Tag: 400-500

Fusion of Aromatic Ring to Azoarenes: One-Pot Access to 5,6-Phenanthroliniums for Mitochondria-Targeted Far-Red/NIR Fluorescent Probes was written by Liu, Zheng;Xian, Yonghua;Lan, Jingbo;Luo, Yuanyuan;Ma, Weixin;You, Jingsong. And the article was included in Organic Letters in 2019.Name: Mesityl(p-tolyl)iodonium trifluoromethanesulfonate The following contents are mentioned in the article:

Disclosed herein is a highly efficient strategy to fuse an aromatic ring to azoarenes for one-pot access to 5,6-phenanthrolinium skeletons via tandem ortho-C-H arylation and aryl quaternization. This protocol enables ortho-hindered azobenzenes to solely form 5-aryl-5,6-phenanthroliniums and ortho-unhindered azobenzenes to exclusively generate 5,7-diaryl-5,6-phenanthroliniums. The diarylated products exhibit far-red to NIR emissions (678-742 nm) with large Stokes shifts, can specifically light up mitochondria in living cells, and, moreover, possess excellent photostability and low cytotoxicity. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Name: Mesityl(p-tolyl)iodonium trifluoromethanesulfonate).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Name: Mesityl(p-tolyl)iodonium trifluoromethanesulfonate

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Quinols As Novel Therapeutic Agents. 7.Synthesis of Antitumor 4-[1-(Arylsulfonyl-1H-indol-2-yl)]-4-hydroxycyclohexa-2,5-dien-1-ones by Sonogashira Reactions was written by McCarroll, Andrew J.;Bradshaw, Tracey D.;Westwell, Andrew D.;Matthews, Charles S.;Stevens, Malcolm F. G.. And the article was included in Journal of Medicinal Chemistry in 2007.Application In Synthesis of 4-Bromo-N-(2-iodophenyl)benzenesulfonamide The following contents are mentioned in the article:

Interaction of 2-iodoaniline or 5-fluoro-2-iodoaniline with a range of arylsulfonyl chlorides affords sulfonamides that undergo Sonogashira couplings under thermal or microwave conditions with the alkyne 4-ethynyl-4-hydroxycyclohexa-2,5-dien-1-one followed by cyclization to 4-[1-(arylsulfonyl-1H-indol-2-yl)]-4-hydroxycyclohexa-2,5-dien-1-ones. This method allows for incorporation of a range of substituents into the arylsulfonyl moiety, and compounds showed selective in vitro inhibition of cancer cell lines of colon and renal origin, a feature of compounds bearing the quinol pharmacophore. This study involved multiple reactions and reactants, such as 4-Bromo-N-(2-iodophenyl)benzenesulfonamide (cas: 349404-93-9Application In Synthesis of 4-Bromo-N-(2-iodophenyl)benzenesulfonamide).

4-Bromo-N-(2-iodophenyl)benzenesulfonamide (cas: 349404-93-9) belongs to iodide derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Application In Synthesis of 4-Bromo-N-(2-iodophenyl)benzenesulfonamide

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Utilization of Copper-Catalyzed Carboarylation-Ring Closure for the Synthesis of New Oxazoline Derivatives was written by Sinai, Adam;Vangel, Dora;Gati, Tamas;Bombicz, Petra;Novak, Zoltan. And the article was included in Organic Letters in 2015.Category: iodides-buliding-blocks The following contents are mentioned in the article:

A copper-catalyzed carboarylation-ring closure strategy was used for the modular synthesis of oxazolines via the reaction of 1-aryl- and 1-alkylpropargylamides and diaryliodonium salts. The novel approach enables the efficient, modular synthesis of oxazoline derivatives bearing fully substituted exo double bonds. E.g., in presence of CuCl in EtOAc at 50 °C, carboarylation-ring closure of N-(3-(2-methylphenyl)prop-2-ynyl)pivalamide with mesityl(phenyl)iodonium trifluoromethanesulfonate gave 76.0% (E)-2-tert-butyl-5-(phenyl(o-tolyl)methylene)-4,5-dihydrooxazole (I). This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Category: iodides-buliding-blocks).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Copper-Catalyzed Regioselective C-H Sulfonyloxylation of Electron-Rich Arenes with p-Toluenesulfonic Acid and Sulfonyloxylation of Aryl(mesityl)iodonium Sulfonates was written by Huang, He;Wu, Yang;Zhang, Wen;Feng, Chun;Wang, Bi-Qin;Cai, Wan-Fei;Hu, Ping;Zhao, Ke-Qing;Xiang, Shi-Kai. And the article was included in Journal of Organic Chemistry in 2017.Reference of 1204518-02-4 The following contents are mentioned in the article:

Copper-catalyzed regioselective C-H sulfonyloxylation of electron-rich arenes with p-toluenesulfonic acid has been developed. Electron-rich benzene derivatives and heteroarenes can undergo this C-H sulfonyloxylation reaction to generate aryl tosylates. Furthermore, sulfonyloxylation of aryl(mesityl)iodonium sulfonates has also been investigated. Both aryl(mesityl)iodonium tosylates and triflates can react smoothly to get aryl sulfonates. The formed aryl sulfonates, e.g., I, can be converted to phenols, as well as used as good partners of cross-coupling reactions. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Reference of 1204518-02-4).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Reference of 1204518-02-4

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Deacetylative Aryl Migration of Diaryliodonium Salts with C(sp²)-N Bond Formation toward ortho-Iodo N-Aryl Sulfonamides was written by Chen, Huangguan;Wang, Limin;Han, Jianwei. And the article was included in Organic Letters in 2020.Name: 4-Bromo-N-(2-iodophenyl)benzenesulfonamide The following contents are mentioned in the article:

An unprecedented approach of metal-free C(sp²)-N bond formation via deacetylation/intramol. aryl migration is demonstrated with novel N-sulfonamide substituted diaryliodonium salts. The reaction provides a variety of ortho-iodo N-aryl sulfonamides. The products were employed in several coupling reactions to afford useful diarylamine scaffolds. Furthermore, the key intermediates of zwitterionic iodoniums in the reaction were isolated and verified by the X-ray crystallog. anal., which showcased unambiguous mechanistic insight into the reactivity of the reaction cascade. This study involved multiple reactions and reactants, such as 4-Bromo-N-(2-iodophenyl)benzenesulfonamide (cas: 349404-93-9Name: 4-Bromo-N-(2-iodophenyl)benzenesulfonamide).

4-Bromo-N-(2-iodophenyl)benzenesulfonamide (cas: 349404-93-9) belongs to iodide derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Name: 4-Bromo-N-(2-iodophenyl)benzenesulfonamide

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Regiocontrolled Direct C-H Arylation of Indoles at the C4 and C5 Positions was written by Yang, Youqing;Gao, Pan;Zhao, Yue;Shi, Zhuangzhi. And the article was included in Angewandte Chemie, International Edition in 2017.Category: iodides-buliding-blocks The following contents are mentioned in the article:

An effective and practical strategy has been established for the direct and site-selective arylation of indoles at the C4 and C5 positions with the aid of a readily accessible, cheap, and removable pivaloyl directing group at the C3 position. This transformation shows good functional-group tolerance and could serve as a powerful synthetic tool for the synthesis of medicinally relevant compounds This method and those developed in previous research together enable the regiocontrolled direct arylation of indole at each C-H bond without prefunctionalization of the reactive sites. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Category: iodides-buliding-blocks).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Regiodivergent C-H Arylation of Triphenylene Derivatives Controlled by Electronic Effects of Diaryliodonium Salts was written by Zhao, Ke;Du, Yu;Peng, Qiong;Yu, Wen-Hao;Wang, Bi-Qin;Feng, Chun;Xiang, Shi-Kai. And the article was included in Journal of Organic Chemistry in 2021.Safety of Mesityl(p-tolyl)iodonium trifluoromethanesulfonate The following contents are mentioned in the article:

A regiodivergent C-H arylation of triphenylene derivatives with diaryliodonium salts was developed. The regiodivergence was controlled by electronic effects of diaryliodonium salts. When the aryl(mesityl)iodonium salts bearing strong electron-donating groups at the para-position of aryl groups were used, the arylation reactions occurred ortho to amide groups. However, if the aryl(mesityl)iodonium salts bearing electron-withdrawing groups or weak electron-donating groups at the para-position of aryl groups were utilized, the arylation reactions occurred meta to amide groups. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Safety of Mesityl(p-tolyl)iodonium trifluoromethanesulfonate).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Safety of Mesityl(p-tolyl)iodonium trifluoromethanesulfonate

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Palladium-Catalyzed C-H ortho Arylation of Benzoic Acids with Diaryliodonium Salts in Water was written by Wu, Zhiqing;Chen, Si;Hu, Chenxu;Li, Zhengkai;Xiang, Haifeng;Zhou, Xiangge. And the article was included in ChemCatChem in 2013.Application of 1204518-02-4 The following contents are mentioned in the article:

We disclose an efficient and practical protocol for the C-H ortho arylation of benzoic acids by using water as an environmentally benign, nontoxic reaction medium. Remarkably, the diaryliodonium salts were first utilized as arylating reagents for C -H arylation of benzoic acids. The choice of water as the solvent is crucial for this reaction, which sets the stage for the broad application of aqueous conditions in C-H functionalization reactions. Overall, this simple catalytic system represents an important complement to previous reports for the preparation of biaryls. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Application of 1204518-02-4).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Application of 1204518-02-4

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Copper-Catalyzed Oxidative Ring Closure and Carboarylation of 2-Ethynylanilides was written by Sinai, Adam;Meszaros, Adam;Gati, Tamas;Kudar, Veronika;Pallo, Anna;Novak, Zoltan. And the article was included in Organic Letters in 2013.Recommanded Product: Mesityl(p-tolyl)iodonium trifluoromethanesulfonate The following contents are mentioned in the article:

A new copper-catalyzed oxidative ring closure of ethynyl anilides with diaryliodonium salts was developed for the highly modular construction of benzoxazines bearing a fully substituted exo double bond. E.g., in presence of Cu(OTf)₂ in DCE, copper-catalyzed oxidative ring closure of o-ethynylanilide (I) with diaryliodonium triflate (II) gave 65% (diarylmethylene)benzoxazine (III, E/Z = 2:3). The oxidative transformation includes an unusual 6-exo-dig cyclization step with the formation of C-O and C-C bonds. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Recommanded Product: Mesityl(p-tolyl)iodonium trifluoromethanesulfonate).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Recommanded Product: Mesityl(p-tolyl)iodonium trifluoromethanesulfonate

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Palladium(II)-catalyzed ortho-arylation via phosphate-group-directed C-H activation was written by Jeon, Woo Hyung;Lee, Tae Seob;Kim, Eun Jin;Moon, Bongjin;Kang, Jahyo. And the article was included in Tetrahedron in 2013.COA of Formula: C17H18F3IO3S The following contents are mentioned in the article:

Aryl dialkyl phosphate, which is readily available from phenol, was a good substrate for the Pd(II) catalyzed aryl-aryl coupling reaction through ortho-C-H activation. Although a phosphate group is regarded as a poor coordinating group, highly regioselective ortho-arylation could be achieved by employing Pd(OTf)₂·2H₂O and Ar₂IOTf as a catalyst and an aryl group source, resp. The phosphate group of the resulting coupled product can be transformed into an aryl anion via reductive cleavage and used for further C-C bond formation. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4COA of Formula: C17H18F3IO3S).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.COA of Formula: C17H18F3IO3S

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com