Tag: M.W=100-200

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Engineering in Life Sciences called Biosynthesis of (R)-epichlorohydrin at high substrate concentration by kinetic resolution of racemic epichlorohydrin with a recombinant epoxide hydrolase, Author is Jin, Huo-Xi; Liu, Zhi-Qiang; Hu, Zhong-Ce; Zheng, Yu-Guo, which mentions a compound: 60827-45-4, SMILESS is OC[C@H](O)CCl, Molecular C3H7ClO2, Safety of (2S)-(+)-3-Chloropropane-1,2-diol.

The substrate concentration and yield were shown to be very low in the production of (R)-epichlorohydrin by hydrolysis of racemic epichlorohydrin using epoxide hydrolases in previous studies. In this work, we synthesized an epoxide hydrolase gene from Agrobacterium radiobacter and expressed it in Escherichia coli by the PCR assembly method. The recombinant A. radiobacter epoxide hydrolase (ArEH) was applied in the preparation of (R)-epichlorohydrin and, a yield of 42.7% with ≥99% enantiomeric excess (ee) from 25.6 mM racemic epichlorohydrin was obtained. However, the ee of (R)-epichlorohydrin was not able to reach 99% due to substrate and product inhibition when the substrate concentration was over 320 mM. Inhibition studies revealed that (S)-3-chloro-1,2-propanediol displayed non-competitive inhibition in the conversion of (S)-epichlorohydrin but non-significant inhibition for (R)-epichlorohydrin. Moreover, ArEH was successfully applied in the preparation of (R)-epichlorohydrin at high substrate concentration by eliminating the substrate inhibition. The substrate concentration increased to 448 mM by intermittent feeding of the substrate and to 512 mM by using a two-phase reaction system, with a high yield (>27%) and ee (>98%) of (R)-epichlorohydrin. This is the first report of high-yield production of (R)-epichlorohydrin at high substrate concentration, laying the foundations for its application on the industrial scale.

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Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Suzuki, Toshio; Kasai, Naoya researched the compound: (2S)-(+)-3-Chloropropane-1,2-diol( cas:60827-45-4 ).Application In Synthesis of (2S)-(+)-3-Chloropropane-1,2-diol.They published the article 《A novel method for the generation of (R)- and (S)-3-chloro-1,2-propanediol by stereospecific dehalogenating bacteria and their use in the preparation of (R)- and (S)-glycidol》 about this compound( cas:60827-45-4 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: resolution chloropropandiol stereospecific dehalogenating bacteria; glycidol. We’ll tell you more about this compound (cas:60827-45-4).

A novel and effective method for the preparation of highly pure optically active (R)- and (S)-3-chloro-1,2-propanediol (99.5% ee and 99.4% ee, resp.) was established based on stereospecific dehalogenation and assimilation with bacteria. From these intermediates highly pure optically active (R)- and (S)-glycidol (99.3% ee and 99.4% ee, resp.) were prepared

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Iodide – Wikipedia,
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Electric Literature of C9H11Cu. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Mesitylcopper(I), is researched, Molecular C9H11Cu, CAS is 75732-01-3, about Synthesis of novel copper-rare earth BINOLate frameworks from a hydrogen bonding DBU-H rare earth BINOLate complex. Author is Panetti, Grace B.; Robinson, Jerome R.; Carroll, Patrick J.; Gau, Michael R.; Manor, Brain C.; Walsh, Patrick J.; Schelter, Eric J..

The preparation of a novel H-bonding DBU-H+ BINOLate Rare Earth Metal complex [RE(S-binol)3·3DBU-H, where RE = La, Pr, and Eu; DBU = 1,8-Diazabicyclo(5.4.0)undec-7-ene] enabled the synthesis of the first copper-Rare Earth Metal BINOLate complex (CuDBU-REMB, Cu3RE(S-binol)3(DBU)3). CuDBU-REMB was compared to the analogous Li complex using x-ray crystallog. and Exchange NMR spectroscopy (EXSY). The results provide insight into the role of the secondary metal cation in the framework’s stabilization.

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Iodide – Wikipedia,
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Category: iodides-buliding-blocks. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about Solid Phase Behavior, Polymorphism, and Crystal Structure Features of Chiral Drug Metaxalone. Author is Bredikhin, Alexander A.; Zakharychev, Dmitry V.; Gubaidullin, Aidar T.; Bredikhina, Zemfira A..

In addition to the previously known A-rac and B-rac polymorphs of the chiral drug metaxalone 1, an enantiopure A-(S)-form was obtained and studied. According to x-ray anal., the crystalline organization of this form is close to the A-rac-1 polymorph. Crystallization of metaxalone melts is accompanied by the formation of a previously unknown metastable C-phase, which in the case of both racemic and enantiomeric samples are transformed into A-rac-1 or A-(S)-1. Anal. of the PXRD and IR spectra of crystalline samples revealed a similarity of the internal structure for the A-(S)-1, A-rac-1, C-(S)-1, and C-rac-1 crystalline forms and the essential difference of all of these phases from the B-rac-1 phase. According to the thermochem. data, the dependences of the change in the Gibbs free energy for all the phases studied are plotted in the interval from the m.p. to 20°. Under standard conditions, the crystalline modifications of metaxalone, relative to ΔG0, form such a series: B-rac-1 < A-(S)-1 ≈ A-rac-1 < C-rac-1 < C-(S)-1. A model that describes all the exptl. revealed features of metaxalone crystallization is proposed. If you want to learn more about this compound((2S)-(+)-3-Chloropropane-1,2-diol)Category: iodides-buliding-blocks, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(60827-45-4).

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Iodide – Wikipedia,
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Computed Properties of C9H11Cu. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Mesitylcopper(I), is researched, Molecular C9H11Cu, CAS is 75732-01-3, about Carbonylation of a Tetrameric Aryloxocopper(I) Cluster. Author is Lopes, Cesar; Hakansson, Mikael; Jagner, Susan.

Carbonylation of 2,6-diphenylphenoxocopper(I), tetrameric [(CuOC6H3Ph2)4] (1), results in a [{Cu(OC6H3Ph2)(CO)}2] dimer (2). The parent aryl oxide, [(CuOC6H3Ph2)4], which was prepared from mesitylcopper(I) and 2,6-diphenylphenol, has an approx. planar Cu4O4 core, in which Cu(I) is two-coordinated and Cu-O bonds range from 1.834(7) to 1.865(7) Å. Its carbonylation product 2 is a μ2-phenoxo-bridged dimer, containing three-coordinated Cu(I), with longer Cu-O bonds, viz. 1.953(7)-1.995(7) Å. Cu-C bond lengths in 2 are 1.78(1) and 1.79(1) Å, resp., with both carbonyl C-O distances equal to 1.12(1) Å, and Cu-C-O angles of 174(1) and 179(1)°, resp. Carbonyl stretching frequencies in the IR are 2099, 2103, and 2112 cm-1 for the solid and 2102 cm-1 in toluene solution, and the 13C NMR signal (toluene solution) is at 168 ppm. From comparison with other carbonyl complexes of Cu(I), the Cu-C bond is judged to be predominantly of σ character, with minimal metal → ligand π* contribution. Both 1 and 2 retain their aggregation states on dissolution in nonpolar solvents, as ascertained by cryoscopic mol. weight determinations of the compounds in benzene. Crystal data: 1, triclinic, space group P1̅, a 12.738(9), b 22.426(5), and c 9.984(3) Å, α 101.62(2), β 91.02(4), and γ 85.93(3)°, Z = 2, R = 0.052 (Rw = 0.058); 2, triclinic, space group P1̅, a 10.67(3), b 15.72(1), and c 10.05(1) Å, α 96.99(8), β 104.66(16), and γ 101.46(12)°, Z = 2, R = 0.049 (Rw = 0.054).

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Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Formula: C3H7ClO2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about Simultaneous production of chirally enriched epoxides and 1,2-diols from racemic epoxides via hydrolytic kinetic resolution. Author is Kureshy, R. I.; Khan, N. H.; Abdi, S. H. R.; Patel, S. T.; Jasra, R. V..

Hydrolytic kinetic resolution of racemic epichlorohydrin, styrene oxide and propene oxide was investigated using a dimeric homochiral Co(III) Schiff base complex derived from the monotartrate salt of (1R,2R)-(-)-cyclohexanediamine with 3,5-di-tert-butylsalicylaldehyde and 5,5′-methylenebis[3-tert-butylsalicylaldehyde] to get high efficiency and recycling capability of the catalyst. Excellent conversions to enantiomerically pure epoxide and diols along with high chiral induction were obtained in all cases. With a loading of <0.3 mol % of the catalyst, the system works well for up to three cycles without any loss in activity and selectivity. Here is a brief introduction to this compound(60827-45-4)Formula: C3H7ClO2, if you want to know about other compounds related to this compound(60827-45-4), you can read my other articles.

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Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 60827-45-4, is researched, SMILESS is OC[C@H](O)CCl, Molecular C3H7ClO2Journal, Article, Research Support, Non-U.S. Gov’t, Experientia called Formation of the active antifertility metabolite of (S)-α-chlorohydrin in boar sperm, Author is Jones, A. R.; Stevenson, D., the main research direction is chlorohydrin metabolism sperm; glycerol chlorohydrin metabolism sperm; enzyme chlorohydrin metabolism sperm.Computed Properties of C3H7ClO2.

Incubation of boar sperm with (S)-α-chlorohydrin (I) [60827-45-4] resulted in formation of (S)-3-chlorolactaldehyde (II) [86747-03-7]. I inhibited the production of 14CO2 when 14C-labeled fructose  [57-48-7] was the substrate but had no effect when 14C-labeled glycerol  [56-81-5] was used. (R,S)-3-Chlorolactaldehyde  [84709-24-0], however, inhibited CO2 formation from glycerol. The oxidation of 14C-labeled glycerol-3-phosphate  [57-03-4] was similarly inhibited by I confirming that the presence of glycerol but not its metabolites prevented the oxidation of I to II. Glycerol reversed the inhibition of fructose metab by I. Addnl., preincubation of sperm with I inhibited glycerol metabolism Apparently, I is metabolized to II in sperm by an enzyme involved in the oxidation of glycerol to glyceraldehyde. The presence of glycerol decreases the activity of this enzyme towards I thereby preventing formation of II, an inhibitor of glyceraldehyde 3-phosphate dehydrogenase  [9001-50-7].

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Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reference of (2S)-(+)-3-Chloropropane-1,2-diol. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about Isolation of a bacterium assimilating (R)-3-chloro-1,2-propanediol and production of (S)-3-chloro-1,2-propanediol using microbial resolution. Author is Suzuki, Toshio; Kasai, Naoya; Yamamoto, Ryoichi; Minamiura, Noshi.

A bacterium capable of assimilating 3-chloro-1,2-propanediol was isolated from soil by enrichment culture. The strain was identified as Alcaligenes sp. by taxonomic studies. The crude extracts of the cells had dehalogenating activities and converted various halohydrins to the corresponding epoxides. 3-Chloro-1,2-propanediol was degraded stereospecifically by the strain, liberating Cl-. The residual isomer was found by use of this strain in 38% yield, and (S)-glycidol (99.4% enantiomeric excess) was subsequently synthesized from the obtained (S)-3-chloro-1,2-propanediol by alk. treatment.

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Iodide – Wikipedia,
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Quality Control of Mesitylcopper(I). Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Mesitylcopper(I), is researched, Molecular C9H11Cu, CAS is 75732-01-3, about Copper nanoparticles generated in situ in imidazolium based ionic liquids. Author is Arquilliere, P.; Haumesser, P. H.; Santini, C. C..

Copper nanoparticles (CuNPs) have been successfully synthesized in imidazolium based ionic liquid (IL) under mild conditions. In this self-ordered medium, particles with narrow size distribution can be formed. No ligand is required to stabilize the suspension, which can be directly used to coat technol. substrates. Several parameters are examined: the nature of IL, stirring, dihydrogen pressure and temperature Under optimal conditions, well dispersed, zero-valent CuNPs of 4.5 nm with narrow size distribution are obtained. These stable suspension of Cu(0)NPs is a promising starting material to form conformal copper seed layers in high aspect ratio interconnect structures.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Mesitylcopper(I)( cas:75732-01-3 ) is researched.Synthetic Route of C9H11Cu.Gustafsson, Bjoern; Hakansson, Mikael; Jagner, Susan published the article 《Copper(II) is harder than copper(I): a novel mixed-valence example from alkoxide chemistry》 about this compound( cas:75732-01-3 ) in New Journal of Chemistry. Keywords: copper mixed valence trinuclear allyl phenoxide preparation; phenol allyl methyl copper mixed valence trinuclear complex; alkene copper mixed valence trinuclear complex allylphenolate; crystal structure copper mixed valence trinuclear allyl methyl phenoxide; mol structure copper mixed valence trinuclear allyl methyl phenoxide. Let’s learn more about this compound (cas:75732-01-3).

Partial oxidation or disproportionation of tetrameric 2-allyl-6-methylphenoxocopper(I) leads to the formation of a novel trinuclear mixed-valence Cu(I)/Cu(II) alkoxide [Cu3[μ-η2-OC6H3-6-Me-2-(CH2CH:CH2)-κO]4], in which the central copper(II) atom is coordinated in a distorted square-planar configuration by four μ-oxide ligands, whereas the peripheral copper(I) centers are each bonded to two C:C groups and two μ-oxide ligands in a tetrahedral arrangement.

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Iodide – Wikipedia,
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