Tag: 300-400

Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity was written by Peters, Hannah L.;Jochmans, Dirk;de Wilde, Adriaan H.;Posthuma, Clara C.;Snijder, Eric J.;Neyts, Johan;Seley-Radtke, Katherine L.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2015.HPLC of Formula: 15813-09-9 This article mentions the following:

A series of doubly flexible nucleoside analogs were designed based on the acyclic sugar scaffold of acyclovir and the flex-base moiety found in the fleximers. The target compounds were evaluated for their antiviral potential and found to inhibit several coronaviruses. Significantly, compound 2 displayed selective antiviral activity (CC₅₀ > 3× EC₅₀) towards human coronavirus (HCoV)-NL63 and Middle East respiratory syndrome-coronavirus, but not severe acute respiratory syndrome-coronavirus. In the case of HCoV-NL63 the activity was highly promising with an EC₅₀ <10 μM and a CC₅₀ >100 μM. As such, these doubly flexible nucleoside analogs are viewed as a novel new class of drug candidates with potential for potent inhibition of coronaviruses. In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9HPLC of Formula: 15813-09-9).

4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.HPLC of Formula: 15813-09-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Halogen and Hydrogen Bond Architectures in Switchable Chains of Di- and Trihaloimidazoles was written by Andrzejewski, Michal;Marciniak, Jedrzej;Rajewski, Kacper W.;Katrusiak, Andrzej. And the article was included in Crystal Growth & Design in 2015.Product Details of 15813-09-9 This article mentions the following:

Halogen bonds have been employed for controlling the structure of NH···N hydrogen-bonded chains in halogenated imidazoles; the CH···halogen contacts stabilize the coplanar arrangement of mols., whereas the halogen···halogen contacts twist the mols. around the NH···N bonds and stretch their N···N distances. The interplay of halogen···halogen and NH···N hydrogen bonds leads to isostructural relations of 4,5-dihaloimidazoles as well as between trichloro- and tribromoimidazole. However, the increasing steric hindrance excludes the triiodoimidazole from this isostructural series, and the triiodo derivative forms an unusual structure with three symmetry-independent mols. All sym. substituted 4,5-dichloro-, dibromo-, and diiodoimidazoles as well as trichloro-, tribromo-, and triiodoimidazoles have been synthesized and crystallized and their structures determined The derived rules also apply to the co-crystal structures of 4,5-diiodoimidazole:2,4,5-triiodoimidazole as well as to 4-iodoimidazole:2,4-diiodoimidazole. The halogen interactions prove an efficient means for engineering and tuning new materials with desired dielec. properties relying on highly polarizable NH···N hydrogen bonds. In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9Product Details of 15813-09-9).

4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Product Details of 15813-09-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Design and Synthesis of Pyrrolo[2,3-d]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate was written by Williamson, Douglas S.;Smith, Garrick P.;Mikkelsen, Gitte K.;Jensen, Thomas;Acheson-Dossang, Pamela;Badolo, Lassina;Bedford, Simon T.;Chell, Victoria;Chen, I-Jen;Dokurno, Pawel;Hentzer, Morten;Newland, Samantha;Ray, Stuart C.;Shaw, Terry;Surgenor, Allan E.;Terry, Lindsey;Wang, Yikang;Christensen, Kenneth V.. And the article was included in Journal of Medicinal Chemistry in 2021.Electric Literature of C6H2Cl2IN3 This article mentions the following:

Inhibitors of leucine-rich repeat kinase 2 (LRRK2) and mutants, such as G2019S, have potential utility in Parkinson’s disease treatment. Fragment hit-derived pyrrolo[2,3-d]pyrimidines underwent optimization using X-ray structures of LRRK2 kinase domain surrogates, based on checkpoint kinase 1 (CHK1) and a CHK1 10-point mutant. (2R)-2-Methylpyrrolidin-1-yl derivative I (LRRK2 G2019S cK_i 0.7 nM, LE 0.66) was identified, with increased potency consistent with an X-ray structure of 18/CHK1 10-pt. mutant showing the 2-Me substituent proximal to Ala147 (Ala2016 in LRRK2). Further structure-guided elaboration of I gave the 2-[(1,3-dimethyl-1H-pyrazol-4-yl)amino] deriv II. Optimization of II afforded diastereomeric oxolan-3-yl derivatives III and IV, which demonstrated a favorable in vitro PK profile, although they displayed species disconnects in the in vivo PK profile, and a propensity for P-gp- and/or BCRP-mediated efflux in a mouse model. Compounds III and IV demonstrated high potency and exquisite selectivity for LRRK2 and utility as chem. probes for the study of LRRK2 inhibition. In the experiment, the researchers used many compounds, for example, 2,4-Dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine (cas: 1012785-51-1Electric Literature of C6H2Cl2IN3).

2,4-Dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine (cas: 1012785-51-1) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Electric Literature of C6H2Cl2IN3

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Iodination of alkylbenzenes with iodine and silver nitrite was written by Sy, Wing Wah;Lodge, Bruce A.. And the article was included in Tetrahedron Letters in 1989.Recommanded Product: 3268-21-1 This article mentions the following:

Iodination of alkylbenzenes with iodine and silver nitrite at room temperature gives iodoalkylbenzenes in good yield. Thus iodination of p-xylene gave 43% 2,5-Me₂C₆H₃I. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Recommanded Product: 3268-21-1).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Recommanded Product: 3268-21-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Nickel-catalyzed chelation-assisted direct arylation of unactivated C(sp³)-H bonds with aryl halides was written by Li, Mingliang;Dong, Jiaxing;Huang, Xiaolei;Li, Kaizhi;Wu, Qian;Song, Feijie;You, Jingsong. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2014.SDS of cas: 77350-52-8 This article mentions the following:

In this work, we have disclosed the nickel-catalyzed unactivated β-C(sp³)-H bond arylation of aliphatic acid derivatives with aryl iodides/bromides via bidentate chelation-assistance of an 8-aminoquinoline moiety. E.g., in presence of a Ni catalyst, arylation of 8-quinolinyl-substituted amide I with 4-IC₆H₄OMe gave 83% II. The best results were obtained by using Ni(OTf)₂ as the catalyst, PPh₃ as the ligand, Na₂CO₃ as the base, PivOH, and DMSO as the additives in dry 1,4-dioxane at 160 °C. These preliminary results indicate the intrinsic catalytic potential of nickel metal for unactivated C(sp³)-H bond arylation. In the experiment, the researchers used many compounds, for example, N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8SDS of cas: 77350-52-8).

N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.SDS of cas: 77350-52-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Discovery of imidazoleisoindole derivatives as potent IDO1 inhibitors: Design, synthesis, biological evaluation and computational studies was written by Zou, Yi;Wang, Fang;Wang, Yan;Sun, Qirui;Hu, Yue;Li, Yuezhen;Liu, Wen;Guo, Wenjie;Huang, Zhangjian;Zhang, Yihua;Xu, Qiang;Lai, Yisheng. And the article was included in European Journal of Medicinal Chemistry in 2017.Product Details of 15813-09-9 This article mentions the following:

Indoleamine-2,3-dioxygenase-1 (IDO1) is an attractive target for cancer immunotherapy. Herein, a series of novel imidazoleisoindole derivatives were prepared and evaluated for their ability to inhibit IDO1. Among these, derivative 11r was the most active compound with nanomolar potency in the Hela cell-based assay, while showed negligible cellular toxicity. UV-visible spectra study demonstrated that compounds 11p and 11r bound to IDO1 and coordinated with the heme iron. Furthermore, they could significantly promote T cell proliferation, increase IFN-γ production, and reduce the numbers of Foxp3⁺ regulatory T cells. Finally, induced fit docking (IFD) and quantum mechanics/mol. mechanics (QM/MM) calculation were performed to understand the interactions of these compounds to IDO1 protein, which provided a comprehensive guide for further structural modification and optimization. In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9Product Details of 15813-09-9).

4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Product Details of 15813-09-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Radical Hydrodeiodination of Aryl, Alkenyl, Alkynyl and Alkyl Iodides with an Alcoholate as Organic Chain Reductant through Electron Catalysis was written by Dewanji, Abhishek;Mueck-Lichtenfeld, Christian;Studer, Armido. And the article was included in Angewandte Chemie, International Edition in 2016.HPLC of Formula: 77350-52-8 This article mentions the following:

A simple and efficient method for radical hydrodeiodination is reported. The novel approach uses electron catalysis. In situ generated Na-alcoholates are introduced as radical chain reducing reagents and reactions work with O₂ as cheap initiator. Hydrodeiodination works on aryl, alkenyl, alkynyl iodides and a tert-alkyl iodide also gets reduced applying the method. Albeit less general, the method is also applicable to the reduction of aryl bromides. The novel reagent is successfully used to conduct typical reductive radical cyclization reactions and mechanistic studies are reported. In the experiment, the researchers used many compounds, for example, N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8HPLC of Formula: 77350-52-8).

N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.HPLC of Formula: 77350-52-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Five-component trigonal nanoprism with six dynamic corners was written by Gaikwad, Sudhakar;Lal Saha, Manik;Samanta, Debabrata;Schmittel, Michael. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2017.Recommanded Product: 1,4-Diiodo-2,3,5,6-tetramethylbenzene This article mentions the following:

The metallo-supramol. trigonal prism P is based on five different components and three unlike dynamic coordination motifs: the heteroleptic phenanthroline-terpyridine complex [Zn(1)(4)]²⁺ (HETTAP), the heteroleptic phenanthroline-pyridine complex [Cu(2)(5A)]⁺ (HETPYP-I), and the pyridine → zinc(II)-porphyrin interaction. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Recommanded Product: 1,4-Diiodo-2,3,5,6-tetramethylbenzene).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Recommanded Product: 1,4-Diiodo-2,3,5,6-tetramethylbenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Continuous flow synthesis of the iodination agent 1,3-diiodo-5,5-dimethyl-imidazolidine-2,4-dione telescoped with semi-continuous product isolation was written by Ferreri, Marta;Drageset, Audun;Gambarotti, Cristian;Bjoersvik, Hans-Rene. And the article was included in Reaction Chemistry & Engineering in 2016.Synthetic Route of C3H2I2N2 This article mentions the following:

A batch synthesis to the iodinating agent 1,3-diiodo-5,5-dimethyl-imidazolidine-2,4-dione (DIH) was devised and developed. This batch process was then up-scaled (10x) and optimized by means of statistical exptl. design and multivariate regression. The optimized batch procedure was then transferred and adapted for continuous flow synthesis using a multi-jet oscillating disk (MJOD) continuous flow reactor platform to provide a flow process that allowed a throughput of 47 g h^-1 with a residence time of 9 min. A semi-continuous work-up step based on vacuum filtration was established and successfully telescoped to be an integrated part of the flow process. An 8 h test run using the optimized flow synthesis in combination with the semi-continuous filtration step afforded 375 g (̃ 90% isolated yield) of the pure title compound that was collected from 14 filtration batches of 25-27 g each. In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9Synthetic Route of C3H2I2N2).

4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Synthetic Route of C3H2I2N2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Two-point halogen bonding between 3,6-dihalopyromellitic diimides was written by Cao, Dennis;Hong, Michael;Blackburn, Anthea K.;Liu, Zhichang;Holcroft, James M.;Stoddart, J. Fraser. And the article was included in Chemical Science in 2014.HPLC of Formula: 3268-21-1 This article mentions the following:

The syntheses of 3,6-dichloro-, -dibromo-, and -diiodopyromellitic diimides-ACl, ABr, and AI, resp.-have been achieved. X-Ray crystallog. of single crystals of ACl and ABr unveils the formation of extensive halogen-bonding networks in the solid state as a consequence of interactions between the lone pairs on the carbonyl oxygen atoms with the σ-holes of the halogen atoms. Further, the solid-state superstructure of diiodopyromellitic diimide is characterized by the formation of associated halogen-π dimers. The co-crystallization of ACl or ABr with a 1,5-diaminonaphthalene derivative DN yields co-crystals of a mixed-stack charge-transfer (CT) complex which are supported by an expansive hydrogen-bonded network in addition to halogen-bonded belts that bring adjacent mixed-stacks into association with each other. 2,6-Dimethoxynaphthalene (DO) proved to be an effective CT complement to AI, yielding solvent-free co-crystals with superstructures which are comprised of a 1 : 2 ratio of AI to DO. This dimeric halogen-bonding motif is reminiscent of the formation of hydrogen-bonded dimers between carboxylic acids. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1HPLC of Formula: 3268-21-1).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.HPLC of Formula: 3268-21-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com