyo Jin; Ryu, Jae-Ha; Jeon, Raok; Bioorganic and Medicinal Chemistry Letters; vol. 22; 9; (2012); p. 3301 – 3304;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

These common heterocyclic compound, 624-76-0, name is 2-Iodoethanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 2-Iodoethanol

To a solution of compound 3 (2.00g, 6.43mmol) in acetone (20mL) was added potassium carbonate (1.33g, 9.64mmol), 2-iodoethanol (0.60mL, 7.72mmol) and stirred overnight at room temperature. After completion of the reaction, 120 water (150mL) and ethyl acetate (150mL) were added and the mixture was extracted with ethyl acetate twice. The combined extracts were washed with water (50mL¡Á2) and brine (50mL¡Á2), and dried over Na2SO4. After filtration, the solvent was removed under vacuum to obtain the crude compound. The crude compound was then purified by column chromatography on silica (60% EA/PE) to give compound 24 4 as a yellow oil (2.10g, yield 92.0%). 1H NMR (400MHz, CDCl3) delta 7.35 (s, 5H), 5.51 – 5.47 (m, 1H), 5.30 – 5.26 (m, 1H), 5.24 – 5.12 (m, 2H), 4.60 – 4.54 (m, 1H), 3.69 – 3.63 (m, 2H), 3.02 – 2.90 (m, 2H), 2.68 – 2.64 (m, 2H), 1.43 (s, 9H). 13C NMR (150MHz, CDCl3) delta 170.96, 155.46, 135.12, 128.76, 128.72, 128.62, 80.45, 67.63, 60.76, 53.77, 53.56, 36.29, 34.91, 28.39. ESI-MS: [M+Na]+ m/z 378.2

The synthetic route of 2-Iodoethanol has been constantly updated, and we look forward to future research findings.

Reference:
Article; Du, Xinming; Qian, Jiawen; Wang, Yujie; Zhang, Mingming; Chu, Yiwei; Li, Yingxia; Bioorganic and Medicinal Chemistry; vol. 27; 13; (2019); p. 2784 – 2800;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 74-88-4, name is Iodomethane, A new synthetic method of this compound is introduced below., Application In Synthesis of Iodomethane

To a solution of 5-bromo-2-iodo-phenol (1.00 g, 3.35 mmol) in acetone (10.0 mL) was added iodomethane (951 mg, 6.70 mmol) and anhydrous potassium carbonate (926 mg, 6.70 mmol) at it. The reaction mixture was stirred at it for 12 hrs. On completion, the reaction mixture was filtered. The filtrate was concentrated in vacuo. The residue was purified by silica gel chromatography (petroleum ether) to give the title compound (1.00 g, 96% yield). MR (400MHz, CDC13) delta = 7.61 (d, J =8.4 Hz, 1H), 6.95 (d, J =1.8 Hz, 1H), 6.87 (dd, J =8.4 Hz, 1.8 Hz, 1H), 3.89 (s, 3H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; RAZE THERAPEUTICS, INC.; MAINOLFI, Nello; (358 pag.)WO2017/156165; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

These common heterocyclic compound, 7681-82-5, name is Sodium iodide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 7681-82-5

Synthesis of 47; A Schlenk tube was charged with complex 46 (67.7 mg, 0.17 mmol), Nal (509.7 mg, 3.4 mmol), and 5 mL of THF. The reaction mixture was stirred at room temperature for 8 h. The solvent was removed under vacuum. The residue was dissolved in toluene, and the resulting suspension was passed through a plug of Celite. All the volatiles were removed, and the residue was washed with diethyl ether (3 x 5 mL) to give 47 as a dark red powder. Yield: 70% (69.8 mg, 0.12 mmol).1H NMR (CD2C12, 400 MHz): delta 7.08 (s, 2H,CHimid), 5.59 (d, J=5.60 Hz, 2H, CHpcym), 5.18 (d, J = 5.56 Hz, 2H, CHpcym), 4.04 (s, 6H, CH3imid), 3.15 (septet, J = 6.88 Hz, 1H, CHisop pcym), 1.96 (s, 3H, CH3pcym), 1.23 (d, J=6.88 Hz, 6H, CH3isop pcym).13C NMR (CD2C12, 100MHz): delta 170.4 (C-Ru), 124.4 (CH^a), 110.0 (Cqpcym), 99.9(Cqpcym), 86.6 (CHpcym), 83.0 (CHpcym), 44.9 32.0 (CHisop pcym), 23.0 (CH3is0p pCym),-19.2 (CH3pcym).Anal, calcd for C16H24Cl2I2N2Ru (47 3CH2C12, 670.2): C, 28.68; H, 3.61; N, 4.18. Found: C, 28.41; H, 3.89; N, 4.33

The synthetic route of Sodium iodide has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NANYANG TECHNOLOGICAL UNIVERSITY; HONG, Soon Hyeok; GHOSH, Subhash Chandra; ZHANG, Yao; MUTHAIAH, Senthilkumar; CHEN, Cheng; XU, Xiangya; WO2011/34506; (2011); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 144-48-9, name is 2-Iodoacetamide, A new synthetic method of this compound is introduced below., Recommanded Product: 144-48-9

To a solution of 4-aminomethyl-3-hydxoxy-benzonitrile hydrochloride (BB1, 2.0 g) and triethylamine (2.19 g) in dichloromethane (20 ml) was added di-tert-butyldicarbonate (2.41 g). The mixture was stirred at r.t. for 3.5 h. The mixture was washed with water (3x), dried, filtered and concentrated. The crude product was dissolved in DMF (15.5 ml). Cesium carbonate (4.00 g) and iodoacetamide (2.27 g) were added and the mixture was stirred at r.t. for 3 days. Water was added and the mixture was extracted with EtOAc. The org. phase was washed with water, dried, filtered and concentrated. The crude product was dissolved in MeOH and then concentrated to obtain a thick suspension. The solid was filtered off and washed with a small amount of MeOH. This procedure was repeated with the mother liquor to give (2-carbamoylmethoxy-4-cyano-benzyL)-carbamic acid tert-butyl ester (a total of 1.88 g) as a colorless solid. MS 304.2 ([M-HD The BOC protecting group of (2-carbamoylmethoxy-4-cyano-benzyl)-carbamic acid tert-butyl ester was removed using HC1 in dioxane to give 2-(2-aminomethyl-5-cyano-phenoxy)-acetamide hydrochloride as an off-white powder. MS 206.1 ([M+H]+)

The synthetic route of 144-48-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2006/27135; (2006); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com