Tag: M.W=100-200

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Solid state properties and effective resolution procedure for guaifenesin, 3-(2-methoxyphenoxy)-1,2-propanediol, published in 2006-11-17, which mentions a compound: 60827-45-4, Name is (2S)-(+)-3-Chloropropane-1,2-diol, Molecular C3H7ClO2, Recommanded Product: 60827-45-4.

Racemic expectorant guaifenesin, 3-(2-methoxyphenoxy)-1,2-propanediol (2) undergoes spontaneous resolution upon crystallization This fact is confirmed by thermal anal. (single eutectic V-shape binary melting phase diagram, adequate entropy and free energy characteristics). Racemic 2 could be effectively resolved into (S)- and (R)-2 by a preferential crystallization procedure. Single enantiomer drugs levomoprolol and levotensin were obtained by starting from enantiomeric 2 through the sulfite route.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 60827-45-4. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about Study on acute toxicity of R,S and (R,S)-3-chloro-1,2-propanediol.

The aim of the paper was to investigate the acute toxicity of R,S and (R,S)-3-chloro-1,2-propanediol (3-MCPD). Ten, seven and seven groups of sexually mature ICR mice were employed for testing the acute toxicity of R, S and (R,S)-3-MCPD, at the doses of 176.78 mg/kg, 198.43 mg/kg, 222.73 mg/kg, 250 mg/kg, 280.61 mg/kg, 314.98 mg/kg, 353.55 mg/kg, 396.84 mg/kg, 445.44 mg/kg, and 499.99 mg/kg for R-3-MCPD, 89.09 mg/kg, 100 mg/kg, 112.25 mg/kg, 125.99 mg/kg, 141.42 mg/kg, 158.74 mg/kg and 178.18 mg/kg for S-3-MCPD, and 130.25 mg/kg, 150 mg/kg, 172.75 mg/kg, 198.95 mg/kg, 229.13 mg/kg, 263.88 mg/kg and 303.91 mg/kg for (R,S)-3-MCPD, resp. The mice were given three forms of 3-MCPD once by gavage and observed for 14 days, the LD50 was calculated by the modified Karber’s method, and organ/body weight ratios were measured and morphol. changes of liver and kidney were examined Results showed that the LD50 (95% CI) of R, S and (R,S)-3-MCPD was 290.54 mg/kg (280.74-300.68), 117.57 mg/kg (113.82-121.45) and 190.73 mg/kg (177.76-204.59), resp. The kidney/weight ratios in R-3-MCPD treated groups were higher than controls at the doses of 250-353.55 mg/kg (P < 0.05), and the brain weight ratios also had an significant increase in the 353.55 mg/kg, 445.44 mg/kg and above doses (P < 0.05). However, no significant changes on organ/body weight ratio of any organs in S-3-MCPD treated groups were observed The kidney/body weight ratio in (R,S)-3-MCPD treated groups increased significantly at the doses of 198.95-303.91 mg/kg (P < 0.05), and the brain weight ratios also had a significant increase at the doses of 229.13-303.91 mg/kg. At the doses of 353.55-499.99mg/kg, R-3-MCPD caused obvious swell of liver cells and the swell and congestion of the liver sinus. At the dose 229.13 mg/kg and above, (R,S)-3-MCPD also induced the swell of liver cells and congestion of the liver sinus. No obvious morphol. change of kidney after administration of R, S and (R,S)-3-MCPD was observed In conclusion, the acute toxicity of S-3-MCPD might be much higher than those of (R,S)-3-MCPD and R-3-MCPD, and both R-3-MCPD and S-3-MCPD seemed to possess neurotoxicity. There is still a lot of research devoted to this compound(SMILES：OC[C@H](O)CCl)Application of 60827-45-4, and with the development of science, more effects of this compound(60827-45-4) can be discovered.

Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Aalten, Henk L.; Van Koten, Gerard; Goubitz, Kees; Stam, Casper H. researched the compound: Mesitylcopper(I)( cas:75732-01-3 ).HPLC of Formula: 75732-01-3.They published the article 《A stable trinuclear mixed (organic)(organo)copper cluster: synthesis and structure of bis(benzoato)(mesityl)tricopper(I)》 about this compound( cas:75732-01-3 ) in Journal of the Chemical Society, Chemical Communications. Keywords: crystal structure bisbenzoatomesityltricopper; copper bisbenzoatomesityl crystal structure; benzoatomesitylcopper crystal structure. We’ll tell you more about this compound (cas:75732-01-3).

The interaggregate exchange reaction of Cu5(C6H2Me3-2,4,6)5 with Cu4(OBz)4 in C6H6 or PhMe gave 40% of the title trinuclear cluster (I). The structure of I was determined by x-ray crystallog. anal.; results were refined to R 0.059 for 1627 reflections. I possesses 2-bridging benzoato groups and 1 bridging, 3-center, 2-electron bonded mesityl group.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called A simplified catalytic system for direct catalytic asymmetric aldol reaction of thioamides; application to an enantioselective synthesis of atorvastatin, published in 2011, which mentions a compound: 75732-01-3, mainly applied to atorvastatin enantioselective synthesis; ketoester preparation amination cyclization; hydroxyalkyl thioamide preparation lithium reagent; thioamide aldehyde aldol reaction Cu catalyst, Application of 75732-01-3.

A new catalytic system was developed for the direct catalytic asym. aldol reaction of thioamides. The new lithium-free Cu catalyst (second-generation catalyst) exhibited enhanced catalytic efficiency over the previously developed catalyst comprising [Cu(CH3CN)4]PF6/Ph-BPE/LiOAr (first-generation catalyst), which required a tedious catalyst preparation process. In the reaction with the second-generation catalyst, the intermediate Cu-aldolate functioned as a Bronsted base to generate thioamide enolate, efficiently driving the catalytic cycle. The present aldol methodol. culminated in a concise asym. synthesis of atorvastatin I (Lipitor: atorvastatin calcium), a widely prescribed HMG-CoA reductase inhibitor for lowering low-d. lipoprotein cholesterol.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Conformation of biaryls. Dipole moment measurements of o-methylbiphenyls》. Authors are Sato, Takeo.The article about the compound:2-Methylglutaronitrilecas:4553-62-2,SMILESS:N#CC(C)CCC#N).Application In Synthesis of 2-Methylglutaronitrile. Through the article, more information about this compound (cas:4553-62-2) is conveyed.

cf. CA 54, 19584a. 5,5′-Dinitro- (I), 5,5′-dichloro-2,2′-dimethylbiphenyl (II), and 2-methyl-3′,5-dinitrobiphenyl (III) were prepared, their dipole moments measured and the interplanar angles calculated The results for I and II showed the rings to be nearly perpendicular to each other, whereas III showed a slight trans arrangement with inclined C6H6 rings at an angle of 76°. 2-Iodo-4-nitrotoluene (100 g.) and 150 g. dry sand heated to 215° 100 g. activated Cu-bronze (IV) added over 1 hr. with good stirring at 215-20°, heated and kept 1.5 hrs. at 250°, the mixture poured into dry sand and extracted with EtOH gave a low yield of I, yellow needles, m. 177-8° (HOAc or Me2CO). 4-Chloro-2-iodotoluene (16 g.) heated at 240-50°, 20 g. IV added over 1 hr., the mixture heated and kept 40 min. at 280-90°, extracted with Me2CO and distilled gave II, b4 140-55°, n20 1.5961. IV (15 g.) added with stirring over 30 min. to a mixture of 4 g. 2-iodo-4-nitrotoluene and 75 g. m-nitroiodobenzene at 220-30°, heated and kept 30 min. at 240-50°, extracted with Me2CO and the solvent evaporated gave III, yellow plates, m. 145-6° (EtOH).

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Cui, Chengzhong; Bonder, Edward M.; Jaekle, Frieder researched the compound: Mesitylcopper(I)( cas:75732-01-3 ).COA of Formula: C9H11Cu.They published the article 《Organoboronium amphiphilic block copolymers》 about this compound( cas:75732-01-3 ) in Journal of Polymer Science, Part A: Polymer Chemistry. Keywords: styrene trimethylsilylstyrene diblock organoboronium amphiphile polymer. We’ll tell you more about this compound (cas:75732-01-3).

A new class of amphiphilic organometallic block copolymers with cationic organoboron pendant groups was developed. Selective replacement of one of the bromine substitutents on each boryl group of the block copolymer PSBBr2-b-PS with an organometallic reagent ArM (ArM = 2,4,6-trimethylphenyl copper, 4-t-butylphenyltrimethyl tin) followed by treatment with 2,2′-bipyridine gave the novel block copolymers [3Ar](Br)n as light yellow solid materials that show good stability in air and moisture and high solubility in most organic solvents. Their structure and composition were confirmed by multinuclear NMR, GPC, and elemental anal. Highly regular micellar aggregates form in block-selective solvents (e.g., MeOH, toluene) as demonstrated by 1H NMR, dynamic light scattering, and transmission electron microscopy. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 6612-6618, 2009.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Robinson, Thomas P.; Price, Richard D.; Davidson, Matthew G.; Fox, Mark A.; Johnson, Andrew L. researched the compound: Mesitylcopper(I)( cas:75732-01-3 ).Recommanded Product: 75732-01-3.They published the article 《Why are the {Cu4N4} rings in copper(I) phosphinimide clusters [Cu{μ-N:PR3}]4 (R = NMe3 or Ph) planar?》 about this compound( cas:75732-01-3 ) in Dalton Transactions. Keywords: crystal structure optimized tetrameric cyclic copper phosphinimide preparation; mol structure optimized tetrameric cyclic copper phosphinimide preparation. We’ll tell you more about this compound (cas:75732-01-3).

The Cu phosphinimide complexes [Cu{μ-N:PR3}]4 (1, R = NMe2 and 2, R = Ph) were obtained in good yields from the reactions of Cu[Mes] (Mes = mesityl, C6H2Me3-2,4,6) with the corresponding iminophosphoranes, HNPR3. The mol. structures of 1 and 2 reveal planar eight-membered {Cu4N4} rings which contrasts with the saddle-shaped {M4N4} rings found in related metal phosphinimide complexes. According to computations, there is negligible aromaticity in the planar {Cu4N4} rings in 1 and 2 and the saddle shape observed in related {M4N4} rings is due to steric factors.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Recommanded Product: (2S)-(+)-3-Chloropropane-1,2-diol. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (2S)-(+)-3-Chloropropane-1,2-diol, is researched, Molecular C3H7ClO2, CAS is 60827-45-4, about Inhibition of glucose catabolism in rat, hamster, rhesus monkey and human spermatozoa by α-chlorohydrin. Author is Ford, W. C. L.; Harrison, Anne; Takkar, G. L.; Waites, G. M. H..

Spermatozoa from the cauda epididymis of rats treated with RS-α-chlorohydrin [96-24-2] (10 mg/kg/day for 7 days, orally) had the same ATP [56-65-5] content as control spermatozoa immediately after collection, but were unable to metabolize glucose [50-99-7] in vitro and so their ATP content declined more rapidly than that of control spermatozoa. The in vitro metabolism of glucose by spermatozoa from rat, hamster, rhesus monkey, and human was inhibited by ≥80% after 15-30 min preincubation in the presence of RS-α-chlorohydrin concentrations of <1, >10, 5-10, and >50 mM, resp. Inhibition of glucose oxidation was correlated with a reduction in ATP concentration in the spermatozoa. α-Chlorohydrin may act as an antifertility agent by inhibition of sperm glycolysis, but RS-α-chlorohydrin would apparently not be an effective contraceptive in man. However, the glucose metabolism of human spermatozoa was significantly inhibited by <10 mM of S-α-chlorohydrin [60827-45-4]. There is still a lot of research devoted to this compound(SMILES：OC[C@H](O)CCl)Recommanded Product: (2S)-(+)-3-Chloropropane-1,2-diol, and with the development of science, more effects of this compound(60827-45-4) can be discovered.

Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

SDS of cas: 75732-01-3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Mesitylcopper(I), is researched, Molecular C9H11Cu, CAS is 75732-01-3, about Main-Group-Metal and Transition-Metal Complexes Containing Fluorinated β-Diketiminate Ligands. Author is Huse, Kevin; Woelper, Christoph; Schulz, Stephan.

The synthesis of fluorinated β-diketimine LH (1) (L = HC[C(CF3)NC6F5]2) and its reactions with main-group-metal and transition-metal complexes, yielding LAlMe2 (4), LZnEt (5), LCu(C6D6) (6) and LCuCO (7), is reported. 1-7 Were characterized by IR and NMR spectroscopy (1H, 13C, 19F), elemental anal. and single-crystal x-ray diffraction. The C6F5 substituents strongly reduce the π-back-bonding capacity of the β-diketiminate ligand as was shown for 7 by IR spectroscopy.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Petukhova, N. I.; Khalimova, L. Kh.; Mitrofanov, D. V.; Gareev, V. M.; Zorin, V. V. researched the compound: (2S)-(+)-3-Chloropropane-1,2-diol( cas:60827-45-4 ).Application In Synthesis of (2S)-(+)-3-Chloropropane-1,2-diol.They published the article 《Rhodococcus sp. 18-19 and Pseudomonas sp. 31-3 as new tools for obtaining of optically active 3-chloro-1,2-propanediol》 about this compound( cas:60827-45-4 ) in Bashkirskii Khimicheskii Zhurnal. Keywords: chloropropanediol kinetic resolution Rhodococcus Pseudomonas. We’ll tell you more about this compound (cas:60827-45-4).

Bacteria synthesizing stereoselective ferments of 3-chloro-1,2-propanediol transformation were isolated from the soil samples. Rhodococcus sp. 18-19 and Pseudomonas sp. 31-3 were revealed to be the most active strains, exhibiting the opposite specificity to diol stereoisomeres. The possibility to use these strains for obtaining of optically active 3-chloro-1,2-propanediol by the kinetic resolution of racemate with help of resting or growing cells was shown. It was found, that (S)-enantiomer (97% ee) can be obtained when using Rhodococcus sp. 18-19 strain, and (R)-enantiomer (96% ee) – when using Pseudomonas sp. 31-3 strain.

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Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com