Tag: M.W=100-200

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 144-48-9, Name is 2-Iodoacetamide, SMILES is NC(=O)CI, in an article , author is Josefsson, Malin, once mentioned of 144-48-9, Formula: C2H4INO.

Sodium Iodide Symporter (NIS) in Gastric Mucosa: Gastric Iodide Secretion

Iodide is actively transported from the bloodstream into the gastric juice and some iodide accumulation occurs in the gastric wall, but no uptake of iodide takes place in the gastric lumen. The cDNA-sequence of the thyroid sodium iodide symporter (NIS) was revealed in 1996 and, in the thyroid gland, iodide is actively transported into the thyrocyte by NIS. Later on NIS was also found to be present, in large amounts, in the gastric mucosa, where it is located basolaterally in the surface epithelial cells. Iodide transport over the gastric mucosa is attenuated by the selective competitive NIS inhibitor perchlorate, and also by ouabain, an inhibitor of Na+/K+-ATPase, which powers NIS transport. Thus, gastric iodide secretion is to a large extent mediated by NIS. The regulation of gastric NIS expression is still unknown. The functional role of NIS in the gastric mucosa is uncertain, but several theories have been put forward. These include mediating recirculation of iodide, as well as securing the presence of iodide in the stomach for antimicrobial or antioxidative purposes. Gastric iodide secretion may also be a protecting mechanism against developing gastric cancer. Gastric NIS has further been suggested to be an important protein for transporting anions other than iodide, i.e., nitrate. In the future NIS expression, or lack thereof, may become a useful parameter in the diagnosis of gastric cancer. Gene transfer of NIS into cancer cells without NIS expression, as well as chemical induction of NIS expression, are methods under exploration. If means to regulate NIS expression in tumor cells are found, it may become possible to use radioiodine therapy in gastric cancer.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 144-48-9, you can contact me at any time and look forward to more communication. Formula: C2H4INO.

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 144-48-9, Name is 2-Iodoacetamide, SMILES is NC(=O)CI, in an article , author is Lou, Hao, once mentioned of 144-48-9, Recommanded Product: 2-Iodoacetamide.

Development of W/O Microemulsion for Transdermal Delivery of Iodide Ions

The objective of this study was to develop a water-in-oil (w/o) microemulsion which can be utilized as a transdermal delivery for iodide ions. Several w/o microemulsion formulations were prepared utilizing Span 20, ethanol, Capryol 90 (R), and water. The selected formulations had 5%, 10%, 15%, 20%, and a maximum of 23% w/w water content. Potassium iodide (KI) was incorporated in all formulations at 5% w/v. Physicochemical characterizations were conducted to evaluate the structure and stability. These studies included: mean droplet size, pH, viscosity, conductivity, and chemical stability tests. In vitro human skin permeation studies were conducted to evaluate the diffusion of the iodide ion through human skin. The w/o microemulsion formulations were stable and compatible with iodide ions with water content ranging from 5% to 23% w/w. The addition of KI influenced the physicochemical properties of microemulsion as compared to blank microemulsion formulations. In vitro human skin permeation studies indicated that selected formulations improved iodide ion diffusion significantly as compared to control (KI solution; P value <0.05). Iodide ions were entrapped within the aqueous core of w/o microemulsion. Span 20, ethanol and Capryol 90 protected the iodide ions against oxidation and formed a stable microemulsion. It is worth to note that according to Hofmeister series, iodide ions tend to lower the interfacial tension between water and oil and consequently enhance overall stability. This work illustrates that microemulsion system can be utilized as a vehicle for the transdermal administration of iodide. But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 144-48-9, you can contact me at any time and look forward to more communication. Recommanded Product: 2-Iodoacetamide.

144-48-9, Name is 2-Iodoacetamide, molecular formula is C2H4INO, belongs to iodides-buliding-blocks compound, is a common compound. In a patnet, author is Machado, Ana, once mentioned the new application about 144-48-9, Category: iodides-buliding-blocks.

Development of a robust, fast screening method for the potentiometric determination of iodide in urine and salt samples

In this work, a potentiometric flow injection method is described for the fast bi-parametric determination of iodide and iodate in urine and salt samples. The developed methodology aimed for iodine speciation with a potentially portable system (running on batteries). The iodate reduction to iodide was effectively attained in line within the same manifold. The iodide determination was accomplished in the dynamic range of 2.50×10(-6) – 1.00×10(-3) M and the total iodine dynamic range, resulted from iodide plus iodate, was 3.50×10(-6) – 2.00×10(-3) M. The calculated limits of detection were 1.39×10(-6) M and 1.77×10(-6) M for iodide and iodate, respectively. A determination rate of 21 h(-1) for the bi-parametric iodide and iodate determination was obtained for sample injection. The urine samples (RSD < 5.8% for iodide and RSD < 7.0% for iodate) results were in agreement with those obtained by the classic Sandell-Kolthoff reaction colorimetric reference procedure (RD < 7.0%) and standard samples from Centers for Disease Control and Prevention, Atlanta, USA (CDC) international inter-laboratory EQUIP program. The developed flow method was also successfully applied to the iodide and iodate determination in salt samples (RSD <3.1% for iodate and iodide), with comparable results to conventional procedures. No significant interferences were observed interference percentage < 9% for both determinations. If you¡¯re interested in learning more about 144-48-9. The above is the message from the blog manager. Category: iodides-buliding-blocks.

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 144-48-9, Name is 2-Iodoacetamide, molecular formula is , belongs to iodides-buliding-blocks compound. In a document, author is GOLSTEIN, P, SDS of cas: 144-48-9.

THE IODIDE CHANNEL OF THE THYROID – A PLASMA-MEMBRANE VESICLE STUDY

The uptake of radioactive iodide or chloride by plasma membrane vesicles of bovine thyroid was studied by a rapid filtration technique. A Na+-I- cotransport was demonstrated. When this Na+-I- cotransport is inactive (i.e., at 4-degrees-C and in the absence of Na+), an uptake of iodide above chemical equilibrium could be induced, driven by the membrane potential. The latter was set up by allowing potassium to diffuse into the membrane vesicles in the presence of valinomycin and of an inward K+ gradient. This potential difference (positive inside) induced the uptake of iodide (or other anion present). The data support the existence of two anionic channels. The first one, observed at low near-physiological iodide concentration (micromolar range), which exhibits a high permeability and specificity for iodide (hence called the iodide channel), has a K(m) of 70 muM. The other one appears similar to the epithelial anion channel as described by Landry et al. (J. Gen. Physiol. 90: 779-798, 1987); it is still about fourfold more permeable to iodide than to chloride and presents a K(m) of 33 mM. Under physiological conditions the latter channel would mediate chloride transport, and the iodide channel, which is proposed to be restricted to the apical plasma membrane domain of the thyrocyte, transports iodide from the cytosol to the colloid space.

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Application of 144-48-9, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 144-48-9, Name is 2-Iodoacetamide, SMILES is NC(=O)CI, belongs to iodides-buliding-blocks compound. In a article, author is Sato, Akihiro, introduce new discover of the category.

CHEMISTRY OF HETEROARYLTRIPHENYLPHOSPHONIUM IODIDES: PREPARATION FROM IODOHETEROAROMATICS AND ELIMINATION OF THE PHOSPHONIUM IODIDE GROUP USING BASIC SOLVENTS

alpha- and gamma-lodoheteroaromatics were found to react with triphenylphosphine to give heteroaromatictriphenylphosphonium iodides in excellent yields. beta-lodoheteroaromatics, which are less reactive with triphenylphosphine compared to alpha- or gamma-compounds, were converted into the corresponding phosphonium iodides using palladium catalysts. Treatment of heteroaromatictriphenylphosphonium iodides resulted in the elimination of the phosphonium iodide group using basic solvents such as aqueous sodium hydroxide or ethanol – triethylamine.

Application of 144-48-9, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 144-48-9 is helpful to your research.

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, COA of Formula: C2H4INO, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 144-48-9, Name is 2-Iodoacetamide, molecular formula is C2H4INO. In an article, author is Kato, S,once mentioned of 144-48-9.

An alternatively facile preparation of acylsulfenyl bromides and iodides

Lead thiocarboxylates [RCOSPbPh3, (RCOS)(2)PbPh2, (RCOS)(2)Pb] were found to readily react with halogen, and N-bromo- and N-iodo-succinimides to give the corresponding acylsulfenyl bromides and iodides.

If you¡¯re interested in learning more about 144-48-9. The above is the message from the blog manager. COA of Formula: C2H4INO.

Electric Literature of 144-48-9, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 144-48-9, Name is 2-Iodoacetamide, SMILES is NC(=O)CI, belongs to iodides-buliding-blocks compound. In a article, author is Zhang, L, introduce new discover of the category.

Nonradioactive iodide effectively induces apoptosis in genetically modified lung cancer cells

We assessed a nonradioactive approach to induce apoptosis in non-small cell lung cancer by a novel iodide uptake and retention mechanism. To enhance tumor apoptosis, we transduced non-small cell lung cancer cells with retroviral vectors containing the sodium iodide symporter (NIS) and thyroperoxidase (TPO) genes. Expression of NIS and TPO facilitated concentration of iodide in tumors. As a consequence of the marked increase in intracellular levels of iodide, apoptosis was seen in >95% of NIS/TPO-modified lung cancer cells. Intraperitoneal injection of potassium iodide resulted in significant tumor volume reduction in NIS/TPO-modified tumor xenografts without apparent adverse effects in SCID mice. Iodide induced an increase in the level of reactive oxygen species. Iodide-induced apoptosis is sensitive to N-acetylcysteine inhibition, suggesting an important role by reactive oxygen species in this apoptotic process. In addition, iodide-induced apoptosis is associated with overexpression of CDKN1A (p21/Waf1) and down-regulation of survivin at both mRNA and protein levels. This is the first report demonstrating that a therapeutic dose of nonradioactive iodide has potent efficacy and high selectivity against lung cancer when used in combination with genetic modification of cancer cells to express the NIS/TPO genes.

Electric Literature of 144-48-9, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 144-48-9.

144-48-9, Name is 2-Iodoacetamide, molecular formula is C2H4INO, Application In Synthesis of 2-Iodoacetamide, belongs to iodides-buliding-blocks compound, is a common compound. In a patnet, author is Feng, Xiujuan, once mentioned the new application about 144-48-9.

Copper-catalyzed conversion of aryl and heteroaryl bromides into the corresponding iodide

An efficient method for the synthesis of aryl and heteroaryl iodides is described in this study. The reactions of aryl and heteroaryl bromides with potassium iodide proceeded smoothly in the presence of a copper catalyst under mild reaction conditions to produce the corresponding iodides in satisfactory to excellent yields. (C) 2016 Elsevier B.V. All rights reserved.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 144-48-9. The above is the message from the blog manager. Application In Synthesis of 2-Iodoacetamide.

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Quality Control of 2-Iodoacetamide144-48-9, Name is 2-Iodoacetamide, SMILES is NC(=O)CI, belongs to iodides-buliding-blocks compound. In a article, author is Bay, L, introduce new discover of the category.

Electrochemical reaction rates in a dye-sensitised solar cell-the iodide/tri-iodide redox system

The electrochemical reaction rate of the redox couple iodide/tri-iodide in acetonitrile is characterised by impedance spectroscopy. Different electrode materials relevant for the function of dye-sensitised solar cells (DSSC) are investigated. Preferably, the reaction with the iodide/tri-iodide couple should be fast at the counter electrode, i.e. this electrode must have a high catalytic activity towards the redox couple, and the same reaction must be slow on the photo electrode. The catalytic activity is investigated for platinum, poly(3,4-ethylenedioxythiophene) (PEDOT), polypyrrole (PPy), and polyaniline (PANI)-all deposited onto fluorine-doped tin oxide (FTO) glass. Both Pt and PEDOT are found to have sufficiently high catalytic activities for practical use as counter electrodes in DSSC. The reaction resistance on FTO and anatase confirmed the beneficial effect of a compact anatase layer on top of the FTO glass in lowering the tri-iodide reduction rate. (c) 2005 Elsevier B.V. All rights reserved.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 144-48-9. Quality Control of 2-Iodoacetamide.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 624-75-9, name is 2-Iodoacetonitrile, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 624-75-9

General procedure: Starting amine (5.0 mmol) was dissolved in dry diethyl ether (17 mL) and iodoacetonitrile (5.5 mmol, 919 mg) was added dropwise under cooling. The mixture was stirred at room temperature for 3-14 days, then precipitate was filtered off, washed with diethyl ether and dried in vacuo to give the corresponding quaternary ammonium salt 2. If the solid precipitate was not formed after 7 days, the mixture was evaporated under reduced pressure. The crude product was washed with diethyl ether (3 ¡Á 15mL) and dried in vacuo. The quaternary ammonium salt 2 was used in the next step without additional purification. The corresponding quaternary ammonium salt (3.0 mmol) was heated at 150 C on oil bath in freshly distilled DMF (7 mL) in a 25 mL round-bottom flask fitted with reflux condenser and CaCl2-tube for 15 minutes. The mixture was cooled to room temperature, diluted with H2O (20 mL) and extracted with PhMe (2 ¡Á 15mL). The organic phase then was washed with H2O (2 ¡Á 15mL) and brine (15 mL), dried over Na2SO4 and evaporated in vacuo to give the desired aminoacetonitrile 4. The latter, if necessary, was purified by column chromatography (it is convenient to visualize aminoacetonitriles on TLC-plate by treating with the diluted solution of ninhydrin in EtOH). Note, that aminoacetonitriles are moisture sensitive. Products after column chromatography were additionally dried by the addition of dry PhMe (5 mL) and evaporation in vacuo.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 624-75-9.

Reference:
Article; Buev, Evgeny M.; Smorodina, Anastasia A.; Stepanov, Maxim A.; Moshkin, Vladimir S.; Sosnovskikh, Vyacheslav Y.; Tetrahedron Letters; vol. 59; 17; (2018); p. 1638 – 1641;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com