Tag: 400-500

Iridium(III)-Catalyzed Direct Arylation of C-H Bonds with Diaryliodonium Salts was written by Gao, Pan;Guo, Wei;Xue, Jingjing;Zhao, Yue;Yuan, Yu;Xia, Yuanzhi;Shi, Zhuangzhi. And the article was included in Journal of the American Chemical Society in 2015.Synthetic Route of C17H18F3IO3S The following contents are mentioned in the article:

By developing a new Ir(III)-catalyzed C-C cross-coupling, a versatile method for direct arylation of sp² and sp³ C-H bonds in ketoximes, nitrogen-containing heterocycles, various arenes, and olefins has been established. The key to this arylation depends on the appropriate choice of catalyst and the use of diaryliodonium triflate salts as the coupling partners. This transformation has good functional group compatibility and can serve as a powerful synthetic tool for late-stage C-H arylation of complex compounds Mechanistic studies by d. functional theory calculations suggested that the sp³ C-H activation was realized by a triflate-involved concerted metalation-deprotonation process, and the following oxidation of Ir(III) to Ir(V) is the most favorable when a bistriflimide is contained in the diaryliodonium salt. Calculations indicated that both steps are enabled by initial anion exchange between the reactant complexes. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Synthetic Route of C17H18F3IO3S).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Synthetic Route of C17H18F3IO3S

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Iridium(III)-Catalyzed Diarylation/Annulation of Benzoic Acids: Facile Access to Multi-Aryl Spirobifluorenes as Pure Hydrocarbon Hosts for High-Performance OLEDs was written by Luo, Yuanyuan;Liu, Zheng;Yang, Ge;Wang, Tianhong;Bin, Zhengyang;Lan, Jingbo;Wu, Di;You, Jingsong. And the article was included in Angewandte Chemie, International Edition in 2021.Product Details of 1204518-02-4 The following contents are mentioned in the article:

Herein disclosed is the 1st example of diarylation/annulation of benzoic acids via an Ir catalyst system. This protocol provides a step-economic and highly efficient pathway to 1-aryl, 1,3-diaryl, 1,7-diaryl and 1,3,7-triaryl spirobifluorenes from readily available starting materials. The applications of multi-aryl spirobifluorenes as pure hydrocarbon (PHC) hosts for red, green, and blue (RGB) phosphorescent organic light-emitting diodes (PhOLEDs) were explored. Due to high triplet energies, 1,3-diaryl spirobifluorenes exhibit the potential as the host material of blue PhOLEDs. 1,7-Diaryl spirobifluorene can serve as the host of green PhOLEDs. 1,3,7-Triaryl spirobifluorene is a high-performance host for red PhOLEDs, which exhibits a high external quantum efficiency (EQE) up to 27.3%. This work not only exemplifies the great potential of multi-aryl spirobifluorenes as PHC hosts, but also offers a new approach for the synthesis of these PHC hosts. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Product Details of 1204518-02-4).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Product Details of 1204518-02-4

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Enantioselective α-Arylation of Ketones via a Novel Cu(I)-Bis(phosphine) Dioxide Catalytic System was written by Escudero-Casao, Margarita;Licini, Giulia;Orlandi, Manuel. And the article was included in Journal of the American Chemical Society in 2021.Safety of Mesityl(p-tolyl)iodonium trifluoromethanesulfonate The following contents are mentioned in the article:

A novel catalytic system based on copper(I) and chiral bis(phosphine) dioxides I (Ar = 3,4,5-trimethoxyphenyl) is described. This allows the arylation of silyl enol ethers (Z)-R¹C(OX)=CHR² (R¹ = MeO, Bu, Ph, 4-methoxy-3,5-dimethylphenyl, etc.; R² = Me, Et, benzyl; X = trimethylsilyl) to access enolizable α-arylated ketones R¹CH(R²)C(O)R³ (R³ = Ph, 2,3-dihydro-1H-inden-5-yl, 2-naphthyl, etc.) and II (Y = CH₂, O) in good yields and enantiomeric excess up to 95%. Noncyclic ketones are amenable substrates with this method, which complements other approaches based on palladium catalysis. Optimization of the ligand structure is accomplished via rational design driven by correlation anal. Preliminary mechanistic hypotheses are also evaluated in order to identify the role of chiral bis(phosphine) dioxides. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Safety of Mesityl(p-tolyl)iodonium trifluoromethanesulfonate).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Safety of Mesityl(p-tolyl)iodonium trifluoromethanesulfonate

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Palladium-catalyzed direct β-arylation of ketones with diaryliodonium salts: a stoichiometric heavy metal-free and user-friendly approach was written by Huang, Zhongxing;Sam, Quynh P.;Dong, Guangbin. And the article was included in Chemical Science in 2015.Quality Control of Mesityl(p-tolyl)iodonium trifluoromethanesulfonate The following contents are mentioned in the article:

A new protocol for the Pd-catalyzed β-arylation of ketones such as cyclohexanone, cyclopentanone, cycloheptanone, etc. without stoichiometric heavy metals has been reported. Widely accessible mesitylaryliodonium salts I (Ar = C₆H₅, naphth-1-yl, 2,5-dimethylthiophen-3-yl, biphenyl-4-yl, etc.) are used as both the oxidant and aryl source. This tandem redox catalysis merges ketone dehydrogenation and conjugate addition without an addnl. oxidant or reductant. This transformation features the use of a unique bis-N-tosylsulfilimine ligand and the combination of potassium trifluoroacetate/trifluoroacetic acid to maintain an appropriate acidity of the reaction medium. The reaction tolerates both air and moisture, and shows a broad substrate scope. Kinetics studies, along with filtration and poisoning tests, support the involvement of palladium nanoparticles in the catalysis. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Quality Control of Mesityl(p-tolyl)iodonium trifluoromethanesulfonate).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Quality Control of Mesityl(p-tolyl)iodonium trifluoromethanesulfonate

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

C(sp³)-H Bond Arylation and Amidation of Si-Bound Methyl Group via Directing Group Strategy was written by Han, Jie-Lian;Qin, Ying;Zhao, Dongbing. And the article was included in ACS Catalysis in 2019.Synthetic Route of C17H18F3IO3S The following contents are mentioned in the article:

Silylmethyl functionalization provides a general and efficient access to diverse organosilanes. The traditional methods for silylmethyl functionalization often involved silylmethylmetals or silylmethyl halides. In recent years, a C-H activation strategy has become one of the most attractive alternatives in organic synthesis. Authors envisioned that the attachment of a coordinating group at silicon of methylsilanes provides the opportunity to modify the silylmethyl group via directed C-H bond functionalization. However, despite employment of silicon tethers bearing a directing group (DG) for C(sp²)-H functionalization has been well established due to the fact that the silicon tethers are easily installable and removable/modifiable, applying this concept toward C(sp³)-H functionalization remains underdeveloped. Herein, authors successfully developed Ir^III/Rh^III-catalyzed C-H bond arylation/amidation of silyl Me group by using directing group strategy, which constitutes the most powerful access to benzylsilanes and amino-substituted silanes. Moreover, they demonstrated that the pyridine directing group on silicon atom can be easily removed, and the starting materials can also be efficiently recovered, which are different from those of pyridine-directed C-H functionalization of C-bound Me group. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Synthetic Route of C17H18F3IO3S).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Synthetic Route of C17H18F3IO3S

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A steric tethering approach enables palladium-catalysed C-H activation of primary amino alcohols was written by Calleja, Jonas;Pla, Daniel;Gorman, Timothy W.;Domingo, Victoriano;Haffemayer, Benjamin;Gaunt, Matthew J.. And the article was included in Nature Chemistry in 2015.Formula: C17H18F3IO3S The following contents are mentioned in the article:

Hemiaminals of β-amino alcs. such as I (R = H, Me) were regioselectively acetoxylated, arylated, cyclocarbonylated, and alkenylated (with subsequent Michael addition and reduction) in the presence of Pd(OAc)₂ to yield protected δ-functionalized-β-amino alcs. such as II (R = H, Me; R¹ = AcO, Ph, 4-ClC₆H₄, 4-BrC₆H₄, 4-FC₆H₄, 4-EtO₂CC₆H₄, 4-MeC₆H₄, 4-MeOC₆H₄, 4-i-BuC₆H₄, 3-F₃CC₆H₄, 3-EtO₂CC₆H₄, 1,3-benzodioxol-5-yl), pyrrolooxazolidinones such as III, and pyrrolooxazolidines such as IV [R² = F₃CCH₂O₂C, 3,5-(F₃C)₂C₆H₃CH₂O₂C, PhSO₂]. The formation of sterically hindered hemiaminal moieties allowed the selective functionalization of amino alcs. by inhibiting the formation of inactive diaminepalladium complexes while allowing intramol. C-H activation to occur. The structure of an intermediate cyclopalladated spirocyclohexaneoxazoline was determined by X-ray crystallog. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Formula: C17H18F3IO3S).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Formula: C17H18F3IO3S

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Scalable electrochemical synthesis of diaryliodonium salts was written by Elsherbini, Mohamed;Moran, Wesley J.. And the article was included in Organic & Biomolecular Chemistry in 2021.Related Products of 1204518-02-4 The following contents are mentioned in the article:

Cyclic and acyclic diaryliodoniums I (R = H, 2-Me, 8-F, 6,8-(Me)₂, 7-CF₃; R¹ = 2-F, 7-Cl, 2-OMe, etc.) and II (R² = 4-F, 4-Br, 2-Ph, etc.; R³ = H, 4-I, 4-Me, 2,4,6-(Me)₃) are synthesized by anodic oxidation of iodobiaryls III and iodoarenes R²C₆H₄I/arene R³C₆H₅ mixtures, resp., in a simple undivided electrolysis cell in MeCN-HFIP-TfOH without any added electrolyte salts. This atom efficient process does not require chem. oxidants and generates no chem. waste. More than 30 cyclic and acyclic diaryliodonium salts I with different substitution patterns were prepared in very good to excellent yields. The reaction was scaled-up to 10 mmol scale giving more than four grams of dibenzo[b,d]iodol-5-ium trifluoromethanesulfonate I (>95%) in less than three hours. The solvent mixture of the large-scale experiment was recovered (>97%) and recycled several times without significant reduction in yield. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Related Products of 1204518-02-4).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Related Products of 1204518-02-4

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com