Tag: 400-500

Cu-Catalyzed Direct C6-Arylation of Indoles was written by Yang, Youqing;Li, Ruirui;Zhao, Yue;Zhao, Dongbing;Shi, Zhuangzhi. And the article was included in Journal of the American Chemical Society in 2016.Application In Synthesis of Mesityl(p-tolyl)iodonium trifluoromethanesulfonate The following contents are mentioned in the article:

The first example of direct and site-selective arylation of indoles at the C6 position has been reported. The key to this high regioselectivity is the appropriate choice of the N-P(O)^tBu₂ directing group and the use of diaryliodonium triflate salts as the coupling partners in the presence of catalytic CuO. The protocol is distinguished by mild reaction system that avoids ligand and additives, exhibiting wide scope of indole and arene coupling components without compromising its efficiency and scalability, thus representing a significant advancement in the implementation of regioselective direct arylation of indoles. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Application In Synthesis of Mesityl(p-tolyl)iodonium trifluoromethanesulfonate).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Application In Synthesis of Mesityl(p-tolyl)iodonium trifluoromethanesulfonate

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Practical synthesis of diaryliodonium(III) triflates using ArI(OAc)₂/TfOH/MeCN reaction system was written by Komiyama, K.;Kobayashi, S.;Shoji, T.;Kikushima, K.;Dohi, T.;Kita, Y.. And the article was included in Russian Chemical Bulletin in 2020.Category: iodides-buliding-blocks The following contents are mentioned in the article:

Diaryliodonium(III) triflates Ar(Ar¹)I^+-OS(O)₂CF₃ (Ar = Ph, 2-bromophenyl, 2,4,6-trimethylphenyl, etc.; Ar¹ = 4-methylphenyl, 4-methoxy-2-(methoxycarbonyl)benzen-1-yl, thiophen-2-yl, etc.) and 3-(p-tolyliodonio)pyridin-1-ium/3-(p-tolyliodonio)quinolin-1-ium bistriflates were synthesized in a safe manner by the reaction of aryliodine(III) diacetates ArI(OAc)₂ and 3-(diacetoxyiodo)pyridine/3-(diacetoxyiodo)quinoline trifluoromethanesulfonic acids, aromatic compounds Ar¹H with triflic acid (TfOH) in MeCN under mild exothermic conditions. This method provides access to a variety of diaryliodonium(III) triflates, including derivatives with two different aryl substituents, with high purity. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Category: iodides-buliding-blocks).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A Selective C-H Deprotonation Strategy to Access Functionalized Arynes by Using Hypervalent Iodine was written by Sundalam, Sunil K.;Nilova, Aleksandra;Seidl, Thomas L.;Stuart, David R.. And the article was included in Angewandte Chemie, International Edition in 2016.Recommanded Product: Mesityl(p-tolyl)iodonium trifluoromethanesulfonate The following contents are mentioned in the article:

Described here is an efficient method to access highly functionalized arynes from unsym. aryl(mesityl)iodonium tosylate salts. The iodonium salts are prepared in a single pot from either com. available aryl iodides or arylboronic acids. The aryne intermediates are generated by ortho-C-H deprotonation of aryl(mesityl)iodonium salt with a com. available amide base and trapped in a cycloaddition reaction with furan in moderate to good yields. Coupling partners for the aryne intermediates beyond furan are also described, including benzyl azide and alicyclic amine nucleophiles. The regio- and chemoselectivity of this reaction is discussed and evidence for the spectator aryl ligand of the iodonium salt as a critical control element in selectivity is presented. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Recommanded Product: Mesityl(p-tolyl)iodonium trifluoromethanesulfonate).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Recommanded Product: Mesityl(p-tolyl)iodonium trifluoromethanesulfonate

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Catalytic and non-catalytic selective aryl transfer from (mesityl)iodonium(III) salts to diarylsulfide compounds was written by Takenaga, Naoko;Yoto, Yusuke;Hayashi, Takumi;Miyamoto, Naoki;Nojiri, Haruna;Kumar, Ravi;Dohi, Toshifumi. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2022.Recommanded Product: Mesityl(p-tolyl)iodonium trifluoromethanesulfonate The following contents are mentioned in the article:

A facile synthesis of triarylsulfonium triflates I [Ar = Ph, 4-MeC₆H₄, 2-naphthyl, etc.; Ar¹ = Ph, 4-BrC₆H₄, 2,4,6-tri-OMeC₆H₂, etc.; Ar² = Ph, 4-CF₃C₆H₄, 4-OMeC₆H₄, etc.] by selective aryl transfer from readily available mesityl iodonium(III) salts to diarylsulfides in the presence of a copper catalyst was described. The advantage of this protocol was the iodonium(III) salts bearing a mesitylene (Mes) auxiliary efficiently promote selective S-arylation of diarylsulfides to produce the desired triarylsulfonium triflates I without the formation of Mes-derived byproduct salts. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Recommanded Product: Mesityl(p-tolyl)iodonium trifluoromethanesulfonate).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Recommanded Product: Mesityl(p-tolyl)iodonium trifluoromethanesulfonate

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Chemoselective Cu-catalyzed synthesis of diverse N-arylindole carboxamides, β-oxo amides and N-arylindole-3-carbonitriles using diaryliodonium salts was written by Kumar Mehra, Manish;Malik, Monika;Kumar, Bintu;Kumar, Dalip. And the article was included in Organic & Biomolecular Chemistry in 2021.SDS of cas: 1204518-02-4 The following contents are mentioned in the article:

Chemoselective copper-catalyzed synthesis of diverse N-arylindole-3-carboxamides, β-oxo amides and N-arylindole-3-carbonitriles from readily accessible indole-3-carbonitriles, α-cyano ketones and diaryliodonium salts has been developed. Diverse N-arylindole-3-carboxamides and β-oxo amides were successfully achieved in high yields under copper-catalyzed neutral reaction conditions, and the addition of an organic base (DIPEA) resulted in a completely different selectivity pattern to produce N-arylindole-3-carbonitriles. Moreover, the importance of the developed methodol. was realized by the synthesis of indoloquinolones and N-((1H-indol-3-yl)methyl)aniline and by a single-step gram-scale synthesis of the naturally occurring cephalandole A analog. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4SDS of cas: 1204518-02-4).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.SDS of cas: 1204518-02-4

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Copper-catalyzed oxidative electrophilic carbofunctionalization of acrylamides for the synthesis of oxindoles was written by Li, Xueqin;Xu, Jian;Zhang, Pengbo;Gao, Yuzhen;Wu, Ju;Tang, Guo;Zhao, Yufen. And the article was included in Synlett in 2014.Formula: C17H18F3IO3S The following contents are mentioned in the article:

A novel and efficient copper-catalyzed tandem oxidative cyclization of N-aryl acrylamides I (R¹ = Me, Ph, PhCH₂, R² = H; R¹ = Me, R² = 4-MeO, 4-F, 3-Me, etc.; R³ = Me, PhCH₂), with diaryliodonium salts R⁴R⁵I^+ –OSO₂CF₃ (R⁴ = R⁵ = Ph; R⁴ = 4-MeC₆H₄, 4-ClC₆H₄, 4-FC₆H₄, R⁵ = 2,4,6-Me₃C₆H₂) is reported. The reaction provided a novel approach for the synthesis of oxindoles II and various functional groups were well tolerated. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Formula: C17H18F3IO3S).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Formula: C17H18F3IO3S

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Copper-catalyzed enantioselective arylalkynylation of alkenes was written by Lei, Guangyue;Zhang, Hanwen;Chen, Bin;Xu, Meichen;Zhang, Guozhu. And the article was included in Chemical Science in 2020.Category: iodides-buliding-blocks The following contents are mentioned in the article:

A copper-catalyzed enantioselective arylalkynation of alkenes, e.g., p-methylstyrene, with a diaryliodonium salt, e.g., diphenyliodonium hexafluorophosphate, and monosubstituted alkynes RCCH (R = Ph, cyclopropyl, thiophen-3-yl, etc.) is reported. The three-component coupling reactions proceed under mild reaction conditions with a broad substrate scope, leading to synthetically valuable 1,2-diaryl-3-butynes, e.g., (R)-[3-(p-tolyl)but-1-yne-1,4-diyl]dibenzene. The key to the success of this chem. is the employment of chiral bisoxazoline-phenylaniline (BOPA) ligand I. A novel reaction pathway involving Ph radical generation under thermal copper catalysis is proposed according to mechanistic studies. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Category: iodides-buliding-blocks).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Base promoted direct C4-arylation of 4-substituted-pyrazolin-5-ones with diaryliodonium salts was written by Mao, Song;Geng, Xu;Yang, Yang;Qian, Xiaofei;Wu, Shengying;Han, Jianwei;Wang, Limin. And the article was included in RSC Advances in 2015.Formula: C17H18F3IO3S The following contents are mentioned in the article:

A metal-free approach for the C4-arylation of 4-substituted-pyrazolin-5-ones I (R = H, H₂CHC:CH₂, H₂CC₆H₅, 4-F-C₆H₄CH₂, etc.; R¹ = CH₃, C₆H₅; R² = C₆H₅, 4-H₃CC₆H₄, 4-F₃CC₆H₄) with diaryliodonium salts was developed. The reaction proceeded smoothly at room temperature in the presence of DMAP (4-dimethylaminopyridine). As a result, a wide range of desired multi-substituted pyrazolin-5-one derivatives II were obtained in good to excellent yields (20-98%). This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Formula: C17H18F3IO3S).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Formula: C17H18F3IO3S

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Cu-Mediated C-H ¹⁸F-Fluorination of Electron-Rich (Hetero)arenes was written by McCammant, Matthew S.;Thompson, Stephen;Brooks, Allen F.;Krska, Shane W.;Scott, Peter J. H.;Sanford, Melanie S.. And the article was included in Organic Letters in 2017.Name: Mesityl(p-tolyl)iodonium trifluoromethanesulfonate The following contents are mentioned in the article:

This communication describes a method for the nucleophilic radiofluorination of electron-rich arenes. The reaction involves the initial C(sp²)-H functionalization of an electron-rich arene with MesI(OH)OTs to form a (mesityl)(aryl)iodonium salt. This salt is then used in situ in a Cu-mediated radiofluorination with [¹⁸F]KF. This approach leverages the stability and availability of electron-rich arene starting materials to enable mild late-stage radiofluorination of toluene, anisole, aniline, pyrrole, and thiophene derivatives The radiofluorination has been automated to access a 41 mCi dose of an ¹⁸F-labeled nimesulide derivative in high (2800 ± 700 Ci/mmol) specific activity. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Name: Mesityl(p-tolyl)iodonium trifluoromethanesulfonate).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Name: Mesityl(p-tolyl)iodonium trifluoromethanesulfonate

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Substrate or Solvent-Controlled Pd^II-Catalyzed Regioselective Arylation of Quinolin-4(1H)-ones Using Diaryliodonium Salts: Facile Access to Benzoxocine and Aaptamine Analogues was written by Mehra, Manish K.;Sharma, Shivani;Rangan, Krishnan;Kumar, Dalip. And the article was included in European Journal of Organic Chemistry in 2020.Related Products of 1204518-02-4 The following contents are mentioned in the article:

Regioselective C3, C5, and C8 arylation of quinolin-4(1H)-ones have been accomplished either by substrate control or by tuning the reaction solvent [e.g., quinolin-4(1H)-one + Ph₂I⁺ OTf^– → I (96%)]. A variety of aryl(mesityl)iodonium triflates could smoothly deliver arylated products in good to excellent yields. Addnl., it offers great flexibility by arylating medicinally potent quinolone related heterocycles such as acridin-9(10H)-one, and phenanthridin-6(5H)-one under standard reaction conditions. This strategy was further extended with diphenyleneiodonium triflate to access oxacine fused quinolines. The post-modifications of synthesized products enhance the further utility of this protocol in organic synthesis. To the best of our knowledge, this is the first report on C5 arylation of quinolin-4(1H)-ones using iodine(III) reagents. This study involved multiple reactions and reactants, such as Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4Related Products of 1204518-02-4).

Mesityl(p-tolyl)iodonium trifluoromethanesulfonate (cas: 1204518-02-4) belongs to iodide derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Related Products of 1204518-02-4

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com