Research on new synthetic routes about 624-76-0

The synthetic route of 624-76-0 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 624-76-0, name is 2-Iodoethanol belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 2-Iodoethanol

Production Example 235-1 Synthesis of 2-iodoethyl acetate 2-Iodoethanol (1.541 g, 8.96 mmol) was dissolved in dichloromethane (30 ml). To the solution, pyridine (1.54 ml, 17.92 mmol), N,N-dimethyl-4-aminopyridine (109 mg, 0.896 mmol), and acetic anhydride (2.54 ml, 26.88 mmol) were added, and the mixture was stirred at room temperature for 3 hours. After reaction, the organic layer was washed with 0.1M hydrochloric acid and a saturated aqueous solution of sodium bicarbonate. The organic layer was dried over magnesium sulfate, and the solvent was distilled off to obtain the title compound (1.108 g, yield: 57.8%) as a yellow oil. 1H-NMR (400 MHz, DMSO-d6) delta: 2.10 (3H, s), 3.30 (2H, t, J=6.8 Hz), 4.33 (2H, t, J=6.8 Hz).

The synthetic route of 624-76-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kabushiki Kaisha Yakult Honsha; Ikeda, Takashi; Ono, Masahiro; Ueno, Satoshi; Yamazaki, Ryuta; Yaegashi, Takashi; Matsuzaki, Takeshi; US2014/343017; (2014); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of INa

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Sodium iodide, and friends who are interested can also refer to it.

Electric Literature of 7681-82-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7681-82-5 name is Sodium iodide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: We used a simple method (branched tube glass) in order to design and preparation of suitable single crystals for X-ray diffraction. The one-pot reaction of a 1:1 M ratio of Cd(II) salts and L in the mixture of EtOH and MeOH afforded the compounds 1-3 in good yields. Cd(NO3)2·4H2O (0.154g, 0.5mmol), NaHal (Hal=Cl, 0.058g; Br, 0.103g; I, 0.150g; 1mmol) and the ligand L (0.208g, 0.5mmol) were placed in the main arm of a branched tube. A mixture of MeOH (7.5mL) and EtOH (7.5mL) was carefully added to fill the arms. The tube was sealed and immersed in an oil bath at 60C while the branched arm was kept at ambient temperature. X-ray suitable crystals were formed during the next days in the cooler arm and were filtered off, washed with acetone and diethyl ether, and dried in air.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Sodium iodide, and friends who are interested can also refer to it.

Reference:
Article; Akbari Afkhami, Farhad; Mahmoudi, Ghodrat; White, Jonathan M.; Lipkowski, Janusz; Konyaeva, Irina A.; Safin, Damir A.; Inorganica Chimica Acta; vol. 484; (2019); p. 481 – 490;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The important role of C2H5IO

Statistics shows that 2-Iodoethanol is playing an increasingly important role. we look forward to future research findings about 624-76-0.

Synthetic Route of 624-76-0, These common heterocyclic compound, 624-76-0, name is 2-Iodoethanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound 4a (617mg, 4.6mmol) was reacted with 2-Iodoethanol (0.54mls, 6.9mmol) and diisopropylethylamine (1.2mls, 6.9mmol) in ACN (20mls) at 30oC for 48 hours. The solvent was evaporated and the residue was purified by silica gel column chromatography with hexane and EtOAc to provide the compound (483mg, 2.7mmol, 59% yield) as a light brown oil. HRMS (ESI, positive) m/z calcd. for C11H18N1O1 [M+H]+: 180.13829, found: 180.13829. 1H NMR (400 MHz, CDCl3) delta 7.28 – 7.19 (t, J = 8.0 Hz, 2H), 6.92 – 6.85 (d, J = 8.2 Hz, 2H), 6.83 – 6.75 (t, J = 7.3 Hz, 1H), 4.03 – 3.88 (hept, J = 6.6 Hz, 1H), 3.70 – 3.62 (t, J = 6.2 Hz, 2H), 3.34 – 3.24 (m, 2H), 1.19 – 1.12 (d, J = 6.6 Hz, 6H).

Statistics shows that 2-Iodoethanol is playing an increasingly important role. we look forward to future research findings about 624-76-0.

Reference:
Article; Bell-Horwath, Tiffany R.; Vadukoot, Anish K.; Thowfeik, Fathima Shazna; Li, Guorui; Wunderlich, Mark; Mulloy, James C.; Merino, Edward J.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 10; (2013); p. 2951 – 2954;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Brief introduction of 74-88-4

According to the analysis of related databases, 74-88-4, the application of this compound in the production field has become more and more popular.

Electric Literature of 74-88-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 74-88-4 as follows.

General procedure: Iodomethane (1.606mmol) was added to a stirred solution of 1a (0.143mmol) and anhydrous potassium carbonate (0.352mmol) in dry CH2Cl2(2 mL), in an N2atmosphere at 55 C. The mixture was stirred for 24h and iodomethane (1.606mmol) was added once again and stirred for another 24h. After 48h, the reaction mixture was diluted in water (50 mL) and the aqueous phase was extracted with dichloromethane (3 x 50 mL). The resulting organic phase was washed with brine, dried over Na2SO4, filtered and evaporated. In order to produce a white solid, the organic phase was purified by silica gel chromatography using a gradient elution of C6H12/CH2Cl2(Yield: 24%).

According to the analysis of related databases, 74-88-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Cargnin, Simone Tasca; Staudt, Andressa Finkler; Medeiros, Patricia; de Medeiros Sol Sol, Daniel; de Azevedo dos Santos, Ana Paula; Zanchi, Fernando Berton; Gosmann, Grace; Puyet, Antonio; Garcia Teles, Carolina Bioni; Gnoatto, Simone Baggio; Bioorganic and Medicinal Chemistry Letters; vol. 28; 3; (2018); p. 265 – 272;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Research on new synthetic routes about C3H7IO

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Adding a certain compound to certain chemical reactions, such as: 627-32-7, name is 3-Iodo-1-propanol, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 627-32-7, HPLC of Formula: C3H7IO

EXAMPLE 1Preparation of (9Z,i7E)-3-(nitrooxy)propyl octadeca-9,ll-dienoate (9Z, 11 E)-3-(nittauooxy)ptauopy octadeca-9,11-dienoate was synthesised in accordance with the procedure set out below:(A) To a solution of silver nitrate (5.34 g, 31.11 mmol) in acetonitrile (100 ml) was added dropwise via syringe 3-iodo-propan-l-ol (2.6 ml, 4.90 g, 26.33 mmol). The reaction mixture was stirred at room temperature for 48 h, then filtered over Celite. The filtrate was concentrated under reduced pressure and the residual oil was purified by flash chromatography (Petroleum Ether / EtOAc 7:3) yielding 3-hydroxypropyl nitrate as a brown oil (3.02 g, 24.95 mmol, 94 %), as shown below:AgNO3O2N(XMeCNRf 0.20 (Pet. Ether / EtOAc 7:3)Bp 56-58 C / 0.15 Torr (lit.)1H NMR 1.96 (p, 2H, J=6.2 Hz, CH2), 2.06 (s, IH, OH), 3.74 (dt, IH, J=2.2,6.1 Hz, CH2O), 4.59 (t, IH, 7=5.3 Hz, CH2ONO2)13C NMR 29.5 (CH2), 58.6 (CH2O), 70.2 (CH2ONO2) IR 1283, 1634, 3368Mass 122 (M+ 1, 10 %), 104 (16 %), 75 (17 %), 59 (27 %), 46 (100 %)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND; WO2009/127398; (2009); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Continuously updated synthesis method about 624-76-0

According to the analysis of related databases, 624-76-0, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 624-76-0, name is 2-Iodoethanol, This compound has unique chemical properties. The synthetic route is as follows., category: iodides-buliding-blocks

1.47 g (3 mmol) of compound (4b) and 1.24 g (9 mmol) of potassium carbonate were added to a 50 ml round-bottomed flask. 25 ml of double distilled DMF was added and 0.7 ml (9 mmol) of iodoethanol was slowly added dropwise and the mixture was stirred at 50 C. for 8-12 h .After the reaction was completed, the reaction mixture was diluted with 100 ml of ethyl acetate and washed with water (25 ml × 4) to remove DMF. The organic phase was dried over anhydrous Na 2 SO 4 for 1 h,The filtrate was spin-dried over the column to give a pale yellow colored solid (5b) 1.08g, 67% yield.

According to the analysis of related databases, 624-76-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Yantai University; Wang Hongbo; Hong Xuechuan; Fu Fenghua; Tian Jingwei; Lv Zhenbin; Lei Lei; Ma Jinbo; Zhai Rong; Lv Guangyao; (11 pag.)CN106317050; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Continuously updated synthesis method about 624-75-9

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Iodoacetonitrile, its application will become more common.

Related Products of 624-75-9,Some common heterocyclic compound, 624-75-9, name is 2-Iodoacetonitrile, molecular formula is C2H2IN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a three-necked flask, add 40 g of raw material 2 and 12 g of catalyst 3 (R = 3,5-trifluoromethylbenzyl, R1 = vinyl, R2 = hydrogen) and 1.5 L of chlorobenzene, cool to 0 C with stirring, and add 300 ml 50% aqueous sodium hydroxide solution. Subsequently, 32 g of a solution of iodoacetonitrile (ICH2CN) in 500 ml of chlorobenzene was added. After the addition, the solution was stirred at 0 C until the TLC detection reaction was completed. 40 g of crude product, chiral purity (HPLC) = 72: 28, yield 80%. The crude product was recrystallized from 300 ml of ethyl acetate to obtain 25.0 g of white solid 4 with a yield of 52%, a specific rotation of + 102 (c = 1, chloroform), and a chiral HPLC ?99.92%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Iodoacetonitrile, its application will become more common.

Reference:
Patent; Shanghai Pharmaceutical Industry Institute; China Pharmaceutical Industry Zongyuan; Li Ruipeng; Zhou Weicheng; Lin Kuaile; Chen Liang; Pan Jing; Zhou Ting; Liu Zhenren; Li Hongyan; (16 pag.)CN110563605; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Discovery of 2-Iodoethanol

According to the analysis of related databases, 624-76-0, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 624-76-0 as follows. COA of Formula: C2H5IO

Example 396 (Z)-3-(2-Hydroxyethyl)-5-[{7-(4-methoxyphenyl)furo[3,2-c]pyridin-2-yl}methylene]thiazolidine-2,4-dione Step 1: Synthesis of 3-(2-hydroxyethyl)thiazolidine-2,4-dione Thiazolidinedione (12.8 mmol), 2-iodoethanol (15.1 mmol), potassium carbonate (17.4 mmol) and tetrabutylammonium iodide (1.3 mmol) were placed in acetone (25 ml), and stirred at 40 C. for 10 hours. The reaction mixture was cooled to room temperature, filtered through Celite, and concentrated under reduced pressure to yield brown oil. The residue thus obtained was purified by silica gel column chromatography (n-hexane/ethyl acetate=4/1, v/v) to obtain the title compound as colorless oil (yield: 54%). 1H NMR (CDCl3, 400 MHz) delta 4.00 (s, 2H), 3.85 (brs, 4H), 1.94 (brs, 1H)

According to the analysis of related databases, 624-76-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; YUHAN CORPORATION; Seo, Hyoung Sig; Kim, Tae Kyun; Lee, Hyun Joo; Kim, Dong Hoon; Lee, Gyu Jin; Park, Jun Chul; Gal, Ji Yeong; Kim, Tae-hoon; Hyun, Kwan Hoon; Ahn, Kyoung Kyu; Park, Kaapjoo; Nam, Su Youn; Lee, Ge Hyeong; Lim, Hee Jong; US2015/191478; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Research on new synthetic routes about 3-Iodo-1-propanol

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 627-32-7, name is 3-Iodo-1-propanol, A new synthetic method of this compound is introduced below., SDS of cas: 627-32-7

E: 3-(4-Bromo-2-(trifluoromethyl)-phenoxy)propan-1-ol; 3-lodopropanol (11.23g) was added to a mixture of 4-bromo-2- (trifluoromethyl)-phenol (15g) and potassium carbonate (17.2g) in acetonitrile (150ml). The above mixture was refluxed for 4 hours then diluted with ethyl acetate (500ml) and water (300ml). Organic layer was seperated, dried over magnesium sulphate, solvent removed under reduced pressure to give expected product clean enough for use at the next step (18.6g). 1H NMR (CDCI3)delta: 7.67 (d, 1 H), 7.58 (dd, 1 H), 6.90 (dd, 1 H), 4.18 (t, 2H), 3.87 (q, 2H), 2.07 (tt, 2H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; N.V. ORGANON; WO2009/10491; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sources of common compounds: C2H5IO

The synthetic route of 624-76-0 has been constantly updated, and we look forward to future research findings.

624-76-0, name is 2-Iodoethanol, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 2-Iodoethanol

Cesium carbonate (3.91 g) is added to a solution of N-(4-chlorobenzyl)-4-hydroxy-2- (hydroxymethyl) thieno [[2, 3-B] PYRIDINE-5-CARBOXAMIDE] (3.49 g, prepared as described in US 6,239, 142) and 2-(2-iodoethoxy)tetrahydro-2H-pyran (2.56 g, prepared by mixing equal molar amounts [OF 2-IODOETHANOL] and 3, 4-dihydro-2H-pyran) in DMF (20 mL). The reaction mixture is stirred at [100 C FOR] 17 hours. The solvent is evaporated and the residue is dissolved in 10% CH30H in [CH2C12.] The mixture is washed with water and the organic layer is dried (MgSO4), filtered, concentrated. The crude product is crystallized from EtOAc to afford 3.8 g of the title compound as a white solid. Physical characteristics. 1H NMR (400 [MHZ,] DMSO-d6) delta 10.59, 8.71, 7.39, 7.38, 7.29, 5.79, 4. [69,] 4.58, 4.54, 4. [48,] 3.96, 3.78, 3.30, 1.54, 1.39, 1. [29 ;] MS (EI) [RNLZ] 476 [(M”), HRMS (FAB) ] 477.1245 (M+H) +.

The synthetic route of 624-76-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PHARMACIA & UPJOHN COMPANY; FLECK, Bruce, Francis; WO2004/22567; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com